MGI:Ghrhr

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0004871	signal transducer activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0807	F	From MGI
	GO:0004872	receptor activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0675	F	From MGI
	GO:0004888	transmembrane signaling receptor activity	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR017981	F	From MGI
	GO:0004930	G-protein coupled receptor activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0297	F	From MGI
	GO:0004930	G-protein coupled receptor activity	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR001879 InterPro:IPR003288 InterPro:IPR000832 InterPro:IPR017983	F	From MGI
	GO:0005515	protein binding	MGI:MGI:1347385 PMID:10537133^[1]	IPI: Inferred from Physical Interaction	UniProtKB:P16043	F	From MGI
	GO:0005622	intracellular	MGI:MGI:1347385 PMID:10537133^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856425	C	From MGI
	GO:0005622	intracellular	MGI:MGI:56721 PMID:3008329^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856425	C	From MGI
	GO:0005622	intracellular	MGI:MGI:61064 PMID:8395283^[3]	IGI: Inferred from Genetic Interaction	MGI:MGI:95709	C	From MGI
	GO:0005622	intracellular	MGI:MGI:61599 PMID:8391647^[4]	IGI: Inferred from Genetic Interaction	MGI:MGI:95709	C	From MGI
	GO:0005622	intracellular	MGI:MGI:80583 PMID:1334535^[5]	IGI: Inferred from Genetic Interaction	MGI:MGI:95709	C	From MGI
	GO:0005623	cell	MGI:MGI:54187 PMID:978118^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856425	C	From MGI
	GO:0005623	cell	MGI:MGI:55531 PMID:6303755^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856425	C	From MGI
	GO:0005624	membrane fraction	MGI:MGI:3833824 PMID:11773624^[8]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005637	nuclear inner membrane	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q02643	C	From MGI
	GO:0005640	nuclear outer membrane	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q02643	C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q02643	C	From MGI
	GO:0005886	plasma membrane	MGI:MGI:1347385 PMID:10537133^[1]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005886	plasma membrane	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q02644	C	From MGI
	GO:0005886	plasma membrane	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q02643	C	From MGI
	GO:0007165	signal transduction	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q02644	P	From MGI
	GO:0007166	cell surface receptor signaling pathway	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR017981	P	From MGI
	GO:0007186	G-protein coupled receptor signaling pathway	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0297	P	From MGI
	GO:0007186	G-protein coupled receptor signaling pathway	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR003288 InterPro:IPR000832 InterPro:IPR017983	P	From MGI
	GO:0007188	G-protein signaling, coupled to cAMP nucleotide second messenger	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q02644	P	From MGI
	GO:0007189	activation of adenylate cyclase activity by G-protein signaling pathway	MGI:MGI:1347385 PMID:10537133^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856425	P	From MGI
	GO:0007189	activation of adenylate cyclase activity by G-protein signaling pathway	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q02644	P	From MGI
	GO:0007189	activation of adenylate cyclase activity by G-protein signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q02643	P	From MGI
	GO:0007189	activation of adenylate cyclase activity by G-protein signaling pathway	MGI:MGI:56721 PMID:3008329^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856425	P	From MGI
	GO:0007189	activation of adenylate cyclase activity by G-protein signaling pathway	MGI:MGI:61064 PMID:8395283^[3]	IGI: Inferred from Genetic Interaction	MGI:MGI:95709	P	From MGI
	GO:0007189	activation of adenylate cyclase activity by G-protein signaling pathway	MGI:MGI:61599 PMID:8391647^[4]	IGI: Inferred from Genetic Interaction	MGI:MGI:95709	P	From MGI
	GO:0007189	activation of adenylate cyclase activity by G-protein signaling pathway	MGI:MGI:80583 PMID:1334535^[5]	IGI: Inferred from Genetic Interaction	MGI:MGI:95709	P	From MGI
	GO:0007190	activation of adenylate cyclase activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q02644	P	From MGI
	GO:0007595	lactation	MGI:MGI:49336 PMID:2980124^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856425	P	From MGI
	GO:0007595	lactation	MGI:MGI:54124 PMID:1270792^[10]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856425	P	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:3833824 PMID:11773624^[8]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q02643	P	From MGI
	GO:0008340	determination of adult lifespan	MGI:MGI:2135699 PMID:11371619^[11]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856425	P	From MGI
	GO:0009986	cell surface	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q02644	C	From MGI
	GO:0009986	cell surface	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q02643	C	From MGI
	GO:0016020	membrane	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0472	C	From MGI
	GO:0016020	membrane	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR017981 InterPro:IPR001879 InterPro:IPR003288 InterPro:IPR017983	C	From MGI
