MGI:Fyn

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000166	nucleotide binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0547	F	From MGI
	GO:0001764	neuron migration	MGI:MGI:3590439 PMID:16162939^[1]	IGI: Inferred from Genetic Interaction	MGI:MGI:98397	P	From MGI
	GO:0001764	neuron migration	MGI:MGI:3610430 PMID:15073522^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1930480	P	From MGI
	GO:0001948	glycoprotein binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62844	F	From MGI
	GO:0001948	glycoprotein binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06241	F	From MGI
	GO:0004672	protein kinase activity	MGI:MGI:2158591 PMID:11826099^[3]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0004672	protein kinase activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62844	F	From MGI
	GO:0004713	protein tyrosine kinase activity	MGI:MGI:1859033 PMID:10872802^[4]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0004713	protein tyrosine kinase activity	MGI:MGI:3768467 PMID:17923684^[5]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0004713	protein tyrosine kinase activity	MGI:MGI:3775717 PMID:16841086^[6]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0004713	protein tyrosine kinase activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62844	F	From MGI
	GO:0004713	protein tyrosine kinase activity	MGI:MGI:65996 PMID:8175795^[7]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0004713	protein tyrosine kinase activity	MGI:MGI:66781 PMID:8196616^[8]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0004715	non-membrane spanning protein tyrosine kinase activity	MGI:MGI:2152096	IEA: Inferred from Electronic Annotation	EC:2.7.10.2	F	From MGI
	GO:0005102	receptor binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62844	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3621856 PMID:12372285^[9]	IPI: Inferred from Physical Interaction	UniProtKB:O75051 UniProtKB:P49619	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3688344 PMID:15102471^[10]	IPI: Inferred from Physical Interaction	UniProtKB:P51807 UniProtKB:Q60749	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3694161 PMID:10713104^[11]	IPI: Inferred from Physical Interaction	UniProtKB:P49710	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3768467 PMID:17923684^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q80W68	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3843433 PMID:16316995^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q9JIA7	F	From MGI
	GO:0005515	protein binding	MGI:MGI:893273 PMID:7799925^[13]	IPI: Inferred from Physical Interaction	UniProtKB:Q60749	F	From MGI
	GO:0005524	ATP binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0067	F	From MGI
	GO:0005524	ATP binding	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR000719 InterPro:IPR017441	F	From MGI
	GO:0005624	membrane fraction	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62844	C	From MGI
	GO:0005739	mitochondrion	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62844	C	From MGI
	GO:0005768	endosome	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06241	C	From MGI
	GO:0005792	microsome	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62844	C	From MGI
	GO:0005886	plasma membrane	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06241	C	From MGI
	GO:0006468	protein phosphorylation	MGI:MGI:1330707 PMID:9892651^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1930480	P	From MGI
	GO:0006468	protein phosphorylation	MGI:MGI:3604261 PMID:16190898^[15]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1930480	P	From MGI
	GO:0007166	cell surface receptor signaling pathway	MGI:MGI:87805 PMID:9177270^[16]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0007275	multicellular organismal development	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0217	P	From MGI
