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MGI:Gipc1
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Gipc1 ( synonyms: Glut1CIP, neurophilin1-IP, Rgs19ip1, Semcap1, synectin, TaxIP2, TIP-2 ) | |
| Protein Name(s) | GIPC PDZ domain containing family, member 1, | |
| External Links | ||
| MGI | MGI:1926252 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0003779 |
actin binding |
MGI:MGI:3610864 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005096 |
GTPase activator activity |
MGI:MGI:1934406 |
TAS: Traceable Author Statement |
F |
From MGI |
|||
| GO:0005102 |
receptor binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:1889199 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3610864 |
IPI: Inferred from Physical Interaction |
UniProtKB:P68134 |
F |
From MGI |
||
| GO:0005515 |
protein binding |
MGI:MGI:3687813 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3807767 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:3610864 |
IPI: Inferred from Physical Interaction |
C |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:3656369 |
IMP: Inferred from Mutant Phenotype |
C |
From MGI |
|||
| GO:0005623 |
cell |
MGI:MGI:3654775 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3663921 |
C |
From MGI |
||
| GO:0005624 |
membrane fraction |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_445793 |
C |
From MGI |
||
| GO:0005624 |
membrane fraction |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005625 |
soluble fraction |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:3654775 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005829 |
cytosol |
MGI:MGI:1890003 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005903 |
brush border |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_445793 |
C |
From MGI |
||
| GO:0005938 |
cell cortex |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006605 |
protein targeting |
MGI:MGI:3610864 |
IPI: Inferred from Physical Interaction |
P |
From MGI |
|||
| GO:0006605 |
protein targeting |
MGI:MGI:3656369 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0007186 |
G-protein coupled receptor signaling pathway |
MGI:MGI:1934406 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0007268 |
synaptic transmission |
MGI:MGI:3654775 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3663921 |
P |
From MGI |
||
| GO:0008021 |
synaptic vesicle |
MGI:MGI:3654775 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0012506 |
vesicle membrane |
MGI:MGI:3610864 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0014047 |
glutamate secretion |
MGI:MGI:3654775 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3663921 |
P |
From MGI |
||
| GO:0016020 |
membrane |
MGI:MGI:1890003 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0016023 |
cytoplasmic membrane-bounded vesicle |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0017022 |
myosin binding |
MGI:MGI:3663985 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0030139 |
endocytic vesicle |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_445793 |
C |
From MGI |
||
| GO:0030165 |
PDZ domain binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_445793 |
F |
From MGI |
||
| GO:0030511 |
positive regulation of transforming growth factor beta receptor signaling pathway |
MGI:MGI:3807767 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0031647 |
regulation of protein stability |
MGI:MGI:3807767 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0032435 |
negative regulation of proteasomal ubiquitin-dependent protein catabolic process |
MGI:MGI:3807767 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0042803 |
protein homodimerization activity |
MGI:MGI:3610864 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0043197 |
dendritic spine |
MGI:MGI:3654775 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0043198 |
dendritic shaft |
MGI:MGI:3654775 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0043542 |
endothelial cell migration |
MGI:MGI:3656369 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0043547 |
positive regulation of GTPase activity |
MGI:MGI:1934406 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0044445 |
cytosolic part |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_445793 |
C |
From MGI |
||
| GO:0048167 |
regulation of synaptic plasticity |
MGI:MGI:3654775 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3663921 |
P |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Reed BC et al. (2005) GLUT1CBP(TIP2/GIPC1) interactions with GLUT1 and myosin VI: evidence supporting an adapter function for GLUT1CBP. Mol Biol Cell 16: 4183-201 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Nagata Y et al. (2001) A novel regulator of G-protein signaling bearing GAP activity for Galphai and Galphaq in megakaryocytes. Blood 97: 3051-60 PubMed GONUTS page
- ↑ Wang LH et al. (1999) A PDZ protein regulates the distribution of the transmembrane semaphorin, M-SemF. J Biol Chem 274: 14137-46 PubMed GONUTS page
- ↑ Gotthardt M et al. (2000) Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction. J Biol Chem 275: 25616-24 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Blobe GC et al. (2001) A novel mechanism for regulating transforming growth factor beta (TGF-beta) signaling. Functional modulation of type III TGF-beta receptor expression through interaction with the PDZ domain protein, GIPC. J Biol Chem 276: 39608-17 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Liu M & Horowitz A (2006) A PDZ-binding motif as a critical determinant of Rho guanine exchange factor function and cell phenotype. Mol Biol Cell 17: 1880-7 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 7.4 7.5 7.6 7.7 Yano H et al. (2006) BDNF-mediated neurotransmission relies upon a myosin VI motor complex. Nat Neurosci 9: 1009-18 PubMed GONUTS page
- ↑ 8.0 8.1 De Vries L et al. (1998) GIPC, a PDZ domain containing protein, interacts specifically with the C terminus of RGS-GAIP. Proc Natl Acad Sci U S A 95: 12340-5 PubMed GONUTS page
- ↑ Naccache SN et al. (2006) Binding of internalized receptors to the PDZ domain of GIPC/synectin recruits myosin VI to endocytic vesicles. Proc Natl Acad Sci U S A 103: 12735-40 PubMed GONUTS page
