MGI:Foxf1a

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	MGI:MGI:1928688 PMID:11124112^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1929432	P	From MGI
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	MGI:MGI:4367570 PMID:18421012^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2179135	P	From MGI
	GO:0001568	blood vessel development	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q12946	P	From MGI
	GO:0001570	vasculogenesis	MGI:MGI:1928688 PMID:11124112^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1929432	P	From MGI
	GO:0001570	vasculogenesis	MGI:MGI:2137114 PMID:11437453^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2179135	P	From MGI
	GO:0001570	vasculogenesis	MGI:MGI:3766861 PMID:17881493^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1929432	P	From MGI
	GO:0001701	in utero embryonic development	MGI:MGI:1928688 PMID:11124112^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1929432	P	From MGI
	GO:0001701	in utero embryonic development	MGI:MGI:2135612 PMID:11493558^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1929432	P	From MGI
	GO:0001701	in utero embryonic development	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q12946	P	From MGI
	GO:0001756	somitogenesis	MGI:MGI:1928688 PMID:11124112^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1929432	P	From MGI
	GO:0002053	positive regulation of mesenchymal cell proliferation	MGI:MGI:1928688 PMID:11124112^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1929432	P	From MGI
	GO:0003197	endocardial cushion development	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q12946	P	From MGI
	GO:0003214	cardiac left ventricle morphogenesis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q12946	P	From MGI
	GO:0003677	DNA binding	MGI:MGI:3588477 PMID:15987774^[6]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003677	DNA binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q12946	F	From MGI
	GO:0003690	double-stranded DNA binding	MGI:MGI:4459044		PANTHER:PTHR11829	F	From MGI
	GO:0003700	sequence-specific DNA binding transcription factor activity	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR001766 InterPro:IPR018122	F	From MGI
	GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity	MGI:MGI:4459044		PANTHER:PTHR11829	F	From MGI
	GO:0005634	nucleus	MGI:MGI:3709924 PMID:17261592^[7]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005667	transcription factor complex	MGI:MGI:4459044		PANTHER:PTHR11829	C	From MGI
	GO:0006351	transcription, DNA-dependent	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0804	P	From MGI
	GO:0006355	regulation of transcription, DNA-dependent	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0805	P	From MGI
	GO:0006355	regulation of transcription, DNA-dependent	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR001766 InterPro:IPR018122	P	From MGI
	GO:0006357	regulation of transcription from RNA polymerase II promoter	MGI:MGI:4459044		PANTHER:PTHR11829	P	From MGI
	GO:0007224	smoothened signaling pathway	MGI:MGI:2135612 PMID:11493558^[5]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0007368	determination of left/right symmetry	MGI:MGI:2135612 PMID:11493558^[5]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0007494	midgut development	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q12946	P	From MGI
	GO:0007498	mesoderm development	MGI:MGI:1928688 PMID:11124112^[1]	IGI: Inferred from Genetic Interaction	MGI:MGI:1197522	P	From MGI
	GO:0007498	mesoderm development	MGI:MGI:2135612 PMID:11493558^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1929432	P	From MGI
	GO:0007507	heart development	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q12946	P	From MGI
	GO:0008134	transcription factor binding	MGI:MGI:4459044		PANTHER:PTHR11829	F	From MGI
	GO:0008301	DNA binding, bending	MGI:MGI:4459044		PANTHER:PTHR11829	F	From MGI
	GO:0009887	organ morphogenesis	MGI:MGI:2177851 PMID:11809759^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2179135	P	From MGI
	GO:0010811	positive regulation of cell-substrate adhesion	MGI:MGI:3709924 PMID:17261592^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2179135	P	From MGI
	GO:0014822	detection of wounding	MGI:MGI:3522465 PMID:12500195^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2179135	P	From MGI
