MGI:Fxn

From GONUTS

Jump to: navigation, search

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0004322	ferroxidase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q16595	F	From MGI
	GO:0005737	cytoplasm	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0963	C	From MGI
	GO:0005739	mitochondrion	MGI:MGI:2682130 PMID:14651853^[1]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005739	mitochondrion	MGI:MGI:3770334 PMID:17597094^[2]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005739	mitochondrion	MGI:MGI:3852644 PMID:18614015^[3]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005739	mitochondrion	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001178881	C	From MGI
	GO:0005739	mitochondrion	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q16595	C	From MGI
	GO:0005829	cytosol	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q16595	C	From MGI
	GO:0006119	oxidative phosphorylation	MGI:MGI:3611157 PMID:16278235^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2177176 MGI:MGI:2176228	P	From MGI
	GO:0006119	oxidative phosphorylation	MGI:MGI:3708076 PMID:17404227^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2177176 MGI:MGI:2182103	P	From MGI
	GO:0006783	heme biosynthetic process	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0350	P	From MGI
	GO:0006810	transport	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0813	P	From MGI
	GO:0006811	ion transport	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0406	P	From MGI
	GO:0006879	cellular iron ion homeostasis	MGI:MGI:2158372 PMID:9405681^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2177176 MGI:MGI:2177175	P	From MGI
	GO:0006879	cellular iron ion homeostasis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q16595	P	From MGI
	GO:0007005	mitochondrion organization	MGI:MGI:2158372 PMID:9405681^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2177176 MGI:MGI:2177175	P	From MGI
	GO:0007005	mitochondrion organization	MGI:MGI:3042499 PMID:14985441^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2177177	P	From MGI
	GO:0007628	adult walking behavior	MGI:MGI:2158372 PMID:9405681^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2177176 MGI:MGI:2177175	P	From MGI
	GO:0007628	adult walking behavior	MGI:MGI:3042499 PMID:14985441^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2177177	P	From MGI
	GO:0008198	ferrous iron binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q16595	F	From MGI
	GO:0008199	ferric iron binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q16595	F	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q16595	P	From MGI
	GO:0009060	aerobic respiration	MGI:MGI:2158372 PMID:9405681^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2177176 MGI:MGI:2177175	P	From MGI
	GO:0009060	aerobic respiration	MGI:MGI:3611157 PMID:16278235^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2177176 MGI:MGI:2176228	P	From MGI
	GO:0009792	embryo development ending in birth or egg hatching	MGI:MGI:1858550 PMID:10767347^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2177162	P	From MGI
	GO:0010039	response to iron ion	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q16595	P	From MGI
	GO:0010722	regulation of ferrochelatase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q16595	P	From MGI
	GO:0016226	iron-sulfur cluster assembly	MGI:MGI:3611157 PMID:16278235^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2177176 MGI:MGI:2176228	P	From MGI
	GO:0016226	iron-sulfur cluster assembly	MGI:MGI:3770334 PMID:17597094^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2177176 MGI:MGI:2176228	P	From MGI
	GO:0016491	oxidoreductase activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0560	F	From MGI
	GO:0016540	protein autoprocessing	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q16595	P	From MGI
	GO:0018283	iron incorporation into metallo-sulfur cluster	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q16595	P	From MGI
	GO:0019230	proprioception	MGI:MGI:2176558 PMID:11175786^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2177176 MGI:MGI:2177175	P	From MGI
	GO:0019230	proprioception	MGI:MGI:3042499 PMID:14985441^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2177177	P	From MGI
	GO:0019899	enzyme binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001178881	F	From MGI
	GO:0030307	positive regulation of cell growth	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q16595	P	From MGI
	GO:0034986	iron chaperone activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q16595	F	From MGI
	GO:0040015	negative regulation of multicellular organism growth	MGI:MGI:3708076 PMID:17404227^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2177176 MGI:MGI:2182103	P	From MGI
	GO:0043066	negative regulation of apoptotic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q16595	P	From MGI
	GO:0045773	positive regulation of axon extension	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001178881	P	From MGI
	GO:0046621	negative regulation of organ growth	MGI:MGI:2158372 PMID:9405681^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2177176 MGI:MGI:2177175	P	From MGI
	GO:0046872	metal ion binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0479	F	From MGI
	GO:0048554	positive regulation of metalloenzyme activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q16595	P	From MGI
	GO:0051347	positive regulation of transferase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q16595	P	From MGI
	GO:0051349	positive regulation of lyase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q16595	P	From MGI
	GO:0051353	positive regulation of oxidoreductase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q16595	P	From MGI
	GO:0051536	iron-sulfur cluster binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q16595	F	From MGI
	GO:0051537	2 iron, 2 sulfur cluster binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q16595	F	From MGI
	GO:0055072	iron ion homeostasis	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0410	P	From MGI
	GO:0055114	oxidation-reduction process	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0560	P	From MGI
	GO:0055114	oxidation-reduction process	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR017789 InterPro:IPR001794	P	From MGI
	GO:0070301	cellular response to hydrogen peroxide	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q16595	P	From MGI
	GO:0090201	negative regulation of release of cytochrome c from mitochondria	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q16595	P	From MGI
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115: 629-40 PubMed GONUTS page
↑ ^2.0 ^2.1 Martelli A et al. (2007) Frataxin is essential for extramitochondrial Fe-S cluster proteins in mammalian tissues. Hum Mol Genet 16: 2651-8 PubMed GONUTS page
↑ Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134: 112-23 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Thierbach R et al. (2005) Targeted disruption of hepatic frataxin expression causes impaired mitochondrial function, decreased life span and tumor growth in mice. Hum Mol Genet 14: 3857-64 PubMed GONUTS page
↑ ^5.0 ^5.1 Pomplun D et al. (2007) Reduced expression of mitochondrial frataxin in mice exacerbates diet-induced obesity. Proc Natl Acad Sci U S A 104: 6377-81 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Oliver PM et al. (1997) Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A. Proc Natl Acad Sci U S A 94: 14730-5 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Simon D et al. (2004) Friedreich ataxia mouse models with progressive cerebellar and sensory ataxia reveal autophagic neurodegeneration in dorsal root ganglia. J Neurosci 24: 1987-95 PubMed GONUTS page
↑ Cossée M et al. (2000) Inactivation of the Friedreich ataxia mouse gene leads to early embryonic lethality without iron accumulation. Hum Mol Genet 9: 1219-26 PubMed GONUTS page
↑ Puccio H et al. (2001) Mouse models for Friedreich ataxia exhibit cardiomyopathy, sensory nerve defect and Fe-S enzyme deficiency followed by intramitochondrial iron deposits. Nat Genet 27: 181-6 PubMed GONUTS page

