MGI:Gsk3b

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000166	nucleotide binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0547	F	From MGI
	GO:0000320	re-entry into mitotic cell cycle	MGI:MGI:2448203 PMID:12502791^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0001085	RNA polymerase II transcription factor binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P49841	F	From MGI
	GO:0001837	epithelial to mesenchymal transition	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P49841	P	From MGI
	GO:0001954	positive regulation of cell-matrix adhesion	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P49841	P	From MGI
	GO:0002039	p53 binding	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:P49841	F	From MGI
	GO:0004672	protein kinase activity	MGI:MGI:3028410 PMID:14730361^[2]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0004674	protein serine/threonine kinase activity	MGI:MGI:1860704 PMID:10894547^[3]	ISS: Inferred from Sequence or Structural Similarity		F	From MGI
	GO:0004674	protein serine/threonine kinase activity	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:P49841	F	From MGI
	GO:0004674	protein serine/threonine kinase activity	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:P49841	F	From MGI
	GO:0004674	protein serine/threonine kinase activity	MGI:MGI:2664026 PMID:12805290^[4]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0004674	protein serine/threonine kinase activity	MGI:MGI:3793516 PMID:17986005^[5]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0004674	protein serine/threonine kinase activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P18266	F	From MGI
	GO:0004674	protein serine/threonine kinase activity	MGI:MGI:5306704 PMID:22057101^[6]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0005178	integrin binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P18266	F	From MGI
	GO:0005515	protein binding	MGI:MGI:2447521 PMID:12432063^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q60737	F	From MGI
	GO:0005515	protein binding	MGI:MGI:2664026 PMID:12805290^[4]	IPI: Inferred from Physical Interaction	UniProtKB:P49769	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3616720 PMID:16510873^[8]	IPI: Inferred from Physical Interaction	UniProtKB:Q6PF82	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3663202 PMID:16959610^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q9WUA5	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3695869 PMID:17182001^[10]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Z0P7	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3817405 PMID:18632848^[11]	IPI: Inferred from Physical Interaction	UniProtKB:O35625	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3839710 PMID:19047045^[12]	IPI: Inferred from Physical Interaction	UniPRotKB:Q04887 UniProtKB:Q3ULA2	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3841497 PMID:19303846^[13]	IPI: Inferred from Physical Interaction	UniProtKB:Q811T9	F	From MGI
	GO:0005515	protein binding	MGI:MGI:4835403 PMID:18721193^[14]	IPI: Inferred from Physical Interaction	UniProtKB:O75581	F	From MGI
	GO:0005515	protein binding	MGI:MGI:4839439 PMID:19107203^[15]	IPI: Inferred from Physical Interaction	UniProtKB:O75581	F	From MGI
	GO:0005515	protein binding	MGI:MGI:5306704 PMID:22057101^[6]	IPI: Inferred from Physical Interaction	UniProtKB:O08553 UniProtKB:P31750	F	From MGI
	GO:0005524	ATP binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P18266	F	From MGI
	GO:0005625	soluble fraction	MGI:MGI:3616720 PMID:16510873^[8]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005625	soluble fraction	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P18266	C	From MGI
	GO:0005634	nucleus	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:P49841	C	From MGI
	GO:0005634	nucleus	MGI:MGI:2448203 PMID:12502791^[1]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:P49841	C	From MGI
	GO:0005813	centrosome	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P49841	C	From MGI
	GO:0005829	cytosol	MGI:MGI:2448203 PMID:12502791^[1]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005829	cytosol	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P18266	C	From MGI
	GO:0005886	plasma membrane	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P49841	C	From MGI
	GO:0005975	carbohydrate metabolic process	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0119	P	From MGI
	GO:0005977	glycogen metabolic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P49841	P	From MGI
	GO:0006349	regulation of gene expression by genetic imprinting	MGI:MGI:5009774 PMID:21047779^[16]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0006468	protein phosphorylation	MGI:MGI:2447521 PMID:12432063^[7]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0006468	protein phosphorylation	MGI:MGI:2664026 PMID:12805290^[4]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0006468	protein phosphorylation	MGI:MGI:3028410 PMID:14730361^[2]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0006468	protein phosphorylation	MGI:MGI:3689248 PMID:17026964^[17]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0006468	protein phosphorylation	MGI:MGI:3844787 PMID:19141611^[18]	IGI: Inferred from Genetic Interaction	MGI:MGI:1919364	P	From MGI