	GO:0016337	cell-cell adhesion	MGI:MGI:1928688 PMID:11124112^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1929432	P	From MGI
	GO:0030198	extracellular matrix organization	MGI:MGI:3617131 PMID:16439479^[10]	IGI: Inferred from Genetic Interaction	MGI:MGI:1347479	P	From MGI
	GO:0030324	lung development	MGI:MGI:2135612 PMID:11493558^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1929432	P	From MGI
	GO:0030324	lung development	MGI:MGI:2137114 PMID:11437453^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2179135	P	From MGI
	GO:0030324	lung development	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q12946	P	From MGI
	GO:0030335	positive regulation of cell migration	MGI:MGI:3709924 PMID:17261592^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2179135	P	From MGI
	GO:0031016	pancreas development	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q12946	P	From MGI
	GO:0043305	negative regulation of mast cell degranulation	MGI:MGI:4367570 PMID:18421012^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2179135	P	From MGI
	GO:0043565	sequence-specific DNA binding	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR001766 InterPro:IPR018122	F	From MGI
	GO:0044212	transcription regulatory region DNA binding	MGI:MGI:3709924 PMID:17261592^[7]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0044212	transcription regulatory region DNA binding	MGI:MGI:77349 PMID:7958446^[11]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0045198	establishment of epithelial cell apical/basal polarity	MGI:MGI:3617131 PMID:16439479^[10]	IGI: Inferred from Genetic Interaction	MGI:MGI:1347479	P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q12946	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:1195834 PMID:9486531^[12]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:3709924 PMID:17261592^[7]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:3709924 PMID:17261592^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2179135	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:77349 PMID:7958446^[11]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:78966 PMID:8626802^[13]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0048286	lung alveolus development	MGI:MGI:2135612 PMID:11493558^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1929432	P	From MGI
	GO:0048371	lateral mesodermal cell differentiation	MGI:MGI:1928688 PMID:11124112^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1929432	P	From MGI
	GO:0048557	embryonic digestive tract morphogenesis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q12946	P	From MGI
	GO:0048565	digestive tract development	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q12946	P	From MGI
	GO:0048566	embryonic digestive tract development	MGI:MGI:3617131 PMID:16439479^[10]	IGI: Inferred from Genetic Interaction	MGI:MGI:1347479	P	From MGI
	GO:0048613	embryonic ectodermal digestive tract morphogenesis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q12946	P	From MGI
	GO:0048617	embryonic foregut morphogenesis	MGI:MGI:2135612 PMID:11493558^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1929432	P	From MGI
	GO:0050728	negative regulation of inflammatory response	MGI:MGI:4367570 PMID:18421012^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2179135	P	From MGI
	GO:0051090	regulation of sequence-specific DNA binding transcription factor activity	MGI:MGI:4459044		PANTHER:PTHR11829	P	From MGI
	GO:0051145	smooth muscle cell differentiation	MGI:MGI:2135612 PMID:11493558^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1929432	P	From MGI
	GO:0051150	regulation of smooth muscle cell differentiation	MGI:MGI:3766861 PMID:17881493^[4]	IGI: Inferred from Genetic Interaction	MGI:MGI:88180	P	From MGI
	GO:0051150	regulation of smooth muscle cell differentiation	MGI:MGI:3766861 PMID:17881493^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1929432	P	From MGI
	GO:0060425	lung morphogenesis	MGI:MGI:2135612 PMID:11493558^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1929432	P	From MGI
	GO:0060426	lung vasculature development	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q12946	P	From MGI
	GO:0060438	trachea development	MGI:MGI:2135612 PMID:11493558^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1929432	P	From MGI
	GO:0060441	epithelial tube branching involved in lung morphogenesis	MGI:MGI:2135612 PMID:11493558^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1929432	P	From MGI
