MGI:Fgf2

From GONUTS

Jump to: navigation, search

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000186	activation of MAPKK activity	MGI:MGI:3614383 PMID:16339969^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0000189	MAPK import into nucleus	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P13109	P	From MGI
	GO:0001525	angiogenesis	MGI:MGI:3027337 PMID:14702107^[2]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0001525	angiogenesis	MGI:MGI:3032824 PMID:14998491^[3]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0001525	angiogenesis	MGI:MGI:3701403 PMID:17187775^[4]	IGI: Inferred from Genetic Interaction	MGI:MGI:98297	P	From MGI
	GO:0001658	branching involved in ureteric bud morphogenesis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P09038	P	From MGI
	GO:0001759	organ induction	MGI:MGI:3511765 PMID:15576401^[5]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0001934	positive regulation of protein phosphorylation	MGI:MGI:3528547 PMID:15608665^[6]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0001938	positive regulation of endothelial cell proliferation	MGI:MGI:3654815 PMID:16291864^[7]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0001938	positive regulation of endothelial cell proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P09038	P	From MGI
	GO:0002042	cell migration involved in sprouting angiogenesis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P09038	P	From MGI
	GO:0005104	fibroblast growth factor receptor binding	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:P09038	F	From MGI
	GO:0005104	fibroblast growth factor receptor binding	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:P13109	F	From MGI
	GO:0005104	fibroblast growth factor receptor binding	MGI:MGI:79015 PMID:2161540^[8]	IPI: Inferred from Physical Interaction	UniProtKB:P16092	F	From MGI
	GO:0005125	cytokine activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P09038	F	From MGI
	GO:0005245	voltage-gated calcium channel activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P13109	F	From MGI
	GO:0005515	protein binding	MGI:MGI:2673744 PMID:12813049^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q91V87	F	From MGI
	GO:0005576	extracellular region	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0964	C	From MGI
	GO:0005615	extracellular space	MGI:MGI:2429373 PMID:12417662^[10]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:3511765 PMID:15576401^[5]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P13109	C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P13109	C	From MGI
	GO:0006355	regulation of transcription, DNA-dependent	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P13109	P	From MGI
	GO:0006661	phosphatidylinositol biosynthetic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P09038	P	From MGI
	GO:0006700	C21-steroid hormone biosynthetic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P13109	P	From MGI
	GO:0006915	apoptotic process	MGI:MGI:68149 PMID:8050499^[11]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0007165	signal transduction	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P13109	P	From MGI
	GO:0007243	intracellular protein kinase cascade	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P13109	P	From MGI
	GO:0007268	synaptic transmission	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P13109	P	From MGI
	GO:0007275	multicellular organismal development	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0217	P	From MGI
	GO:0008083	growth factor activity	MGI:MGI:3528547 PMID:15608665^[6]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0008083	growth factor activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P09038	F	From MGI
	GO:0008201	heparin binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0358	F	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:1202291 PMID:9463347^[12]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:P09038	P	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:3039221 PMID:15051883^[13]	IGI: Inferred from Genetic Interaction	MGI:MGI:95290	P	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:3521553 PMID:15509736^[14]	IGI: Inferred from Genetic Interaction	MGI:MGI:97363 MGI:MGI:96522	P	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:3604918 PMID:16141225^[15]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P13109	P	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:78517 PMID:7494107^[16]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0008285	negative regulation of cell proliferation	MGI:MGI:1329746 PMID:10027293^[17]	IGI: Inferred from Genetic Interaction	MGI:MGI:98297	P	From MGI
