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MGI:Fcgr2b
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Fcgr2b ( synonyms: CD32, Fc gamma RIIB, Fc(g)RII, FcgammaRIIB, Fcgr2, Fcgr2a, FcgRII, Fcr-2, Fcr-3, Ly-17, Ly-m20, LyM-1 ) | |
| Protein Name(s) | Fc receptor, IgG, low affinity IIb, | |
| External Links | ||
| MGI | MGI:95499 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001811 |
negative regulation of type I hypersensitivity |
MGI:MGI:78617 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857166 |
P |
From MGI |
||
| GO:0002638 |
negative regulation of immunoglobulin production |
MGI:MGI:3608295 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857166 |
P |
From MGI |
||
| GO:0002862 |
negative regulation of inflammatory response to antigenic stimulus |
MGI:MGI:3620376 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857166 |
P |
From MGI |
||
| GO:0002865 |
negative regulation of acute inflammatory response to antigenic stimulus |
MGI:MGI:3608295 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857166 |
P |
From MGI |
||
| GO:0002924 |
negative regulation of humoral immune response mediated by circulating immunoglobulin |
MGI:MGI:3608295 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857166 |
P |
From MGI |
||
| GO:0004872 |
receptor activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0675 |
F |
From MGI |
||
| GO:0005057 |
receptor signaling protein activity |
MGI:MGI:2179576 |
TAS: Traceable Author Statement |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2670845 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005576 |
extracellular region |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0964 |
C |
From MGI |
||
| GO:0005737 |
cytoplasm |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0963 |
C |
From MGI |
||
| GO:0005856 |
cytoskeleton |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0206 |
C |
From MGI |
||
| GO:0005886 |
plasma membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-1003 |
C |
From MGI |
||
| GO:0005887 |
integral to plasma membrane |
MGI:MGI:78617 |
IC: Inferred by Curator |
GO:0016021 GO:0009897 |
C |
From MGI |
||
| GO:0006911 |
phagocytosis, engulfment |
MGI:MGI:82508 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006952 |
defense response |
MGI:MGI:2179576 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857166 |
P |
From MGI |
||
| GO:0006955 |
immune response |
MGI:MGI:2179576 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857166 |
P |
From MGI |
||
| GO:0007166 |
cell surface receptor signaling pathway |
MGI:MGI:78617 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857166 |
P |
From MGI |
||
| GO:0009617 |
response to bacterium |
MGI:MGI:3608295 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857166 |
P |
From MGI |
||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:78617 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:82508 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016021 |
integral to membrane |
MGI:MGI:78617 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0016064 |
immunoglobulin mediated immune response |
MGI:MGI:1340171 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857166 |
P |
From MGI |
||
| GO:0016064 |
immunoglobulin mediated immune response |
MGI:MGI:2687086 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857166 |
P |
From MGI |
||
| GO:0019864 |
IgG binding |
MGI:MGI:2679188 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0019886 |
antigen processing and presentation of exogenous peptide antigen via MHC class II |
MGI:MGI:2687086 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857166 |
P |
From MGI |
||
| GO:0030889 |
negative regulation of B cell proliferation |
MGI:MGI:3608295 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857166 |
P |
From MGI |
||
| GO:0030889 |
negative regulation of B cell proliferation |
MGI:MGI:78617 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857166 |
P |
From MGI |
||
| GO:0032693 |
negative regulation of interleukin-10 production |
MGI:MGI:3608295 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857166 |
P |
From MGI |
||
| GO:0050765 |
negative regulation of phagocytosis |
MGI:MGI:3608295 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857166 |
P |
From MGI |
||
| GO:0050766 |
positive regulation of phagocytosis |
MGI:MGI:82508 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0050777 |
negative regulation of immune response |
MGI:MGI:1340171 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857166 |
P |
From MGI |
||
| GO:0050777 |
negative regulation of immune response |
MGI:MGI:78617 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857166 |
P |
From MGI |
||
| GO:0071219 |
cellular response to molecule of bacterial origin |
MGI:MGI:3608295 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857166 |
P |
From MGI |
||
|
NOT |
GO:0045576 |
mast cell activation |
MGI:MGI:82508 |
IDA: Inferred from Direct Assay |
P |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Takai T et al. (1996) Augmented humoral and anaphylactic responses in Fc gamma RII-deficient mice. Nature 379: 346-9 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Gjertsson I et al. (2002) The impact of Fcgamma receptors on Staphylococcus aureus infection. Microb Pathog 33: 145-52 PubMed GONUTS page
- ↑ Nishimura H & Strominger JL (2006) Involvement of a tissue-specific autoantibody in skin disorders of murine systemic lupus erythematosus and autoinflammatory diseases. Proc Natl Acad Sci U S A 103: 3292-7 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Bolland S et al. (2002) Genetic modifiers of systemic lupus erythematosus in FcgammaRIIB(-/-) mice. J Exp Med 195: 1167-74 PubMed GONUTS page
- ↑ Kumagai H et al. (2003) Identification and characterization of a new pair of immunoglobulin-like receptors LMIR1 and 2 derived from murine bone marrow-derived mast cells. Biochem Biophys Res Commun 307: 719-29 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 Hazenbos WL et al. (1996) Impaired IgG-dependent anaphylaxis and Arthus reaction in Fc gamma RIII (CD16) deficient mice. Immunity 5: 181-8 PubMed GONUTS page
- ↑ 7.0 7.1 Wernersson S et al. (1999) IgG-mediated enhancement of antibody responses is low in Fc receptor gamma chain-deficient mice and increased in Fc gamma RII-deficient mice. J Immunol 163: 618-22 PubMed GONUTS page
- ↑ 8.0 8.1 Yada A et al. (2003) Accelerated antigen presentation and elicitation of humoral response in vivo by FcgammaRIIB- and FcgammaRI/III-mediated immune complex uptake. Cell Immunol 225: 21-32 PubMed GONUTS page
- ↑ Gavin AL et al. (1998) Identification of the mouse IgG3 receptor: implications for antibody effector function at the interface between innate and adaptive immunity. J Immunol 160: 20-3 PubMed GONUTS page