	GO:0016021	integral to membrane	MGI:MGI:1347385 PMID:10537133^[1]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0016021	integral to membrane	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:P78470	C	From MGI
	GO:0016021	integral to membrane	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q02643	C	From MGI
	GO:0016363	nuclear matrix	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q02643	C	From MGI
	GO:0016520	growth hormone-releasing hormone receptor activity	MGI:MGI:1347385 PMID:10537133^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856425	F	From MGI
	GO:0016520	growth hormone-releasing hormone receptor activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q02644	F	From MGI
	GO:0016520	growth hormone-releasing hormone receptor activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q02643	F	From MGI
	GO:0016520	growth hormone-releasing hormone receptor activity	MGI:MGI:61599 PMID:8391647^[4]	IGI: Inferred from Genetic Interaction	MGI:MGI:95709	F	From MGI
	GO:0017046	peptide hormone binding	MGI:MGI:3833824 PMID:11773624^[8]	IPI: Inferred from Physical Interaction	UniProtKB:P16043	F	From MGI
	GO:0017046	peptide hormone binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q02644	F	From MGI
	GO:0017046	peptide hormone binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q02643	F	From MGI
	GO:0019838	growth factor binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q02643	F	From MGI
	GO:0019933	cAMP-mediated signaling	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q02643	P	From MGI
	GO:0021984	adenohypophysis development	MGI:MGI:51713 PMID:1504465^[12]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856425	P	From MGI
	GO:0021984	adenohypophysis development	MGI:MGI:54124 PMID:1270792^[10]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856425	P	From MGI
	GO:0021984	adenohypophysis development	MGI:MGI:63703 PMID:1329576^[13]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856425	P	From MGI
	GO:0030104	water homeostasis	MGI:MGI:64922 PMID:7510770^[14]	IGI: Inferred from Genetic Interaction	MGI:MGI:96432	P	From MGI
	GO:0030141	secretory granule	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q02643	C	From MGI
	GO:0030252	growth hormone secretion	MGI:MGI:54187 PMID:978118^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856425	P	From MGI
	GO:0030252	growth hormone secretion	MGI:MGI:55531 PMID:6303755^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856425	P	From MGI
	GO:0030816	positive regulation of cAMP metabolic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q02644	P	From MGI
	GO:0030819	positive regulation of cAMP biosynthetic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q02643	P	From MGI
	GO:0030879	mammary gland development	MGI:MGI:3616136 PMID:15059953^[15]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856425	P	From MGI
	GO:0032868	response to insulin stimulus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q02643	P	From MGI
	GO:0032869	cellular response to insulin stimulus	MGI:MGI:3769319 PMID:16513828^[16]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0033143	regulation of intracellular steroid hormone receptor signaling pathway	MGI:MGI:1340790 PMID:10459853^[17]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856425	P	From MGI
	GO:0040018	positive regulation of multicellular organism growth	MGI:MGI:1353772 PMID:10689811^[18]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856425	P	From MGI
	GO:0040018	positive regulation of multicellular organism growth	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:P78470	P	From MGI
	GO:0040018	positive regulation of multicellular organism growth	MGI:MGI:3528097 PMID:15690087^[19]	IGI: Inferred from Genetic Interaction	MGI:MGI:1201787	P	From MGI
	GO:0040018	positive regulation of multicellular organism growth	MGI:MGI:3528097 PMID:15690087^[19]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856425	P	From MGI
	GO:0040018	positive regulation of multicellular organism growth	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q02643	P	From MGI
	GO:0040018	positive regulation of multicellular organism growth	MGI:MGI:50317 PMID:1778592^[20]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856425	P	From MGI
	GO:0040018	positive regulation of multicellular organism growth	MGI:MGI:52244 PMID:7679139^[21]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856425	P	From MGI
	GO:0040018	positive regulation of multicellular organism growth	MGI:MGI:54124 PMID:1270792^[10]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856425	P	From MGI
	GO:0042445	hormone metabolic process	MGI:MGI:54124 PMID:1270792^[10]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856425	P	From MGI
	GO:0043567	regulation of insulin-like growth factor receptor signaling pathway	MGI:MGI:52244 PMID:7679139^[21]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856425	P	From MGI
	GO:0043567	regulation of insulin-like growth factor receptor signaling pathway	MGI:MGI:54816 PMID:7390396^[22]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856425	P	From MGI
	GO:0043627	response to estrogen stimulus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q02643	P	From MGI
	GO:0046887	positive regulation of hormone secretion	MGI:MGI:52244 PMID:7679139^[21]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856425	P	From MGI
	GO:0048469	cell maturation	MGI:MGI:49336 PMID:2980124^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856425	P	From MGI
