MGI:Gnas

From GONUTS

Jump to: navigation, search

Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Gnas ( synonyms: G alpha s, Galphas, Gnas1, Gnasxl, Gs alpha, Gs-alpha, Gsa, Nesp, Nesp55, Nespl, neuroendocrine-specific Golgi protein p55 isoform 1, Oedsml, P1, P2, P3, XLalphas )
Protein Name(s)	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus,
External Links
MGI	MGI:95777

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000166	nucleotide binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0547	F	From MGI
	GO:0001501	skeletal system development	MGI:MGI:3619837 PMID:15797856^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3043361	P	From MGI
	GO:0001726	ruffle	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P63095	C	From MGI
	GO:0001894	tissue homeostasis	MGI:MGI:4454202 PMID:20427744^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:4459474	P	From MGI
	GO:0001958	endochondral ossification	MGI:MGI:3619837 PMID:15797856^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3043361	P	From MGI
	GO:0001965	G-protein alpha-subunit binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P63095	F	From MGI
	GO:0003924	GTPase activity	MGI:MGI:4459044		PANTHER:PTHR10218	F	From MGI
	GO:0003924	GTPase activity	MGI:MGI:56877 PMID:3092218^[3]	ISA: Inferred from Sequence Alignment	EMBL:M13006	F	From MGI
	GO:0003924	GTPase activity	MGI:MGI:58524 PMID:2508088^[4]	TAS: Traceable Author Statement		F	From MGI
	GO:0004871	signal transducer activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P63095	F	From MGI
	GO:0004871	signal transducer activity	MGI:MGI:4459044		PANTHER:PTHR10218	F	From MGI
	GO:0005159	insulin-like growth factor receptor binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P63095	F	From MGI
	GO:0005515	protein binding	MGI:MGI:85829 PMID:9016340^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q61616	F	From MGI
	GO:0005525	GTP binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P63095	F	From MGI
	GO:0005576	extracellular region	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0964	C	From MGI
	GO:0005622	intracellular	MGI:MGI:1098382 PMID:9322912^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2152744	C	From MGI
	GO:0005622	intracellular	MGI:MGI:1195394 PMID:2826231^[7]	IMP: Inferred from Mutant Phenotype		C	From MGI
	GO:0005622	intracellular	MGI:MGI:3701153 PMID:17194762^[8]	IGI: Inferred from Genetic Interaction	MGI:MGI:95774 MGI:MGI:99578	C	From MGI
	GO:0005622	intracellular	MGI:MGI:56877 PMID:3092218^[3]	IMP: Inferred from Mutant Phenotype		C	From MGI
	GO:0005622	intracellular	MGI:MGI:78329 PMID:2499043^[9]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005624	membrane fraction	MGI:MGI:1098382 PMID:9322912^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2152744	C	From MGI
	GO:0005624	membrane fraction	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P63095	C	From MGI
	GO:0005624	membrane fraction	MGI:MGI:85829 PMID:9016340^[5]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P63095	C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:A6NI00	C	From MGI
	GO:0005768	endosome	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P63095	C	From MGI
	GO:0005829	cytosol	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P63095	C	From MGI
	GO:0005834	heterotrimeric G-protein complex	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P63095	C	From MGI
	GO:0005834	heterotrimeric G-protein complex	MGI:MGI:4459044		PANTHER:PTHR10218	C	From MGI
	GO:0005834	heterotrimeric G-protein complex	MGI:MGI:56877 PMID:3092218^[3]	ISA: Inferred from Sequence Alignment	EMBL:M13006	C	From MGI
	GO:0005834	heterotrimeric G-protein complex	MGI:MGI:58524 PMID:2508088^[4]	TAS: Traceable Author Statement		C	From MGI
	GO:0005886	plasma membrane	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P63095	C	From MGI
	GO:0006112	energy reserve metabolic process	MGI:MGI:1354139 PMID:10712433^[10]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2152743	P	From MGI
	GO:0006184	GTP catabolic process	MGI:MGI:4459044		PANTHER:PTHR10218	P	From MGI
	GO:0006306	DNA methylation	MGI:MGI:4454202 PMID:20427744^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:4459474	P	From MGI
	GO:0007165	signal transduction	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0807	P	From MGI
	GO:0007165	signal transduction	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR011025	P	From MGI
	GO:0007165	signal transduction	MGI:MGI:4459044		PANTHER:PTHR10218	P	From MGI
	GO:0007186	G-protein coupled receptor signaling pathway	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P63095	P	From MGI
	GO:0007186	G-protein coupled receptor signaling pathway	MGI:MGI:58524 PMID:2508088^[4]	TAS: Traceable Author Statement		P	From MGI
	GO:0007189	activation of adenylate cyclase activity by G-protein signaling pathway	MGI:MGI:1098382 PMID:9322912^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2152744	P	From MGI
	GO:0007189	activation of adenylate cyclase activity by G-protein signaling pathway	MGI:MGI:1195394 PMID:2826231^[7]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0007189	activation of adenylate cyclase activity by G-protein signaling pathway	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P63095	P	From MGI
	GO:0007189	activation of adenylate cyclase activity by G-protein signaling pathway	MGI:MGI:56877 PMID:3092218^[3]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0007189	activation of adenylate cyclase activity by G-protein signaling pathway	MGI:MGI:78329 PMID:2499043^[9]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0007191	activation of adenylate cyclase activity by dopamine receptor signaling pathway	MGI:MGI:3701153 PMID:17194762^[8]	IGI: Inferred from Genetic Interaction	MGI:MGI:95774 MGI:MGI:99578	P	From MGI
	GO:0007606	sensory perception of chemical stimulus	MGI:MGI:4459044		PANTHER:PTHR10218	P	From MGI
	GO:0007610	behavior	MGI:MGI:4454202 PMID:20427744^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:4459474	P	From MGI
	GO:0009791	post-embryonic development	MGI:MGI:3619837 PMID:15797856^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3043361	P	From MGI
	GO:0009791	post-embryonic development	MGI:MGI:4454202 PMID:20427744^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:4459474	P	From MGI
	GO:0010765	positive regulation of sodium ion transport	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P63095	P	From MGI
