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MGI:Gli3
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Gli3 ( synonyms: Bph, brachyphalangy ) | |
| Protein Name(s) | GLI-Kruppel family member GLI3, | |
| External Links | ||
| MGI | MGI:95729 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0001656 |
metanephros development |
MGI:MGI:3611729 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:98297 |
P |
From MGI |
||
| GO:0001658 |
branching involved in ureteric bud morphogenesis |
MGI:MGI:3611729 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:98297 |
P |
From MGI |
||
| GO:0001701 |
in utero embryonic development |
MGI:MGI:3692156 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856276 |
P |
From MGI |
||
| GO:0001822 |
kidney development |
MGI:MGI:3664714 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:95728 |
P |
From MGI |
||
| GO:0002052 |
positive regulation of neuroblast proliferation |
MGI:MGI:4837563 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856282 |
P |
From MGI |
||
| GO:0003676 |
nucleic acid binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0238 |
F |
From MGI |
||
| GO:0003682 |
chromatin binding |
MGI:MGI:3611729 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:108075 |
F |
From MGI |
||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:4942260 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:1861566 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2445270 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3848565 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4357736 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4440990 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:2445270 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3692156 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4440990 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005730 |
nucleolus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:2445270 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4440990 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005829 |
cytosol |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005929 |
cilium |
MGI:MGI:3692156 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005929 |
cilium |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006351 |
transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0804 |
P |
From MGI |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:87012 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856275 |
P |
From MGI |
||
| GO:0007224 |
smoothened signaling pathway |
MGI:MGI:2445271 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:108075 |
P |
From MGI |
||
| GO:0007224 |
smoothened signaling pathway |
MGI:MGI:3608261 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:96533 |
P |
From MGI |
||
| GO:0007224 |
smoothened signaling pathway |
MGI:MGI:3611729 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:98297 |
P |
From MGI |
||
| GO:0007224 |
smoothened signaling pathway |
MGI:MGI:3624182 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:98297 |
P |
From MGI |
||
| GO:0007224 |
smoothened signaling pathway |
MGI:MGI:3686547 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:98297 |
P |
From MGI |
||
| GO:0007389 |
pattern specification process |
MGI:MGI:2683891 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:95728 |
P |
From MGI |
||
| GO:0007411 |
axon guidance |
MGI:MGI:3628676 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856276 |
P |
From MGI |
||
| GO:0007411 |
axon guidance |
MGI:MGI:4837563 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856282 |
P |
From MGI |
||
| GO:0007417 |
central nervous system development |
MGI:MGI:2445271 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:108075 |
P |
From MGI |
||
| GO:0007417 |
central nervous system development |
MGI:MGI:2445272 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856276 |
P |
From MGI |
||
| GO:0007420 |
brain development |
MGI:MGI:2445242 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856276 |
P |
From MGI |
||
| GO:0007420 |
brain development |
MGI:MGI:3709667 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856276 |
P |
From MGI |
||
| GO:0007420 |
brain development |