	GO:0051246	regulation of protein metabolic process	MGI:MGI:64922 PMID:7510770^[14]	IGI: Inferred from Genetic Interaction	MGI:MGI:96432	P	From MGI
	GO:0051384	response to glucocorticoid stimulus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q02643	P	From MGI
	GO:0060124	positive regulation of growth hormone secretion	MGI:MGI:56721 PMID:3008329^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856425	P	From MGI
	GO:0060133	somatotropin secreting cell development	MGI:MGI:55682 PMID:6194978^[23]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856425	P	From MGI
	GO:0060133	somatotropin secreting cell development	MGI:MGI:63474 PMID:6116352^[24]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856425	P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Gaylinn BD et al. (1999) The mutant growth hormone-releasing hormone (GHRH) receptor of the little mouse does not bind GHRH. Endocrinology 140: 5066-74 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Jansson JO et al. (1986) Receptor-associated resistance to growth hormone-releasing factor in dwarf "little" mice. Science 232: 511-2 PubMed GONUTS page
↑ ^3.0 ^3.1 Godfrey P et al. (1993) GHRH receptor of little mice contains a missense mutation in the extracellular domain that disrupts receptor function. Nat Genet 4: 227-32 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Lin SC et al. (1993) Molecular basis of the little mouse phenotype and implications for cell type-specific growth. Nature 364: 208-13 PubMed GONUTS page
↑ ^5.0 ^5.1 Lin C et al. (1992) Pit-1-dependent expression of the receptor for growth hormone releasing factor mediates pituitary cell growth. Nature 360: 765-8 PubMed GONUTS page
↑ ^6.0 ^6.1 Beamer WH & Eicher EM (1976) Stimulation of growth in the little mouse. J Endocrinol 71: 37-45 PubMed GONUTS page
↑ ^7.0 ^7.1 Herington AC et al. (1983) Hepatic binding of human and bovine growth hormones and ovine prolactin in the dwarf "little" mouse. Endocrinology 112: 2032-8 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Kiaris H et al. (2002) Expression of a splice variant of the receptor for GHRH in 3T3 fibroblasts activates cell proliferation responses to GHRH analogs. Proc Natl Acad Sci U S A 99: 196-200 PubMed GONUTS page
↑ ^9.0 ^9.1 Wilson DB & Wyatt DP (1986) Growth hormone and prolactin immunoreactivity in the pituitary gland of postnatal little (lit) mice. Histol Histopathol 1: 309-13 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Eicher EM & Beamer WG (1976) Inherited ateliotic dwarfism in mice. Characteristics of the mutation, little, on chromosome 6. J Hered 67: 87-91 PubMed GONUTS page
↑ Flurkey K et al. (2001) Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production. Proc Natl Acad Sci U S A 98: 6736-41 PubMed GONUTS page
↑ Wilson DB & Wyatt DP (1992) Histopathology of the pituitary gland in neonatal little (lit) mutant mice. Histol Histopathol 7: 451-5 PubMed GONUTS page
↑ Wilson DB & Wyatt DP (1992) Adrenocorticotropic cell distribution in adult and embryonic pituitaries of the little (lit) mutant mouse. Anat Embryol (Berl) 186: 347-53 PubMed GONUTS page
↑ ^14.0 ^14.1 Donahue LR et al. (1993) Regulation of metabolic water and protein compartments by insulin-like growth factor-I and testosterone in growth hormone-deficient lit/lit mice. J Endocrinol 139: 431-9 PubMed GONUTS page
↑ Richards RG et al. (2004) Mammary gland branching morphogenesis is diminished in mice with a deficiency of insulin-like growth factor-I (IGF-I), but not in mice with a liver-specific deletion of IGF-I. Endocrinology 145: 3106-10 PubMed GONUTS page
↑ Luque RM & Kineman RD (2006) Impact of obesity on the growth hormone axis: evidence for a direct inhibitory effect of hyperinsulinemia on pituitary function. Endocrinology 147: 2754-63 PubMed GONUTS page
↑ Niermann GL & Watson GL (1999) Growth hormone and insulin-like growth factor-I enhance beta-glucuronidase gene activation by androgen in mouse kidney. Mol Cell Endocrinol 153: 47-55 PubMed GONUTS page
↑ Bünger L & Hill WG (1999) Role of growth hormone in the genetic change of mice divergently selected for body weight and fatness. Genet Res 74: 351-60 PubMed GONUTS page
↑ ^19.0 ^19.1 Greenhalgh CJ et al. (2005) SOCS2 negatively regulates growth hormone action in vitro and in vivo. J Clin Invest 115: 397-406 PubMed GONUTS page
↑ Woodall SM et al. (1991) The effect of the frequency of subcutaneous insulin-like growth factor-1 administration on weight gain in growth hormone deficient mice. Horm Metab Res 23: 581-4 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 Donahue LR & Beamer WG (1993) Growth hormone deficiency in 'little' mice results in aberrant body composition, reduced insulin-like growth factor-I and insulin-like growth factor-binding protein-3 (IGFBP-3), but does not affect IGFBP-2, -1 or -4. J Endocrinol 136: 91-104 PubMed GONUTS page
↑ Nissley SP et al. (1980) Somatomedin activity in sera of genetically small mice. Horm Metab Res 12: 158-64 PubMed GONUTS page
↑ Cheng TC et al. (1983) Etiology of growth hormone deficiency in little, Ames, and Snell dwarf mice. Endocrinology 113: 1669-78 PubMed GONUTS page
↑ Christensen E & Wilson DB (1981) Fine structure of somatotrophs and mammotrophs in the pituitary pars distalis of the little (lit) mutant mouse. Virchows Arch B Cell Pathol Incl Mol Pathol 37: 89-96 PubMed GONUTS page