	GO:0008285	negative regulation of cell proliferation	MGI:MGI:4821204 PMID:20570969^[18]	IGI: Inferred from Genetic Interaction	MGI:MGI:95729	P	From MGI
	GO:0008543	fibroblast growth factor receptor signaling pathway	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:P09038	P	From MGI
	GO:0008543	fibroblast growth factor receptor signaling pathway	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:P09038	P	From MGI
	GO:0008543	fibroblast growth factor receptor signaling pathway	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:P13109	P	From MGI
	GO:0008543	fibroblast growth factor receptor signaling pathway	MGI:MGI:78517 PMID:7494107^[16]	IGI: Inferred from Genetic Interaction	MGI:MGI:95522	P	From MGI
	GO:0009790	embryo development	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P13109	P	From MGI
	GO:0010001	glial cell differentiation	MGI:MGI:2669074 PMID:12878680^[19]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2384003	P	From MGI
	GO:0010595	positive regulation of endothelial cell migration	MGI:MGI:3654815 PMID:16291864^[7]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0010628	positive regulation of gene expression	MGI:MGI:894889 PMID:9244299^[20]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0010764	negative regulation of fibroblast migration	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P09038	P	From MGI
	GO:0010863	positive regulation of phospholipase C activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P09038	P	From MGI
	GO:0017134	fibroblast growth factor binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P13109	F	From MGI
	GO:0017158	regulation of calcium ion-dependent exocytosis	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P13109	P	From MGI
	GO:0021762	substantia nigra development	MGI:MGI:3696489 PMID:17234579^[21]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857458	P	From MGI
	GO:0021940	positive regulation of cerebellar granule cell precursor proliferation	MGI:MGI:1329746 PMID:10027293^[17]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0030154	cell differentiation	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0221	P	From MGI
	GO:0030214	hyaluronan catabolic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P09038	P	From MGI
	GO:0030308	negative regulation of cell growth	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P13109	P	From MGI
	GO:0030324	lung development	MGI:MGI:3511765 PMID:15576401^[5]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0030324	lung development	MGI:MGI:3701403 PMID:17187775^[4]	IGI: Inferred from Genetic Interaction	MGI:MGI:98297	P	From MGI
	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P09038	F	From MGI
	GO:0032958	inositol phosphate biosynthetic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P09038	P	From MGI
	GO:0042056	chemoattractant activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P09038	F	From MGI
	GO:0042660	positive regulation of cell fate specification	MGI:MGI:3807614 PMID:18635606^[22]	ISO: Inferred from Sequence Orthology	UniProtKB:P09038	P	From MGI
	GO:0043536	positive regulation of blood vessel endothelial cell migration	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P09038	P	From MGI
	GO:0043537	negative regulation of blood vessel endothelial cell migration	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P09038	P	From MGI
	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P09038	P	From MGI
	GO:0045597	positive regulation of cell differentiation	MGI:MGI:2429373 PMID:12417662^[10]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045597	positive regulation of cell differentiation	MGI:MGI:3584218 PMID:15781473^[23]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045669	positive regulation of osteoblast differentiation	MGI:MGI:4821204 PMID:20570969^[18]	IGI: Inferred from Genetic Interaction	MGI:MGI:95729	P	From MGI
	GO:0045766	positive regulation of angiogenesis	MGI:MGI:3629251 PMID:16648142^[24]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045766	positive regulation of angiogenesis	MGI:MGI:3629251 PMID:16648142^[24]	IGI: Inferred from Genetic Interaction	MGI:MGI:97306	P	From MGI
	GO:0045766	positive regulation of angiogenesis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P09038	P	From MGI