MGI:MGI:65615 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856282 |
P |
From MGI |
||
| GO:0007442 |
hindgut morphogenesis |
MGI:MGI:2148409 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:95728 |
P |
From MGI |
||
| GO:0007507 |
heart development |
MGI:MGI:3664714 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:95728 |
P |
From MGI |
||
| GO:0008013 |
beta-catenin binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0008270 |
zinc ion binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0008285 |
negative regulation of cell proliferation |
MGI:MGI:3611729 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:98297 |
P |
From MGI |
||
| GO:0008285 |
negative regulation of cell proliferation |
MGI:MGI:3611729 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856275 |
P |
From MGI |
||
| GO:0008285 |
negative regulation of cell proliferation |
MGI:MGI:3709778 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856276 |
P |
From MGI |
||
| GO:0008285 |
negative regulation of cell proliferation |
MGI:MGI:4821204 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:95516 |
P |
From MGI |
||
| GO:0008285 |
negative regulation of cell proliferation |
MGI:MGI:4821204 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856276 |
P |
From MGI |
||
| GO:0009952 |
anterior/posterior pattern specification |
MGI:MGI:3053244 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856276 |
P |
From MGI |
||
| GO:0009953 |
dorsal/ventral pattern formation |
MGI:MGI:2445272 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856276 |
P |
From MGI |
||
| GO:0009953 |
dorsal/ventral pattern formation |
MGI:MGI:3028732 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856275 |
P |
From MGI |
||
| GO:0009953 |
dorsal/ventral pattern formation |
MGI:MGI:3624182 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856276 |
P |
From MGI |
||
| GO:0009954 |
proximal/distal pattern formation |
MGI:MGI:3617688 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:95728 |
P |
From MGI |
||
| GO:0009954 |
proximal/distal pattern formation |
MGI:MGI:3617688 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856276 |
P |
From MGI |
||
| GO:0010468 |
regulation of gene expression |
MGI:MGI:3822094 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:98297 |
P |
From MGI |
||
| GO:0016485 |
protein processing |
MGI:MGI:3821634 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0017053 |
transcriptional repressor complex |
MGI:MGI:2445270 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0021513 |
spinal cord dorsal/ventral patterning |
MGI:MGI:3051712 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:95728 |
P |
From MGI |
||
| GO:0021513 |
spinal cord dorsal/ventral patterning |
MGI:MGI:3612806 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:99833 |
P |
From MGI |
||
| GO:0021537 |
telencephalon development |
MGI:MGI:1352305 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856276 |
P |
From MGI |
||
| GO:0021537 |
telencephalon development |
MGI:MGI:3821634 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856276 |
P |
From MGI |
||
| GO:0021537 |
telencephalon development |
MGI:MGI:3833168 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856276 |
P |
From MGI |
||
| GO:0021543 |
pallium development |
MGI:MGI:1340205 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856276 |
P |
From MGI |
||
| GO:0021544 |
subpallium development |
MGI:MGI:4837563 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856282 |
P |
From MGI |
||
| GO:0021631 |
optic nerve morphogenesis |
MGI:MGI:3617688 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856276 |
P |
From MGI |
||
| GO:0021775 |
smoothened signaling pathway involved in ventral spinal cord interneuron specification |
MGI:MGI:3051712 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:95728 |
P |
From MGI |
||
| GO:0021776 |
smoothened signaling pathway involved in spinal cord motor neuron cell fate specification |
MGI:MGI:3051712 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:95728 |
P |
From MGI |
||
| GO:0021798 |
forebrain dorsal/ventral pattern formation |
MGI:MGI:1352305 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856276 |
P |
From MGI |
||
| GO:0021801 |
