MGI:Gck

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000166	nucleotide binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0547	F	From MGI
	GO:0000287	magnesium ion binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17712	F	From MGI
	GO:0001678	cellular glucose homeostasis	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17712	P	From MGI
	GO:0001678	cellular glucose homeostasis	MGI:MGI:76786 PMID:7553875^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857469	P	From MGI
	GO:0004340	glucokinase activity	MGI:MGI:1099128 PMID:9357804^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1861929	F	From MGI
	GO:0004340	glucokinase activity	MGI:MGI:3630095 PMID:7510884^[3]	IMP: Inferred from Mutant Phenotype		F	From MGI
	GO:0004340	glucokinase activity	MGI:MGI:3691164 PMID:9873043^[4]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0004340	glucokinase activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17712	F	From MGI
	GO:0004340	glucokinase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35557	F	From MGI
	GO:0004340	glucokinase activity	MGI:MGI:54301 PMID:141272^[5]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0004340	glucokinase activity	MGI:MGI:56520 PMID:3931624^[6]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0004340	glucokinase activity	MGI:MGI:76298 PMID:7665557^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1861929	F	From MGI
	GO:0004340	glucokinase activity	MGI:MGI:76949 PMID:7556622^[8]	IMP: Inferred from Mutant Phenotype		F	From MGI
	GO:0004396	hexokinase activity	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR019807	F	From MGI
	GO:0005515	protein binding	MGI:MGI:2671672 PMID:12931191^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q8R5H5 UniProtKB:Q61337 UniProtKB:P05132	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3778846 PMID:18223655^[10]	IPI: Inferred from Physical Interaction	UniProtKB:Q61337	F	From MGI
	GO:0005524	ATP binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17712	F	From MGI
	GO:0005524	ATP binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35557	F	From MGI
	GO:0005536	glucose binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17712	F	From MGI
	GO:0005536	glucose binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35557	F	From MGI
	GO:0005625	soluble fraction	MGI:MGI:54301 PMID:141272^[5]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:1354534 PMID:10713097^[11]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17712	C	From MGI
	GO:0005654	nucleoplasm	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17712	C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17712	C	From MGI
	GO:0005739	mitochondrion	MGI:MGI:2671672 PMID:12931191^[9]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005739	mitochondrion	MGI:MGI:2682130 PMID:14651853^[12]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005739	mitochondrion	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17712	C	From MGI
	GO:0005829	cytosol	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17712	C	From MGI
	GO:0005938	cell cortex	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17712	C	From MGI
	GO:0005975	carbohydrate metabolic process	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR001312 InterPro:IPR022673 InterPro:IPR022672	P	From MGI
	GO:0005978	glycogen biosynthetic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17712	P	From MGI
	GO:0006003	fructose 2,6-bisphosphate metabolic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17712	P	From MGI
	GO:0006006	glucose metabolic process	MGI:MGI:1099128 PMID:9357804^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1861929	P	From MGI
	GO:0006006	glucose metabolic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17712	P	From MGI
	GO:0006006	glucose metabolic process	MGI:MGI:54301 PMID:141272^[5]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0006006	glucose metabolic process	MGI:MGI:56520 PMID:3931624^[6]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0006006	glucose metabolic process	MGI:MGI:76298 PMID:7665557^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1861929	P	From MGI
	GO:0006006	glucose metabolic process	MGI:MGI:76949 PMID:7556622^[8]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0006096	glycolysis	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17712	P	From MGI
	GO:0006739	NADP metabolic process	MGI:MGI:3691164 PMID:9873043^[4]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0007204	elevation of cytosolic calcium ion concentration	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17712	P	From MGI
	GO:0016301	kinase activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0418	F	From MGI
	GO:0016310	phosphorylation	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0418	P	From MGI
	GO:0016740	transferase activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0808	F	From MGI
	GO:0016773	phosphotransferase activity, alcohol group as acceptor	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR001312 InterPro:IPR022673 InterPro:IPR022672	F	From MGI
	GO:0019903	protein phosphatase binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17712	F	From MGI
	GO:0019932	second-messenger-mediated signaling	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17712	P	From MGI
	GO:0030141	secretory granule	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17712	C	From MGI
	GO:0032024	positive regulation of insulin secretion	MGI:MGI:3819280 PMID:18477811^[13]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0032024	positive regulation of insulin secretion	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17712	P	From MGI
	GO:0032024	positive regulation of insulin secretion	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35557	P	From MGI
	GO:0032024	positive regulation of insulin secretion	MGI:MGI:76949 PMID:7556622^[8]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0032811	negative regulation of epinephrine secretion	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17712	P	From MGI
	GO:0032869	cellular response to insulin stimulus	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17712	P	From MGI
	GO:0042149	cellular response to glucose starvation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17712	P	From MGI
	GO:0042327	positive regulation of phosphorylation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17712	P	From MGI
	GO:0042593	glucose homeostasis	MGI:MGI:1099128 PMID:9357804^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1861929	P	From MGI