	GO:0045892	negative regulation of transcription, DNA-dependent	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P13109	P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P13109	P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P09038	P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:4943617 PMID:20299672^[25]	TAS: Traceable Author Statement		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:1340783 PMID:10391928^[26]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P09038	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:83672 PMID:8898217^[27]	IGI: Inferred from Genetic Interaction	MGI:MGI:97168	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:86732 PMID:9102311^[28]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0046668	regulation of retinal cell programmed cell death	MGI:MGI:2155023 PMID:11747369^[29]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0048678	response to axon injury	MGI:MGI:3611962 PMID:16009496^[30]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857458	P	From MGI
	GO:0048864	stem cell development	MGI:MGI:2667422 PMID:12843296^[31]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0050679	positive regulation of epithelial cell proliferation	MGI:MGI:3701403 PMID:17187775^[4]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0050918	positive chemotaxis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P09038	P	From MGI
	GO:0051209	release of sequestered calcium ion into cytosol	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P09038	P	From MGI
	GO:0051726	regulation of cell cycle	MGI:MGI:1202291 PMID:9463347^[12]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0051781	positive regulation of cell division	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0497	P	From MGI
	GO:0051925	regulation of calcium ion transport via voltage-gated calcium channel activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P13109	P	From MGI
	GO:0060038	cardiac muscle cell proliferation	MGI:MGI:4943617 PMID:20299672^[25]	TAS: Traceable Author Statement		P	From MGI
	GO:0060045	positive regulation of cardiac muscle cell proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P09038	P	From MGI
	GO:0060128	corticotropin hormone secreting cell differentiation	MGI:MGI:1202291 PMID:9463347^[12]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0060129	thyroid-stimulating hormone-secreting cell differentiation	MGI:MGI:1202291 PMID:9463347^[12]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0060548	negative regulation of cell death	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P09038	P	From MGI
	GO:0060591	chondroblast differentiation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P09038	P	From MGI
	GO:0060644	mammary gland epithelial cell differentiation	MGI:MGI:49188 PMID:1376141^[32]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0061045	negative regulation of wound healing	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P09038	P	From MGI
	GO:0070374	positive regulation of ERK1 and ERK2 cascade	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P09038	P	From MGI
	GO:0070588	calcium ion transmembrane transport	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P13109	P	From MGI
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Ozaki K et al. (2005) Efficient suppression of FGF-2-induced ERK activation by the cooperative interaction among mammalian Sprouty isoforms. J Cell Sci 118: 5861-71 PubMed GONUTS page
↑ Ling Q et al. (2004) Annexin II regulates fibrin homeostasis and neoangiogenesis in vivo. J Clin Invest 113: 38-48 PubMed GONUTS page
↑ Marchiò S et al. (2004) Aminopeptidase A is a functional target in angiogenic blood vessels. Cancer Cell 5: 151-62 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 van Tuyl M et al. (2007) Angiogenic factors stimulate tubular branching morphogenesis of sonic hedgehog-deficient lungs. Dev Biol 303: 514-26 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Serls AE et al. (2005) Different thresholds of fibroblast growth factors pattern the ventral foregut into liver and lung. Development 132: 35-47 PubMed GONUTS page
↑ ^6.0 ^6.1 Dell'Era P et al. (2005) FGF2-induced upregulation of DNA polymerase-delta p12 subunit in endothelial cells. Oncogene 24: 1117-21 PubMed GONUTS page
↑ ^7.0 ^7.1 Shin JW et al. (2006) Prox1 promotes lineage-specific expression of fibroblast growth factor (FGF) receptor-3 in lymphatic endothelium: a role for FGF signaling in lymphangiogenesis. Mol Biol Cell 17: 576-84 PubMed GONUTS page
↑ Mansukhani A et al. (1990) A murine fibroblast growth factor (FGF) receptor expressed in CHO cells is activated by basic FGF and Kaposi FGF. Proc Natl Acad Sci U S A 87: 4378-82 PubMed GONUTS page