cerebral cortex radial glia guided migration |
MGI:MGI:1097510 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856282 |
P |
From MGI |
||
| GO:0021861 |
forebrain radial glial cell differentiation |
MGI:MGI:1097510 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856282 |
P |
From MGI |
||
| GO:0021915 |
neural tube development |
MGI:MGI:52587 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856276 |
P |
From MGI |
||
| GO:0022018 |
lateral ganglionic eminence cell proliferation |
MGI:MGI:4837563 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856282 |
P |
From MGI |
||
| GO:0030318 |
melanocyte differentiation |
MGI:MGI:3796727 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3720956 |
P |
From MGI |
||
| GO:0030324 |
lung development |
MGI:MGI:1095776 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856276 |
P |
From MGI |
||
| GO:0030324 |
lung development |
MGI:MGI:3051935 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:98297 |
P |
From MGI |
||
| GO:0030326 |
embryonic limb morphogenesis |
MGI:MGI:2384366 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856276 |
P |
From MGI |
||
| GO:0030326 |
embryonic limb morphogenesis |
MGI:MGI:2445242 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856276 |
P |
From MGI |
||
| GO:0030326 |
embryonic limb morphogenesis |
MGI:MGI:2445270 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856276 |
P |
From MGI |
||
| GO:0030326 |
embryonic limb morphogenesis |
MGI:MGI:3608261 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:96533 |
P |
From MGI |
||
| GO:0030326 |
embryonic limb morphogenesis |
MGI:MGI:3851667 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:98297 |
P |
From MGI |
||
| GO:0030326 |
embryonic limb morphogenesis |
MGI:MGI:4367286 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856276 |
P |
From MGI |
||
| GO:0030326 |
embryonic limb morphogenesis |
MGI:MGI:52587 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856276 |
P |
From MGI |
||
| GO:0030879 |
mammary gland development |
MGI:MGI:3656358 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856276 |
P |
From MGI |
||
| GO:0030900 |
forebrain development |
MGI:MGI:3610448 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856276 |
P |
From MGI |
||
| GO:0032332 |
positive regulation of chondrocyte differentiation |
MGI:MGI:3709778 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856276 |
P |
From MGI |
||
| GO:0033077 |
T cell differentiation in thymus |
MGI:MGI:3695957 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856276 |
P |
From MGI |
||
| GO:0035035 |
histone acetyltransferase binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0035108 |
limb morphogenesis |
MGI:MGI:1095762 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856276 |
P |
From MGI |
||
| GO:0035108 |
limb morphogenesis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0035295 |
tube development |
MGI:MGI:1277743 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:95728 |
P |
From MGI |
||
| GO:0042127 |
regulation of cell proliferation |
MGI:MGI:3695832 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:96533 |
P |
From MGI |
||
| GO:0042307 |
positive regulation of protein import into nucleus |
MGI:MGI:3686547 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:108075 |
P |
From MGI |
||
| GO:0042475 |
odontogenesis of dentin-containing tooth |
MGI:MGI:1277041 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:95728 |
P |
From MGI |
||
| GO:0042733 |
embryonic digit morphogenesis |
MGI:MGI:1095762 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:88180 |
P |
From MGI |
||
| GO:0042733 |
embryonic digit morphogenesis |
MGI:MGI:1095762 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856276 |
P |
From MGI |
||
| GO:0042733 |
embryonic digit morphogenesis |
MGI:MGI:3692156 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856276 |
P |
From MGI |
||
| GO:0042733 |
embryonic digit morphogenesis |
MGI:MGI:3765370 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:96205 |
P |
From MGI |
||
| GO:0042733 |
embryonic digit morphogenesis |
MGI:MGI:3821634 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856276 |
P |
From MGI |
||
| GO:0042826 |
