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MGI:Gdnf
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Gdnf ( synonyms: glial cell line-derived neurotrophic factor ) | |
| Protein Name(s) | glial cell line derived neurotrophic factor, | |
| External Links | ||
| MGI | MGI:107430 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001656 |
metanephros development |
MGI:MGI:3043010 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1315205 |
P |
From MGI |
||
| GO:0001656 |
metanephros development |
MGI:MGI:3714574 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:109442 |
P |
From MGI |
||
| GO:0001656 |
metanephros development |
MGI:MGI:3714574 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2136843 |
P |
From MGI |
||
| GO:0001656 |
metanephros development |
MGI:MGI:81285 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0001657 |
ureteric bud development |
MGI:MGI:3530708 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1345139 |
P |
From MGI |
||
| GO:0001657 |
ureteric bud development |
MGI:MGI:3582141 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0001658 |
branching involved in ureteric bud morphogenesis |
MGI:MGI:2675756 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0001658 |
branching involved in ureteric bud morphogenesis |
MGI:MGI:4949995 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0001658 |
branching involved in ureteric bud morphogenesis |
MGI:MGI:81287 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0001755 |
neural crest cell migration |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0001759 |
organ induction |
MGI:MGI:3530708 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1345139 |
P |
From MGI |
||
| GO:0001941 |
postsynaptic membrane organization |
MGI:MGI:3487183 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0005160 |
transforming growth factor beta receptor binding |
MGI:MGI:1336613 |
TAS: Traceable Author Statement |
F |
From MGI |
|||
| GO:0005576 |
extracellular region |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005615 |
extracellular space |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006916 |
anti-apoptosis |
MGI:MGI:3527364 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3528739 |
P |
From MGI |
||
| GO:0007169 |
transmembrane receptor protein tyrosine kinase signaling pathway |
MGI:MGI:2153440 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0007179 |
transforming growth factor beta receptor signaling pathway |
MGI:MGI:1336613 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0007399 |
nervous system development |
MGI:MGI:81285 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2136843 |
P |
From MGI |
||
| GO:0007422 |
peripheral nervous system development |
MGI:MGI:2157194 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2136846 |
P |
From MGI |
||
| GO:0007422 |
peripheral nervous system development |
MGI:MGI:3527364 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3528739 |
P |
From MGI |
||
| GO:0008083 |
growth factor activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0008283 |
cell proliferation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0009611 |
response to wounding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0021784 |
postganglionic parasympathetic nervous system development |
MGI:MGI:81287 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0030116 |
glial cell line-derived neurotrophic factor receptor binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0030182 |
neuron differentiation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030432 |
peristalsis |
MGI:MGI:2157194 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2136846 |
P |
From MGI |
||
| GO:0030432 |
peristalsis |
MGI:MGI:81287 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0031175 |
neuron projection development |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032770 |
positive regulation of monooxygenase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042803 |
protein homodimerization activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0043235 |
receptor complex |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0043524 |
negative regulation of neuron apoptotic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0048255 |
mRNA stabilization |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0048484 |
enteric nervous system development |
MGI:MGI:81285 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0048484 |
enteric nervous system development |
MGI:MGI:81286 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0048485 |
sympathetic nervous system development |
MGI:MGI:81285 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0051584 |
regulation of dopamine uptake |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0060676 |
ureteric bud formation |
MGI:MGI:81287 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0060688 |
regulation of morphogenesis of a branching structure |
MGI:MGI:2675756 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0072107 |
positive regulation of ureteric bud formation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0072108 |
positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis |
MGI:MGI:81286 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0090190 |
positive regulation of branching involved in ureteric bud morphogenesis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0090190 |
positive regulation of branching involved in ureteric bud morphogenesis |
MGI:MGI:5284782 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:2001240 |
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Grieshammer U et al. (2004) SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site. Dev Cell 6: 709-17 PubMed GONUTS page
- ↑ 2.0 2.1 Linton JM et al. (2007) The ECM protein nephronectin promotes kidney development via integrin alpha8beta1-mediated stimulation of Gdnf expression. Development 134: 2501-9 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Moore MW et al. (1996) Renal and neuronal abnormalities in mice lacking GDNF. Nature 382: 76-9 PubMed GONUTS page
- ↑ 4.0 4.1 Basson MA et al. (2005) Sprouty1 is a critical regulator of GDNF/RET-mediated kidney induction. Dev Cell 8: 229-39 PubMed GONUTS page
- ↑ Kuure S et al. (2005) Crosstalk between Jagged1 and GDNF/Ret/GFRalpha1 signalling regulates ureteric budding and branching. Mech Dev 122: 765-80 PubMed GONUTS page
- ↑ 6.0 6.1 Zhang H et al. (2003) Transcriptional activation of placental growth factor by the forkhead/winged helix transcription factor FoxD1. Curr Biol 13: 1625-9 PubMed GONUTS page
- ↑ Nie X et al. (2011) Six1 regulates Grem1 expression in the metanephric mesenchyme to initiate branching morphogenesis. Dev Biol 352: 141-51 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 Pichel JG et al. (1996) Defects in enteric innervation and kidney development in mice lacking GDNF. Nature 382: 73-6 PubMed GONUTS page
- ↑ Yang LX & Nelson PG (2004) Glia cell line-derived neurotrophic factor regulates the distribution of acetylcholine receptors in mouse primary skeletal muscle cells. Neuroscience 128: 497-509 PubMed GONUTS page
- ↑ 10.0 10.1 Fundin BT et al. (1999) A rapid and dynamic regulation of GDNF-family ligands and receptors correlate with the developmental dependency of cutaneous sensory innervation. Development 126: 2597-610 PubMed GONUTS page
- ↑ 11.0 11.1 Whitehead J et al. (2005) Glial cell-line derived neurotrophic factor-dependent fusimotor neuron survival during development. Mech Dev 122: 27-41 PubMed GONUTS page
- ↑ Brophy PD et al. (2001) Regulation of ureteric bud outgrowth by Pax2-dependent activation of the glial derived neurotrophic factor gene. Development 128: 4747-56 PubMed GONUTS page
- ↑ 13.0 13.1 Shen L et al. (2002) Gdnf haploinsufficiency causes Hirschsprung-like intestinal obstruction and early-onset lethality in mice. Am J Hum Genet 70: 435-47 PubMed GONUTS page
- ↑ 14.0 14.1 Sánchez MP et al. (1996) Renal agenesis and the absence of enteric neurons in mice lacking GDNF. Nature 382: 70-3 PubMed GONUTS page
- ↑ Michael L et al. (2007) The lectin Dolichos biflorus agglutinin is a sensitive indicator of branching morphogenetic activity in the developing mouse metanephric collecting duct system. J Anat 210: 89-97 PubMed GONUTS page
