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MGI:Gja1
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Gja1 ( synonyms: alpha 1 connexin, connexin 43, connexin43, Cx43, Cx43alpha1, Gja-1 ) | |
| Protein Name(s) | gap junction protein, alpha 1, | |
| External Links | ||
| MGI | MGI:95713 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001701 |
in utero embryonic development |
MGI:MGI:1201220 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857177 |
P |
From MGI |
||
| GO:0001764 |
neuron migration |
MGI:MGI:3612915 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857177 |
P |
From MGI |
||
| GO:0001947 |
heart looping |
MGI:MGI:1201220 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857177 |
P |
From MGI |
||
| GO:0002070 |
epithelial cell maturation |
MGI:MGI:3624198 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3051881 |
P |
From MGI |
||
| GO:0003347 |
epicardial cell to mesenchymal cell transition |
MGI:MGI:4943617 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0004871 |
signal transducer activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005102 |
receptor binding |
MGI:MGI:3053262 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005243 |
gap junction channel activity |
MGI:MGI:2157676 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005243 |
gap junction channel activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3808971 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005624 |
membrane fraction |
MGI:MGI:4420359 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005741 |
mitochondrial outer membrane |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005764 |
lysosome |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005768 |
endosome |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005769 |
early endosome |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005770 |
late endosome |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005771 |
multivesicular body |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005794 |
Golgi apparatus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005829 |
cytosol |
MGI:MGI:3053262 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:3053262 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005911 |
cell-cell junction |
MGI:MGI:3053262 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005916 |
fascia adherens |
MGI:MGI:2154656 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005916 |
fascia adherens |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005921 |
gap junction |
MGI:MGI:2665243 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005921 |
gap junction |
MGI:MGI:2679790 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005921 |
gap junction |
MGI:MGI:3607852 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005921 |
gap junction |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005921 |
gap junction |
MGI:MGI:4838957 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005922 |
connexon complex |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006915 |
apoptotic process |
MGI:MGI:3849919 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2445472 |
P |
From MGI |
||
| GO:0006915 |
apoptotic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007154 |
cell communication |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007165 |
signal transduction |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007267 |
cell-cell signaling |
MGI:MGI:2157676 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007267 |
cell-cell signaling |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007507 |
heart development |
MGI:MGI:3624198 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3051881 |
P |
From MGI |
||
| GO:0007512 |
adult heart development |
MGI:MGI:1201220 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857177 |
P |
From MGI |
||
| GO:0008016 |
regulation of heart contraction |
MGI:MGI:2157676 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857177 |
P |
From MGI |
||
| GO:0008016 |
regulation of heart contraction |
MGI:MGI:3051209 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3051881 |
P |
From MGI |
||
| GO:0008285 |
negative regulation of cell proliferation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0009268 |
response to pH |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0010232 |
vascular transport |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0010628 |
positive regulation of gene expression |
MGI:MGI:3849919 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2445472 |
P |
From MGI |
||
| GO:0010629 |
negative regulation of gene expression |
MGI:MGI:3849919 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2445472 |
P |
From MGI |
||
| GO:0015867 |
ATP transport |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016021 |
integral to membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0812 |
C |
From MGI |
||
| GO:0017124 |
SH3 domain binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0019904 |
protein domain specific binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0022857 |
transmembrane transporter activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0030054 |
