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MGI:Gfap

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Contents

Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Gfap
Protein Name(s) glial fibrillary acidic protein,
External Links
MGI MGI:95697

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005178

integrin binding

MGI:MGI:2154458

ISO: Inferred from Sequence Orthology

UniProtKB:P47819

F

From MGI

GO:0005198

structural molecule activity

MGI:MGI:2384242
PMID:12177195[1]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2384719

F

From MGI

GO:0005200

structural constituent of cytoskeleton

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P47819

F

From MGI

GO:0005515

protein binding

MGI:MGI:3713044
PMID:17356066[2]

IPI: Inferred from Physical Interaction

UniProtKB:Q70IV5

F

From MGI

GO:0005624

membrane fraction

MGI:MGI:3706622
PMID:11283023[3]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:1926701
PMID:11064363[4]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:2158988
PMID:11834298[5]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:2429331
PMID:12355421[6]

ISO: Inferred from Sequence Orthology

UniProtKB:P14136

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:3583881
PMID:15965470[7]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:3604278
PMID:12074840[8]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:3772421
PMID:18076286[9]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005882

intermediate filament

MGI:MGI:1099676
PMID:9364068[10]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005882

intermediate filament

MGI:MGI:2449889
PMID:12533615[11]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005882

intermediate filament

MGI:MGI:2669074
PMID:12878680[12]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005882

intermediate filament

MGI:MGI:3531237
PMID:15656993[13]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005882

intermediate filament

MGI:MGI:3719550
PMID:11487638[14]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009611

response to wounding

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P47819

P

From MGI

GO:0010625

positive regulation of Schwann cell proliferation

MGI:MGI:3664718
PMID:16988027[15]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857176

P

From MGI

GO:0010977

negative regulation of neuron projection development

MGI:MGI:3719550
PMID:11487638[14]

IGI: Inferred from Genetic Interaction

MGI:MGI:98932

P

From MGI

GO:0010977

negative regulation of neuron projection development

MGI:MGI:3719550
PMID:11487638[14]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2183221

P

From MGI

GO:0014002

astrocyte development

MGI:MGI:3719550
PMID:11487638[14]

IGI: Inferred from Genetic Interaction

MGI:MGI:98932

P

From MGI

GO:0019900

kinase binding

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P47819

F

From MGI

GO:0030198

extracellular matrix organization

MGI:MGI:3719550
PMID:11487638[14]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2183221

P

From MGI

GO:0031102

neuron projection regeneration

MGI:MGI:3664718
PMID:16988027[15]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857176

P

From MGI

GO:0042995

cell projection

MGI:MGI:2157598
PMID:10989258[16]

IDA: Inferred from Direct Assay

C

From MGI

GO:0044297

cell body

MGI:MGI:2159503
PMID:8793730[17]

IDA: Inferred from Direct Assay

C

From MGI

GO:0044297

cell body

MGI:MGI:4867628
PMID:20578039[18]

IDA: Inferred from Direct Assay

C

From MGI

GO:0044464

cell part

MGI:MGI:3761040
PMID:17882221[19]

IDA: Inferred from Direct Assay

C

From MGI

GO:0045103

intermediate filament-based process

MGI:MGI:2384242
PMID:12177195[1]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2384719

P

From MGI

GO:0045109

intermediate filament organization

MGI:MGI:1889059
PMID:8692820[20]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857176

P

From MGI

GO:0045109

intermediate filament organization

MGI:MGI:3719550
PMID:11487638[14]

IGI: Inferred from Genetic Interaction

MGI:MGI:98932

P

From MGI

GO:0051580

regulation of neurotransmitter uptake

MGI:MGI:3046158
PMID:15135219[21]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857176

P

From MGI

GO:0060020

Bergmann glial cell differentiation

MGI:MGI:1858866
PMID:10816608[22]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2183221

P

From MGI

GO:0060252

positive regulation of glial cell proliferation

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P47819

P

From MGI

GO:0060291

long-term synaptic potentiation

MGI:MGI:1889059
PMID:8692820[20]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857176