	GO:0042593	glucose homeostasis	MGI:MGI:1327006 PMID:9867845^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2177710	P	From MGI
	GO:0042593	glucose homeostasis	MGI:MGI:3819280 PMID:18477811^[13]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0042593	glucose homeostasis	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17712	P	From MGI
	GO:0042593	glucose homeostasis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35557	P	From MGI
	GO:0042593	glucose homeostasis	MGI:MGI:76949 PMID:7556622^[8]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0042593	glucose homeostasis	MGI:MGI:77846 PMID:8530440^[15]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2177703	P	From MGI
	GO:0043266	regulation of potassium ion transport	MGI:MGI:1266883 PMID:9662046^[16]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2177703	P	From MGI
	GO:0043531	ADP binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17712	F	From MGI
	GO:0044320	cellular response to leptin stimulus	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17712	P	From MGI
	GO:0044448	cell cortex part	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17712	C	From MGI
	GO:0045721	negative regulation of gluconeogenesis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35557	P	From MGI
	GO:0045725	positive regulation of glycogen biosynthetic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35557	P	From MGI
	GO:0045821	positive regulation of glycolysis	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17712	P	From MGI
	GO:0046835	carbohydrate phosphorylation	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR019807	P	From MGI
	GO:0046835	carbohydrate phosphorylation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17712	P	From MGI
	GO:0046835	carbohydrate phosphorylation	MGI:MGI:54301 PMID:141272^[5]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0046835	carbohydrate phosphorylation	MGI:MGI:56520 PMID:3931624^[6]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0046835	carbohydrate phosphorylation	MGI:MGI:76298 PMID:7665557^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1861929	P	From MGI
	GO:0046835	carbohydrate phosphorylation	MGI:MGI:76949 PMID:7556622^[8]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0050796	regulation of insulin secretion	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35557	P	From MGI
	GO:0050796	regulation of insulin secretion	MGI:MGI:77846 PMID:8530440^[15]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2177703	P	From MGI
	GO:0050796	regulation of insulin secretion	MGI:MGI:85404 PMID:8954920^[17]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2177703	P	From MGI
	GO:0051156	glucose 6-phosphate metabolic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17712	P	From MGI
	GO:0051156	glucose 6-phosphate metabolic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35557	P	From MGI
	GO:0051594	detection of glucose	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17712	P	From MGI
	GO:0051594	detection of glucose	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35557	P	From MGI
	GO:0070509	calcium ion import	MGI:MGI:3819280 PMID:18477811^[13]	IMP: Inferred from Mutant Phenotype		P	From MGI
colocalizes_with	GO:0005884	actin filament	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17712	C	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Grupe A et al. (1995) Transgenic knockouts reveal a critical requirement for pancreatic beta cell glucokinase in maintaining glucose homeostasis. Cell 83: 69-78 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Rossetti L et al. (1997) Abnormal regulation of HGP by hyperglycemia in mice with a disrupted glucokinase allele. Am J Physiol 273: E743-50 PubMed GONUTS page
↑ Efrat S et al. (1994) Ribozyme-mediated attenuation of pancreatic beta-cell glucokinase expression in transgenic mice results in impaired glucose-induced insulin secretion. Proc Natl Acad Sci U S A 91: 2051-5 PubMed GONUTS page
↑ ^4.0 ^4.1 Piston DW et al. (1999) Adenovirus-mediated knockout of a conditional glucokinase gene in isolated pancreatic islets reveals an essential role for proximal metabolic coupling events in glucose-stimulated insulin secretion. J Biol Chem 274: 1000-4 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Coleman DL (1977) Genetic control of glucokinase activity in mice. Biochem Genet 15: 297-305 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 James PA et al. (1985) Comparison of glucokinase in C3H/He and C58 mice that differ in their hepatic activity. Biochem Genet 23: 525-38 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Bali D et al. (1995) Animal model for maturity-onset diabetes of the young generated by disruption of the mouse glucokinase gene. J Biol Chem 270: 21464-7 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 Ishihara H et al. (1995) Inhibition of pancreatic beta-cell glucokinase by antisense RNA expression in transgenic mice: mouse strain-dependent alteration of glucose tolerance. FEBS Lett 371: 329-32 PubMed GONUTS page
↑ ^9.0 ^9.1 Danial NN et al. (2003) BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis. Nature 424: 952-6 PubMed GONUTS page
↑ Danial NN et al. (2008) Dual role of proapoptotic BAD in insulin secretion and beta cell survival. Nat Med 14: 144-53 PubMed GONUTS page
↑ Grimsby J et al. (2000) Characterization of glucokinase regulatory protein-deficient mice. J Biol Chem 275: 7826-31 PubMed GONUTS page
↑ Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115: 629-40 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Goldsworthy M et al. (2008) Role of the transcription factor sox4 in insulin secretion and impaired glucose tolerance. Diabetes 57: 2234-44 PubMed GONUTS page
↑ Postic C et al. (1999) Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. J Biol Chem 274: 305-15 PubMed GONUTS page
↑ ^15.0 ^15.1 Terauchi Y et al. (1995) Pancreatic beta-cell-specific targeted disruption of glucokinase gene. Diabetes mellitus due to defective insulin secretion to glucose. J Biol Chem 270: 30253-6 PubMed GONUTS page
↑ Sakura H et al. (1998) Glucose modulation of ATP-sensitive K-currents in wild-type, homozygous and heterozygous glucokinase knock-out mice. Diabetologia 41: 654-9 PubMed GONUTS page
↑ Aizawa T et al. (1996) Analysis of the pancreatic beta cell in the mouse with targeted disruption of the pancreatic beta cell-specific glucokinase gene. Biochem Biophys Res Commun 229: 460-5 PubMed GONUTS page