	GO:0006468	protein phosphorylation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P18266	P	From MGI
	GO:0006468	protein phosphorylation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P49841	P	From MGI
	GO:0006611	protein export from nucleus	MGI:MGI:2157270 PMID:11782539^[19]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0006916	anti-apoptosis	MGI:MGI:1860704 PMID:10894547^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1888887	P	From MGI
	GO:0006917	induction of apoptosis	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P18266	P	From MGI
	GO:0006950	response to stress	MGI:MGI:2157270 PMID:11782539^[19]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0006983	ER overload response	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:P49841	P	From MGI
	GO:0006983	ER overload response	MGI:MGI:3032464 PMID:14744935^[20]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0007010	cytoskeleton organization	MGI:MGI:5306704 PMID:22057101^[6]	TAS: Traceable Author Statement		P	From MGI
	GO:0007163	establishment or maintenance of cell polarity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P18266	P	From MGI
	GO:0007275	multicellular organismal development	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0217	P	From MGI
	GO:0007399	nervous system development	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0524	P	From MGI
	GO:0007409	axonogenesis	MGI:MGI:3806438 PMID:18716223^[21]	IGI: Inferred from Genetic Interaction	MGI:MGI:98956	P	From MGI
	GO:0007520	myoblast fusion	MGI:MGI:3522557 PMID:15282335^[22]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0007520	myoblast fusion	MGI:MGI:3522557 PMID:15282335^[22]	IGI: Inferred from Genetic Interaction	MGI:MGI:98573	P	From MGI
	GO:0008013	beta-catenin binding	MGI:MGI:2677113 PMID:12874278^[23]	IPI: Inferred from Physical Interaction	UniProtKB:Q02248	F	From MGI
	GO:0008013	beta-catenin binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P49841	F	From MGI
	GO:0008283	cell proliferation	MGI:MGI:1860704 PMID:10894547^[3]	TAS: Traceable Author Statement		P	From MGI
	GO:0009887	organ morphogenesis	MGI:MGI:1860704 PMID:10894547^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1888887	P	From MGI
	GO:0009968	negative regulation of signal transduction	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0734	P	From MGI
	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	MGI:MGI:3793516 PMID:17986005^[5]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0014902	myotube differentiation	MGI:MGI:3522557 PMID:15282335^[22]	IGI: Inferred from Genetic Interaction	MGI:MGI:98573	P	From MGI
	GO:0016020	membrane	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P18266	C	From MGI
	GO:0016055	Wnt receptor signaling pathway	MGI:MGI:3640889 PMID:16815997^[24]	IGI: Inferred from Genetic Interaction	MGI:MGI:108559	P	From MGI
	GO:0016301	kinase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P49841	F	From MGI
	GO:0016310	phosphorylation	MGI:MGI:3695869 PMID:17182001^[10]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0016477	cell migration	MGI:MGI:3793516 PMID:17986005^[5]	IGI: Inferred from Genetic Interaction	MGI:MGI:98958	P	From MGI
	GO:0016740	transferase activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0808	F	From MGI
	GO:0016772	transferase activity, transferring phosphorus-containing groups	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR011009	F	From MGI
	GO:0018105	peptidyl-serine phosphorylation	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:P49841	P	From MGI
	GO:0018105	peptidyl-serine phosphorylation	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:P49841	P	From MGI
	GO:0018105	peptidyl-serine phosphorylation	MGI:MGI:3793516 PMID:17986005^[5]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0019901	protein kinase binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P18266	F	From MGI
	GO:0019901	protein kinase binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P49841	F	From MGI
	GO:0021766	hippocampus development	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P49841	P	From MGI
	GO:0030010	establishment of cell polarity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P18266	P	From MGI
	GO:0030154	cell differentiation	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0221	P	From MGI
	GO:0030426	growth cone	MGI:MGI:2664026 PMID:12805290^[4]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0030529	ribonucleoprotein complex	MGI:MGI:5085959 PMID:21709260^[25]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0030877	beta-catenin destruction complex	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P18266	C	From MGI
	GO:0030877	beta-catenin destruction complex	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P49841	C	From MGI
