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MGI:Gcg
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Gcg ( synonyms: GLP-1, glucagon-like peptide I ) | |
| Protein Name(s) | glucagon, | |
| External Links | ||
| MGI | MGI:95674 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0005179 |
hormone activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005576 |
extracellular region |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0964 |
C |
From MGI |
||
| GO:0005576 |
extracellular region |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0005615 |
extracellular space |
MGI:MGI:3761982 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005615 |
extracellular space |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:4453294 |
IMP: Inferred from Mutant Phenotype |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4453294 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4889014 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0007188 |
G-protein signaling, coupled to cAMP nucleotide second messenger |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0010737 |
protein kinase A signaling cascade |
MGI:MGI:4453294 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0010800 |
positive regulation of peptidyl-threonine phosphorylation |
MGI:MGI:4453294 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0030819 |
positive regulation of cAMP biosynthetic process |
MGI:MGI:4453294 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0031769 |
glucagon receptor binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0032092 |
positive regulation of protein binding |
MGI:MGI:4453294 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0032099 |
negative regulation of appetite |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0033138 |
positive regulation of peptidyl-serine phosphorylation |
MGI:MGI:4453294 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0035774 |
positive regulation of insulin secretion involved in cellular response to glucose stimulus |
MGI:MGI:4453294 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0043066 |
negative regulation of apoptotic process |
MGI:MGI:4453294 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045860 |
positive regulation of protein kinase activity |
MGI:MGI:4453294 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0050796 |
regulation of insulin secretion |
MGI:MGI:3040550 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0070374 |
positive regulation of ERK1 and ERK2 cascade |
MGI:MGI:4453294 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0090280 |
positive regulation of calcium ion import |
MGI:MGI:4453294 |
IDA: Inferred from Direct Assay |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Lee NK et al. (2007) Endocrine regulation of energy metabolism by the skeleton. Cell 130: 456-69 PubMed GONUTS page
- ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 Quoyer J et al. (2010) GLP-1 mediates antiapoptotic effect by phosphorylating Bad through a beta-arrestin 1-mediated ERK1/2 activation in pancreatic beta-cells. J Biol Chem 285: 1989-2002 PubMed GONUTS page
- ↑ Marroquí L et al. (2011) Leptin downregulates expression of the gene encoding glucagon in alphaTC1-9 cells and mouse islets. Diabetologia 54: 843-51 PubMed GONUTS page
- ↑ Härndahl L et al. (2004) Beta-cell-targeted overexpression of phosphodiesterase 3B in mice causes impaired insulin secretion, glucose intolerance, and deranged islet morphology. J Biol Chem 279: 15214-22 PubMed GONUTS page
