GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.
You can help reduce stress on the server by:
- not reloading pages frequently - this just adds
- opening links in new windows (so you can read the old page)
MGI:Fkbp1b
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Fkbp1b ( synonyms: 12.6kDa, calstabin2, FKBP12.6 ) | |
| Protein Name(s) | FK506 binding protein 1b, | |
| External Links | ||
| MGI | MGI:1336205 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000413 |
protein peptidyl-prolyl isomerization |
MGI:MGI:3620455 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0000413 |
protein peptidyl-prolyl isomerization |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0002027 |
regulation of heart rate |
MGI:MGI:3639647 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3623214 |
P |
From MGI |
||
| GO:0003755 |
peptidyl-prolyl cis-trans isomerase activity |
MGI:MGI:3620455 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003755 |
peptidyl-prolyl cis-trans isomerase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005102 |
receptor binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3028710 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3620455 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005528 |
FK506 binding |
MGI:MGI:3028710 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005528 |
FK506 binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005528 |
FK506 binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:3028710 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2182644 |
C |
From MGI |
||
| GO:0005622 |
intracellular |
MGI:MGI:3621834 |
IMP: Inferred from Mutant Phenotype |
C |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:3639647 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3623214 |
C |
From MGI |
||
| GO:0005623 |
cell |
MGI:MGI:3795616 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3796253 |
C |
From MGI |
||
| GO:0005737 |
cytoplasm |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0963 |
C |
From MGI |
||
| GO:0005792 |
microsome |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006457 |
protein folding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0697 |
P |
From MGI |
||
| GO:0006457 |
protein folding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0006939 |
smooth muscle contraction |
MGI:MGI:3028710 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2182644 |
P |
From MGI |
||
| GO:0007204 |
elevation of cytosolic calcium ion concentration |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0009749 |
response to glucose stimulus |
MGI:MGI:3795616 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3796253 |
P |
From MGI |
||
| GO:0010459 |
negative regulation of heart rate |
MGI:MGI:3621834 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0010881 |
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion |
MGI:MGI:3621834 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0014808 |
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum |
MGI:MGI:3028710 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2182644 |
P |
From MGI |
||
| GO:0014808 |
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum |
MGI:MGI:3639647 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3623214 |
P |
From MGI |
||
| GO:0016529 |
sarcoplasmic reticulum |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0703 |
C |
From MGI |
||
| GO:0016853 |
isomerase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0413 |
F |
From MGI |
||
| GO:0018208 |
peptidyl-proline modification |
MGI:MGI:4459044 |
PANTHER:PTHR10516 |
P |
From MGI |
|||
| GO:0019227 |
neuronal action potential propagation |
MGI:MGI:2681350 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2182644 |
P |
From MGI |
||
| GO:0030073 |
insulin secretion |
MGI:MGI:3795616 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3796253 |
P |
From MGI |
||
| GO:0030551 |
cyclic nucleotide binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0032513 |
negative regulation of protein phosphatase type 2B activity |
MGI:MGI:4459044 |
PANTHER:PTHR10516 |
P |
From MGI |
|||
| GO:0032513 |
negative regulation of protein phosphatase type 2B activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0033017 |
sarcoplasmic reticulum membrane |
MGI:MGI:3028710 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0033017 |
sarcoplasmic reticulum membrane |
MGI:MGI:3620455 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0034704 |
calcium channel complex |
MGI:MGI:4459044 |
PANTHER:PTHR10516 |
C |
From MGI |
|||
| GO:0034704 |
calcium channel complex |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0042098 |
T cell proliferation |
MGI:MGI:2681350 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2182644 |
P |
From MGI |
||
| GO:0051209 |
release of sequestered calcium ion into cytosol |
MGI:MGI:3615100 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2182644 |
P |
From MGI |
||
| GO:0051775 |
response to redox state |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0060314 |
regulation of ryanodine-sensitive calcium-release channel activity |
MGI:MGI:3621834 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0060314 |
regulation of ryanodine-sensitive calcium-release channel activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
|
NOT |
GO:0060314 |
regulation of ryanodine-sensitive calcium-release channel activity |
MGI:MGI:3836106 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Huang F et al. (2006) Analysis of calstabin2 (FKBP12.6)-ryanodine receptor interactions: rescue of heart failure by calstabin2 in mice. Proc Natl Acad Sci U S A 103: 3456-61 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Lehnart SE et al. (2006) Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias. Proc Natl Acad Sci U S A 103: 7906-10 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 Wang YX et al. (2004) FKBP12.6 and cADPR regulation of Ca2+ release in smooth muscle cells. Am J Physiol Cell Physiol 286: C538-46 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Wehrens XH et al. (2003) FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death. Cell 113: 829-40 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Noguchi N et al. (2008) FKBP12.6 disruption impairs glucose-induced insulin secretion. Biochem Biophys Res Commun 371: 735-40 PubMed GONUTS page
- ↑ 6.0 6.1 Dubois S et al. (2003) Distinct pathways involving the FK506-binding proteins 12 and 12.6 underlie IL-2-versus IL-15-mediated proliferation of T cells. Proc Natl Acad Sci U S A 100: 14169-74 PubMed GONUTS page
- ↑ Ji G et al. (2004) RYR2 proteins contribute to the formation of Ca(2+) sparks in smooth muscle. J Gen Physiol 123: 377-86 PubMed GONUTS page
- ↑ Xiao J et al. (2007) Removal of FKBP12.6 does not alter the conductance and activation of the cardiac ryanodine receptor or the susceptibility to stress-induced ventricular arrhythmias. J Biol Chem 282: 34828-38 PubMed GONUTS page
