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MGI:Gnal

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Contents

Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Gnal ( synonyms: G alpha 10, Galphaolf, Gna10, Golf )
Protein Name(s) guanine nucleotide binding protein, alpha stimulating, olfactory type,
External Links
MGI MGI:95774

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000166

nucleotide binding

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0547

F

From MGI

GO:0001664

G-protein coupled receptor binding

MGI:MGI:4459044

PANTHER:PTHR10218

F

From MGI

GO:0001975

response to amphetamine

MGI:MGI:3719553
PMID:11404425[1]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2151207

P

From MGI

GO:0003924

GTPase activity

MGI:MGI:4459044

PANTHER:PTHR10218

F

From MGI

GO:0003924

GTPase activity

MGI:MGI:58524
PMID:2508088[2]

ISA: Inferred from Sequence Alignment

EMBL:U38501

F

From MGI

GO:0004016

adenylate cyclase activity

MGI:MGI:4459044

PANTHER:PTHR10218

F

From MGI

GO:0004871

signal transducer activity

MGI:MGI:4459044

PANTHER:PTHR10218

F

From MGI

GO:0005525

GTP binding

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0342

F

From MGI

GO:0005525

GTP binding

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR000367

F

From MGI

GO:0005622

intracellular

MGI:MGI:3701153
PMID:17194762[3]

IGI: Inferred from Genetic Interaction

MGI:MGI:95777
MGI:MGI:99578

C

From MGI

GO:0005622

intracellular

MGI:MGI:78329
PMID:2499043[4]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005834

heterotrimeric G-protein complex

MGI:MGI:4459044

PANTHER:PTHR10218

C

From MGI

GO:0005834

heterotrimeric G-protein complex

MGI:MGI:58524
PMID:2508088[2]

ISA: Inferred from Sequence Alignment

EMBL:U38501

C

From MGI

GO:0006171

cAMP biosynthetic process

MGI:MGI:4459044

PANTHER:PTHR10218

P

From MGI

GO:0006184

GTP catabolic process

MGI:MGI:4459044

PANTHER:PTHR10218

P

From MGI

GO:0007165

signal transduction

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0807

P

From MGI

GO:0007165

signal transduction

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR011025

P

From MGI

GO:0007165

signal transduction

MGI:MGI:4459044

PANTHER:PTHR10218

P

From MGI

GO:0007186

G-protein coupled receptor signaling pathway

MGI:MGI:58524
PMID:2508088[2]

ISA: Inferred from Sequence Alignment

EMBL:U38501

P

From MGI

GO:0007189

activation of adenylate cyclase activity by G-protein signaling pathway

MGI:MGI:78329
PMID:2499043[4]

IDA: Inferred from Direct Assay

P

From MGI

GO:0007190

activation of adenylate cyclase activity

MGI:MGI:2450485
PMID:12488442[5]

IDA: Inferred from Direct Assay

P

From MGI

GO:0007191

activation of adenylate cyclase activity by dopamine receptor signaling pathway

MGI:MGI:3701153
PMID:17194762[3]

IGI: Inferred from Genetic Interaction

MGI:MGI:95777
MGI:MGI:99578

P

From MGI

GO:0007608

sensory perception of smell

MGI:MGI:1195583
PMID:9459443[6]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2151207

P

From MGI

GO:0019001

guanyl nucleotide binding

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR001019

F

From MGI

GO:0031000

response to caffeine

MGI:MGI:3719553
PMID:11404425[1]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2151207

P

From MGI

GO:0031234

extrinsic to internal side of plasma membrane

MGI:MGI:4459044

PANTHER:PTHR10218

C

From MGI

GO:0031683

G-protein beta/gamma-subunit complex binding

MGI:MGI:4459044

PANTHER:PTHR10218

F

From MGI

GO:0046872

metal ion binding

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0479

F

From MGI

GO:0050827

toxin receptor binding

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P38406

F

From MGI


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 Hervé D et al. (2001) Galpha(olf) levels are regulated by receptor usage and control dopamine and adenosine action in the striatum. J Neurosci 21: 4390-9 PubMed GONUTS page
  2. 2.0 2.1 2.2 Strathmann M et al. (1989) Diversity of the G-protein family: sequences from five additional alpha subunits in the mouse. Proc Natl Acad Sci U S A 86: 7407-9 PubMed GONUTS page
  3. 3.0 3.1 Rashid AJ et al. (2007) D1-D2 dopamine receptor heterooligomers with unique pharmacology are coupled to rapid activation of Gq/11 in the striatum. Proc Natl Acad Sci U S A 104: 654-9 PubMed GONUTS page
  4. 4.0 4.1 Jones DT & Reed RR (1989) Golf: an olfactory neuron specific-G protein involved in odorant signal transduction. Science 244: 790-5 PubMed GONUTS page
  5. Schwindinger WF et al. (2003) Loss of G protein gamma 7 alters behavior and reduces striatal alpha(olf) level and cAMP production. J Biol Chem 278: 6575-9 PubMed GONUTS page
  6. Belluscio L et al. (1998) Mice deficient in G(olf) are anosmic. Neuron 20: 69-81 PubMed GONUTS page
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