	GO:0008360	regulation of cell shape	MGI:MGI:2158591 PMID:11826099^[3]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0010629	negative regulation of gene expression	MGI:MGI:4850200 PMID:20978343^[17]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0014069	postsynaptic density	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62844	C	From MGI
	GO:0015631	tubulin binding	MGI:MGI:2158591 PMID:11826099^[3]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0016020	membrane	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0472	C	From MGI
	GO:0016301	kinase activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0418	F	From MGI
	GO:0016310	phosphorylation	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0418	P	From MGI
	GO:0016740	transferase activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0808	F	From MGI
	GO:0016772	transferase activity, transferring phosphorus-containing groups	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR011009	F	From MGI
	GO:0018108	peptidyl-tyrosine phosphorylation	MGI:MGI:1098368 PMID:9381182^[18]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1930480	P	From MGI
	GO:0018108	peptidyl-tyrosine phosphorylation	MGI:MGI:1859033 PMID:10872802^[4]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0018108	peptidyl-tyrosine phosphorylation	MGI:MGI:3768467 PMID:17923684^[5]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0018108	peptidyl-tyrosine phosphorylation	MGI:MGI:3768467 PMID:17923684^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857172	P	From MGI
	GO:0018108	peptidyl-tyrosine phosphorylation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62844	P	From MGI
	GO:0018108	peptidyl-tyrosine phosphorylation	MGI:MGI:65996 PMID:8175795^[7]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0018108	peptidyl-tyrosine phosphorylation	MGI:MGI:66781 PMID:8196616^[8]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0030900	forebrain development	MGI:MGI:3590439 PMID:16162939^[1]	IGI: Inferred from Genetic Interaction	MGI:MGI:98397	P	From MGI
	GO:0030900	forebrain development	MGI:MGI:3610430 PMID:15073522^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:98397	P	From MGI
	GO:0032403	protein complex binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62844	F	From MGI
	GO:0042177	negative regulation of protein catabolic process	MGI:MGI:3775717 PMID:16841086^[6]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0042552	myelination	MGI:MGI:2158591 PMID:11826099^[3]	TAS: Traceable Author Statement		P	From MGI
	GO:0042608	T cell receptor binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62844	F	From MGI
	GO:0042609	CD4 receptor binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62844	F	From MGI
	GO:0042610	CD8 receptor binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62844	F	From MGI
	GO:0043548	phosphatidylinositol 3-kinase binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62844	F	From MGI
	GO:0044325	ion channel binding	MGI:MGI:2653708 PMID:12538589^[19]	IPI: Inferred from Physical Interaction	UniProtKB:Q9EPK8	F	From MGI
	GO:0045471	response to ethanol	MGI:MGI:1098368 PMID:9381182^[18]	IGI: Inferred from Genetic Interaction	MGI:MGI:95819	P	From MGI
	GO:0046777	protein autophosphorylation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62844	P	From MGI
	GO:0046777	protein autophosphorylation	MGI:MGI:65996 PMID:8175795^[7]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0046872	metal ion binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0479	F	From MGI
	GO:0046875	ephrin receptor binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06241	F	From MGI
	GO:0048813	dendrite morphogenesis	MGI:MGI:3621856 PMID:12372285^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1930480	P	From MGI
	GO:0050798	activated T cell proliferation	MGI:MGI:2148425 PMID:1516132^[20]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2179145	P	From MGI
	GO:0050852	T cell receptor signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06241	P	From MGI