	GO:0031333	negative regulation of protein complex assembly	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P49841	P	From MGI
	GO:0031334	positive regulation of protein complex assembly	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P49841	P	From MGI
	GO:0031625	ubiquitin protein ligase binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P49841	F	From MGI
	GO:0032091	negative regulation of protein binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P49841	P	From MGI
	GO:0032092	positive regulation of protein binding	MGI:MGI:3844787 PMID:19141611^[18]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0032855	positive regulation of Rac GTPase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P49841	P	From MGI
	GO:0032886	regulation of microtubule-based process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P49841	P	From MGI
	GO:0032886	regulation of microtubule-based process	MGI:MGI:4947903 PMID:21295697^[26]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0033138	positive regulation of peptidyl-serine phosphorylation	MGI:MGI:3793516 PMID:17986005^[5]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0034236	protein kinase A catalytic subunit binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P49841	F	From MGI
	GO:0034747	Axin-APC-beta-catenin-GSK3B complex	MGI:MGI:1336856 PMID:10318824^[27]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0034747	Axin-APC-beta-catenin-GSK3B complex	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P18266	C	From MGI
	GO:0034747	Axin-APC-beta-catenin-GSK3B complex	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P49841	C	From MGI
	GO:0035255	ionotropic glutamate receptor binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P18266	F	From MGI
	GO:0035372	protein localization to microtubule	MGI:MGI:3806438 PMID:18716223^[21]	IGI: Inferred from Genetic Interaction	MGI:MGI:94941	P	From MGI
	GO:0035556	intracellular signal transduction	MGI:MGI:3027417 PMID:14749367^[28]	ISO: Inferred from Sequence Orthology	UniProtKB:P49841	P	From MGI
	GO:0043025	neuronal cell body	MGI:MGI:2664026 PMID:12805290^[4]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0043066	negative regulation of apoptotic process	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:P49841	P	From MGI
	GO:0043197	dendritic spine	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P18266	C	From MGI
	GO:0043198	dendritic shaft	MGI:MGI:2664026 PMID:12805290^[4]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0043227	membrane-bounded organelle	MGI:MGI:2664026 PMID:12805290^[4]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0043234	protein complex	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P18266	C	From MGI
	GO:0043407	negative regulation of MAP kinase activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P18266	P	From MGI
	GO:0044027	hypermethylation of CpG island	MGI:MGI:5009774 PMID:21047779^[16]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0044337	canonical Wnt receptor signaling pathway involved in positive regulation of apoptotic process	MGI:MGI:4821081 PMID:12154096^[29]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0045121	membrane raft	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P18266	C	From MGI
	GO:0045444	fat cell differentiation	MGI:MGI:2448203 PMID:12502791^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045892	negative regulation of transcription, DNA-dependent	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P18266	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:5009774 PMID:21047779^[16]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0046827	positive regulation of protein export from nucleus	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:P49841	P	From MGI
	GO:0048156	tau protein binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P18266	F	From MGI
	GO:0048168	regulation of neuronal synaptic plasticity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P18266	P	From MGI
	GO:0050321	tau-protein kinase activity	MGI:MGI:3047434 PMID:15192701^[30]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0050321	tau-protein kinase activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P18266	F	From MGI
	GO:0050321	tau-protein kinase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P49841	F	From MGI
	GO:0050774	negative regulation of dendrite morphogenesis	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P18266	P	From MGI
	GO:0051059	NF-kappaB binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P49841	F	From MGI
	GO:0051534	negative regulation of NFAT protein import into nucleus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P49841	P	From MGI
	GO:0060070	canonical Wnt receptor signaling pathway	MGI:MGI:3522557 PMID:15282335^[22]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0060070	canonical Wnt receptor signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P49841	P	From MGI
