MGI:Gata6

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q92908	P	From MGI
	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	MGI:MGI:4950308 PMID:21350014^[1]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q92908	F	From MGI
	GO:0001103	RNA polymerase II repressing transcription factor binding	MGI:MGI:3610837 PMID:16293227^[2]	IPI: Inferred from Physical Interaction	UniProtKB:Q9UBP5	F	From MGI
	GO:0001158	enhancer sequence-specific DNA binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P46153	F	From MGI
	GO:0001701	in utero embryonic development	MGI:MGI:1315079 PMID:9832509^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2177785	P	From MGI
	GO:0001701	in utero embryonic development	MGI:MGI:4422111 PMID:20123909^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3793425	P	From MGI
	GO:0001889	liver development	MGI:MGI:3575862 PMID:15767668^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3576383	P	From MGI
	GO:0003148	outflow tract septum morphogenesis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q92908	P	From MGI
	GO:0003309	type B pancreatic cell differentiation	MGI:MGI:3701716 PMID:16887115^[6]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0003310	pancreatic A cell differentiation	MGI:MGI:3701716 PMID:16887115^[6]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0003677	DNA binding	MGI:MGI:2158590 PMID:11733512^[7]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003677	DNA binding	MGI:MGI:3588477 PMID:15987774^[8]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003677	DNA binding	MGI:MGI:3603876 PMID:16199866^[9]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003677	DNA binding	MGI:MGI:3628672 PMID:16621466^[10]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003677	DNA binding	MGI:MGI:3654711 PMID:16912278^[11]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003682	chromatin binding	MGI:MGI:3603876 PMID:16199866^[9]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003690	double-stranded DNA binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P46153	F	From MGI
	GO:0003700	sequence-specific DNA binding transcription factor activity	MGI:MGI:2180986 PMID:11914369^[12]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003700	sequence-specific DNA binding transcription factor activity	MGI:MGI:3628672 PMID:16621466^[10]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003700	sequence-specific DNA binding transcription factor activity	MGI:MGI:3695537 PMID:17164424^[13]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003700	sequence-specific DNA binding transcription factor activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q92908	F	From MGI
	GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity	MGI:MGI:81672 PMID:8660897^[14]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0005515	protein binding	MGI:MGI:2158098 PMID:11724781^[15]	IPI: Inferred from Physical Interaction	UniProtKB:O88323	F	From MGI
	GO:0005515	protein binding	MGI:MGI:2158590 PMID:11733512^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P50220	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3603876 PMID:16199866^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q8VEE1	F	From MGI
	GO:0005634	nucleus	MGI:MGI:1206067 PMID:9566909^[16]	ISO: Inferred from Sequence Orthology	UniProtKB:Q641I8 UniProtKB:Q92908	C	From MGI
	GO:0005634	nucleus	MGI:MGI:2384240 PMID:12130579^[17]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:3603876 PMID:16199866^[9]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:3696911 PMID:16940177^[18]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P46153	C	From MGI
	GO:0005634	nucleus	MGI:MGI:4422111 PMID:20123909^[4]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q92908	C	From MGI
	GO:0005667	transcription factor complex	MGI:MGI:3695537 PMID:17164424^[13]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0006351	transcription, DNA-dependent	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0804	P	From MGI
	GO:0006355	regulation of transcription, DNA-dependent	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0805	P	From MGI
	GO:0006355	regulation of transcription, DNA-dependent	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR000679 InterPro:IPR013088	P	From MGI
	GO:0006357	regulation of transcription from RNA polymerase II promoter	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q92908	P	From MGI
	GO:0006366	transcription from RNA polymerase II promoter	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q92908	P	From MGI
	GO:0006644	phospholipid metabolic process	MGI:MGI:3695537 PMID:17164424^[13]	IGI: Inferred from Genetic Interaction	MGI:MGI:108067	P	From MGI
	GO:0006915	apoptotic process	MGI:MGI:1315079 PMID:9832509^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2177785	P	From MGI
	GO:0007492	endoderm development	MGI:MGI:1315079 PMID:9832509^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2177785	P	From MGI
	GO:0007493	endodermal cell fate determination	MGI:MGI:4442295 PMID:20308546^[19]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0008134	transcription factor binding	MGI:MGI:3701716 PMID:16887115^[6]	IPI: Inferred from Physical Interaction	UniProtKB:P42586	F	From MGI
	GO:0008134	transcription factor binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P46153	F	From MGI
	GO:0008134	transcription factor binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q92908	F	From MGI
	GO:0008270	zinc ion binding	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR008013 InterPro:IPR000679 InterPro:IPR013088	F	From MGI
