MGI:G6pc

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0003824	catalytic activity	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR016118 InterPro:IPR000326	F	From MGI
	GO:0004346	glucose-6-phosphatase activity	MGI:MGI:1351534 PMID:10625614^[1]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0004346	glucose-6-phosphatase activity	MGI:MGI:1351534 PMID:10625614^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2387343	F	From MGI
	GO:0004346	glucose-6-phosphatase activity	MGI:MGI:1931953 PMID:11121425^[2]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0004346	glucose-6-phosphatase activity	MGI:MGI:3045822 PMID:15087461^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2387343	F	From MGI
	GO:0004346	glucose-6-phosphatase activity	MGI:MGI:3576961 PMID:15661744^[4]	ISO: Inferred from Sequence Orthology	UniProtKB:P35575	F	From MGI
	GO:0004346	glucose-6-phosphatase activity	MGI:MGI:3706740 PMID:10787428^[5]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0004346	glucose-6-phosphatase activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P43428	F	From MGI
	GO:0004346	glucose-6-phosphatase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35575	F	From MGI
	GO:0004346	glucose-6-phosphatase activity	MGI:MGI:63286 PMID:8407995^[6]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0004346	glucose-6-phosphatase activity	MGI:MGI:80692 PMID:8640227^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2387343	F	From MGI
	GO:0005783	endoplasmic reticulum	MGI:MGI:3706740 PMID:10787428^[5]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005792	microsome	MGI:MGI:1351534 PMID:10625614^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2387343	C	From MGI
	GO:0005792	microsome	MGI:MGI:1931953 PMID:11121425^[2]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005792	microsome	MGI:MGI:3045822 PMID:15087461^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2387343	C	From MGI
	GO:0005792	microsome	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P43428	C	From MGI
	GO:0005977	glycogen metabolic process	MGI:MGI:80692 PMID:8640227^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2387343	P	From MGI
	GO:0005980	glycogen catabolic process	MGI:MGI:1351534 PMID:10625614^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2387343	P	From MGI
	GO:0006094	gluconeogenesis	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P43428	P	From MGI
	GO:0006094	gluconeogenesis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35575	P	From MGI
	GO:0006641	triglyceride metabolic process	MGI:MGI:1351534 PMID:10625614^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2387343	P	From MGI
	GO:0006641	triglyceride metabolic process	MGI:MGI:80692 PMID:8640227^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2387343	P	From MGI
	GO:0006796	phosphate-containing compound metabolic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P43428	P	From MGI
	GO:0008152	metabolic process	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0378	P	From MGI
	GO:0008152	metabolic process	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR016118 InterPro:IPR000326	P	From MGI
	GO:0008202	steroid metabolic process	MGI:MGI:3722531 PMID:17588937^[8]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0010468	regulation of gene expression	MGI:MGI:3722531 PMID:17588937^[8]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0015760	glucose-6-phosphate transport	MGI:MGI:1351534 PMID:10625614^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0015760	glucose-6-phosphate transport	MGI:MGI:1351534 PMID:10625614^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2387343	P	From MGI
	GO:0015760	glucose-6-phosphate transport	MGI:MGI:3045822 PMID:15087461^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2387343	P	From MGI
	GO:0015760	glucose-6-phosphate transport	MGI:MGI:80692 PMID:8640227^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2387343	P	From MGI
	GO:0016020	membrane	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0472	C	From MGI
	GO:0016020	membrane	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR000326	C	From MGI
	GO:0016021	integral to membrane	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35575	C	From MGI
	GO:0016773	phosphotransferase activity, alcohol group as acceptor	MGI:MGI:63286 PMID:8407995^[6]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0016787	hydrolase activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0378	F	From MGI
	GO:0035264	multicellular organism growth	MGI:MGI:80692 PMID:8640227^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2387343	P	From MGI
	GO:0042301	phosphate ion binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35575	F	From MGI
	GO:0042593	glucose homeostasis	MGI:MGI:1351534 PMID:10625614^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2387343	P	From MGI
	GO:0042593	glucose homeostasis	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P43428	P	From MGI
	GO:0042593	glucose homeostasis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35575	P	From MGI
	GO:0042593	glucose homeostasis	MGI:MGI:80692 PMID:8640227^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2387343	P	From MGI
	GO:0042632	cholesterol homeostasis	MGI:MGI:1351534 PMID:10625614^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2387343	P	From MGI
	GO:0042632	cholesterol homeostasis	MGI:MGI:80692 PMID:8640227^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2387343	P	From MGI
	GO:0046415	urate metabolic process	MGI:MGI:80692 PMID:8640227^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2387343	P	From MGI
	GO:0046838	phosphorylated carbohydrate dephosphorylation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P43428	P	From MGI
	GO:0051156	glucose 6-phosphate metabolic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P43428	P	From MGI
	GO:0051156	glucose 6-phosphate metabolic process	MGI:MGI:80692 PMID:8640227^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2387343	P	From MGI
	GO:0055088	lipid homeostasis	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P43428	P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 Zingone A et al. (2000) Correction of glycogen storage disease type 1a in a mouse model by gene therapy. J Biol Chem 275: 828-32 PubMed GONUTS page
↑ ^2.0 ^2.1 Hiraiwa H et al. (2001) A molecular link between the common phenotypes of type 1 glycogen storage disease and HNF1alpha-null mice. J Biol Chem 276: 7963-7 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Shieh JJ et al. (2004) A potential new role for muscle in blood glucose homeostasis. J Biol Chem 279: 26215-9 PubMed GONUTS page
↑ Ghosh A et al. (2005) Brain contains a functional glucose-6-phosphatase complex capable of endogenous glucose production. J Biol Chem 280: 11114-9 PubMed GONUTS page
↑ ^5.0 ^5.1 Garver WS et al. (2000) Localization of the murine Niemann-Pick C1 protein to two distinct intracellular compartments. J Lipid Res 41: 673-87 PubMed GONUTS page
↑ ^6.0 ^6.1 Shelly LL et al. (1993) Isolation of the gene for murine glucose-6-phosphatase, the enzyme deficient in glycogen storage disease type 1A. J Biol Chem 268: 21482-5 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 ^7.8 Lei KJ et al. (1996) Glucose-6-phosphatase dependent substrate transport in the glycogen storage disease type-1a mouse. Nat Genet 13: 203-9 PubMed GONUTS page
↑ ^8.0 ^8.1 Walker EA et al. (2007) 11beta-Hydroxysteroid Dehydrogenase Type 1 Regulation by Intracellular Glucose 6-Phosphate Provides Evidence for a Novel Link between Glucose Metabolism and Hypothalamo-Pituitary-Adrenal Axis Function. J Biol Chem 282: 27030-6 PubMed GONUTS page