histone deacetylase binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0042981 |
regulation of apoptotic process |
MGI:MGI:65615 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856282 |
P |
From MGI |
||
| GO:0042995 |
cell projection |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0966 |
C |
From MGI |
||
| GO:0043010 |
camera-type eye development |
MGI:MGI:3807419 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:98297 |
P |
From MGI |
||
| GO:0043066 |
negative regulation of apoptotic process |
MGI:MGI:3833168 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856276 |
P |
From MGI |
||
| GO:0043231 |
intracellular membrane-bounded organelle |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0043565 |
sequence-specific DNA binding |
MGI:MGI:3624046 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0043586 |
tongue development |
MGI:MGI:3809315 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856276 |
P |
From MGI |
||
| GO:0045060 |
negative thymic T cell selection |
MGI:MGI:4355451 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0045595 |
regulation of cell differentiation |
MGI:MGI:3608261 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:96533 |
P |
From MGI |
||
| GO:0045596 |
negative regulation of cell differentiation |
MGI:MGI:3608261 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:96533 |
P |
From MGI |
||
| GO:0045665 |
negative regulation of neuron differentiation |
MGI:MGI:3833168 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856276 |
P |
From MGI |
||
| GO:0045669 |
positive regulation of osteoblast differentiation |
MGI:MGI:4821204 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:95516 |
P |
From MGI |
||
| GO:0045669 |
positive regulation of osteoblast differentiation |
MGI:MGI:4821204 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856276 |
P |
From MGI |
||
| GO:0045879 |
negative regulation of smoothened signaling pathway |
MGI:MGI:4355451 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0045892 |
negative regulation of transcription, DNA-dependent |
MGI:MGI:2445270 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045892 |
negative regulation of transcription, DNA-dependent |
MGI:MGI:3710725 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0045892 |
negative regulation of transcription, DNA-dependent |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:3709778 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:3710725 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:4942260 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4355451 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0046638 |
positive regulation of alpha-beta T cell differentiation |
MGI:MGI:3695957 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0046639 |
negative regulation of alpha-beta T cell differentiation |
MGI:MGI:4355451 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0046872 |
metal ion binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0479 |
F |
From MGI |
||
| GO:0048557 |
embryonic digestive tract morphogenesis |
MGI:MGI:3608164 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856276 |
P |
From MGI |
||
| GO:0048566 |
embryonic digestive tract development |
MGI:MGI:1353327 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856276 |
P |
From MGI |
||
| GO:0048589 |
developmental growth |
MGI:MGI:1095776 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856276 |
P |
From MGI |
||
| GO:0048593 |
camera-type eye morphogenesis |
MGI:MGI:52587 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856276 |
P |
From MGI |
||
| GO:0048598 |
embryonic morphogenesis |
MGI:MGI:52587 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856276 |
P |
From MGI |
||
| GO:0048646 |
anatomical structure formation involved in morphogenesis |
MGI:MGI:1277743 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:95728 |
P |
From MGI |
||
| GO:0048663 |
neuron fate commitment |
MGI:MGI:3610448 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856276 |
P |
From MGI |
||
| GO:0048704 |
embryonic skeletal system morphogenesis |
MGI:MGI:3604843 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1277234 |
P |
From MGI |
||
| GO:0048709 |
oligodendrocyte differentiation |
MGI:MGI:3703379 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:98297 |