P

From MGI


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 Takemura M et al. (2002) Protective role of phosphorylation in turnover of glial fibrillary acidic protein in mice. J Neurosci 22: 6972-9 PubMed GONUTS page
  2. Jing R et al. (2007) Synemin is expressed in reactive astrocytes in neurotrauma and interacts differentially with vimentin and GFAP intermediate filament networks. J Cell Sci 120: 1267-77 PubMed GONUTS page
  3. Kleene R et al. (2001) The neural recognition molecule L1 is a sialic acid-binding lectin for CD24, which induces promotion and inhibition of neurite outgrowth. J Biol Chem 276: 21656-63 PubMed GONUTS page
  4. Kinoshita A et al. (2000) Differential localization of septins in the mouse brain. J Comp Neurol 428: 223-39 PubMed GONUTS page
  5. Kuramochi Y et al. (2002) Characterization of mouse homolog of brain acyl-CoA hydrolase: molecular cloning and neuronal localization. Brain Res Mol Brain Res 98: 81-92 PubMed GONUTS page
  6. Ju WK & Neufeld AH (2002) Cellular localization of cyclooxygenase-1 and cyclooxygenase-2 in the normal mouse, rat, and human retina. J Comp Neurol 452: 392-9 PubMed GONUTS page
  7. Eiraku M et al. (2005) DNER acts as a neuron-specific Notch ligand during Bergmann glial development. Nat Neurosci 8: 873-80 PubMed GONUTS page
  8. Fukami S et al. (2002) Abeta-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with Abeta pathology. Neurosci Res 43: 39-56 PubMed GONUTS page
  9. Kittappa R et al. (2007) The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age. PLoS Biol 5: e325 PubMed GONUTS page
  10. Shibata T et al. (1997) Glutamate transporter GLAST is expressed in the radial glia-astrocyte lineage of developing mouse spinal cord. J Neurosci 17: 9212-9 PubMed GONUTS page
  11. Sakai K et al. (2003) Neutral amino acid transporter ASCT1 is preferentially expressed in L-Ser-synthetic/storing glial cells in the mouse brain with transient expression in developing capillaries. J Neurosci 23: 550-60 PubMed GONUTS page
  12. Reuss B et al. (2003) Functions of fibroblast growth factor (FGF)-2 and FGF-5 in astroglial differentiation and blood-brain barrier permeability: evidence from mouse mutants. J Neurosci 23: 6404-12 PubMed GONUTS page
  13. Gingras H et al. (2005) Biochemical characterization of the mammalian Cux2 protein. Gene 344: 273-85 PubMed GONUTS page
  14. 14.0 14.1 14.2 14.3 14.4 14.5 Menet V et al. (2001) Inactivation of the glial fibrillary acidic protein gene, but not that of vimentin, improves neuronal survival and neurite growth by modifying adhesion molecule expression. J Neurosci 21: 6147-58 PubMed GONUTS page
  15. 15.0 15.1 Triolo D et al. (2006) Loss of glial fibrillary acidic protein (GFAP) impairs Schwann cell proliferation and delays nerve regeneration after damage. J Cell Sci 119: 3981-93 PubMed GONUTS page
  16. Ha BK & King JS (2000) Localization of gp130 in the developing and adult mouse cerebellum. J Chem Neuroanat 19: 129-41 PubMed GONUTS page
  17. Molthagen M et al. (1996) Apoptotic cell death of photoreceptor cells in mice deficient for the adhesion molecule on glia (AMOG, the beta 2- subunit of the Na, K-ATPase). J Neurocytol 25: 243-55 PubMed GONUTS page
  18. Parenti R et al. (2010) Dynamic expression of Cx47 in mouse brain development and in the cuprizone model of myelin plasticity. Glia 58: 1594-609 PubMed GONUTS page
  19. Seandel M et al. (2007) Generation of functional multipotent adult stem cells from GPR125+ germline progenitors. Nature 449: 346-50 PubMed GONUTS page
  20. 20.0 20.1 McCall MA et al. (1996) Targeted deletion in astrocyte intermediate filament (Gfap) alters neuronal physiology. Proc Natl Acad Sci U S A 93: 6361-6 PubMed GONUTS page
  21. Hughes EG et al. (2004) Loss of glial fibrillary acidic protein results in decreased glutamate transport and inhibition of PKA-induced EAAT2 cell surface trafficking. Brain Res Mol Brain Res 124: 114-23 PubMed GONUTS page
  22. Giménez Y Ribotta M et al. (2000) Comparative anatomy of the cerebellar cortex in mice lacking vimentin, GFAP, and both vimentin and GFAP. Glia 31: 69-83 PubMed GONUTS page
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