GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.
You can help reduce stress on the server by:
- not reloading pages frequently - this just adds
- opening links in new windows (so you can read the old page)
MGI:Ghr
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Ghr ( synonyms: GHBP, GHR/BP ) | |
| Protein Name(s) | growth hormone receptor, | |
| External Links | ||
| MGI | MGI:95708 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000187 |
activation of MAPK activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0000255 |
allantoin metabolic process |
MGI:MGI:3804595 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0004872 |
receptor activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0675 |
F |
From MGI |
||
| GO:0004896 |
cytokine receptor activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0004903 |
growth hormone receptor activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004903 |
growth hormone receptor activity |
MGI:MGI:55531 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:82362 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005576 |
extracellular region |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0964 |
C |
From MGI |
||
| GO:0005615 |
extracellular space |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005615 |
extracellular space |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:87717 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005739 |
mitochondrion |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:87717 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005887 |
integral to plasma membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006101 |
citrate metabolic process |
MGI:MGI:3804595 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0006103 |
2-oxoglutarate metabolic process |
MGI:MGI:3804595 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0006105 |
succinate metabolic process |
MGI:MGI:3804595 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0006107 |
oxaloacetate metabolic process |
MGI:MGI:3804595 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0006549 |
isoleucine metabolic process |
MGI:MGI:3804595 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0006573 |
valine metabolic process |
MGI:MGI:3804595 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0006600 |
creatine metabolic process |
MGI:MGI:3804595 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0006631 |
fatty acid metabolic process |
MGI:MGI:3804595 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0006897 |
endocytosis |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0254 |
P |
From MGI |
||
| GO:0007259 |
JAK-STAT cascade |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0009755 |
hormone-mediated signaling pathway |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0009986 |
cell surface |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016020 |
membrane |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0016021 |
integral to membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0017046 |
peptide hormone binding |
MGI:MGI:1347647 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0017046 |
peptide hormone binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0017046 |
peptide hormone binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0019221 |
cytokine-mediated signaling pathway |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0019221 |
cytokine-mediated signaling pathway |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0019530 |
taurine metabolic process |
MGI:MGI:3804595 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0019838 |
growth factor binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0019898 |
extrinsic to membrane |
MGI:MGI:2158948 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0019901 |
protein kinase binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0019903 |
protein phosphatase binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0031623 |
receptor internalization |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032355 |
response to estradiol stimulus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032870 |
cellular response to hormone stimulus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0040014 |
regulation of multicellular organism growth |
MGI:MGI:3804595 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0040018 |
positive regulation of multicellular organism growth |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042169 |
SH2 domain binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0042803 |
protein homodimerization activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0042976 |
activation of Janus kinase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042977 |
activation of JAK2 kinase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043025 |
neuronal cell body |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0043235 |
receptor complex |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0043526 |
neuroprotection |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0044236 |
multicellular organismal metabolic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0046427 |
positive regulation of JAK-STAT cascade |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0046449 |
creatinine metabolic process |
MGI:MGI:3804595 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0046898 |
response to cycloheximide |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0048009 |
insulin-like growth factor receptor signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0050731 |
positive regulation of peptidyl-tyrosine phosphorylation |
MGI:MGI:82362 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0060396 |
growth hormone receptor signaling pathway |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0060396 |
growth hormone receptor signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0060396 |
growth hormone receptor signaling pathway |
MGI:MGI:82362 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0070195 |
growth hormone receptor complex |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 Schirra HJ et al. (2008) Altered metabolism of growth hormone receptor mutant mice: a combined NMR metabonomics and microarray study. PLoS One 3: e2764 PubMed GONUTS page
- ↑ Herington AC et al. (1983) Hepatic binding of human and bovine growth hormones and ovine prolactin in the dwarf "little" mouse. Endocrinology 112: 2032-8 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Xu BC et al. (1996) Growth hormone promotes the association of transcription factor STAT5 with the growth hormone receptor. J Biol Chem 271: 19768-73 PubMed GONUTS page
- ↑ 4.0 4.1 Pantaleon M et al. (1997) Functional growth hormone (GH) receptors and GH are expressed by preimplantation mouse embryos: a role for GH in early embryogenesis? Proc Natl Acad Sci U S A 94: 5125-30 PubMed GONUTS page
- ↑ González L et al. (1999) Up-regulation of GH-binding protein by mouse GH in transgenic mice overexpressing GH-releasing hormone. J Endocrinol 163: 299-307 PubMed GONUTS page
- ↑ Cerio RJ et al. (2002) Structurally distinct membrane-associated and soluble forms of GH-binding protein in the mouse. J Endocrinol 172: 321-31 PubMed GONUTS page
