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MGI:Gfap
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Gfap | |
| Protein Name(s) | glial fibrillary acidic protein, | |
| External Links | ||
| MGI | MGI:95697 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0005178 |
integrin binding |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005198 |
structural molecule activity |
MGI:MGI:2384242 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2384719 |
F |
From MGI |
||
| GO:0005200 |
structural constituent of cytoskeleton |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3713044 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005624 |
membrane fraction |
MGI:MGI:3706622 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:1926701 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:2158988 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:2429331 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:3583881 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:3604278 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:3772421 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005882 |
intermediate filament |
MGI:MGI:1099676 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005882 |
intermediate filament |
MGI:MGI:2449889 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005882 |
intermediate filament |
MGI:MGI:2669074 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005882 |
intermediate filament |
MGI:MGI:3531237 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005882 |
intermediate filament |
MGI:MGI:3719550 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009611 |
response to wounding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0010625 |
positive regulation of Schwann cell proliferation |
MGI:MGI:3664718 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857176 |
P |
From MGI |
||
| GO:0010977 |
negative regulation of neuron projection development |
MGI:MGI:3719550 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:98932 |
P |
From MGI |
||
| GO:0010977 |
negative regulation of neuron projection development |
MGI:MGI:3719550 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2183221 |
P |
From MGI |
||
| GO:0014002 |
astrocyte development |
MGI:MGI:3719550 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:98932 |
P |
From MGI |
||
| GO:0019900 |
kinase binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0030198 |
extracellular matrix organization |
MGI:MGI:3719550 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2183221 |
P |
From MGI |
||
| GO:0031102 |
neuron projection regeneration |
MGI:MGI:3664718 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857176 |
P |
From MGI |
||
| GO:0042995 |
cell projection |
MGI:MGI:2157598 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0044297 |
cell body |
MGI:MGI:2159503 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0044297 |
cell body |
MGI:MGI:4867628 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0044464 |
cell part |
MGI:MGI:3761040 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0045103 |
intermediate filament-based process |
MGI:MGI:2384242 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2384719 |
P |
From MGI |
||
| GO:0045109 |
intermediate filament organization |
MGI:MGI:1889059 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857176 |
P |
From MGI |
||
| GO:0045109 |
intermediate filament organization |
MGI:MGI:3719550 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:98932 |
P |
From MGI |
||
| GO:0051580 |
regulation of neurotransmitter uptake |
MGI:MGI:3046158 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857176 |
P |
From MGI |
||
| GO:0060020 |
Bergmann glial cell differentiation |
MGI:MGI:1858866 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2183221 |
P |
From MGI |
||
| GO:0060252 |
positive regulation of glial cell proliferation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0060291 |
long-term synaptic potentiation |
MGI:MGI:1889059 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857176 |
P |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Takemura M et al. (2002) Protective role of phosphorylation in turnover of glial fibrillary acidic protein in mice. J Neurosci 22: 6972-9 PubMed GONUTS page
- ↑ Jing R et al. (2007) Synemin is expressed in reactive astrocytes in neurotrauma and interacts differentially with vimentin and GFAP intermediate filament networks. J Cell Sci 120: 1267-77 PubMed GONUTS page
- ↑ Kleene R et al. (2001) The neural recognition molecule L1 is a sialic acid-binding lectin for CD24, which induces promotion and inhibition of neurite outgrowth. J Biol Chem 276: 21656-63 PubMed GONUTS page
- ↑ Kinoshita A et al. (2000) Differential localization of septins in the mouse brain. J Comp Neurol 428: 223-39 PubMed GONUTS page
- ↑ Kuramochi Y et al. (2002) Characterization of mouse homolog of brain acyl-CoA hydrolase: molecular cloning and neuronal localization. Brain Res Mol Brain Res 98: 81-92 PubMed GONUTS page
- ↑ Ju WK & Neufeld AH (2002) Cellular localization of cyclooxygenase-1 and cyclooxygenase-2 in the normal mouse, rat, and human retina. J Comp Neurol 452: 392-9 PubMed GONUTS page
- ↑ Eiraku M et al. (2005) DNER acts as a neuron-specific Notch ligand during Bergmann glial development. Nat Neurosci 8: 873-80 PubMed GONUTS page
- ↑ Fukami S et al. (2002) Abeta-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with Abeta pathology. Neurosci Res 43: 39-56 PubMed GONUTS page
- ↑ Kittappa R et al. (2007) The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age. PLoS Biol 5: e325 PubMed GONUTS page
- ↑ Shibata T et al. (1997) Glutamate transporter GLAST is expressed in the radial glia-astrocyte lineage of developing mouse spinal cord. J Neurosci 17: 9212-9 PubMed GONUTS page
- ↑ Sakai K et al. (2003) Neutral amino acid transporter ASCT1 is preferentially expressed in L-Ser-synthetic/storing glial cells in the mouse brain with transient expression in developing capillaries. J Neurosci 23: 550-60 PubMed GONUTS page
- ↑ Reuss B et al. (2003) Functions of fibroblast growth factor (FGF)-2 and FGF-5 in astroglial differentiation and blood-brain barrier permeability: evidence from mouse mutants. J Neurosci 23: 6404-12 PubMed GONUTS page
- ↑ Gingras H et al. (2005) Biochemical characterization of the mammalian Cux2 protein. Gene 344: 273-85 PubMed GONUTS page
- ↑ 14.0 14.1 14.2 14.3 14.4 14.5 Menet V et al. (2001) Inactivation of the glial fibrillary acidic protein gene, but not that of vimentin, improves neuronal survival and neurite growth by modifying adhesion molecule expression. J Neurosci 21: 6147-58 PubMed GONUTS page
- ↑ 15.0 15.1 Triolo D et al. (2006) Loss of glial fibrillary acidic protein (GFAP) impairs Schwann cell proliferation and delays nerve regeneration after damage. J Cell Sci 119: 3981-93 PubMed GONUTS page
- ↑ Ha BK & King JS (2000) Localization of gp130 in the developing and adult mouse cerebellum. J Chem Neuroanat 19: 129-41 PubMed GONUTS page
- ↑ Molthagen M et al. (1996) Apoptotic cell death of photoreceptor cells in mice deficient for the adhesion molecule on glia (AMOG, the beta 2- subunit of the Na, K-ATPase). J Neurocytol 25: 243-55 PubMed GONUTS page
- ↑ Parenti R et al. (2010) Dynamic expression of Cx47 in mouse brain development and in the cuprizone model of myelin plasticity. Glia 58: 1594-609 PubMed GONUTS page
- ↑ Seandel M et al. (2007) Generation of functional multipotent adult stem cells from GPR125+ germline progenitors. Nature 449: 346-50 PubMed GONUTS page
- ↑ 20.0 20.1 McCall MA et al. (1996) Targeted deletion in astrocyte intermediate filament (Gfap) alters neuronal physiology. Proc Natl Acad Sci U S A 93: 6361-6 PubMed GONUTS page
- ↑ Hughes EG et al. (2004) Loss of glial fibrillary acidic protein results in decreased glutamate transport and inhibition of PKA-induced EAAT2 cell surface trafficking. Brain Res Mol Brain Res 124: 114-23 PubMed GONUTS page
- ↑ Giménez Y Ribotta M et al. (2000) Comparative anatomy of the cerebellar cortex in mice lacking vimentin, GFAP, and both vimentin and GFAP. Glia 31: 69-83 PubMed GONUTS page