	GO:0071109	superior temporal gyrus development	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P49841	P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Tang QQ et al. (2003) Mitotic clonal expansion: a synchronous process required for adipogenesis. Proc Natl Acad Sci U S A 100: 44-9 PubMed GONUTS page
↑ ^2.0 ^2.1 Song J et al. (2004) The costimulation-regulated duration of PKB activation controls T cell longevity. Nat Immunol 5: 150-8 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Hoeflich KP et al. (2000) Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation. Nature 406: 86-90 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Pigino G et al. (2003) Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport. J Neurosci 23: 4499-508 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Yamamoto H et al. (2007) Wnt5a modulates glycogen synthase kinase 3 to induce phosphorylation of receptor tyrosine kinase Ror2. Genes Cells 12: 1215-23 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Wakatsuki S et al. (2011) ZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B-dependent CRMP2 phosphorylation. Nat Cell Biol 13: 1415-23 PubMed GONUTS page
↑ ^7.0 ^7.1 Bek S & Kemler R (2002) Protein kinase CKII regulates the interaction of beta-catenin with alpha-catenin and its protein stability. J Cell Sci 115: 4743-53 PubMed GONUTS page
↑ ^8.0 ^8.1 Wu X et al. (2006) Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin. Genes Dev 20: 571-85 PubMed GONUTS page
↑ Wang Y et al. (2006) Epm2a suppresses tumor growth in an immunocompromised host by inhibiting Wnt signaling. Cancer Cell 10: 179-90 PubMed GONUTS page
↑ ^10.0 ^10.1 Takenaka K et al. (2007) GSK3beta positively regulates Hedgehog signaling through Sufu in mammalian cells. Biochem Biophys Res Commun 353: 501-8 PubMed GONUTS page
↑ Kim MJ et al. (2008) SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability. FASEB J 22: 3785-94 PubMed GONUTS page
↑ Topol L et al. (2009) Sox9 inhibits Wnt signaling by promoting beta-catenin phosphorylation in the nucleus. J Biol Chem 284: 3323-33 PubMed GONUTS page
↑ Mao Y et al. (2009) Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling. Cell 136: 1017-31 PubMed GONUTS page
↑ Lappalainen S et al. (2009) LRP5 in premature adrenarche and in metabolic characteristics of prepubertal children. Clin Endocrinol (Oxf) 70: 725-31 PubMed GONUTS page
↑ Piao S et al. (2008) Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling. PLoS One 3: e4046 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 Popkie AP et al. (2010) Phosphatidylinositol 3-kinase (PI3K) signaling via glycogen synthase kinase-3 (Gsk-3) regulates DNA methylation of imprinted loci. J Biol Chem 285: 41337-47 PubMed GONUTS page
↑ Yeh TY et al. (2006) Mitotic phosphorylation of tankyrase, a PARP that promotes spindle assembly, by GSK3. Biochem Biophys Res Commun 350: 574-9 PubMed GONUTS page
↑ ^18.0 ^18.1 Chen T et al. (2009) Identification of zinc-finger BED domain-containing 3 (Zbed3) as a novel Axin-interacting protein that activates Wnt/beta-catenin signaling. J Biol Chem 284: 6683-9 PubMed GONUTS page
↑ ^19.0 ^19.1 Antos CL et al. (2002) Activated glycogen synthase-3 beta suppresses cardiac hypertrophy in vivo. Proc Natl Acad Sci U S A 99: 907-12 PubMed GONUTS page
↑ Qu L et al. (2004) Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. Genes Dev 18: 261-77 PubMed GONUTS page
↑ ^21.0 ^21.1 Purro SA et al. (2008) Wnt regulates axon behavior through changes in microtubule growth directionality: a new role for adenomatous polyposis coli. J Neurosci 28: 8644-54 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 ^22.3 Rochat A et al. (2004) Insulin and wnt1 pathways cooperate to induce reserve cell activation in differentiation and myotube hypertrophy. Mol Biol Cell 15: 4544-55 PubMed GONUTS page
↑ Kanamori M et al. (2003) The PDZ protein tax-interacting protein-1 inhibits beta-catenin transcriptional activity and growth of colorectal cancer cells. J Biol Chem 278: 38758-64 PubMed GONUTS page
↑ Chen HJ et al. (2006) The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway. Genes Dev 20: 1933-45 PubMed GONUTS page
↑ Sharma S et al. (2011) Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex. Proc Natl Acad Sci U S A 108: 11381-6 PubMed GONUTS page
↑ Wu X et al. (2011) Skin stem cells orchestrate directional migration by regulating microtubule-ACF7 connections through GSK3β. Cell 144: 341-52 PubMed GONUTS page
↑ Sakanaka C & Williams LT (1999) Functional domains of axin. Importance of the C terminus as an oligomerization domain. J Biol Chem 274: 14090-3 PubMed GONUTS page
↑ Remy I & Michnick SW (2004) Regulation of apoptosis by the Ft1 protein, a new modulator of protein kinase B/Akt. Mol Cell Biol 24: 1493-504 PubMed GONUTS page
↑ Longo KA et al. (2002) Wnt signaling protects 3T3-L1 preadipocytes from apoptosis through induction of insulin-like growth factors. J Biol Chem 277: 38239-44 PubMed GONUTS page
↑ Baki L et al. (2004) PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations. EMBO J 23: 2586-96 PubMed GONUTS page

