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MGI:Fn1

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Contents

Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Fn1 ( synonyms: Fn, Fn-1 )
Protein Name(s) fibronectin 1,
External Links
MGI MGI:95566

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0002020

protease binding

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P04937

F

From MGI

GO:0005515

protein binding

MGI:MGI:3785344
PMID:18281502[1]

IPI: Inferred from Physical Interaction

UniProtKB:P55002

F

From MGI

GO:0005577

fibrinogen complex

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P02751

C

From MGI

GO:0005578

proteinaceous extracellular matrix

MGI:MGI:1101335
PMID:9421166[2]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005578

proteinaceous extracellular matrix

MGI:MGI:2384464
PMID:12153613[3]

TAS: Traceable Author Statement

C

From MGI

GO:0005578

proteinaceous extracellular matrix

MGI:MGI:3577694
PMID:15728191[4]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005604

basement membrane

MGI:MGI:2149189
PMID:11511678[5]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005604

basement membrane

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P04937

C

From MGI

GO:0005604

basement membrane

MGI:MGI:77581
PMID:8984825[6]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005615

extracellular space

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P02751

C

From MGI

GO:0005793

endoplasmic reticulum-Golgi intermediate compartment

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P02751

C

From MGI

GO:0006916

anti-apoptosis

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P04937

P

From MGI

GO:0007044

cell-substrate junction assembly

MGI:MGI:2667760
PMID:12867986[7]

IDA: Inferred from Direct Assay

P

From MGI

GO:0007155

cell adhesion

MGI:MGI:1195020
PMID:9441684[8]

IDA: Inferred from Direct Assay

P

From MGI

GO:0007155

cell adhesion

MGI:MGI:2180235
PMID:12021259[9]

IDA: Inferred from Direct Assay

P

From MGI

GO:0007160

cell-matrix adhesion

MGI:MGI:3577694
PMID:15728191[4]

IDA: Inferred from Direct Assay

P

From MGI

GO:0007160

cell-matrix adhesion

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P04937

P

From MGI

GO:0007161

calcium-independent cell-matrix adhesion

MGI:MGI:4397493
PMID:19651211[10]

IDA: Inferred from Direct Assay

P

From MGI

GO:0016324

apical plasma membrane

MGI:MGI:1355040
PMID:10742111[11]

IDA: Inferred from Direct Assay

C

From MGI

GO:0016504

peptidase activator activity

MGI:MGI:3607633
PMID:16061471[12]

IDA: Inferred from Direct Assay

F

From MGI

GO:0018149

peptide cross-linking

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P02751

P

From MGI

GO:0030198

extracellular matrix organization

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P04937

P

From MGI

GO:0031012

extracellular matrix

MGI:MGI:2149189
PMID:11511678[5]

IDA: Inferred from Direct Assay

C

From MGI

GO:0031012

extracellular matrix

MGI:MGI:3628676
PMID:15065125[13]

IDA: Inferred from Direct Assay

C

From MGI

GO:0031012

extracellular matrix

MGI:MGI:3806197
PMID:18559979[14]

IDA: Inferred from Direct Assay

C

From MGI

GO:0031012

extracellular matrix

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P02751

C

From MGI

GO:0031012

extracellular matrix

MGI:MGI:80427
PMID:2209468[15]

IDA: Inferred from Direct Assay

C

From MGI

GO:0034446

substrate adhesion-dependent cell spreading

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P02751

P

From MGI

GO:0042060

wound healing

MGI:MGI:2667261
PMID:12847088[16]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2655542

P

From MGI

GO:0045340

mercury ion binding

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P04937

F

From MGI


Notes

References

See Help:References for how to manage references in GONUTS.
  1. Werneck CC et al. (2008) Mice lacking the extracellular matrix protein MAGP1 display delayed thrombotic occlusion following vessel injury. Blood 111: 4137-44 PubMed GONUTS page
  2. Brown HC et al. (1997) Adhesion molecules involved in macrophage responses to Wallerian degeneration in the murine peripheral nervous system. Eur J Neurosci 9: 2057-63 PubMed GONUTS page
  3. Luan X & Diekwisch TG (2002) CP27 affects viability, proliferation, attachment and gene expression in embryonic fibroblasts. Cell Prolif 35: 207-19 PubMed GONUTS page
  4. 4.0 4.1 Pratt SJ et al. (2005) The LIM protein Ajuba influences p130Cas localization and Rac1 activity during cell migration. J Cell Biol 168: 813-24 PubMed GONUTS page
  5. 5.0 5.1 Lozanoff S et al. (2001) Immunohistochemical localization of Pax2 and associated proteins in the developing kidney of mice with renal hypoplasia. J Histochem Cytochem 49: 1081-97 PubMed GONUTS page
  6. Ohsaki Y et al. (1995) Localization of types I and III collagen and fibronectin in the developing mouse palatal shelves. Acta Anat (Basel) 153: 161-7 PubMed GONUTS page
  7. Jiang G et al. (2003) Two-piconewton slip bond between fibronectin and the cytoskeleton depends on talin. Nature 424: 334-7 PubMed GONUTS page
  8. Wong M et al. (1997) Cyr61, product of a growth factor-inducible immediate-early gene, regulates chondrogenesis in mouse limb bud mesenchymal cells. Dev Biol 192: 492-508 PubMed GONUTS page
  9. Sengbusch JK et al. (2002) Dual functions of [alpha]4[beta]1 integrin in epicardial development: initial migration and long-term attachment. J Cell Biol 157: 873-82 PubMed GONUTS page
  10. Gebauer JM et al. (2009) Mouse AMACO, a kidney and skin basement membrane associated molecule that mediates RGD-dependent cell attachment. Matrix Biol 28: 456-62 PubMed GONUTS page
  11. Littlewood Evans A & Müller U (2000) Stereocilia defects in the sensory hair cells of the inner ear in mice deficient in integrin alpha8beta1. Nat Genet 24: 424-8 PubMed GONUTS page
  12. Lee NV et al. (2005) Fibulin-1 acts as a cofactor for the matrix metalloprotease ADAMTS-1. J Biol Chem 280: 34796-804 PubMed GONUTS page
  13. Balmer CW & LaMantia AS (2004) Loss of Gli3 and Shh function disrupts olfactory axon trajectories. J Comp Neurol 472: 292-307 PubMed GONUTS page
  14. Trindade A et al. (2008) Overexpression of delta-like 4 induces arterialization and attenuates vessel formation in developing mouse embryos. Blood 112: 1720-9 PubMed GONUTS page
  15. Heine UI et al. (1990) Colocalization of TGF-beta 1 and collagen I and III, fibronectin and glycosaminoglycans during lung branching morphogenesis. Development 109: 29-36 PubMed GONUTS page
  16. Muro AF et al. (2003) Regulated splicing of the fibronectin EDA exon is essential for proper skin wound healing and normal lifespan. J Cell Biol 162: 149-60 PubMed GONUTS page
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