	GO:0060446	branching involved in open tracheal system development	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q12946	P	From MGI
	GO:0060461	right lung morphogenesis	MGI:MGI:2135612 PMID:11493558^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1929432	P	From MGI
	GO:0060463	lung lobe morphogenesis	MGI:MGI:2135612 PMID:11493558^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1929432	P	From MGI
	GO:0060841	venous blood vessel development	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q12946	P	From MGI
	GO:0061030	epithelial cell differentiation involved in mammary gland alveolus development	MGI:MGI:3640953 PMID:16691571^[14]	IGI: Inferred from Genetic Interaction	MGI:MGI:96432	P	From MGI
	GO:0071345	cellular response to cytokine stimulus	MGI:MGI:1195834 PMID:9486531^[12]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0071407	cellular response to organic cyclic compound	MGI:MGI:4367570 PMID:18421012^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2179135	P	From MGI
	GO:0072001	renal system development	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q12946	P	From MGI
	GO:0072189	ureter development	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q12946	P	From MGI
	GO:0090131	mesenchyme migration	MGI:MGI:3709924 PMID:17261592^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2179135	P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Mahlapuu M et al. (2001) The forkhead transcription factor Foxf1 is required for differentiation of extra-embryonic and lateral plate mesoderm. Development 128: 155-66 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Kalin TV et al. (2008) Pulmonary mastocytosis and enhanced lung inflammation in mice heterozygous null for the Foxf1 gene. Am J Respir Cell Mol Biol 39: 390-9 PubMed GONUTS page
↑ ^3.0 ^3.1 Kalinichenko VV et al. (2001) Defects in pulmonary vasculature and perinatal lung hemorrhage in mice heterozygous null for the Forkhead Box f1 transcription factor. Dev Biol 235: 489-506 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Astorga J & Carlsson P (2007) Hedgehog induction of murine vasculogenesis is mediated by Foxf1 and Bmp4. Development 134: 3753-61 PubMed GONUTS page
↑ ^5.00 ^5.01 ^5.02 ^5.03 ^5.04 ^5.05 ^5.06 ^5.07 ^5.08 ^5.09 ^5.10 ^5.11 ^5.12 Mahlapuu M et al. (2001) Haploinsufficiency of the forkhead gene Foxf1, a target for sonic hedgehog signaling, causes lung and foregut malformations. Development 128: 2397-406 PubMed GONUTS page
↑ Rojas A et al. (2005) Gata4 expression in lateral mesoderm is downstream of BMP4 and is activated directly by Forkhead and GATA transcription factors through a distal enhancer element. Development 132: 3405-17 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 Malin D et al. (2007) Forkhead box F1 is essential for migration of mesenchymal cells and directly induces integrin-beta3 expression. Mol Cell Biol 27: 2486-98 PubMed GONUTS page
↑ Kalinichenko VV et al. (2002) Haploinsufficiency of the mouse Forkhead Box f1 gene causes defects in gall bladder development. J Biol Chem 277: 12369-74 PubMed GONUTS page
↑ Kalinichenko VV et al. (2003) Foxf1 +/- mice exhibit defective stellate cell activation and abnormal liver regeneration following CCl4 injury. Hepatology 37: 107-17 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Ormestad M et al. (2006) Foxf1 and Foxf2 control murine gut development by limiting mesenchymal Wnt signaling and promoting extracellular matrix production. Development 133: 833-43 PubMed GONUTS page
↑ ^11.0 ^11.1 Clevidence DE et al. (1994) Members of the HNF-3/forkhead family of transcription factors exhibit distinct cellular expression patterns in lung and regulate the surfactant protein B promoter. Dev Biol 166: 195-209 PubMed GONUTS page
↑ ^12.0 ^12.1 Peterson RS et al. (1997) The winged helix transcriptional activator HFH-8 is expressed in the mesoderm of the primitive streak stage of mouse embryos and its cellular derivatives. Mech Dev 69: 53-69 PubMed GONUTS page
↑ Hellqvist M et al. (1996) Differential activation of lung-specific genes by two forkhead proteins, FREAC-1 and FREAC-2. J Biol Chem 271: 4482-90 PubMed GONUTS page
↑ Moreno-Barriuso N et al. (2006) Alterations in alveolar epithelium differentiation and vasculogenesis in lungs of LIF/IGF-I double deficient embryos. Dev Dyn 235: 2040-50 PubMed GONUTS page