[PMID:12502791-0] 1.0 ^1.1 ^1.2 ^1.3 Tang QQ et al. (2003) Mitotic clonal expansion: a synchronous process required for adipogenesis. Proc Natl Acad Sci U S A 100: 44-9 PubMed GONUTS page

[PMID:14730361-1] 2.0 ^2.1 Song J et al. (2004) The costimulation-regulated duration of PKB activation controls T cell longevity. Nat Immunol 5: 150-8 PubMed GONUTS page

[PMID:10894547-2] 3.0 ^3.1 ^3.2 ^3.3 Hoeflich KP et al. (2000) Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation. Nature 406: 86-90 PubMed GONUTS page

[PMID:12805290-3] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Pigino G et al. (2003) Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport. J Neurosci 23: 4499-508 PubMed GONUTS page

[PMID:17986005-4] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Yamamoto H et al. (2007) Wnt5a modulates glycogen synthase kinase 3 to induce phosphorylation of receptor tyrosine kinase Ror2. Genes Cells 12: 1215-23 PubMed GONUTS page

[PMID:22057101-5] 6.0 ^6.1 ^6.2 Wakatsuki S et al. (2011) ZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B-dependent CRMP2 phosphorylation. Nat Cell Biol 13: 1415-23 PubMed GONUTS page

[PMID:12432063-6] 7.0 ^7.1 Bek S & Kemler R (2002) Protein kinase CKII regulates the interaction of beta-catenin with alpha-catenin and its protein stability. J Cell Sci 115: 4743-53 PubMed GONUTS page

[PMID:16510873-7] 8.0 ^8.1 Wu X et al. (2006) Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin. Genes Dev 20: 571-85 PubMed GONUTS page

[PMID:16959610-8] Wang Y et al. (2006) Epm2a suppresses tumor growth in an immunocompromised host by inhibiting Wnt signaling. Cancer Cell 10: 179-90 PubMed GONUTS page

[PMID:17182001-9] 10.0 ^10.1 Takenaka K et al. (2007) GSK3beta positively regulates Hedgehog signaling through Sufu in mammalian cells. Biochem Biophys Res Commun 353: 501-8 PubMed GONUTS page

[PMID:18632848-10] Kim MJ et al. (2008) SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability. FASEB J 22: 3785-94 PubMed GONUTS page

[PMID:19047045-11] Topol L et al. (2009) Sox9 inhibits Wnt signaling by promoting beta-catenin phosphorylation in the nucleus. J Biol Chem 284: 3323-33 PubMed GONUTS page