[PMID:14651853-0] Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115: 629-40 PubMed GONUTS page

[PMID:17597094-1] 2.0 ^2.1 Martelli A et al. (2007) Frataxin is essential for extramitochondrial Fe-S cluster proteins in mammalian tissues. Hum Mol Genet 16: 2651-8 PubMed GONUTS page

[PMID:18614015-2] Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134: 112-23 PubMed GONUTS page

[PMID:16278235-3] 4.0 ^4.1 ^4.2 Thierbach R et al. (2005) Targeted disruption of hepatic frataxin expression causes impaired mitochondrial function, decreased life span and tumor growth in mice. Hum Mol Genet 14: 3857-64 PubMed GONUTS page

[PMID:17404227-4] 5.0 ^5.1 Pomplun D et al. (2007) Reduced expression of mitochondrial frataxin in mice exacerbates diet-induced obesity. Proc Natl Acad Sci U S A 104: 6377-81 PubMed GONUTS page

[PMID:9405681-5] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Oliver PM et al. (1997) Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A. Proc Natl Acad Sci U S A 94: 14730-5 PubMed GONUTS page

[PMID:14985441-6] 7.0 ^7.1 ^7.2 Simon D et al. (2004) Friedreich ataxia mouse models with progressive cerebellar and sensory ataxia reveal autophagic neurodegeneration in dorsal root ganglia. J Neurosci 24: 1987-95 PubMed GONUTS page

[PMID:10767347-7] Cossée M et al. (2000) Inactivation of the Friedreich ataxia mouse gene leads to early embryonic lethality without iron accumulation. Hum Mol Genet 9: 1219-26 PubMed GONUTS page

[PMID:11175786-8] Puccio H et al. (2001) Mouse models for Friedreich ataxia exhibit cardiomyopathy, sensory nerve defect and Fe-S enzyme deficiency followed by intramitochondrial iron deposits. Nat Genet 27: 181-6 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Fxn ( synonyms: Frda )
Protein Name(s)	frataxin,
External Links
MGI	MGI:1096879

MGI:Fxn

Contents

Annotations

Notes

References

2

a

b

c

d

e

f

f cont.

g

h

i

m

n

o

p

r

s

t

v

Personal tools

Namespaces

Variants

Views

Actions

Search

Navigation

Cacao

Journal Clubs

page contributors

Toolbox