[PMID:11124112-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Mahlapuu M et al. (2001) The forkhead transcription factor Foxf1 is required for differentiation of extra-embryonic and lateral plate mesoderm. Development 128: 155-66 PubMed GONUTS page

[PMID:18421012-1] 2.0 ^2.1 ^2.2 ^2.3 Kalin TV et al. (2008) Pulmonary mastocytosis and enhanced lung inflammation in mice heterozygous null for the Foxf1 gene. Am J Respir Cell Mol Biol 39: 390-9 PubMed GONUTS page

[PMID:11437453-2] 3.0 ^3.1 Kalinichenko VV et al. (2001) Defects in pulmonary vasculature and perinatal lung hemorrhage in mice heterozygous null for the Forkhead Box f1 transcription factor. Dev Biol 235: 489-506 PubMed GONUTS page

[PMID:17881493-3] 4.0 ^4.1 ^4.2 Astorga J & Carlsson P (2007) Hedgehog induction of murine vasculogenesis is mediated by Foxf1 and Bmp4. Development 134: 3753-61 PubMed GONUTS page

[PMID:11493558-4] 5.00 ^5.01 ^5.02 ^5.03 ^5.04 ^5.05 ^5.06 ^5.07 ^5.08 ^5.09 ^5.10 ^5.11 ^5.12 Mahlapuu M et al. (2001) Haploinsufficiency of the forkhead gene Foxf1, a target for sonic hedgehog signaling, causes lung and foregut malformations. Development 128: 2397-406 PubMed GONUTS page

[PMID:15987774-5] Rojas A et al. (2005) Gata4 expression in lateral mesoderm is downstream of BMP4 and is activated directly by Forkhead and GATA transcription factors through a distal enhancer element. Development 132: 3405-17 PubMed GONUTS page

[PMID:17261592-6] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 Malin D et al. (2007) Forkhead box F1 is essential for migration of mesenchymal cells and directly induces integrin-beta3 expression. Mol Cell Biol 27: 2486-98 PubMed GONUTS page

[PMID:11809759-7] Kalinichenko VV et al. (2002) Haploinsufficiency of the mouse Forkhead Box f1 gene causes defects in gall bladder development. J Biol Chem 277: 12369-74 PubMed GONUTS page

[PMID:12500195-8] Kalinichenko VV et al. (2003) Foxf1 +/- mice exhibit defective stellate cell activation and abnormal liver regeneration following CCl4 injury. Hepatology 37: 107-17 PubMed GONUTS page

[PMID:16439479-9] 10.0 ^10.1 ^10.2 Ormestad M et al. (2006) Foxf1 and Foxf2 control murine gut development by limiting mesenchymal Wnt signaling and promoting extracellular matrix production. Development 133: 833-43 PubMed GONUTS page

[PMID:7958446-10] 11.0 ^11.1 Clevidence DE et al. (1994) Members of the HNF-3/forkhead family of transcription factors exhibit distinct cellular expression patterns in lung and regulate the surfactant protein B promoter. Dev Biol 166: 195-209 PubMed GONUTS page

[PMID:9486531-11] 12.0 ^12.1 Peterson RS et al. (1997) The winged helix transcriptional activator HFH-8 is expressed in the mesoderm of the primitive streak stage of mouse embryos and its cellular derivatives. Mech Dev 69: 53-69 PubMed GONUTS page

[PMID:8626802-12] Hellqvist M et al. (1996) Differential activation of lung-specific genes by two forkhead proteins, FREAC-1 and FREAC-2. J Biol Chem 271: 4482-90 PubMed GONUTS page

[PMID:16691571-13] Moreno-Barriuso N et al. (2006) Alterations in alveolar epithelium differentiation and vasculogenesis in lungs of LIF/IGF-I double deficient embryos. Dev Dyn 235: 2040-50 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Foxf1a ( synonyms: Foxf1, Freac-1, FREAC1, HFH-8, Hfh8 )
Protein Name(s)	forkhead box F1a,
External Links
MGI	MGI:1347470

MGI:Foxf1a

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