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MGI:Fh1

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Contents

Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Fh1 ( synonyms: fumarase )
Protein Name(s) fumarate hydratase 1,
External Links
MGI MGI:95530

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0003824

catalytic activity

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR020557
InterPro:IPR008948

F

From MGI

GO:0004333

fumarate hydratase activity

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P14408

F

From MGI

GO:0005737

cytoplasm

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0963

C

From MGI

GO:0005739

mitochondrion

MGI:MGI:2682130
PMID:14651853[1]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005739

mitochondrion

MGI:MGI:3852644
PMID:18614015[2]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005739

mitochondrion

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P14408

C

From MGI

GO:0006099

tricarboxylic acid cycle

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P14408

P

From MGI

GO:0006106

fumarate metabolic process

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P14408

P

From MGI

GO:0006108

malate metabolic process

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P14408

P

From MGI

GO:0016829

lyase activity

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0456

F

From MGI

GO:0016829

lyase activity

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR018951

F

From MGI

GO:0045239

tricarboxylic acid cycle enzyme complex

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR005677

C

From MGI

GO:0048873

homeostasis of number of cells within a tissue

MGI:MGI:3708434
PMID:17418408[3]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3710112
MGI:MGI:2665300

P

From MGI


Notes

References

See Help:References for how to manage references in GONUTS.
  1. Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115: 629-40 PubMed GONUTS page
  2. Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134: 112-23 PubMed GONUTS page
  3. Pollard PJ et al. (2007) Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway. Cancer Cell 11: 311-9 PubMed GONUTS page
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