MGI:Gpr98

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0002142	stereocilia ankle link complex	MGI:MGI:3714249 PMID:17567809^[1]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0004871	signal transducer activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0807	F	From MGI
	GO:0004872	receptor activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0675	F	From MGI
	GO:0004888	transmembrane signaling receptor activity	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR017981	F	From MGI
	GO:0004930	G-protein coupled receptor activity	MGI:MGI:2156124 PMID:11606593^[2]	NAS: Non-traceable Author Statement		F	From MGI
	GO:0005509	calcium ion binding	MGI:MGI:2156124 PMID:11606593^[2]	NAS: Non-traceable Author Statement		F	From MGI
	GO:0005509	calcium ion binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q8WXG9	F	From MGI
	GO:0005576	extracellular region	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0964	C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q8WXG9	C	From MGI
	GO:0005886	plasma membrane	MGI:MGI:3629345 PMID:16775142^[3]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0007154	cell communication	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR003644	P	From MGI
	GO:0007165	signal transduction	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0807	P	From MGI
	GO:0007166	cell surface receptor signaling pathway	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR017981	P	From MGI
	GO:0007218	neuropeptide signaling pathway	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR000203	P	From MGI
	GO:0007275	multicellular organismal development	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0217	P	From MGI
	GO:0007399	nervous system development	MGI:MGI:2156124 PMID:11606593^[2]	NAS: Non-traceable Author Statement		P	From MGI
	GO:0007601	visual perception	MGI:MGI:3629345 PMID:16775142^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3046273	P	From MGI
	GO:0007605	sensory perception of sound	MGI:MGI:3575610 PMID:15820310^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2389570	P	From MGI
	GO:0007605	sensory perception of sound	MGI:MGI:3695056 PMID:16137990^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2389570	P	From MGI
	GO:0007605	sensory perception of sound	MGI:MGI:3703302 PMID:17329413^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3708270	P	From MGI
	GO:0007605	sensory perception of sound	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q8WXG9	P	From MGI
	GO:0009986	cell surface	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q8WXG9	C	From MGI
	GO:0016020	membrane	MGI:MGI:2156124 PMID:11606593^[2]	NAS: Non-traceable Author Statement		C	From MGI
	GO:0016021	integral to membrane	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0812	C	From MGI
	GO:0016021	integral to membrane	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR003644 InterPro:IPR000832	C	From MGI
	GO:0016337	cell-cell adhesion	MGI:MGI:2156124 PMID:11606593^[2]	NAS: Non-traceable Author Statement		P	From MGI
	GO:0017022	myosin binding	MGI:MGI:3714249 PMID:17567809^[1]	IPI: Inferred from Physical Interaction	UniProtKB:P97479	F	From MGI
	GO:0045494	photoreceptor cell maintenance	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q8WXG9	P	From MGI
	GO:0048496	maintenance of organ identity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q8WXG9	P	From MGI
	GO:0048839	inner ear development	MGI:MGI:3629345 PMID:16775142^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3046273	P	From MGI
	GO:0050877	neurological system process	MGI:MGI:2149857 PMID:11545713^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2389570	P	From MGI
	GO:0050877	neurological system process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q8WXG9	P	From MGI
	GO:0050896	response to stimulus	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0716	P	From MGI
	GO:0050910	detection of mechanical stimulus involved in sensory perception of sound	MGI:MGI:3629345 PMID:16775142^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3046273	P	From MGI
	GO:0050953	sensory perception of light stimulus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q8WXG9	P	From MGI
	GO:0060122	inner ear receptor stereocilium organization	MGI:MGI:3714249 PMID:17567809^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3527179	P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Michalski N et al. (2007) Molecular characterization of the ankle-link complex in cochlear hair cells and its role in the hair bundle functioning. J Neurosci 27: 6478-88 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 McMillan DR et al. (2002) Very large G protein-coupled receptor-1, the largest known cell surface protein, is highly expressed in the developing central nervous system. J Biol Chem 277: 785-92 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 McGee J et al. (2006) The very large G-protein-coupled receptor VLGR1: a component of the ankle link complex required for the normal development of auditory hair bundles. J Neurosci 26: 6543-53 PubMed GONUTS page
↑ Johnson KR et al. (2005) The Mass1frings mutation underlies early onset hearing impairment in BUB/BnJ mice, a model for the auditory pathology of Usher syndrome IIC. Genomics 85: 582-90 PubMed GONUTS page
↑ Klein BD et al. (2005) Auditory deficits associated with the frings mgr1 (mass1) mutation in mice. Dev Neurosci 27: 321-32 PubMed GONUTS page
↑ Schwander M et al. (2007) A forward genetics screen in mice identifies recessive deafness traits and reveals that pejvakin is essential for outer hair cell function. J Neurosci 27: 2163-75 PubMed GONUTS page
↑ Skradski SL et al. (2001) A novel gene causing a mendelian audiogenic mouse epilepsy. Neuron 31: 537-44 PubMed GONUTS page

[PMID:17567809-0] 1.0 ^1.1 ^1.2 Michalski N et al. (2007) Molecular characterization of the ankle-link complex in cochlear hair cells and its role in the hair bundle functioning. J Neurosci 27: 6478-88 PubMed GONUTS page

[PMID:11606593-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 McMillan DR et al. (2002) Very large G protein-coupled receptor-1, the largest known cell surface protein, is highly expressed in the developing central nervous system. J Biol Chem 277: 785-92 PubMed GONUTS page

[PMID:16775142-2] 3.0 ^3.1 ^3.2 ^3.3 McGee J et al. (2006) The very large G-protein-coupled receptor VLGR1: a component of the ankle link complex required for the normal development of auditory hair bundles. J Neurosci 26: 6543-53 PubMed GONUTS page

[PMID:15820310-3] Johnson KR et al. (2005) The Mass1frings mutation underlies early onset hearing impairment in BUB/BnJ mice, a model for the auditory pathology of Usher syndrome IIC. Genomics 85: 582-90 PubMed GONUTS page

[PMID:16137990-4] Klein BD et al. (2005) Auditory deficits associated with the frings mgr1 (mass1) mutation in mice. Dev Neurosci 27: 321-32 PubMed GONUTS page

[PMID:17329413-5] Schwander M et al. (2007) A forward genetics screen in mice identifies recessive deafness traits and reveals that pejvakin is essential for outer hair cell function. J Neurosci 27: 2163-75 PubMed GONUTS page

[PMID:11545713-6] Skradski SL et al. (2001) A novel gene causing a mendelian audiogenic mouse epilepsy. Neuron 31: 537-44 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Gpr98 ( synonyms: Mass1, Mgr1, VLGR1 )
Protein Name(s)	G protein-coupled receptor 98,
External Links
MGI	MGI:1274784

MGI:Gpr98

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