	GO:0050966	detection of mechanical stimulus involved in sensory perception of pain	MGI:MGI:3604261 PMID:16190898^[15]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1930480	P	From MGI
	GO:0051428	peptide hormone receptor binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62844	F	From MGI
	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62844	P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Kuo G et al. (2005) Absence of Fyn and Src causes a reeler-like phenotype. J Neurosci 25: 8578-86 PubMed GONUTS page
↑ ^2.0 ^2.1 Yuasa S et al. (2004) Defective neocortical development in Fyn-tyrosine-kinase-deficient mice. Neuroreport 15: 819-22 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Klein C et al. (2002) Process outgrowth of oligodendrocytes is promoted by interaction of fyn kinase with the cytoskeletal protein tau. J Neurosci 22: 698-707 PubMed GONUTS page
↑ ^4.0 ^4.1 Iseki M et al. (2000) Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins. Biochem Biophys Res Commun 272: 45-54 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Garg P et al. (2007) Neph1 cooperates with nephrin to transduce a signal that induces actin polymerization. Mol Cell Biol 27: 8698-712 PubMed GONUTS page
↑ ^6.0 ^6.1 Tang X et al. (2007) Src-family tyrosine kinase fyn phosphorylates phosphatidylinositol 3-kinase enhancer-activating Akt, preventing its apoptotic cleavage and promoting cell survival. Cell Death Differ 14: 368-77 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Burns CM et al. (1994) CD45 regulation of tyrosine phosphorylation and enzyme activity of src family kinases. J Biol Chem 269: 13594-600 PubMed GONUTS page
↑ ^8.0 ^8.1 Gauen LK et al. (1994) Interactions of p59fyn and ZAP-70 with T-cell receptor activation motifs: defining the nature of a signalling motif. Mol Cell Biol 14: 3729-41 PubMed GONUTS page
↑ ^9.0 ^9.1 Sasaki Y et al. (2002) Fyn and Cdk5 mediate semaphorin-3A signaling, which is involved in regulation of dendrite orientation in cerebral cortex. Neuron 35: 907-20 PubMed GONUTS page
↑ Papin J & Subramaniam S (2004) Bioinformatics and cellular signaling. Curr Opin Biotechnol 15: 78-81 PubMed GONUTS page
↑ Ingley E et al. (2000) HS1 interacts with Lyn and is critical for erythropoietin-induced differentiation of erythroid cells. J Biol Chem 275: 7887-93 PubMed GONUTS page
↑ Olivera A et al. (2006) IgE-dependent activation of sphingosine kinases 1 and 2 and secretion of sphingosine 1-phosphate requires Fyn kinase and contributes to mast cell responses. J Biol Chem 281: 2515-25 PubMed GONUTS page
↑ Richard S et al. (1995) Association of p62, a multifunctional SH2- and SH3-domain-binding protein, with src family tyrosine kinases, Grb2, and phospholipase C gamma-1. Mol Cell Biol 15: 186-97 PubMed GONUTS page
↑ Tezuka T et al. (1999) PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit NR2A. Proc Natl Acad Sci U S A 96: 435-40 PubMed GONUTS page
↑ ^15.0 ^15.1 Abe T et al. (2005) Fyn kinase-mediated phosphorylation of NMDA receptor NR2B subunit at Tyr1472 is essential for maintenance of neuropathic pain. Eur J Neurosci 22: 1445-54 PubMed GONUTS page
↑ Sammar M et al. (1997) Mouse CD24 as a signaling molecule for integrin-mediated cell binding: functional and physical association with src-kinases. Biochem Biophys Res Commun 234: 330-4 PubMed GONUTS page
↑ Li W et al. (2010) CD36 participates in a signaling pathway that regulates ROS formation in murine VSMCs. J Clin Invest 120: 3996-4006 PubMed GONUTS page
↑ ^18.0 ^18.1 Miyakawa T et al. (1997) Fyn-kinase as a determinant of ethanol sensitivity: relation to NMDA-receptor function. Science 278: 698-701 PubMed GONUTS page
↑ Xu H et al. (2003) Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation. SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its response to hypotonic stress. J Biol Chem 278: 11520-7 PubMed GONUTS page
↑ Appleby MW et al. (1992) Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn. Cell 70: 751-63 PubMed GONUTS page