	GO:0010468	regulation of gene expression	MGI:MGI:3790568 PMID:18400219^[20]	IGI: Inferred from Genetic Interaction	MGI:MGI:95664	P	From MGI
	GO:0019901	protein kinase binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q92908	F	From MGI
	GO:0030513	positive regulation of BMP signaling pathway	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P46153	P	From MGI
	GO:0030855	epithelial cell differentiation	MGI:MGI:3701716 PMID:16887115^[6]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0031016	pancreas development	MGI:MGI:3701716 PMID:16887115^[6]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0032911	negative regulation of transforming growth factor beta1 production	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q92908	P	From MGI
	GO:0032912	negative regulation of transforming growth factor beta2 production	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q92908	P	From MGI
	GO:0035239	tube morphogenesis	MGI:MGI:3790568 PMID:18400219^[20]	IGI: Inferred from Genetic Interaction	MGI:MGI:95664	P	From MGI
	GO:0042493	response to drug	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q92908	P	From MGI
	GO:0043065	positive regulation of apoptotic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P46153	P	From MGI
	GO:0043066	negative regulation of apoptotic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q92908	P	From MGI
	GO:0043565	sequence-specific DNA binding	MGI:MGI:2180986 PMID:11914369^[12]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0043627	response to estrogen stimulus	MGI:MGI:1095695 PMID:9231805^[21]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0044212	transcription regulatory region DNA binding	MGI:MGI:1206067 PMID:9566909^[16]	ISO: Inferred from Sequence Orthology	UniProtKB:Q641I8 UniProtKB:Q92908	F	From MGI
	GO:0044212	transcription regulatory region DNA binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P46153	F	From MGI
	GO:0044212	transcription regulatory region DNA binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q92908	F	From MGI
	GO:0045766	positive regulation of angiogenesis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q92908	P	From MGI
	GO:0045892	negative regulation of transcription, DNA-dependent	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q92908	P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:1289810 PMID:9738004^[22]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:2158590 PMID:11733512^[7]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:81672 PMID:8660897^[14]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:1315079 PMID:9832509^[3]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:2180986 PMID:11914369^[12]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:3530679 PMID:15539431^[23]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:3603876 PMID:16199866^[9]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:3628672 PMID:16621466^[10]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:3695537 PMID:17164424^[13]	IGI: Inferred from Genetic Interaction	MGI:MGI:108067	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:3709528 PMID:16510470^[24]	IGI: Inferred from Genetic Interaction	MGI:MGI:107516 MGI:MGI:106658	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:3709528 PMID:16510470^[24]	IGI: Inferred from Genetic Interaction	MGI:MGI:108067	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:3828404 PMID:16137232^[25]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P46153	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q92908	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:4950308 PMID:21350014^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3623678	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:81672 PMID:8660897^[14]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0046872	metal ion binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0479	F	From MGI
	GO:0048645	organ formation	MGI:MGI:3701716 PMID:16887115^[6]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0051145	smooth muscle cell differentiation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q92908	P	From MGI
	GO:0055007	cardiac muscle cell differentiation	MGI:MGI:3790568 PMID:18400219^[20]	IGI: Inferred from Genetic Interaction	MGI:MGI:95664	P	From MGI
	GO:0055007	cardiac muscle cell differentiation	MGI:MGI:3790568 PMID:18400219^[20]	IGI: Inferred from Genetic Interaction	MGI:MGI:95664	P	From MGI
	GO:0055007	cardiac muscle cell differentiation	MGI:MGI:3790568 PMID:18400219^[20]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3793425	P	From MGI
	GO:0060045	positive regulation of cardiac muscle cell proliferation	MGI:MGI:3833786 PMID:19084512^[26]	IGI: Inferred from Genetic Interaction	MGI:MGI:102541	P	From MGI
	GO:0060430	lung saccule development	MGI:MGI:3695537 PMID:17164424^[13]	IGI: Inferred from Genetic Interaction	MGI:MGI:108067	P	From MGI
	GO:0060486	Clara cell differentiation	MGI:MGI:3695537 PMID:17164424^[13]	IGI: Inferred from Genetic Interaction	MGI:MGI:108067	P	From MGI
	GO:0060510	Type II pneumocyte differentiation	MGI:MGI:3695537 PMID:17164424^[13]	IGI: Inferred from Genetic Interaction	MGI:MGI:108067	P	From MGI
	GO:0060575	intestinal epithelial cell differentiation	MGI:MGI:1206067 PMID:9566909^[16]	ISO: Inferred from Sequence Orthology	UniProtKB:Q92908	P	From MGI
	GO:0060947	cardiac vascular smooth muscle cell differentiation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q92908	P	From MGI
	GO:0070848	response to growth factor stimulus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q92908	P	From MGI