↑ Trueb B et al. (2003) Characterization of FGFRL1, a novel fibroblast growth factor (FGF) receptor preferentially expressed in skeletal tissues. J Biol Chem 278: 33857-65 PubMed GONUTS page
↑ ^10.0 ^10.1 Mueller KL et al. (2002) Fibroblast growth factor signaling regulates pillar cell development in the organ of corti. J Neurosci 22: 9368-77 PubMed GONUTS page
↑ Kondo S et al. (1994) bcl-2 gene prevents apoptosis of basic fibroblast growth factor-deprived murine aortic endothelial cells. Exp Cell Res 213: 428-32 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Ericson J et al. (1998) Integrated FGF and BMP signaling controls the progression of progenitor cell differentiation and the emergence of pattern in the embryonic anterior pituitary. Development 125: 1005-15 PubMed GONUTS page
↑ Derouet D et al. (2004) Neuropoietin, a new IL-6-related cytokine signaling through the ciliary neurotrophic factor receptor. Proc Natl Acad Sci U S A 101: 4827-32 PubMed GONUTS page
↑ Yoon K et al. (2004) Fibroblast growth factor receptor signaling promotes radial glial identity and interacts with Notch1 signaling in telencephalic progenitors. J Neurosci 24: 9497-506 PubMed GONUTS page
↑ Yu L et al. (2005) Shox2-deficient mice exhibit a rare type of incomplete clefting of the secondary palate. Development 132: 4397-406 PubMed GONUTS page
↑ ^16.0 ^16.1 Huang MT (1995) T cell development in CD3-zeta mutant mice. Int Rev Immunol 13: 29-41 PubMed GONUTS page
↑ ^17.0 ^17.1 Wechsler-Reya RJ & Scott MP (1999) Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog. Neuron 22: 103-14 PubMed GONUTS page
↑ ^18.0 ^18.1 Rice DP et al. (2010) Gli3Xt-J/Xt-J mice exhibit lambdoid suture craniosynostosis which results from altered osteoprogenitor proliferation and differentiation. Hum Mol Genet 19: 3457-67 PubMed GONUTS page
↑ Reuss B et al. (2003) Functions of fibroblast growth factor (FGF)-2 and FGF-5 in astroglial differentiation and blood-brain barrier permeability: evidence from mouse mutants. J Neurosci 23: 6404-12 PubMed GONUTS page
↑ Neubüser A et al. (1997) Antagonistic interactions between FGF and BMP signaling pathways: a mechanism for positioning the sites of tooth formation. Cell 90: 247-55 PubMed GONUTS page
↑ Timmer M et al. (2007) Fibroblast growth factor (FGF)-2 and FGF receptor 3 are required for the development of the substantia nigra, and FGF-2 plays a crucial role for the rescue of dopaminergic neurons after 6-hydroxydopamine lesion. J Neurosci 27: 459-71 PubMed GONUTS page
↑ Lokmane L et al. (2008) Crucial role of vHNF1 in vertebrate hepatic specification. Development 135: 2777-86 PubMed GONUTS page
↑ Davidson D et al. (2005) Fibroblast growth factor (FGF) 18 signals through FGF receptor 3 to promote chondrogenesis. J Biol Chem 280: 20509-15 PubMed GONUTS page
↑ ^24.0 ^24.1 Munchhof AM et al. (2006) Neurofibroma-associated growth factors activate a distinct signaling network to alter the function of neurofibromin-deficient endothelial cells. Hum Mol Genet 15: 1858-69 PubMed GONUTS page
↑ ^25.0 ^25.1 Olivey HE & Svensson EC (2010) Epicardial-myocardial signaling directing coronary vasculogenesis. Circ Res 106: 818-32 PubMed GONUTS page
↑ Hollnagel A et al. (1999) Id genes are direct targets of bone morphogenetic protein induction in embryonic stem cells. J Biol Chem 274: 19838-45 PubMed GONUTS page
↑ Chen Y et al. (1996) Msx1 controls inductive signaling in mammalian tooth morphogenesis. Development 122: 3035-44 PubMed GONUTS page
↑ Küry P et al. (1997) Protease nexin-1 is expressed at the mouse met-/mesencephalic junction and FGF signaling regulates its promoter activity in primary met-/mesencephalic cells. Development 124: 1251-62 PubMed GONUTS page
↑ Wahlin KJ et al. (2001) Neurotrophic signaling in normal and degenerating rodent retinas. Exp Eye Res 73: 693-701 PubMed GONUTS page
↑ Jungnickel J et al. (2005) Regulation of neuronal death and calcitonin gene-related peptide by fibroblast growth factor-2 and FGFR3 after peripheral nerve injury: evidence from mouse mutants. Neuroscience 134: 1343-50 PubMed GONUTS page
↑ Viti J et al. (2003) Wnt regulation of progenitor maturation in the cortex depends on Shh or fibroblast growth factor 2. J Neurosci 23: 5919-27 PubMed GONUTS page
↑ Venesio T et al. (1992) The int-2 gene product acts as a growth factor and substitutes for basic fibroblast growth factor in promoting the differentiation of a normal mouse mammary epithelial cell line. Cell Growth Differ 3: 63-71 PubMed GONUTS page

