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MGI:Fzd1
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Fzd1 ( synonyms: FZ-1, Fz1 ) | |
| Protein Name(s) | frizzled homolog 1 (Drosophila), | |
| External Links | ||
| MGI | MGI:1196625 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001934 |
positive regulation of protein phosphorylation |
MGI:MGI:3045675 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0001944 |
vasculature development |
MGI:MGI:4459044 |
PANTHER:PTHR11309 |
P |
From MGI |
|||
| GO:0003149 |
membranous septum morphogenesis |
MGI:MGI:4837757 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1888513 |
P |
From MGI |
||
| GO:0003150 |
muscular septum morphogenesis |
MGI:MGI:4837757 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1888513 |
P |
From MGI |
||
| GO:0003151 |
outflow tract morphogenesis |
MGI:MGI:4837757 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1888513 |
P |
From MGI |
||
| GO:0004871 |
signal transducer activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0807 |
F |
From MGI |
||
| GO:0004872 |
receptor activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0675 |
F |
From MGI |
||
| GO:0004888 |
transmembrane signaling receptor activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0004930 |
G-protein coupled receptor activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0297 |
F |
From MGI |
||
| GO:0005102 |
receptor binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4459044 |
PANTHER:PTHR11309 |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006357 |
regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4459044 |
PANTHER:PTHR11309 |
P |
From MGI |
|||
| GO:0007165 |
signal transduction |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0807 |
P |
From MGI |
||
| GO:0007166 |
cell surface receptor signaling pathway |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0007186 |
G-protein coupled receptor signaling pathway |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0297 |
P |
From MGI |
||
| GO:0007199 |
G-protein signaling, coupled to cGMP nucleotide second messenger |
MGI:MGI:4459044 |
PANTHER:PTHR11309 |
P |
From MGI |
|||
| GO:0007223 |
Wnt receptor signaling pathway, calcium modulating pathway |
MGI:MGI:4459044 |
PANTHER:PTHR11309 |
P |
From MGI |
|||
| GO:0007267 |
cell-cell signaling |
MGI:MGI:3577819 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007267 |
cell-cell signaling |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007275 |
multicellular organismal development |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0217 |
P |
From MGI |
||
| GO:0007409 |
axonogenesis |
MGI:MGI:4459044 |
PANTHER:PTHR11309 |
P |
From MGI |
|||
| GO:0007420 |
brain development |
MGI:MGI:4459044 |
PANTHER:PTHR11309 |
P |
From MGI |
|||
| GO:0008406 |
gonad development |
MGI:MGI:4459044 |
PANTHER:PTHR11309 |
P |
From MGI |
|||
| GO:0009986 |
cell surface |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016020 |
membrane |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0016021 |
integral to membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0812 |
C |
From MGI |
||
| GO:0016055 |
Wnt receptor signaling pathway |
MGI:MGI:3581375 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:98961 |
P |
From MGI |
||
| GO:0016055 |
Wnt receptor signaling pathway |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0017147 |
Wnt-protein binding |
MGI:MGI:3581375 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0017147 |
Wnt-protein binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0019717 |
synaptosome |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0030165 |
PDZ domain binding |
MGI:MGI:4459044 |
PANTHER:PTHR11309 |
F |
From MGI |
|||
| GO:0030165 |
PDZ domain binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0030514 |
negative regulation of BMP signaling pathway |
MGI:MGI:3033512 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0030855 |
epithelial cell differentiation |
MGI:MGI:3577819 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0030855 |
epithelial cell differentiation |
MGI:MGI:3577819 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:103124 |
P |
From MGI |
||
| GO:0032589 |
neuron projection membrane |
MGI:MGI:4459044 |
PANTHER:PTHR11309 |
C |
From MGI |
|||
| GO:0035414 |
negative regulation of catenin import into nucleus |
MGI:MGI:3033512 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0035425 |
autocrine signaling |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042493 |
response to drug |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042803 |
protein homodimerization activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0042813 |
Wnt-activated receptor activity |
MGI:MGI:4459044 |
PANTHER:PTHR11309 |
F |
From MGI |
|||
| GO:0042813 |
Wnt-activated receptor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0044338 |
canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0044339 |
canonical Wnt receptor signaling pathway involved in osteoblast differentiation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045177 |
apical part of cell |
MGI:MGI:4459044 |
PANTHER:PTHR11309 |
C |
From MGI |
|||
| GO:0045892 |
negative regulation of transcription, DNA-dependent |
MGI:MGI:3656361 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0046982 |
protein heterodimerization activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0048286 |
lung alveolus development |
MGI:MGI:4459044 |
PANTHER:PTHR11309 |
P |
From MGI |
|||
| GO:0051091 |
positive regulation of sequence-specific DNA binding transcription factor activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051091 |
positive regulation of sequence-specific DNA binding transcription factor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0060022 |
hard palate development |
MGI:MGI:4837757 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1888513 |
P |
From MGI |
||
| GO:0060070 |
canonical Wnt receptor signaling pathway |
MGI:MGI:3045675 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0060070 |
canonical Wnt receptor signaling pathway |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0060070 |
canonical Wnt receptor signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0060412 |
ventricular septum morphogenesis |
MGI:MGI:4837757 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1888513 |
P |
From MGI |
||
| GO:0090090 |
negative regulation of canonical Wnt receptor signaling pathway |
MGI:MGI:3033546 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0090179 |
planar cell polarity pathway involved in neural tube closure |
MGI:MGI:4837757 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1888513 |
P |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 González-Sancho JM et al. (2004) Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin. Mol Cell Biol 24: 4757-68 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Yu H et al. (2010) Frizzled 1 and frizzled 2 genes function in palate, ventricular septum and neural tube closure: general implications for tissue fusion processes. Development 137: 3707-17 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Kim BM et al. (2005) The stomach mesenchymal transcription factor Barx1 specifies gastric epithelial identity through inhibition of transient Wnt signaling. Dev Cell 8: 611-22 PubMed GONUTS page
- ↑ 4.0 4.1 Wang Z et al. (2005) Wnt7b activates canonical signaling in epithelial and vascular smooth muscle cells through interactions with Fzd1, Fzd10, and LRP5. Mol Cell Biol 25: 5022-30 PubMed GONUTS page
- ↑ 5.0 5.1 Roman-Roman S et al. (2004) Murine Frizzled-1 behaves as an antagonist of the canonical Wnt/beta-catenin signaling. J Biol Chem 279: 5725-33 PubMed GONUTS page
- ↑ Borello U et al. (2006) The Wnt/beta-catenin pathway regulates Gli-mediated Myf5 expression during somitogenesis. Development 133: 3723-32 PubMed GONUTS page
- ↑ Beigneux AP et al. (2004) ATP-citrate lyase deficiency in the mouse. J Biol Chem 279: 9557-64 PubMed GONUTS page
