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MGI:H2-Aa
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | H2-Aa ( synonyms: A alpha, Aalpha, H-2Aa, I-Aalpha, Ia-1, Ia1 ) | |
| Protein Name(s) | histocompatibility 2, class II antigen A, alpha, | |
| External Links | ||
| MGI | MGI:95895 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0002504 |
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0491 |
P |
From MGI |
||
| GO:0005515 |
protein binding |
MGI:MGI:3033762 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005764 |
lysosome |
MGI:MGI:3033879 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:3033879 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006955 |
immune response |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:1933465 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:2671681 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:3033881 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:52620 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:79110 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:79111 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:79272 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016020 |
membrane |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0016021 |
integral to membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0812 |
C |
From MGI |
||
| GO:0019882 |
antigen processing and presentation |
MGI:MGI:3033881 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0019886 |
antigen processing and presentation of exogenous peptide antigen via MHC class II |
MGI:MGI:1913231 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0019886 |
antigen processing and presentation of exogenous peptide antigen via MHC class II |
MGI:MGI:2153656 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0019886 |
antigen processing and presentation of exogenous peptide antigen via MHC class II |
MGI:MGI:2671681 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0019886 |
antigen processing and presentation of exogenous peptide antigen via MHC class II |
MGI:MGI:3033881 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0019886 |
antigen processing and presentation of exogenous peptide antigen via MHC class II |
MGI:MGI:3033882 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0019886 |
antigen processing and presentation of exogenous peptide antigen via MHC class II |
MGI:MGI:52620 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0019886 |
antigen processing and presentation of exogenous peptide antigen via MHC class II |
MGI:MGI:79110 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0019886 |
antigen processing and presentation of exogenous peptide antigen via MHC class II |
MGI:MGI:79111 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0034341 |
response to interferon-gamma |
MGI:MGI:5009185 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0042130 |
negative regulation of T cell proliferation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042605 |
peptide antigen binding |
MGI:MGI:1913231 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0042605 |
peptide antigen binding |
MGI:MGI:3033881 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0042613 |
MHC class II protein complex |
MGI:MGI:1933465 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0042613 |
MHC class II protein complex |
MGI:MGI:2671681 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0042613 |
MHC class II protein complex |
MGI:MGI:3033762 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0042613 |
MHC class II protein complex |
MGI:MGI:52620 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0042613 |
MHC class II protein complex |
MGI:MGI:79110 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0042613 |
MHC class II protein complex |
MGI:MGI:79111 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0042613 |
MHC class II protein complex |
MGI:MGI:79272 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0045582 |
positive regulation of T cell differentiation |
MGI:MGI:79111 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0046982 |
protein heterodimerization activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0048002 |
antigen processing and presentation of peptide antigen |
MGI:MGI:1913231 |
IDA: Inferred from Direct Assay |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Karlsson L et al. (1994) Reconstitution of an operational MHC class II compartment in nonantigen-presenting cells. Science 266: 1569-73 PubMed GONUTS page
- ↑ 2.0 2.1 Lankar D et al. (2002) Dynamics of major histocompatibility complex class II compartments during B cell receptor-mediated cell activation. J Exp Med 195: 461-72 PubMed GONUTS page
- ↑ 3.0 3.1 Walter W et al. (2001) H2-Mbeta 1 and H2-Mbeta 2 heterodimers equally promote clip removal in I-A(q) molecules from autoimmune-prone DBA/1 mice. J Biol Chem 276: 11086-91 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Liljedahl M et al. (1998) Altered antigen presentation in mice lacking H2-O. Immunity 8: 233-43 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Kovats S et al. (1998) Invariant chain-independent function of H-2M in the formation of endogenous peptide-major histocompatibility complex class II complexes in vivo. J Exp Med 187: 245-51 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Viville S et al. (1993) Mice lacking the MHC class II-associated invariant chain. Cell 72: 635-48 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 Miyazaki T et al. (1996) Mice lacking H2-M complexes, enigmatic elements of the MHC class II peptide-loading pathway. Cell 84: 531-41 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 Martin WD et al. (1996) H2-M mutant mice are defective in the peptide loading of class II molecules, antigen presentation, and T cell repertoire selection. Cell 84: 543-50 PubMed GONUTS page
- ↑ 9.0 9.1 Fung-Leung WP et al. (1996) Antigen presentation and T cell development in H2-M-deficient mice. Science 271: 1278-81 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 Perraudeau M et al. (2000) Altered major histocompatibility complex class II peptide loading in H2-O-deficient mice. Eur J Immunol 30: 2871-80 PubMed GONUTS page
- ↑ Alfonso C et al. (2001) The impact of H2-DM on humoral immune responses. J Immunol 167: 6348-55 PubMed GONUTS page
- ↑ Walter W et al. (2000) MHC class II antigen presentation pathway in murine tumours: tumour evasion from immunosurveillance? Br J Cancer 83: 1192-201 PubMed GONUTS page
- ↑ Lüder CG et al. (2001) Toxoplasma gondii down-regulates MHC class II gene expression and antigen presentation by murine macrophages via interference with nuclear translocation of STAT1alpha. Eur J Immunol 31: 1475-84 PubMed GONUTS page