P |
From MGI |
||
| GO:0048754 |
branching morphogenesis of a tube |
MGI:MGI:3608164 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856276 |
P |
From MGI |
||
| GO:0048839 |
inner ear development |
MGI:MGI:3709667 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:98297 |
P |
From MGI |
||
| GO:0048856 |
anatomical structure development |
MGI:MGI:2148409 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:95728 |
P |
From MGI |
||
| GO:0060021 |
palate development |
MGI:MGI:3809315 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856276 |
P |
From MGI |
||
| GO:0060173 |
limb development |
MGI:MGI:3710725 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0060364 |
frontal suture morphogenesis |
MGI:MGI:4821204 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856276 |
P |
From MGI |
||
| GO:0060366 |
lambdoid suture morphogenesis |
MGI:MGI:4821204 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856276 |
P |
From MGI |
||
| GO:0060367 |
sagittal suture morphogenesis |
MGI:MGI:4821204 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856276 |
P |
From MGI |
||
| GO:0060594 |
mammary gland specification |
MGI:MGI:3629001 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1099809 |
P |
From MGI |
||
| GO:0060831 |
smoothened signaling pathway involved in dorsal/ventral neural tube patterning |
MGI:MGI:3709667 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:95728 |
P |
From MGI |
||
| GO:0060840 |
artery development |
MGI:MGI:3702792 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:98297 |
P |
From MGI |
||
| GO:0060873 |
anterior semicircular canal development |
MGI:MGI:3709667 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856276 |
P |
From MGI |
||
| GO:0060875 |
lateral semicircular canal development |
MGI:MGI:3709667 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856276 |
P |
From MGI |
||
| GO:0061005 |
cell differentiation involved in kidney development |
MGI:MGI:4367286 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:105373 |
P |
From MGI |
||
| GO:0070242 |
thymocyte apoptotic process |
MGI:MGI:4355451 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0090090 |
negative regulation of canonical Wnt receptor signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Hu MC et al. (2006) GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis. Development 133: 569-78 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Haycraft CJ et al. (2005) Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function. PLoS Genet 1: e53 PubMed GONUTS page
- ↑ 3.0 3.1 Kim PC et al. (2001) Murine models of VACTERL syndrome: Role of sonic hedgehog signaling pathway. J Pediatr Surg 36: 381-4 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Magnani D et al. (2010) The Gli3 hypomorphic mutation Pdn causes selective impairment in the growth, patterning, and axon guidance capability of the lateral ganglionic eminence. J Neurosci 30: 13883-94 PubMed GONUTS page
- ↑ 5.0 5.1 Mizugishi K et al. (2001) Molecular properties of Zic proteins as transcriptional regulators and their relationship to GLI proteins. J Biol Chem 276: 2180-8 PubMed GONUTS page
- ↑ Simon-Chazottes D et al. (2000) Genomic organization, chromosomal assignment, and expression analysis of the mouse suppressor of fused gene (Sufu) coding a Gli protein partner. Mamm Genome 11: 614-21 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 7.4 7.5 Dai P et al. (2002) Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3. Genes Dev 16: 2843-8 PubMed GONUTS page
- ↑ Wuelling M et al. (2009) Trps1, a regulator of chondrocyte proliferation and differentiation, interacts with the activator form of Gli3. Dev Biol 328: 40-53 PubMed GONUTS page
- ↑ Cheung HO et al. (2009) The kinesin protein Kif7 is a critical regulator of Gli transcription factors in mammalian hedgehog signaling. Sci Signal 2: ra29 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 Humke EW et al. (2010) The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins. Genes Dev 24: 670-82 PubMed GONUTS page
- ↑ Büscher D et al. (1997) Evidence for genetic control of Sonic hedgehog by Gli3 in mouse limb development. Mech Dev 62: 175-82 PubMed GONUTS page
