MGI:Fgf9

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0001525	angiogenesis	MGI:MGI:3629544 PMID:16778080^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0001525	angiogenesis	MGI:MGI:3629544 PMID:16778080^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2135961	P	From MGI
	GO:0001525	angiogenesis	MGI:MGI:3716021 PMID:17544391^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2135961	P	From MGI
	GO:0001649	osteoblast differentiation	MGI:MGI:3716021 PMID:17544391^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2135961	P	From MGI
	GO:0002053	positive regulation of mesenchymal cell proliferation	MGI:MGI:3611702 PMID:16308329^[3]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0002053	positive regulation of mesenchymal cell proliferation	MGI:MGI:3611702 PMID:16308329^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2135961	P	From MGI
	GO:0002053	positive regulation of mesenchymal cell proliferation	MGI:MGI:3621094 PMID:16540513^[4]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0002053	positive regulation of mesenchymal cell proliferation	MGI:MGI:3773938 PMID:18231602^[5]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0002053	positive regulation of mesenchymal cell proliferation	MGI:MGI:3801531 PMID:18533146^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2135961	P	From MGI
	GO:0002062	chondrocyte differentiation	MGI:MGI:3716021 PMID:17544391^[2]	IGI: Inferred from Genetic Interaction	MGI:MGI:95522	P	From MGI
	GO:0002062	chondrocyte differentiation	MGI:MGI:3716021 PMID:17544391^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2135961	P	From MGI
	GO:0003214	cardiac left ventricle morphogenesis	MGI:MGI:4943617 PMID:20299672^[7]	TAS: Traceable Author Statement		P	From MGI
	GO:0003231	cardiac ventricle development	MGI:MGI:4943617 PMID:20299672^[7]	TAS: Traceable Author Statement		P	From MGI
	GO:0005104	fibroblast growth factor receptor binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P36364	F	From MGI
	GO:0005576	extracellular region	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0964	C	From MGI
	GO:0005604	basement membrane	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P36364	C	From MGI
	GO:0005615	extracellular space	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:P31371	C	From MGI
	GO:0005622	intracellular	MGI:MGI:3051710 PMID:15229180^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2135961	C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P36364	C	From MGI
	GO:0006606	protein import into nucleus	MGI:MGI:3051710 PMID:15229180^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2135961	P	From MGI
	GO:0007267	cell-cell signaling	MGI:MGI:3056034 PMID:15328018^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2135961	P	From MGI
	GO:0007275	multicellular organismal development	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0217	P	From MGI
	GO:0008083	growth factor activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P36364	F	From MGI
	GO:0008201	heparin binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0358	F	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:P31371	P	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:3051710 PMID:15229180^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2135961	P	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:3609509 PMID:16185683^[10]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:3629544 PMID:16778080^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2135961	P	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P36364	P	From MGI
	GO:0008543	fibroblast growth factor receptor signaling pathway	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:P31371	P	From MGI
	GO:0008543	fibroblast growth factor receptor signaling pathway	MGI:MGI:3051710 PMID:15229180^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2135961	P	From MGI
	GO:0008543	fibroblast growth factor receptor signaling pathway	MGI:MGI:3527351 PMID:15621532^[11]	IGI: Inferred from Genetic Interaction	MGI:MGI:95523 MGI:MGI:95522	P	From MGI
	GO:0008543	fibroblast growth factor receptor signaling pathway	MGI:MGI:3611702 PMID:16308329^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2135961	P	From MGI
	GO:0008543	fibroblast growth factor receptor signaling pathway	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P36364	P	From MGI
	GO:0008584	male gonad development	MGI:MGI:3051710 PMID:15229180^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2135961	P	From MGI
	GO:0008584	male gonad development	MGI:MGI:3621114 PMID:16540514^[12]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2135961	P	From MGI
	GO:0010628	positive regulation of gene expression	MGI:MGI:1314703 PMID:9847236^[13]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0030154	cell differentiation	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0221	P	From MGI
	GO:0030178	negative regulation of Wnt receptor signaling pathway	MGI:MGI:3639791 PMID:16700629^[14]	IGI: Inferred from Genetic Interaction	MGI:MGI:98957	P	From MGI
	GO:0030238	male sex determination	MGI:MGI:3639791 PMID:16700629^[14]	IGI: Inferred from Genetic Interaction	MGI:MGI:98660 MGI:MGI:98371 MGI:MGI:98957	P	From MGI
	GO:0030238	male sex determination	MGI:MGI:3639791 PMID:16700629^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2135961	P	From MGI
	GO:0030324	lung development	MGI:MGI:2135653 PMID:11493531^[15]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2135961	P	From MGI
	GO:0030324	lung development	MGI:MGI:3621094 PMID:16540513^[4]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0030326	embryonic limb morphogenesis	MGI:MGI:3714711 PMID:17576930^[16]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2135961	P	From MGI
	GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway	MGI:MGI:3716021 PMID:17544391^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2135961	P	From MGI
	GO:0042472	inner ear morphogenesis	MGI:MGI:3056034 PMID:15328018^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2135961	P	From MGI
	GO:0043410	positive regulation of MAPK cascade	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:P36364	P	From MGI
	GO:0045880	positive regulation of smoothened signaling pathway	MGI:MGI:3621094 PMID:16540513^[4]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045880	positive regulation of smoothened signaling pathway	MGI:MGI:3629544 PMID:16778080^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2135961	P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:4943617 PMID:20299672^[7]	TAS: Traceable Author Statement		P	From MGI
	GO:0048505	regulation of timing of cell differentiation	MGI:MGI:3716021 PMID:17544391^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2135961	P	From MGI
	GO:0048566	embryonic digestive tract development	MGI:MGI:3611702 PMID:16308329^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2135961	P	From MGI
	GO:0048706	embryonic skeletal system development	MGI:MGI:3716021 PMID:17544391^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2135961	P	From MGI
	GO:0050679	positive regulation of epithelial cell proliferation	MGI:MGI:3611702 PMID:16308329^[3]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0050679	positive regulation of epithelial cell proliferation	MGI:MGI:3611702 PMID:16308329^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2135961	P	From MGI
	GO:0050679	positive regulation of epithelial cell proliferation	MGI:MGI:3621094 PMID:16540513^[4]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0051781	positive regulation of cell division	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0497	P	From MGI
	GO:0060045	positive regulation of cardiac muscle cell proliferation	MGI:MGI:3527351 PMID:15621532^[11]	IGI: Inferred from Genetic Interaction	MGI:MGI:95522 MGI:MGI:95523	P	From MGI
	GO:0060045	positive regulation of cardiac muscle cell proliferation	MGI:MGI:3527351 PMID:15621532^[11]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0060045	positive regulation of cardiac muscle cell proliferation	MGI:MGI:4943617 PMID:20299672^[7]	TAS: Traceable Author Statement		P	From MGI
	GO:0060484	lung-associated mesenchyme development	MGI:MGI:3801531 PMID:18533146^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2135961	P	From MGI
	GO:0060979	vasculogenesis involved in coronary vascular morphogenesis	MGI:MGI:4943617 PMID:20299672^[7]	TAS: Traceable Author Statement		P	From MGI
	GO:0090263	positive regulation of canonical Wnt receptor signaling pathway	MGI:MGI:3801531 PMID:18533146^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2135961	P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Lavine KJ et al. (2006) Fibroblast growth factor signals regulate a wave of Hedgehog activation that is essential for coronary vascular development. Genes Dev 20: 1651-66 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Hung IH et al. (2007) FGF9 regulates early hypertrophic chondrocyte differentiation and skeletal vascularization in the developing stylopod. Dev Biol 307: 300-13 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Zhang X et al. (2006) Reciprocal epithelial-mesenchymal FGF signaling is required for cecal development. Development 133: 173-80 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 White AC et al. (2006) FGF9 and SHH signaling coordinate lung growth and development through regulation of distinct mesenchymal domains. Development 133: 1507-17 PubMed GONUTS page
↑ De Langhe SP et al. (2008) Formation and differentiation of multiple mesenchymal lineages during lung development is regulated by beta-catenin signaling. PLoS One 3: e1516 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Yin Y et al. (2008) An FGF-WNT gene regulatory network controls lung mesenchyme development. Dev Biol 319: 426-36 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Olivey HE & Svensson EC (2010) Epicardial-myocardial signaling directing coronary vasculogenesis. Circ Res 106: 818-32 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 Schmahl J et al. (2004) Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination. Development 131: 3627-36 PubMed GONUTS page
↑ ^9.0 ^9.1 Pirvola U et al. (2004) Fgf9 signaling regulates inner ear morphogenesis through epithelial-mesenchymal interactions. Dev Biol 273: 350-60 PubMed GONUTS page
↑ Wilhelm D et al. (2005) Sertoli cell differentiation is induced both cell-autonomously and through prostaglandin signaling during mammalian sex determination. Dev Biol 287: 111-24 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Lavine KJ et al. (2005) Endocardial and epicardial derived FGF signals regulate myocardial proliferation and differentiation in vivo. Dev Cell 8: 85-95 PubMed GONUTS page
↑ DiNapoli L et al. (2006) FGF9 promotes survival of germ cells in the fetal testis. Development 133: 1519-27 PubMed GONUTS page
↑ Tucker AS et al. (1999) Conserved regulation of mesenchymal gene expression by Fgf-8 in face and limb development. Development 126: 221-8 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Kim Y et al. (2006) Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination. PLoS Biol 4: e187 PubMed GONUTS page
↑ Colvin JS et al. (2001) Lung hypoplasia and neonatal death in Fgf9-null mice identify this gene as an essential regulator of lung mesenchyme. Development 128: 2095-106 PubMed GONUTS page
↑ Ha L et al. (2007) ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence. Proc Natl Acad Sci U S A 104: 10968-73 PubMed GONUTS page