[PMID:16339969-0] Ozaki K et al. (2005) Efficient suppression of FGF-2-induced ERK activation by the cooperative interaction among mammalian Sprouty isoforms. J Cell Sci 118: 5861-71 PubMed GONUTS page

[PMID:14702107-1] Ling Q et al. (2004) Annexin II regulates fibrin homeostasis and neoangiogenesis in vivo. J Clin Invest 113: 38-48 PubMed GONUTS page

[PMID:14998491-2] Marchiò S et al. (2004) Aminopeptidase A is a functional target in angiogenic blood vessels. Cancer Cell 5: 151-62 PubMed GONUTS page

[PMID:17187775-3] 4.0 ^4.1 ^4.2 van Tuyl M et al. (2007) Angiogenic factors stimulate tubular branching morphogenesis of sonic hedgehog-deficient lungs. Dev Biol 303: 514-26 PubMed GONUTS page

[PMID:15576401-4] 5.0 ^5.1 ^5.2 Serls AE et al. (2005) Different thresholds of fibroblast growth factors pattern the ventral foregut into liver and lung. Development 132: 35-47 PubMed GONUTS page

[PMID:15608665-5] 6.0 ^6.1 Dell'Era P et al. (2005) FGF2-induced upregulation of DNA polymerase-delta p12 subunit in endothelial cells. Oncogene 24: 1117-21 PubMed GONUTS page

[PMID:16291864-6] 7.0 ^7.1 Shin JW et al. (2006) Prox1 promotes lineage-specific expression of fibroblast growth factor (FGF) receptor-3 in lymphatic endothelium: a role for FGF signaling in lymphangiogenesis. Mol Biol Cell 17: 576-84 PubMed GONUTS page

[PMID:2161540-7] Mansukhani A et al. (1990) A murine fibroblast growth factor (FGF) receptor expressed in CHO cells is activated by basic FGF and Kaposi FGF. Proc Natl Acad Sci U S A 87: 4378-82 PubMed GONUTS page

[PMID:12813049-8] Trueb B et al. (2003) Characterization of FGFRL1, a novel fibroblast growth factor (FGF) receptor preferentially expressed in skeletal tissues. J Biol Chem 278: 33857-65 PubMed GONUTS page

[PMID:12417662-9] 10.0 ^10.1 Mueller KL et al. (2002) Fibroblast growth factor signaling regulates pillar cell development in the organ of corti. J Neurosci 22: 9368-77 PubMed GONUTS page

[PMID:8050499-10] Kondo S et al. (1994) bcl-2 gene prevents apoptosis of basic fibroblast growth factor-deprived murine aortic endothelial cells. Exp Cell Res 213: 428-32 PubMed GONUTS page

[PMID:9463347-11] 12.0 ^12.1 ^12.2 ^12.3 Ericson J et al. (1998) Integrated FGF and BMP signaling controls the progression of progenitor cell differentiation and the emergence of pattern in the embryonic anterior pituitary. Development 125: 1005-15 PubMed GONUTS page

[PMID:15051883-12] Derouet D et al. (2004) Neuropoietin, a new IL-6-related cytokine signaling through the ciliary neurotrophic factor receptor. Proc Natl Acad Sci U S A 101: 4827-32 PubMed GONUTS page

[PMID:15509736-13] Yoon K et al. (2004) Fibroblast growth factor receptor signaling promotes radial glial identity and interacts with Notch1 signaling in telencephalic progenitors. J Neurosci 24: 9497-506 PubMed GONUTS page

[PMID:16141225-14] Yu L et al. (2005) Shox2-deficient mice exhibit a rare type of incomplete clefting of the secondary palate. Development 132: 4397-406 PubMed GONUTS page

[PMID:7494107-15] 16.0 ^16.1 Huang MT (1995) T cell development in CD3-zeta mutant mice. Int Rev Immunol 13: 29-41 PubMed GONUTS page

[PMID:10027293-16] 17.0 ^17.1 Wechsler-Reya RJ & Scott MP (1999) Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog. Neuron 22: 103-14 PubMed GONUTS page

[PMID:20570969-17] 18.0 ^18.1 Rice DP et al. (2010) Gli3Xt-J/Xt-J mice exhibit lambdoid suture craniosynostosis which results from altered osteoprogenitor proliferation and differentiation. Hum Mol Genet 19: 3457-67 PubMed GONUTS page