[PMID:10537133-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Gaylinn BD et al. (1999) The mutant growth hormone-releasing hormone (GHRH) receptor of the little mouse does not bind GHRH. Endocrinology 140: 5066-74 PubMed GONUTS page

[PMID:3008329-1] 2.0 ^2.1 ^2.2 Jansson JO et al. (1986) Receptor-associated resistance to growth hormone-releasing factor in dwarf "little" mice. Science 232: 511-2 PubMed GONUTS page

[PMID:8395283-2] 3.0 ^3.1 Godfrey P et al. (1993) GHRH receptor of little mice contains a missense mutation in the extracellular domain that disrupts receptor function. Nat Genet 4: 227-32 PubMed GONUTS page

[PMID:8391647-3] 4.0 ^4.1 ^4.2 Lin SC et al. (1993) Molecular basis of the little mouse phenotype and implications for cell type-specific growth. Nature 364: 208-13 PubMed GONUTS page

[PMID:1334535-4] 5.0 ^5.1 Lin C et al. (1992) Pit-1-dependent expression of the receptor for growth hormone releasing factor mediates pituitary cell growth. Nature 360: 765-8 PubMed GONUTS page

[PMID:978118-5] 6.0 ^6.1 Beamer WH & Eicher EM (1976) Stimulation of growth in the little mouse. J Endocrinol 71: 37-45 PubMed GONUTS page

[PMID:6303755-6] 7.0 ^7.1 Herington AC et al. (1983) Hepatic binding of human and bovine growth hormones and ovine prolactin in the dwarf "little" mouse. Endocrinology 112: 2032-8 PubMed GONUTS page

[PMID:11773624-7] 8.0 ^8.1 ^8.2 Kiaris H et al. (2002) Expression of a splice variant of the receptor for GHRH in 3T3 fibroblasts activates cell proliferation responses to GHRH analogs. Proc Natl Acad Sci U S A 99: 196-200 PubMed GONUTS page