[PMID:7553875-0] Grupe A et al. (1995) Transgenic knockouts reveal a critical requirement for pancreatic beta cell glucokinase in maintaining glucose homeostasis. Cell 83: 69-78 PubMed GONUTS page

[PMID:9357804-1] 2.0 ^2.1 ^2.2 Rossetti L et al. (1997) Abnormal regulation of HGP by hyperglycemia in mice with a disrupted glucokinase allele. Am J Physiol 273: E743-50 PubMed GONUTS page

[PMID:7510884-2] Efrat S et al. (1994) Ribozyme-mediated attenuation of pancreatic beta-cell glucokinase expression in transgenic mice results in impaired glucose-induced insulin secretion. Proc Natl Acad Sci U S A 91: 2051-5 PubMed GONUTS page

[PMID:9873043-3] 4.0 ^4.1 Piston DW et al. (1999) Adenovirus-mediated knockout of a conditional glucokinase gene in isolated pancreatic islets reveals an essential role for proximal metabolic coupling events in glucose-stimulated insulin secretion. J Biol Chem 274: 1000-4 PubMed GONUTS page

[PMID:141272-4] 5.0 ^5.1 ^5.2 ^5.3 Coleman DL (1977) Genetic control of glucokinase activity in mice. Biochem Genet 15: 297-305 PubMed GONUTS page

[PMID:3931624-5] 6.0 ^6.1 ^6.2 James PA et al. (1985) Comparison of glucokinase in C3H/He and C58 mice that differ in their hepatic activity. Biochem Genet 23: 525-38 PubMed GONUTS page

[PMID:7665557-6] 7.0 ^7.1 ^7.2 Bali D et al. (1995) Animal model for maturity-onset diabetes of the young generated by disruption of the mouse glucokinase gene. J Biol Chem 270: 21464-7 PubMed GONUTS page

[PMID:7556622-7] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 Ishihara H et al. (1995) Inhibition of pancreatic beta-cell glucokinase by antisense RNA expression in transgenic mice: mouse strain-dependent alteration of glucose tolerance. FEBS Lett 371: 329-32 PubMed GONUTS page

[PMID:12931191-8] 9.0 ^9.1 Danial NN et al. (2003) BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis. Nature 424: 952-6 PubMed GONUTS page

[PMID:18223655-9] Danial NN et al. (2008) Dual role of proapoptotic BAD in insulin secretion and beta cell survival. Nat Med 14: 144-53 PubMed GONUTS page

[PMID:10713097-10] Grimsby J et al. (2000) Characterization of glucokinase regulatory protein-deficient mice. J Biol Chem 275: 7826-31 PubMed GONUTS page

[PMID:14651853-11] Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115: 629-40 PubMed GONUTS page

[PMID:18477811-12] 13.0 ^13.1 ^13.2 Goldsworthy M et al. (2008) Role of the transcription factor sox4 in insulin secretion and impaired glucose tolerance. Diabetes 57: 2234-44 PubMed GONUTS page

[PMID:9867845-13] Postic C et al. (1999) Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. J Biol Chem 274: 305-15 PubMed GONUTS page

[PMID:8530440-14] 15.0 ^15.1 Terauchi Y et al. (1995) Pancreatic beta-cell-specific targeted disruption of glucokinase gene. Diabetes mellitus due to defective insulin secretion to glucose. J Biol Chem 270: 30253-6 PubMed GONUTS page

[PMID:9662046-15] Sakura H et al. (1998) Glucose modulation of ATP-sensitive K-currents in wild-type, homozygous and heterozygous glucokinase knock-out mice. Diabetologia 41: 654-9 PubMed GONUTS page

[PMID:8954920-16] Aizawa T et al. (1996) Analysis of the pancreatic beta cell in the mouse with targeted disruption of the pancreatic beta cell-specific glucokinase gene. Biochem Biophys Res Commun 229: 460-5 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Gck ( synonyms: Gk, hexokinase 4, HK4, MODY2 )
Protein Name(s)	glucokinase,
External Links
MGI	MGI:1270854

MGI:Gck

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