	GO:0016020	membrane	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0472	C	From MGI
	GO:0019001	guanyl nucleotide binding	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR001019	F	From MGI
	GO:0019904	protein domain specific binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P63095	F	From MGI
	GO:0030819	positive regulation of cAMP biosynthetic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P63095	P	From MGI
	GO:0031224	intrinsic to membrane	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P63092	C	From MGI
	GO:0031234	extrinsic to internal side of plasma membrane	MGI:MGI:4459044		PANTHER:PTHR10218	C	From MGI
	GO:0031410	cytoplasmic vesicle	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0968	C	From MGI
	GO:0031681	G-protein beta-subunit binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P63095	F	From MGI
	GO:0031683	G-protein beta/gamma-subunit complex binding	MGI:MGI:4459044		PANTHER:PTHR10218	F	From MGI
	GO:0031698	beta-2 adrenergic receptor binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P63095	F	From MGI
	GO:0031852	mu-type opioid receptor binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P63095	F	From MGI
	GO:0031852	mu-type opioid receptor binding	MGI:MGI:4459044		PANTHER:PTHR10218	F	From MGI
	GO:0031982	vesicle	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P63095	C	From MGI
	GO:0032588	trans-Golgi network membrane	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P63092	C	From MGI
	GO:0035116	embryonic hindlimb morphogenesis	MGI:MGI:3619837 PMID:15797856^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3043361	P	From MGI
	GO:0035255	ionotropic glutamate receptor binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P63095	F	From MGI
	GO:0035255	ionotropic glutamate receptor binding	MGI:MGI:4459044		PANTHER:PTHR10218	F	From MGI
	GO:0035264	multicellular organism growth	MGI:MGI:4454202 PMID:20427744^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:4459474	P	From MGI
	GO:0035814	negative regulation of renal sodium excretion	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P63095	P	From MGI
	GO:0040032	post-embryonic body morphogenesis	MGI:MGI:3619837 PMID:15797856^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3043361	P	From MGI
	GO:0042493	response to drug	MGI:MGI:2136536 PMID:11438605^[11]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2152744	P	From MGI
	GO:0042995	cell projection	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0966	C	From MGI
	GO:0043014	alpha-tubulin binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P63095	F	From MGI
	GO:0043588	skin development	MGI:MGI:4454202 PMID:20427744^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:4459474	P	From MGI
	GO:0045121	membrane raft	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P63095	C	From MGI
	GO:0045669	positive regulation of osteoblast differentiation	MGI:MGI:3619837 PMID:15797856^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3043361	P	From MGI
	GO:0045672	positive regulation of osteoclast differentiation	MGI:MGI:3619837 PMID:15797856^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3043361	P	From MGI
	GO:0045776	negative regulation of blood pressure	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P63095	P	From MGI
	GO:0046872	metal ion binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0479	F	From MGI
	GO:0048701	embryonic cranial skeleton morphogenesis	MGI:MGI:3619837 PMID:15797856^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3043361	P	From MGI
	GO:0051216	cartilage development	MGI:MGI:3619837 PMID:15797856^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3043361	P	From MGI
	GO:0051430	corticotropin-releasing hormone receptor 1 binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P63095	F	From MGI
	GO:0071514	genetic imprinting	MGI:MGI:4454202 PMID:20427744^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:4459474	P	From MGI
colocalizes_with	GO:0042383	sarcolemma	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P63095	C	From MGI
colocalizes_with	GO:0044424	intracellular part	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P63095	C	From MGI
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 Sakamoto A et al. (2005) Deficiency of the G-protein alpha-subunit G(s)alpha in osteoblasts leads to differential effects on trabecular and cortical bone. J Biol Chem 280: 21369-75 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Fröhlich LF et al. (2010) Targeted deletion of the Nesp55 DMR defines another Gnas imprinting control region and provides a mouse model of autosomal dominant PHP-Ib. Proc Natl Acad Sci U S A 107: 9275-80 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Sullivan KA et al. (1986) Inhibitory and stimulatory G proteins of adenylate cyclase: cDNA and amino acid sequences of the alpha chains. Proc Natl Acad Sci U S A 83: 6687-91 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Strathmann M et al. (1989) Diversity of the G-protein family: sequences from five additional alpha subunits in the mouse. Proc Natl Acad Sci U S A 86: 7407-9 PubMed GONUTS page
↑ ^5.0 ^5.1 Friedman E et al. (1997) D1-like dopaminergic activation of phosphoinositide hydrolysis is independent of D1A dopamine receptors: evidence from D1A knockout mice. Mol Pharmacol 51: 6-11 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Schwindinger WF et al. (1997) Targeted disruption of Gnas in embryonic stem cells. Endocrinology 138: 4058-63 PubMed GONUTS page
↑ ^7.0 ^7.1 Rall T & Harris BA (1987) Identification of the lesion in the stimulatory GTP-binding protein of the uncoupled S49 lymphoma. FEBS Lett 224: 365-71 PubMed GONUTS page
↑ ^8.0 ^8.1 Rashid AJ et al. (2007) D1-D2 dopamine receptor heterooligomers with unique pharmacology are coupled to rapid activation of Gq/11 in the striatum. Proc Natl Acad Sci U S A 104: 654-9 PubMed GONUTS page
↑ ^9.0 ^9.1 Jones DT & Reed RR (1989) Golf: an olfactory neuron specific-G protein involved in odorant signal transduction. Science 244: 790-5 PubMed GONUTS page
↑ Yu S et al. (2000) Paternal versus maternal transmission of a stimulatory G-protein alpha subunit knockout produces opposite effects on energy metabolism. J Clin Invest 105: 615-23 PubMed GONUTS page
↑ Wand G et al. (2001) The cAMP-protein kinase A signal transduction pathway modulates ethanol consumption and sedative effects of ethanol. J Neurosci 21: 5297-303 PubMed GONUTS page