cell junction |
MGI:MGI:3513707 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0030165 |
PDZ domain binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0035050 |
embryonic heart tube development |
MGI:MGI:2686766 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857177 |
P |
From MGI |
||
| GO:0043123 |
positive regulation of I-kappaB kinase/NF-kappaB cascade |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043292 |
contractile fiber |
MGI:MGI:5052199 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0043403 |
skeletal muscle tissue regeneration |
MGI:MGI:3513707 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045121 |
membrane raft |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0045732 |
positive regulation of protein catabolic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045844 |
positive regulation of striated muscle tissue development |
MGI:MGI:3513707 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2676327 |
P |
From MGI |
||
| GO:0048514 |
blood vessel morphogenesis |
MGI:MGI:3624198 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3051881 |
P |
From MGI |
||
| GO:0048812 |
neuron projection morphogenesis |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051259 |
protein oligomerization |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051924 |
regulation of calcium ion transport |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0055085 |
transmembrane transport |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0060174 |
limb bud formation |
MGI:MGI:3849919 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2445472 |
P |
From MGI |
||
| GO:0060312 |
regulation of blood vessel remodeling |
MGI:MGI:4943617 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0090162 |
establishment of epithelial cell polarity |
MGI:MGI:4943617 |
TAS: Traceable Author Statement |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Ya J et al. (1998) Heart defects in connexin43-deficient mice. Circ Res 82: 360-6 PubMed GONUTS page
- ↑ Fushiki S et al. (2003) Changes in neuronal migration in neocortex of connexin43 null mutant mice. J Neuropathol Exp Neurol 62: 304-14 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Liu S et al. (2006) Distinct cardiac malformations caused by absence of connexin 43 in the neural crest and in the non-crest neural tube. Development 133: 2063-73 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Olivey HE & Svensson EC (2010) Epicardial-myocardial signaling directing coronary vasculogenesis. Circ Res 106: 818-32 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Fortes FS et al. (2004) Modulation of intercellular communication in macrophages: possible interactions between GAP junctions and P2 receptors. J Cell Sci 117: 4717-26 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Vaidya D et al. (2001) Null mutation of connexin43 causes slow propagation of ventricular activation in the late stages of mouse embryonic development. Circ Res 88: 1196-202 PubMed GONUTS page
- ↑ Wörsdörfer P et al. (2008) Connexin expression and functional analysis of gap junctional communication in mouse embryonic stem cells. Stem Cells 26: 431-9 PubMed GONUTS page
- ↑ Sato M et al. (2009) Activator of G protein signaling 8 (AGS8) is required for hypoxia-induced apoptosis of cardiomyocytes: role of G betagamma and connexin 43 (CX43). J Biol Chem 284: 31431-40 PubMed GONUTS page
- ↑ Zhang JQ et al. (2001) Ultrastructural and biochemical localization of N-RAP at the interface between myofibrils and intercalated disks in the mouse heart. Biochemistry 40: 14898-906 PubMed GONUTS page
- ↑ Iijima Y et al. (2003) Beating is necessary for transdifferentiation of skeletal muscle-derived cells into cardiomyocytes. FASEB J 17: 1361-3 PubMed GONUTS page
- ↑ Forge A et al. (2003) Gap junctions in the inner ear: comparison of distribution patterns in different vertebrates and assessement of connexin composition in mammals. J Comp Neurol 467: 207-31 PubMed GONUTS page
- ↑ Johnson CM et al. (2002) Redistribution of connexin45 in gap junctions of connexin43-deficient hearts. Cardiovasc Res 53: 921-35 PubMed GONUTS page
- ↑ Bhalla-Gehi R et al. (2010) Pannexin1 and pannexin3 delivery, cell surface dynamics, and cytoskeletal interactions. J Biol Chem 285: 9147-60 PubMed GONUTS page
- ↑ 14.0 14.1 14.2 14.3 Dobrowolski R et al. (2009) Loss of connexin43-mediated gap junctional coupling in the mesenchyme of limb buds leads to altered expression of morphogens in mice. Hum Mol Genet 18: 2899-911 PubMed GONUTS page
- ↑ Gutstein DE et al. (2001) Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin43. Circ Res 88: 333-9 PubMed GONUTS page
- ↑ 16.0 16.1 16.2 Araya R et al. (2005) Expression of connexins during differentiation and regeneration of skeletal muscle: functional relevance of connexin43. J Cell Sci 118: 27-37 PubMed GONUTS page
- ↑ Simon AM et al. (2004) Heart and head defects in mice lacking pairs of connexins. Dev Biol 265: 369-83 PubMed GONUTS page
- ↑ Crippa S et al. (2011) miR669a and miR669q prevent skeletal muscle differentiation in postnatal cardiac progenitors. J Cell Biol 193: 1197-212 PubMed GONUTS page