- ↑ 12.0 12.1 Wijgerde M et al. (2002) A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord. Genes Dev 16: 2849-64 PubMed GONUTS page
- ↑ 13.0 13.1 13.2 13.3 Koziel L et al. (2005) Gli3 acts as a repressor downstream of Ihh in regulating two distinct steps of chondrocyte differentiation. Development 132: 5249-60 PubMed GONUTS page
- ↑ 14.0 14.1 Blaess S et al. (2006) Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain region. Development 133: 1799-809 PubMed GONUTS page
- ↑ 15.0 15.1 Kim JW & Lemke G (2006) Hedgehog-regulated localization of Vax2 controls eye development. Genes Dev 20: 2833-47 PubMed GONUTS page
- ↑ Buttitta L et al. (2003) Interplays of Gli2 and Gli3 and their requirement in mediating Shh-dependent sclerotome induction. Development 130: 6233-43 PubMed GONUTS page
- ↑ Balmer CW & LaMantia AS (2004) Loss of Gli3 and Shh function disrupts olfactory axon trajectories. J Comp Neurol 472: 292-307 PubMed GONUTS page
- ↑ 18.0 18.1 Persson M et al. (2002) Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity. Genes Dev 16: 2865-78 PubMed GONUTS page
- ↑ 19.0 19.1 Aoto K et al. (2002) Mouse GLI3 regulates Fgf8 expression and apoptosis in the developing neural tube, face, and limb bud. Dev Biol 251: 320-32 PubMed GONUTS page
- ↑ 20.0 20.1 20.2 20.3 20.4 Bok J et al. (2007) Opposing gradients of Gli repressor and activators mediate Shh signaling along the dorsoventral axis of the inner ear. Development 134: 1713-22 PubMed GONUTS page
- ↑ 21.0 21.1 Keino H et al. (1994) Apoptotic degeneration in the arhinencephalic brain of the mouse mutant Pdn/Pdn. Brain Res Dev Brain Res 78: 161-8 PubMed GONUTS page
- ↑ 22.0 22.1 Mo R et al. (2001) Anorectal malformations caused by defects in sonic hedgehog signaling. Am J Pathol 159: 765-74 PubMed GONUTS page
- ↑ 23.0 23.1 23.2 Mau E et al. (2007) PTHrP regulates growth plate chondrocyte differentiation and proliferation in a Gli3 dependent manner utilizing hedgehog ligand dependent and independent mechanisms. Dev Biol 305: 28-39 PubMed GONUTS page
- ↑ 24.0 24.1 24.2 24.3 24.4 24.5 24.6 Rice DP et al. (2010) Gli3Xt-J/Xt-J mice exhibit lambdoid suture craniosynostosis which results from altered osteoprogenitor proliferation and differentiation. Hum Mol Genet 19: 3457-67 PubMed GONUTS page
- ↑ Ahn S & Joyner AL (2004) Dynamic changes in the response of cells to positive hedgehog signaling during mouse limb patterning. Cell 118: 505-16 PubMed GONUTS page
- ↑ Bai CB et al. (2004) All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3. Dev Cell 6: 103-15 PubMed GONUTS page
- ↑ 27.0 27.1 27.2 Furimsky M & Wallace VA (2006) Complementary Gli activity mediates early patterning of the mouse visual system. Dev Dyn 235: 594-605 PubMed GONUTS page
- ↑ Tucker ES et al. (2008) Molecular specification and patterning of progenitor cells in the lateral and medial ganglionic eminences. J Neurosci 28: 9504-18 PubMed GONUTS page
- ↑ 29.0 29.1 29.2 Willaredt MA et al. (2008) A crucial role for primary cilia in cortical morphogenesis. J Neurosci 28: 12887-900 PubMed GONUTS page
- ↑ 30.0 30.1 30.2 Lei Q et al. (2004) Transduction of graded Hedgehog signaling by a combination of Gli2 and Gli3 activator functions in the developing spinal cord. Development 131: 3593-604 PubMed GONUTS page
- ↑ Eggenschwiler JT et al. (2006) Mouse Rab23 regulates hedgehog signaling from smoothened to Gli proteins. Dev Biol 290: 1-12 PubMed GONUTS page
- ↑ 32.0 32.1 Tole S et al. (2000) Dorsoventral patterning of the telencephalon is disrupted in the mouse mutant extra-toes(J). Dev Biol 217: 254-65 PubMed GONUTS page
- ↑ 33.0 33.1 33.2 Yu T et al. (2009) Analysis of early ventral telencephalic defects in mice lacking functional Gli3 protein. J Comp Neurol 512: 613-27 PubMed GONUTS page
- ↑ Theil T et al. (1999) Gli3 is required for Emx gene expression during dorsal telencephalon development. Development 126: 3561-71 PubMed GONUTS page
- ↑ 35.0 35.1 Ueda S et al. (1997) Local disturbance of neuronal migration in the S-100beta-retarded mutant mouse. Cell Tissue Res 289: 547-51 PubMed GONUTS page
- ↑ 36.0 36.1 36.2 36.3 Hui CC & Joyner AL (1993) A mouse model of greig cephalopolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the Gli3 gene. Nat Genet 3: 241-6 PubMed GONUTS page