	GO:0071158	positive regulation of cell cycle arrest	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q92908	P	From MGI
	GO:0071371	cellular response to gonadotropin stimulus	MGI:MGI:1095695 PMID:9231805^[21]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0071456	cellular response to hypoxia	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q92908	P	From MGI
	GO:0071773	cellular response to BMP stimulus	MGI:MGI:4830625 PMID:20501701^[27]	IDA: Inferred from Direct Assay		P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Tian Y et al. (2011) Regulation of lung endoderm progenitor cell behavior by miR302/367. Development 138: 1235-45 PubMed GONUTS page
↑ Shirvani S et al. (2006) CHF1/Hey2 suppresses SM-MHC promoter activity through an interaction with GATA-6. Biochem Biophys Res Commun 339: 151-6 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Morrisey EE et al. (1998) GATA6 regulates HNF4 and is required for differentiation of visceral endoderm in the mouse embryo. Genes Dev 12: 3579-90 PubMed GONUTS page
↑ ^4.0 ^4.1 Niakan KK et al. (2010) Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal. Genes Dev 24: 312-26 PubMed GONUTS page
↑ Zhao R et al. (2005) GATA6 is essential for embryonic development of the liver but dispensable for early heart formation. Mol Cell Biol 25: 2622-31 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Decker K et al. (2006) Gata6 is an important regulator of mouse pancreas development. Dev Biol 298: 415-29 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Liu C et al. (2002) GATA-6 and thyroid transcription factor-1 directly interact and regulate surfactant protein-C gene expression. J Biol Chem 277: 4519-25 PubMed GONUTS page
↑ Rojas A et al. (2005) Gata4 expression in lateral mesoderm is downstream of BMP4 and is activated directly by Forkhead and GATA transcription factors through a distal enhancer element. Development 132: 3405-17 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 Rath N et al. (2005) LMCD1/Dyxin is a novel transcriptional cofactor that restricts GATA6 function by inhibiting DNA binding. Mol Cell Biol 25: 8864-73 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Alexandrovich A et al. (2006) Wnt2 is a direct downstream target of GATA6 during early cardiogenesis. Mech Dev 123: 297-311 PubMed GONUTS page
↑ Kyrmizi I et al. (2006) Plasticity and expanding complexity of the hepatic transcription factor network during liver development. Genes Dev 20: 2293-305 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Weidenfeld J et al. (2002) The WNT7b promoter is regulated by TTF-1, GATA6, and Foxa2 in lung epithelium. J Biol Chem 277: 21061-70 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 Zhang Y et al. (2007) GATA and Nkx factors synergistically regulate tissue-specific gene expression and development in vivo. Development 134: 189-98 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Morrisey EE et al. (1996) GATA-6: a zinc finger transcription factor that is expressed in multiple cell lineages derived from lateral mesoderm. Dev Biol 177: 309-22 PubMed GONUTS page
↑ Crawford SE et al. (2002) Defects of the heart, eye, and megakaryocytes in peroxisome proliferator activator receptor-binding protein (PBP) null embryos implicate GATA family of transcription factors. J Biol Chem 277: 3585-92 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 Gao X et al. (1998) Distinct functions are implicated for the GATA-4, -5, and -6 transcription factors in the regulation of intestine epithelial cell differentiation. Mol Cell Biol 18: 2901-11 PubMed GONUTS page
↑ Kiiveri S et al. (2002) Differential expression of GATA-4 and GATA-6 in fetal and adult mouse and human adrenal tissue. Endocrinology 143: 3136-43 PubMed GONUTS page
↑ Bosse T et al. (2006) Gata4 is essential for the maintenance of jejunal-ileal identities in the adult mouse small intestine. Mol Cell Biol 26: 9060-70 PubMed GONUTS page
↑ Morris SA et al. (2010) Origin and formation of the first two distinct cell types of the inner cell mass in the mouse embryo. Proc Natl Acad Sci U S A 107: 6364-9 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 ^20.3 ^20.4 Zhao R et al. (2008) Loss of both GATA4 and GATA6 blocks cardiac myocyte differentiation and results in acardia in mice. Dev Biol 317: 614-9 PubMed GONUTS page
↑ ^21.0 ^21.1 Heikinheimo M et al. (1997) Expression and hormonal regulation of transcription factors GATA-4 and GATA-6 in the mouse ovary. Endocrinology 138: 3505-14 PubMed GONUTS page
↑ Di Lisi R et al. (1998) Combinatorial cis-acting elements control tissue-specific activation of the cardiac troponin I gene in vitro and in vivo. J Biol Chem 273: 25371-80 PubMed GONUTS page
↑ Ritz-Laser B et al. (2005) The zinc finger-containing transcription factor Gata-4 is expressed in the developing endocrine pancreas and activates glucagon gene expression. Mol Endocrinol 19: 759-70 PubMed GONUTS page
↑ ^24.0 ^24.1 Yin Z et al. (2006) Hop functions downstream of Nkx2.1 and GATA6 to mediate HDAC-dependent negative regulation of pulmonary gene expression. Am J Physiol Lung Cell Mol Physiol 291: L191-9 PubMed GONUTS page
↑ Brewer AC et al. (2005) GATA factors lie upstream of Nkx 2.5 in the transcriptional regulatory cascade that effects cardiogenesis. Stem Cells Dev 14: 425-39 PubMed GONUTS page
↑ Maitra M et al. (2009) Interaction of Gata4 and Gata6 with Tbx5 is critical for normal cardiac development. Dev Biol 326: 368-77 PubMed GONUTS page
↑ Karamboulas K et al. (2010) Regulation of BMP-dependent chondrogenesis in early limb mesenchyme by TGFbeta signals. J Cell Sci 123: 2068-76 PubMed GONUTS page