[PMID:12878680-18] Reuss B et al. (2003) Functions of fibroblast growth factor (FGF)-2 and FGF-5 in astroglial differentiation and blood-brain barrier permeability: evidence from mouse mutants. J Neurosci 23: 6404-12 PubMed GONUTS page

[PMID:9244299-19] Neubüser A et al. (1997) Antagonistic interactions between FGF and BMP signaling pathways: a mechanism for positioning the sites of tooth formation. Cell 90: 247-55 PubMed GONUTS page

[PMID:17234579-20] Timmer M et al. (2007) Fibroblast growth factor (FGF)-2 and FGF receptor 3 are required for the development of the substantia nigra, and FGF-2 plays a crucial role for the rescue of dopaminergic neurons after 6-hydroxydopamine lesion. J Neurosci 27: 459-71 PubMed GONUTS page

[PMID:18635606-21] Lokmane L et al. (2008) Crucial role of vHNF1 in vertebrate hepatic specification. Development 135: 2777-86 PubMed GONUTS page

[PMID:15781473-22] Davidson D et al. (2005) Fibroblast growth factor (FGF) 18 signals through FGF receptor 3 to promote chondrogenesis. J Biol Chem 280: 20509-15 PubMed GONUTS page

[PMID:16648142-23] 24.0 ^24.1 Munchhof AM et al. (2006) Neurofibroma-associated growth factors activate a distinct signaling network to alter the function of neurofibromin-deficient endothelial cells. Hum Mol Genet 15: 1858-69 PubMed GONUTS page

[PMID:20299672-24] 25.0 ^25.1 Olivey HE & Svensson EC (2010) Epicardial-myocardial signaling directing coronary vasculogenesis. Circ Res 106: 818-32 PubMed GONUTS page

[PMID:10391928-25] Hollnagel A et al. (1999) Id genes are direct targets of bone morphogenetic protein induction in embryonic stem cells. J Biol Chem 274: 19838-45 PubMed GONUTS page

[PMID:8898217-26] Chen Y et al. (1996) Msx1 controls inductive signaling in mammalian tooth morphogenesis. Development 122: 3035-44 PubMed GONUTS page

[PMID:9102311-27] Küry P et al. (1997) Protease nexin-1 is expressed at the mouse met-/mesencephalic junction and FGF signaling regulates its promoter activity in primary met-/mesencephalic cells. Development 124: 1251-62 PubMed GONUTS page

[PMID:11747369-28] Wahlin KJ et al. (2001) Neurotrophic signaling in normal and degenerating rodent retinas. Exp Eye Res 73: 693-701 PubMed GONUTS page

[PMID:16009496-29] Jungnickel J et al. (2005) Regulation of neuronal death and calcitonin gene-related peptide by fibroblast growth factor-2 and FGFR3 after peripheral nerve injury: evidence from mouse mutants. Neuroscience 134: 1343-50 PubMed GONUTS page

[PMID:12843296-30] Viti J et al. (2003) Wnt regulation of progenitor maturation in the cortex depends on Shh or fibroblast growth factor 2. J Neurosci 23: 5919-27 PubMed GONUTS page

[PMID:1376141-31] Venesio T et al. (1992) The int-2 gene product acts as a growth factor and substitutes for basic fibroblast growth factor in promoting the differentiation of a normal mouse mammary epithelial cell line. Cell Growth Differ 3: 63-71 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

[19]

[20]

[21]

[22]

[23]

[24]

[25]

[26]

[27]

[28]

[29]

[30]

[31]

[32]

Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Fgf2 ( synonyms: bFGF, Fgf-2, Fgfb )
Protein Name(s)	fibroblast growth factor 2,
External Links
MGI	MGI:95516

MGI:Fgf2

Contents

Annotations

Notes

References

a

b

c

e

f

g

h

i

i cont.

l

m

n

o

p

p cont.

r

s

t

v

Personal tools

Namespaces

Variants

Views

Actions

Search

Navigation

Cacao

Journal Clubs

page contributors

Toolbox