[PMID:15797856-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 Sakamoto A et al. (2005) Deficiency of the G-protein alpha-subunit G(s)alpha in osteoblasts leads to differential effects on trabecular and cortical bone. J Biol Chem 280: 21369-75 PubMed GONUTS page

[PMID:20427744-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Fröhlich LF et al. (2010) Targeted deletion of the Nesp55 DMR defines another Gnas imprinting control region and provides a mouse model of autosomal dominant PHP-Ib. Proc Natl Acad Sci U S A 107: 9275-80 PubMed GONUTS page

[PMID:3092218-2] 3.0 ^3.1 ^3.2 ^3.3 Sullivan KA et al. (1986) Inhibitory and stimulatory G proteins of adenylate cyclase: cDNA and amino acid sequences of the alpha chains. Proc Natl Acad Sci U S A 83: 6687-91 PubMed GONUTS page

[PMID:2508088-3] 4.0 ^4.1 ^4.2 Strathmann M et al. (1989) Diversity of the G-protein family: sequences from five additional alpha subunits in the mouse. Proc Natl Acad Sci U S A 86: 7407-9 PubMed GONUTS page

[PMID:9016340-4] 5.0 ^5.1 Friedman E et al. (1997) D1-like dopaminergic activation of phosphoinositide hydrolysis is independent of D1A dopamine receptors: evidence from D1A knockout mice. Mol Pharmacol 51: 6-11 PubMed GONUTS page

[PMID:9322912-5] 6.0 ^6.1 ^6.2 Schwindinger WF et al. (1997) Targeted disruption of Gnas in embryonic stem cells. Endocrinology 138: 4058-63 PubMed GONUTS page

[PMID:2826231-6] 7.0 ^7.1 Rall T & Harris BA (1987) Identification of the lesion in the stimulatory GTP-binding protein of the uncoupled S49 lymphoma. FEBS Lett 224: 365-71 PubMed GONUTS page

[PMID:17194762-7] 8.0 ^8.1 Rashid AJ et al. (2007) D1-D2 dopamine receptor heterooligomers with unique pharmacology are coupled to rapid activation of Gq/11 in the striatum. Proc Natl Acad Sci U S A 104: 654-9 PubMed GONUTS page

[PMID:2499043-8] 9.0 ^9.1 Jones DT & Reed RR (1989) Golf: an olfactory neuron specific-G protein involved in odorant signal transduction. Science 244: 790-5 PubMed GONUTS page

[PMID:10712433-9] Yu S et al. (2000) Paternal versus maternal transmission of a stimulatory G-protein alpha subunit knockout produces opposite effects on energy metabolism. J Clin Invest 105: 615-23 PubMed GONUTS page

[PMID:11438605-10] Wand G et al. (2001) The cAMP-protein kinase A signal transduction pathway modulates ethanol consumption and sedative effects of ethanol. J Neurosci 21: 5297-303 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

MGI:Gnas

Contents

Annotations

Notes

References

a

b

c

d

e

g

g cont.

h

i

m

n

n cont.

p

r

s

t

v

Personal tools

Namespaces

Variants

Views

Actions

Search

Navigation

Cacao

Journal Clubs

page contributors

Toolbox