[PMID:21350014-0] 1.0 ^1.1 Tian Y et al. (2011) Regulation of lung endoderm progenitor cell behavior by miR302/367. Development 138: 1235-45 PubMed GONUTS page

[PMID:16293227-1] Shirvani S et al. (2006) CHF1/Hey2 suppresses SM-MHC promoter activity through an interaction with GATA-6. Biochem Biophys Res Commun 339: 151-6 PubMed GONUTS page

[PMID:9832509-2] 3.0 ^3.1 ^3.2 ^3.3 Morrisey EE et al. (1998) GATA6 regulates HNF4 and is required for differentiation of visceral endoderm in the mouse embryo. Genes Dev 12: 3579-90 PubMed GONUTS page

[PMID:20123909-3] 4.0 ^4.1 Niakan KK et al. (2010) Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal. Genes Dev 24: 312-26 PubMed GONUTS page

[PMID:15767668-4] Zhao R et al. (2005) GATA6 is essential for embryonic development of the liver but dispensable for early heart formation. Mol Cell Biol 25: 2622-31 PubMed GONUTS page

[PMID:16887115-5] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Decker K et al. (2006) Gata6 is an important regulator of mouse pancreas development. Dev Biol 298: 415-29 PubMed GONUTS page

[PMID:11733512-6] 7.0 ^7.1 ^7.2 Liu C et al. (2002) GATA-6 and thyroid transcription factor-1 directly interact and regulate surfactant protein-C gene expression. J Biol Chem 277: 4519-25 PubMed GONUTS page

[PMID:15987774-7] Rojas A et al. (2005) Gata4 expression in lateral mesoderm is downstream of BMP4 and is activated directly by Forkhead and GATA transcription factors through a distal enhancer element. Development 132: 3405-17 PubMed GONUTS page

[PMID:16199866-8] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 Rath N et al. (2005) LMCD1/Dyxin is a novel transcriptional cofactor that restricts GATA6 function by inhibiting DNA binding. Mol Cell Biol 25: 8864-73 PubMed GONUTS page

[PMID:16621466-9] 10.0 ^10.1 ^10.2 Alexandrovich A et al. (2006) Wnt2 is a direct downstream target of GATA6 during early cardiogenesis. Mech Dev 123: 297-311 PubMed GONUTS page