[PMID:16162939-0] 1.0 ^1.1 Kuo G et al. (2005) Absence of Fyn and Src causes a reeler-like phenotype. J Neurosci 25: 8578-86 PubMed GONUTS page

[PMID:15073522-1] 2.0 ^2.1 Yuasa S et al. (2004) Defective neocortical development in Fyn-tyrosine-kinase-deficient mice. Neuroreport 15: 819-22 PubMed GONUTS page

[PMID:11826099-2] 3.0 ^3.1 ^3.2 ^3.3 Klein C et al. (2002) Process outgrowth of oligodendrocytes is promoted by interaction of fyn kinase with the cytoskeletal protein tau. J Neurosci 22: 698-707 PubMed GONUTS page

[PMID:10872802-3] 4.0 ^4.1 Iseki M et al. (2000) Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins. Biochem Biophys Res Commun 272: 45-54 PubMed GONUTS page

[PMID:17923684-4] 5.0 ^5.1 ^5.2 ^5.3 Garg P et al. (2007) Neph1 cooperates with nephrin to transduce a signal that induces actin polymerization. Mol Cell Biol 27: 8698-712 PubMed GONUTS page

[PMID:16841086-5] 6.0 ^6.1 Tang X et al. (2007) Src-family tyrosine kinase fyn phosphorylates phosphatidylinositol 3-kinase enhancer-activating Akt, preventing its apoptotic cleavage and promoting cell survival. Cell Death Differ 14: 368-77 PubMed GONUTS page

[PMID:8175795-6] 7.0 ^7.1 ^7.2 Burns CM et al. (1994) CD45 regulation of tyrosine phosphorylation and enzyme activity of src family kinases. J Biol Chem 269: 13594-600 PubMed GONUTS page

[PMID:8196616-7] 8.0 ^8.1 Gauen LK et al. (1994) Interactions of p59fyn and ZAP-70 with T-cell receptor activation motifs: defining the nature of a signalling motif. Mol Cell Biol 14: 3729-41 PubMed GONUTS page

[PMID:12372285-8] 9.0 ^9.1 Sasaki Y et al. (2002) Fyn and Cdk5 mediate semaphorin-3A signaling, which is involved in regulation of dendrite orientation in cerebral cortex. Neuron 35: 907-20 PubMed GONUTS page

[PMID:15102471-9] Papin J & Subramaniam S (2004) Bioinformatics and cellular signaling. Curr Opin Biotechnol 15: 78-81 PubMed GONUTS page

[PMID:10713104-10] Ingley E et al. (2000) HS1 interacts with Lyn and is critical for erythropoietin-induced differentiation of erythroid cells. J Biol Chem 275: 7887-93 PubMed GONUTS page

[PMID:16316995-11] Olivera A et al. (2006) IgE-dependent activation of sphingosine kinases 1 and 2 and secretion of sphingosine 1-phosphate requires Fyn kinase and contributes to mast cell responses. J Biol Chem 281: 2515-25 PubMed GONUTS page

[PMID:7799925-12] Richard S et al. (1995) Association of p62, a multifunctional SH2- and SH3-domain-binding protein, with src family tyrosine kinases, Grb2, and phospholipase C gamma-1. Mol Cell Biol 15: 186-97 PubMed GONUTS page

[PMID:9892651-13] Tezuka T et al. (1999) PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit NR2A. Proc Natl Acad Sci U S A 96: 435-40 PubMed GONUTS page

[PMID:16190898-14] 15.0 ^15.1 Abe T et al. (2005) Fyn kinase-mediated phosphorylation of NMDA receptor NR2B subunit at Tyr1472 is essential for maintenance of neuropathic pain. Eur J Neurosci 22: 1445-54 PubMed GONUTS page

[PMID:9177270-15] Sammar M et al. (1997) Mouse CD24 as a signaling molecule for integrin-mediated cell binding: functional and physical association with src-kinases. Biochem Biophys Res Commun 234: 330-4 PubMed GONUTS page

[PMID:20978343-16] Li W et al. (2010) CD36 participates in a signaling pathway that regulates ROS formation in murine VSMCs. J Clin Invest 120: 3996-4006 PubMed GONUTS page

[PMID:9381182-17] 18.0 ^18.1 Miyakawa T et al. (1997) Fyn-kinase as a determinant of ethanol sensitivity: relation to NMDA-receptor function. Science 278: 698-701 PubMed GONUTS page

[PMID:12538589-18] Xu H et al. (2003) Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation. SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its response to hypotonic stress. J Biol Chem 278: 11520-7 PubMed GONUTS page

[PMID:1516132-19] Appleby MW et al. (1992) Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn. Cell 70: 751-63 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Fyn ( synonyms: Src Kinase p59 )
Protein Name(s)	Fyn proto-oncogene,
External Links
MGI	MGI:95602

MGI:Fyn

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