[PMID:19303846-12] Mao Y et al. (2009) Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling. Cell 136: 1017-31 PubMed GONUTS page

[PMID:18721193-13] Lappalainen S et al. (2009) LRP5 in premature adrenarche and in metabolic characteristics of prepubertal children. Clin Endocrinol (Oxf) 70: 725-31 PubMed GONUTS page

[PMID:19107203-14] Piao S et al. (2008) Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling. PLoS One 3: e4046 PubMed GONUTS page

[PMID:21047779-15] 16.0 ^16.1 ^16.2 Popkie AP et al. (2010) Phosphatidylinositol 3-kinase (PI3K) signaling via glycogen synthase kinase-3 (Gsk-3) regulates DNA methylation of imprinted loci. J Biol Chem 285: 41337-47 PubMed GONUTS page

[PMID:17026964-16] Yeh TY et al. (2006) Mitotic phosphorylation of tankyrase, a PARP that promotes spindle assembly, by GSK3. Biochem Biophys Res Commun 350: 574-9 PubMed GONUTS page

[PMID:19141611-17] 18.0 ^18.1 Chen T et al. (2009) Identification of zinc-finger BED domain-containing 3 (Zbed3) as a novel Axin-interacting protein that activates Wnt/beta-catenin signaling. J Biol Chem 284: 6683-9 PubMed GONUTS page

[PMID:11782539-18] 19.0 ^19.1 Antos CL et al. (2002) Activated glycogen synthase-3 beta suppresses cardiac hypertrophy in vivo. Proc Natl Acad Sci U S A 99: 907-12 PubMed GONUTS page

[PMID:14744935-19] Qu L et al. (2004) Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. Genes Dev 18: 261-77 PubMed GONUTS page

[PMID:18716223-20] 21.0 ^21.1 Purro SA et al. (2008) Wnt regulates axon behavior through changes in microtubule growth directionality: a new role for adenomatous polyposis coli. J Neurosci 28: 8644-54 PubMed GONUTS page

[PMID:15282335-21] 22.0 ^22.1 ^22.2 ^22.3 Rochat A et al. (2004) Insulin and wnt1 pathways cooperate to induce reserve cell activation in differentiation and myotube hypertrophy. Mol Biol Cell 15: 4544-55 PubMed GONUTS page

[PMID:12874278-22] Kanamori M et al. (2003) The PDZ protein tax-interacting protein-1 inhibits beta-catenin transcriptional activity and growth of colorectal cancer cells. J Biol Chem 278: 38758-64 PubMed GONUTS page

[PMID:16815997-23] Chen HJ et al. (2006) The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway. Genes Dev 20: 1933-45 PubMed GONUTS page

[PMID:21709260-24] Sharma S et al. (2011) Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex. Proc Natl Acad Sci U S A 108: 11381-6 PubMed GONUTS page

[PMID:21295697-25] Wu X et al. (2011) Skin stem cells orchestrate directional migration by regulating microtubule-ACF7 connections through GSK3β. Cell 144: 341-52 PubMed GONUTS page

[PMID:10318824-26] Sakanaka C & Williams LT (1999) Functional domains of axin. Importance of the C terminus as an oligomerization domain. J Biol Chem 274: 14090-3 PubMed GONUTS page

[PMID:14749367-27] Remy I & Michnick SW (2004) Regulation of apoptosis by the Ft1 protein, a new modulator of protein kinase B/Akt. Mol Cell Biol 24: 1493-504 PubMed GONUTS page

[PMID:12154096-28] Longo KA et al. (2002) Wnt signaling protects 3T3-L1 preadipocytes from apoptosis through induction of insulin-like growth factors. J Biol Chem 277: 38239-44 PubMed GONUTS page

[PMID:15192701-29] Baki L et al. (2004) PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations. EMBO J 23: 2586-96 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Gsk3b ( synonyms: GSK-3, GSK-3beta, GSK3 )
Protein Name(s)	glycogen synthase kinase 3 beta,
External Links
MGI	MGI:1861437

MGI:Gsk3b

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