[PMID:2980124-8] 9.0 ^9.1 Wilson DB & Wyatt DP (1986) Growth hormone and prolactin immunoreactivity in the pituitary gland of postnatal little (lit) mice. Histol Histopathol 1: 309-13 PubMed GONUTS page

[PMID:1270792-9] 10.0 ^10.1 ^10.2 ^10.3 Eicher EM & Beamer WG (1976) Inherited ateliotic dwarfism in mice. Characteristics of the mutation, little, on chromosome 6. J Hered 67: 87-91 PubMed GONUTS page

[PMID:11371619-10] Flurkey K et al. (2001) Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production. Proc Natl Acad Sci U S A 98: 6736-41 PubMed GONUTS page

[PMID:1504465-11] Wilson DB & Wyatt DP (1992) Histopathology of the pituitary gland in neonatal little (lit) mutant mice. Histol Histopathol 7: 451-5 PubMed GONUTS page

[PMID:1329576-12] Wilson DB & Wyatt DP (1992) Adrenocorticotropic cell distribution in adult and embryonic pituitaries of the little (lit) mutant mouse. Anat Embryol (Berl) 186: 347-53 PubMed GONUTS page

[PMID:7510770-13] 14.0 ^14.1 Donahue LR et al. (1993) Regulation of metabolic water and protein compartments by insulin-like growth factor-I and testosterone in growth hormone-deficient lit/lit mice. J Endocrinol 139: 431-9 PubMed GONUTS page

[PMID:15059953-14] Richards RG et al. (2004) Mammary gland branching morphogenesis is diminished in mice with a deficiency of insulin-like growth factor-I (IGF-I), but not in mice with a liver-specific deletion of IGF-I. Endocrinology 145: 3106-10 PubMed GONUTS page

[PMID:16513828-15] Luque RM & Kineman RD (2006) Impact of obesity on the growth hormone axis: evidence for a direct inhibitory effect of hyperinsulinemia on pituitary function. Endocrinology 147: 2754-63 PubMed GONUTS page

[PMID:10459853-16] Niermann GL & Watson GL (1999) Growth hormone and insulin-like growth factor-I enhance beta-glucuronidase gene activation by androgen in mouse kidney. Mol Cell Endocrinol 153: 47-55 PubMed GONUTS page

[PMID:10689811-17] Bünger L & Hill WG (1999) Role of growth hormone in the genetic change of mice divergently selected for body weight and fatness. Genet Res 74: 351-60 PubMed GONUTS page

[PMID:15690087-18] 19.0 ^19.1 Greenhalgh CJ et al. (2005) SOCS2 negatively regulates growth hormone action in vitro and in vivo. J Clin Invest 115: 397-406 PubMed GONUTS page

[PMID:1778592-19] Woodall SM et al. (1991) The effect of the frequency of subcutaneous insulin-like growth factor-1 administration on weight gain in growth hormone deficient mice. Horm Metab Res 23: 581-4 PubMed GONUTS page

[PMID:7679139-20] 21.0 ^21.1 ^21.2 Donahue LR & Beamer WG (1993) Growth hormone deficiency in 'little' mice results in aberrant body composition, reduced insulin-like growth factor-I and insulin-like growth factor-binding protein-3 (IGFBP-3), but does not affect IGFBP-2, -1 or -4. J Endocrinol 136: 91-104 PubMed GONUTS page

[PMID:7390396-21] Nissley SP et al. (1980) Somatomedin activity in sera of genetically small mice. Horm Metab Res 12: 158-64 PubMed GONUTS page

[PMID:6194978-22] Cheng TC et al. (1983) Etiology of growth hormone deficiency in little, Ames, and Snell dwarf mice. Endocrinology 113: 1669-78 PubMed GONUTS page

[PMID:6116352-23] Christensen E & Wilson DB (1981) Fine structure of somatotrophs and mammotrophs in the pituitary pars distalis of the little (lit) mutant mouse. Virchows Arch B Cell Pathol Incl Mol Pathol 37: 89-96 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Ghrhr ( synonyms: Ghrfr )
Protein Name(s)	growth hormone releasing hormone receptor,
External Links
MGI	MGI:95710

MGI:Ghrhr

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