[PMID:10625614-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 Zingone A et al. (2000) Correction of glycogen storage disease type 1a in a mouse model by gene therapy. J Biol Chem 275: 828-32 PubMed GONUTS page

[PMID:11121425-1] 2.0 ^2.1 Hiraiwa H et al. (2001) A molecular link between the common phenotypes of type 1 glycogen storage disease and HNF1alpha-null mice. J Biol Chem 276: 7963-7 PubMed GONUTS page

[PMID:15087461-2] 3.0 ^3.1 ^3.2 Shieh JJ et al. (2004) A potential new role for muscle in blood glucose homeostasis. J Biol Chem 279: 26215-9 PubMed GONUTS page

[PMID:15661744-3] Ghosh A et al. (2005) Brain contains a functional glucose-6-phosphatase complex capable of endogenous glucose production. J Biol Chem 280: 11114-9 PubMed GONUTS page

[PMID:10787428-4] 5.0 ^5.1 Garver WS et al. (2000) Localization of the murine Niemann-Pick C1 protein to two distinct intracellular compartments. J Lipid Res 41: 673-87 PubMed GONUTS page

[PMID:8407995-5] 6.0 ^6.1 Shelly LL et al. (1993) Isolation of the gene for murine glucose-6-phosphatase, the enzyme deficient in glycogen storage disease type 1A. J Biol Chem 268: 21482-5 PubMed GONUTS page

[PMID:8640227-6] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 ^7.8 Lei KJ et al. (1996) Glucose-6-phosphatase dependent substrate transport in the glycogen storage disease type-1a mouse. Nat Genet 13: 203-9 PubMed GONUTS page

[PMID:17588937-7] 8.0 ^8.1 Walker EA et al. (2007) 11beta-Hydroxysteroid Dehydrogenase Type 1 Regulation by Intracellular Glucose 6-Phosphate Provides Evidence for a Novel Link between Glucose Metabolism and Hypothalamo-Pituitary-Adrenal Axis Function. J Biol Chem 282: 27030-6 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	G6pc ( synonyms: G6Pase, G6pt, Glc-6-Pase, Glc-6-Pase-alpha )
Protein Name(s)	glucose-6-phosphatase, catalytic,
External Links
MGI	MGI:95607

MGI:G6pc

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References

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