[PMID:16912278-10] Kyrmizi I et al. (2006) Plasticity and expanding complexity of the hepatic transcription factor network during liver development. Genes Dev 20: 2293-305 PubMed GONUTS page

[PMID:11914369-11] 12.0 ^12.1 ^12.2 Weidenfeld J et al. (2002) The WNT7b promoter is regulated by TTF-1, GATA6, and Foxa2 in lung epithelium. J Biol Chem 277: 21061-70 PubMed GONUTS page

[PMID:17164424-12] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 Zhang Y et al. (2007) GATA and Nkx factors synergistically regulate tissue-specific gene expression and development in vivo. Development 134: 189-98 PubMed GONUTS page

[PMID:8660897-13] 14.0 ^14.1 ^14.2 Morrisey EE et al. (1996) GATA-6: a zinc finger transcription factor that is expressed in multiple cell lineages derived from lateral mesoderm. Dev Biol 177: 309-22 PubMed GONUTS page

[PMID:11724781-14] Crawford SE et al. (2002) Defects of the heart, eye, and megakaryocytes in peroxisome proliferator activator receptor-binding protein (PBP) null embryos implicate GATA family of transcription factors. J Biol Chem 277: 3585-92 PubMed GONUTS page

[PMID:9566909-15] 16.0 ^16.1 ^16.2 Gao X et al. (1998) Distinct functions are implicated for the GATA-4, -5, and -6 transcription factors in the regulation of intestine epithelial cell differentiation. Mol Cell Biol 18: 2901-11 PubMed GONUTS page

[PMID:12130579-16] Kiiveri S et al. (2002) Differential expression of GATA-4 and GATA-6 in fetal and adult mouse and human adrenal tissue. Endocrinology 143: 3136-43 PubMed GONUTS page

[PMID:16940177-17] Bosse T et al. (2006) Gata4 is essential for the maintenance of jejunal-ileal identities in the adult mouse small intestine. Mol Cell Biol 26: 9060-70 PubMed GONUTS page

[PMID:20308546-18] Morris SA et al. (2010) Origin and formation of the first two distinct cell types of the inner cell mass in the mouse embryo. Proc Natl Acad Sci U S A 107: 6364-9 PubMed GONUTS page

[PMID:18400219-19] 20.0 ^20.1 ^20.2 ^20.3 ^20.4 Zhao R et al. (2008) Loss of both GATA4 and GATA6 blocks cardiac myocyte differentiation and results in acardia in mice. Dev Biol 317: 614-9 PubMed GONUTS page

[PMID:9231805-20] 21.0 ^21.1 Heikinheimo M et al. (1997) Expression and hormonal regulation of transcription factors GATA-4 and GATA-6 in the mouse ovary. Endocrinology 138: 3505-14 PubMed GONUTS page

[PMID:9738004-21] Di Lisi R et al. (1998) Combinatorial cis-acting elements control tissue-specific activation of the cardiac troponin I gene in vitro and in vivo. J Biol Chem 273: 25371-80 PubMed GONUTS page

[PMID:15539431-22] Ritz-Laser B et al. (2005) The zinc finger-containing transcription factor Gata-4 is expressed in the developing endocrine pancreas and activates glucagon gene expression. Mol Endocrinol 19: 759-70 PubMed GONUTS page

[PMID:16510470-23] 24.0 ^24.1 Yin Z et al. (2006) Hop functions downstream of Nkx2.1 and GATA6 to mediate HDAC-dependent negative regulation of pulmonary gene expression. Am J Physiol Lung Cell Mol Physiol 291: L191-9 PubMed GONUTS page

[PMID:16137232-24] Brewer AC et al. (2005) GATA factors lie upstream of Nkx 2.5 in the transcriptional regulatory cascade that effects cardiogenesis. Stem Cells Dev 14: 425-39 PubMed GONUTS page

[PMID:19084512-25] Maitra M et al. (2009) Interaction of Gata4 and Gata6 with Tbx5 is critical for normal cardiac development. Dev Biol 326: 368-77 PubMed GONUTS page

[PMID:20501701-26] Karamboulas K et al. (2010) Regulation of BMP-dependent chondrogenesis in early limb mesenchyme by TGFbeta signals. J Cell Sci 123: 2068-76 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Gata6
Protein Name(s)	GATA binding protein 6,
External Links
MGI	MGI:107516

MGI:Gata6

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