[PMID:16778080-0] 1.0 ^1.1 ^1.2 ^1.3 Lavine KJ et al. (2006) Fibroblast growth factor signals regulate a wave of Hedgehog activation that is essential for coronary vascular development. Genes Dev 20: 1651-66 PubMed GONUTS page

[PMID:17544391-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Hung IH et al. (2007) FGF9 regulates early hypertrophic chondrocyte differentiation and skeletal vascularization in the developing stylopod. Dev Biol 307: 300-13 PubMed GONUTS page

[PMID:16308329-2] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Zhang X et al. (2006) Reciprocal epithelial-mesenchymal FGF signaling is required for cecal development. Development 133: 173-80 PubMed GONUTS page

[PMID:16540513-3] 4.0 ^4.1 ^4.2 ^4.3 White AC et al. (2006) FGF9 and SHH signaling coordinate lung growth and development through regulation of distinct mesenchymal domains. Development 133: 1507-17 PubMed GONUTS page

[PMID:18231602-4] De Langhe SP et al. (2008) Formation and differentiation of multiple mesenchymal lineages during lung development is regulated by beta-catenin signaling. PLoS One 3: e1516 PubMed GONUTS page

[PMID:18533146-5] 6.0 ^6.1 ^6.2 Yin Y et al. (2008) An FGF-WNT gene regulatory network controls lung mesenchyme development. Dev Biol 319: 426-36 PubMed GONUTS page

[PMID:20299672-6] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Olivey HE & Svensson EC (2010) Epicardial-myocardial signaling directing coronary vasculogenesis. Circ Res 106: 818-32 PubMed GONUTS page

[PMID:15229180-7] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 Schmahl J et al. (2004) Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination. Development 131: 3627-36 PubMed GONUTS page

[PMID:15328018-8] 9.0 ^9.1 Pirvola U et al. (2004) Fgf9 signaling regulates inner ear morphogenesis through epithelial-mesenchymal interactions. Dev Biol 273: 350-60 PubMed GONUTS page

[PMID:16185683-9] Wilhelm D et al. (2005) Sertoli cell differentiation is induced both cell-autonomously and through prostaglandin signaling during mammalian sex determination. Dev Biol 287: 111-24 PubMed GONUTS page

[PMID:15621532-10] 11.0 ^11.1 ^11.2 Lavine KJ et al. (2005) Endocardial and epicardial derived FGF signals regulate myocardial proliferation and differentiation in vivo. Dev Cell 8: 85-95 PubMed GONUTS page

[PMID:16540514-11] DiNapoli L et al. (2006) FGF9 promotes survival of germ cells in the fetal testis. Development 133: 1519-27 PubMed GONUTS page

[PMID:9847236-12] Tucker AS et al. (1999) Conserved regulation of mesenchymal gene expression by Fgf-8 in face and limb development. Development 126: 221-8 PubMed GONUTS page

[PMID:16700629-13] 14.0 ^14.1 ^14.2 Kim Y et al. (2006) Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination. PLoS Biol 4: e187 PubMed GONUTS page

[PMID:11493531-14] Colvin JS et al. (2001) Lung hypoplasia and neonatal death in Fgf9-null mice identify this gene as an essential regulator of lung mesenchyme. Development 128: 2095-106 PubMed GONUTS page

[PMID:17576930-15] Ha L et al. (2007) ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence. Proc Natl Acad Sci U S A 104: 10968-73 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Fgf9 ( synonyms: Eks, glia activating factor )
Protein Name(s)	fibroblast growth factor 9,
External Links
MGI	MGI:104723

MGI:Fgf9

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