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MGI:Ghrh
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Ghrh ( synonyms: Ghrf ) | |
| Protein Name(s) | growth hormone releasing hormone, | |
| External Links | ||
| MGI | MGI:95709 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0005179 |
hormone activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005576 |
extracellular region |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0964 |
C |
From MGI |
||
| GO:0005576 |
extracellular region |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0005615 |
extracellular space |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005615 |
extracellular space |
MGI:MGI:66217 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005615 |
extracellular space |
MGI:MGI:69453 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005615 |
extracellular space |
MGI:MGI:71439 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:1347385 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:61064 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:95710 |
C |
From MGI |
||
| GO:0005622 |
intracellular |
MGI:MGI:61599 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:95710 |
C |
From MGI |
||
| GO:0005622 |
intracellular |
MGI:MGI:80583 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:95710 |
C |
From MGI |
||
| GO:0005623 |
cell |
MGI:MGI:1098976 |
IMP: Inferred from Mutant Phenotype |
C |
From MGI |
|||
| GO:0005623 |
cell |
MGI:MGI:3607618 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3051561 |
C |
From MGI |
||
| GO:0007188 |
G-protein signaling, coupled to cAMP nucleotide second messenger |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007189 |
activation of adenylate cyclase activity by G-protein signaling pathway |
MGI:MGI:1347385 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007189 |
activation of adenylate cyclase activity by G-protein signaling pathway |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007189 |
activation of adenylate cyclase activity by G-protein signaling pathway |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007189 |
activation of adenylate cyclase activity by G-protein signaling pathway |
MGI:MGI:61064 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:95710 |
P |
From MGI |
||
| GO:0007189 |
activation of adenylate cyclase activity by G-protein signaling pathway |
MGI:MGI:61599 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:95710 |
P |
From MGI |
||
| GO:0007189 |
activation of adenylate cyclase activity by G-protein signaling pathway |
MGI:MGI:80583 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:95710 |
P |
From MGI |
||
| GO:0007204 |
elevation of cytosolic calcium ion concentration |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008284 |
positive regulation of cell proliferation |
MGI:MGI:3833824 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0008284 |
positive regulation of cell proliferation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0010667 |
negative regulation of cardiac muscle cell apoptotic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0016608 |
growth hormone-releasing hormone activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0016608 |
growth hormone-releasing hormone activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0019933 |
cAMP-mediated signaling |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0021984 |
adenohypophysis development |
MGI:MGI:3607618 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3051561 |
P |
From MGI |
||
| GO:0030252 |
growth hormone secretion |
MGI:MGI:1098976 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0030252 |
growth hormone secretion |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030252 |
growth hormone secretion |
MGI:MGI:3039217 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0030252 |
growth hormone secretion |
MGI:MGI:3607618 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3051561 |
P |
From MGI |
||
| GO:0030252 |
growth hormone secretion |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030816 |
positive regulation of cAMP metabolic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030819 |
positive regulation of cAMP biosynthetic process |
MGI:MGI:3833824 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0030819 |
positive regulation of cAMP biosynthetic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0031770 |
growth hormone-releasing hormone receptor binding |
MGI:MGI:3833824 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0031770 |
growth hormone-releasing hormone receptor binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0032094 |
response to food |
MGI:MGI:3769319 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0040018 |
positive regulation of multicellular organism growth |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0040018 |
positive regulation of multicellular organism growth |
MGI:MGI:3607618 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3051561 |
P |
From MGI |
||
| GO:0040018 |
positive regulation of multicellular organism growth |
MGI:MGI:3695097 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:95707 |
P |
From MGI |
||
| GO:0040018 |
positive regulation of multicellular organism growth |
MGI:MGI:3695097 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3051561 |
P |
From MGI |
||
| GO:0043005 |
neuron projection |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0043195 |
terminal button |
MGI:MGI:64254 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0043204 |
perikaryon |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0043679 |
axon terminus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0046010 |
positive regulation of circadian sleep/wake cycle, non-REM sleep |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0046887 |
positive regulation of hormone secretion |
MGI:MGI:1098976 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0046887 |
positive regulation of hormone secretion |
MGI:MGI:3607618 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3051561 |
P |
From MGI |
||
| GO:0046887 |
positive regulation of hormone secretion |
MGI:MGI:3695097 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3051561 |
P |
From MGI |
||
| GO:0060124 |
positive regulation of growth hormone secretion |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0060124 |
positive regulation of growth hormone secretion |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Miki N et al. (1994) Characterization and localization of mouse hypothalamic growth hormone-releasing factor and effect of gold thioglucose-induced hypothalamic lesions. J Neuroendocrinol 6: 71-8 PubMed GONUTS page
- ↑ Yamaguchi M et al. (1994) Transforming growth factor-beta 1 post-transcriptionally inhibits mouse growth hormone releasing factor secretion in placenta. Biochem Biophys Res Commun 204: 1206-11 PubMed GONUTS page
- ↑ Yamaguchi M et al. (1995) Inhibition of growth hormone-releasing factor production in mouse placenta by cytokines using gp130 as a signal transducer. Endocrinology 136: 1072-8 PubMed GONUTS page
- ↑ 4.0 4.1 Gaylinn BD et al. (1999) The mutant growth hormone-releasing hormone (GHRH) receptor of the little mouse does not bind GHRH. Endocrinology 140: 5066-74 PubMed GONUTS page
- ↑ 5.0 5.1 Godfrey P et al. (1993) GHRH receptor of little mice contains a missense mutation in the extracellular domain that disrupts receptor function. Nat Genet 4: 227-32 PubMed GONUTS page
- ↑ 6.0 6.1 Lin SC et al. (1993) Molecular basis of the little mouse phenotype and implications for cell type-specific growth. Nature 364: 208-13 PubMed GONUTS page
- ↑ 7.0 7.1 Lin C et al. (1992) Pit-1-dependent expression of the receptor for growth hormone releasing factor mediates pituitary cell growth. Nature 360: 765-8 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 Kovacs M et al. (1997) Effects of antagonists of growth hormone-releasing hormone (GHRH) on GH and insulin-like growth factor I levels in transgenic mice overexpressing the human GHRH gene, an animal model of acromegaly. Endocrinology 138: 4536-42 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 9.3 9.4 Alba M et al. (2005) Effects of long-term treatment with growth hormone-releasing peptide-2 in the GHRH knockout mouse. Am J Physiol Endocrinol Metab 289: E762-7 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 Kiaris H et al. (2002) Expression of a splice variant of the receptor for GHRH in 3T3 fibroblasts activates cell proliferation responses to GHRH analogs. Proc Natl Acad Sci U S A 99: 196-200 PubMed GONUTS page
- ↑ Sun Y et al. (2004) Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor. Proc Natl Acad Sci U S A 101: 4679-84 PubMed GONUTS page
- ↑ Luque RM & Kineman RD (2006) Impact of obesity on the growth hormone axis: evidence for a direct inhibitory effect of hyperinsulinemia on pituitary function. Endocrinology 147: 2754-63 PubMed GONUTS page
- ↑ 13.0 13.1 13.2 Fintini D et al. (2005) Influence of estrogen administration on the growth response to growth hormone (GH) in GH-deficient mice. Exp Biol Med (Maywood) 230: 715-20 PubMed GONUTS page
- ↑ Phelps CJ et al. (1993) Growth hormone-releasing hormone peptide and mRNA are overexpressed in GH-deficient Ames dwarf mice. Endocrinology 133: 3034-7 PubMed GONUTS page
