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MGI:Furin
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Furin ( synonyms: Fur, PACE, Pcsk3, SPC1 ) | |
| Protein Name(s) | furin (paired basic amino acid cleaving enzyme), | |
| External Links | ||
| MGI | MGI:97513 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0002020 |
protease binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004175 |
endopeptidase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004252 |
serine-type endopeptidase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004252 |
serine-type endopeptidase activity |
MGI:MGI:4459044 |
PANTHER:PTHR10795 |
F |
From MGI |
|||
| GO:0004252 |
serine-type endopeptidase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004867 |
serine-type endopeptidase inhibitor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:1326769 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005615 |
extracellular space |
MGI:MGI:4459044 |
PANTHER:PTHR10795 |
C |
From MGI |
|||
| GO:0005769 |
early endosome |
MGI:MGI:2388536 |
TAS: Traceable Author Statement |
C |
From MGI |
|||
| GO:0005789 |
endoplasmic reticulum membrane |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005794 |
Golgi apparatus |
MGI:MGI:4459044 |
PANTHER:PTHR10795 |
C |
From MGI |
|||
| GO:0005802 |
trans-Golgi network |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006465 |
signal peptide processing |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006508 |
proteolysis |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0645 |
P |
From MGI |
||
| GO:0006508 |
proteolysis |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0008152 |
metabolic process |
MGI:MGI:4459044 |
PANTHER:PTHR10795 |
P |
From MGI |
|||
| GO:0008233 |
peptidase activity |
MGI:MGI:3042677 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0008233 |
peptidase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0008236 |
serine-type peptidase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0720 |
F |
From MGI |
||
| GO:0008283 |
cell proliferation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0009966 |
regulation of signal transduction |
MGI:MGI:3763867 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0009986 |
cell surface |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0010951 |
negative regulation of endopeptidase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0012510 |
trans-Golgi network transport vesicle membrane |
MGI:MGI:2388536 |
TAS: Traceable Author Statement |
C |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016021 |
integral to membrane |
MGI:MGI:2388536 |
TAS: Traceable Author Statement |
C |
From MGI |
|||
| GO:0016485 |
protein processing |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0016485 |
protein processing |
MGI:MGI:4829577 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0016485 |
protein processing |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0016486 |
peptide hormone processing |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0016787 |
hydrolase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0378 |
F |
From MGI |
||
| GO:0030140 |
trans-Golgi network transport vesicle |
MGI:MGI:3040541 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0030335 |
positive regulation of cell migration |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030511 |
positive regulation of transforming growth factor beta receptor signaling pathway |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0031985 |
Golgi cisterna |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0032804 |
negative regulation of low-density lipoprotein particle receptor catabolic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032902 |
nerve growth factor production |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032911 |
negative regulation of transforming growth factor beta1 production |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032940 |
secretion by cell |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042176 |
regulation of protein catabolic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042277 |
peptide binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0043043 |
peptide biosynthetic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045121 |
membrane raft |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0046872 |
metal ion binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0479 |
F |
From MGI |
||
| GO:0048406 |
nerve growth factor binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0052548 |
regulation of endopeptidase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Liu G et al. (1997) Cytoskeletal protein ABP-280 directs the intracellular trafficking of furin and modulates proprotein processing in the endocytic pathway. J Cell Biol 139: 1719-33 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Thomas G (2002) Furin at the cutting edge: from protein traffic to embryogenesis and disease. Nat Rev Mol Cell Biol 3: 753-66 PubMed GONUTS page
- ↑ Marschang P et al. (2004) Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1. Mol Cell Biol 24: 3782-93 PubMed GONUTS page
- ↑ Andersson O et al. (2007) Distinct and cooperative roles of mammalian Vg1 homologs GDF1 and GDF3 during early embryonic development. Dev Biol 311: 500-11 PubMed GONUTS page
- ↑ Yang T et al. (2010) E-selectin ligand-1 regulates growth plate homeostasis in mice by inhibiting the intracellular processing and secretion of mature TGF-beta. J Clin Invest 120: 2474-85 PubMed GONUTS page
- ↑ Seaman MN (2004) Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer. J Cell Biol 165: 111-22 PubMed GONUTS page