- ↑ Matera I et al. (2008) A sensitized mutagenesis screen identifies Gli3 as a modifier of Sox10 neurocristopathy. Hum Mol Genet 17: 2118-31 PubMed GONUTS page
- ↑ 38.0 38.1 Grindley JC et al. (1997) Evidence for the involvement of the Gli gene family in embryonic mouse lung development. Dev Biol 188: 337-48 PubMed GONUTS page
- ↑ Li Y et al. (2004) Sonic hedgehog signaling regulates Gli3 processing, mesenchymal proliferation, and differentiation during mouse lung organogenesis. Dev Biol 270: 214-31 PubMed GONUTS page
- ↑ O'Rourke MP et al. (2002) Twist plays an essential role in FGF and SHH signal transduction during mouse limb development. Dev Biol 248: 143-56 PubMed GONUTS page
- ↑ Lallemand Y et al. (2009) Msx genes are important apoptosis effectors downstream of the Shh/Gli3 pathway in the limb. Dev Biol 331: 189-98 PubMed GONUTS page
- ↑ 42.0 42.1 Cain JE et al. (2009) GLI3 repressor controls nephron number via regulation of Wnt11 and Ret in ureteric tip cells. PLoS One 4: e7313 PubMed GONUTS page
- ↑ Hatsell SJ & Cowin P (2006) Gli3-mediated repression of Hedgehog targets is required for normal mammary development. Development 133: 3661-70 PubMed GONUTS page
- ↑ 44.0 44.1 Theil T (2005) Gli3 is required for the specification and differentiation of preplate neurons. Dev Biol 286: 559-71 PubMed GONUTS page
- ↑ 45.0 45.1 Hager-Theodorides AL et al. (2005) The transcription factor Gli3 regulates differentiation of fetal CD4- CD8- double-negative thymocytes. Blood 106: 1296-304 PubMed GONUTS page
- ↑ 46.0 46.1 46.2 Dunn NR et al. (1997) Haploinsufficient phenotypes in Bmp4 heterozygous null mice and modification by mutations in Gli3 and Alx4. Dev Biol 188: 235-47 PubMed GONUTS page
- ↑ 47.0 47.1 Motoyama J et al. (1998) Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus. Nat Genet 20: 54-7 PubMed GONUTS page
- ↑ Shibukawa Y et al. (2007) Temporomandibular joint formation and condyle growth require Indian hedgehog signaling. Dev Dyn 236: 426-34 PubMed GONUTS page
- ↑ Hardcastle Z et al. (1998) The Shh signalling pathway in tooth development: defects in Gli2 and Gli3 mutants. Development 125: 2803-11 PubMed GONUTS page
- ↑ Sheth R et al. (2007) Hoxd and Gli3 interactions modulate digit number in the amniote limb. Dev Biol 310: 430-41 PubMed GONUTS page
- ↑ Dakubo GD et al. (2008) Indian hedgehog signaling from endothelial cells is required for sclera and retinal pigment epithelium development in the mouse eye. Dev Biol 320: 242-55 PubMed GONUTS page
- ↑ Pan Y et al. (2006) Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation. Mol Cell Biol 26: 3365-77 PubMed GONUTS page
- ↑ 53.0 53.1 Huang X et al. (2008) Gli3-deficient mice exhibit cleft palate associated with abnormal tongue development. Dev Dyn 237: 3079-87 PubMed GONUTS page
- ↑ 54.0 54.1 54.2 54.3 54.4 Hager-Theodorides AL et al. (2009) The Gli3 transcription factor expressed in the thymus stroma controls thymocyte negative selection via Hedgehog-dependent and -independent mechanisms. J Immunol 183: 3023-32 PubMed GONUTS page
- ↑ 55.0 55.1 55.2 Wang C et al. (2007) The Shh-independent activator function of the full-length Gli3 protein and its role in vertebrate limb digit patterning. Dev Biol 305: 460-9 PubMed GONUTS page
- ↑ 56.0 56.1 Kim JH et al. (2005) Gli3 null mice display glandular overgrowth of the developing stomach. Dev Dyn 234: 984-91 PubMed GONUTS page
- ↑ Kimmel SG et al. (2000) New mouse models of congenital anorectal malformations. J Pediatr Surg 35: 227-30; discussion 230-1 PubMed GONUTS page
- ↑ Kuijper S et al. (2005) Genetics of shoulder girdle formation: roles of Tbx15 and aristaless-like genes. Development 132: 1601-10 PubMed GONUTS page
- ↑ Oh S et al. (2005) Specific requirements of sonic hedgehog signaling during oligodendrocyte development. Dev Dyn 234: 489-96 PubMed GONUTS page
- ↑ Veltmaat JM et al. (2006) Gli3-mediated somitic Fgf10 expression gradients are required for the induction and patterning of mammary epithelium along the embryonic axes. Development 133: 2325-35 PubMed GONUTS page
- ↑ Alt B et al. (2006) Arteries define the position of the thyroid gland during its developmental relocalisation. Development 133: 3797-804 PubMed GONUTS page
