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MGI:Fas

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Contents

Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Fas ( synonyms: APO-1, CD95, TNFR6, Tnfrsf6 )
Protein Name(s) Fas (TNF receptor superfamily member 6),
External Links
MGI MGI:95484

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0002377

immunoglobulin production

MGI:MGI:3773559
PMID:18199416[1]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856334

P

From MGI

GO:0003014

renal system process

MGI:MGI:79355
PMID:8640868[2]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856334

P

From MGI

GO:0004872

receptor activity

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0675

F

From MGI

GO:0004888

transmembrane signaling receptor activity

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR008063

F

From MGI

GO:0005031

tumor necrosis factor-activated receptor activity

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q63199

F

From MGI

GO:0005515

protein binding

MGI:MGI:1913166
PMID:11034606[3]

IPI: Inferred from Physical Interaction

UniProtKB:Q9ERH7

F

From MGI

GO:0005515

protein binding

MGI:MGI:3687424
PMID:7536190[4]

IPI: Inferred from Physical Interaction

UniProtKB:Q13158

F

From MGI

GO:0005515

protein binding

MGI:MGI:4839460
PMID:11483955[5]

IPI: Inferred from Physical Interaction

UniProtKB:O35613
UniProtKB:Q9UER7

F

From MGI

GO:0005515

protein binding

MGI:MGI:5294527
PMID:20935634[6]

IPI: Inferred from Physical Interaction

UniProtKB:Q13158

F

From MGI

GO:0005515

protein binding

MGI:MGI:893321
PMID:9215629[7]

IPI: Inferred from Physical Interaction

UniProtKB:O35613
UniProtKB:Q9UER7

F

From MGI

GO:0005576

extracellular region

MGI:MGI:76989
PMID:7595210[8]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:F5GWX3

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:F5GWX3

C

From MGI

GO:0005886

plasma membrane

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:F5GWX3

C

From MGI

GO:0006915

apoptotic process

MGI:MGI:2154458

ISO: Inferred from Sequence Orthology

UniProtKB:P25445

P

From MGI

GO:0006915

apoptotic process

MGI:MGI:3612236
PMID:16365167[9]

IGI: Inferred from Genetic Interaction

MGI:MGI:97847

P

From MGI

GO:0006915

apoptotic process

MGI:MGI:3818355
PMID:17980593[10]

IDA: Inferred from Direct Assay

P

From MGI

GO:0006915

apoptotic process

MGI:MGI:81811
PMID:8700551[11]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856334

P

From MGI

GO:0006924

activation-induced cell death of T cells

MGI:MGI:2670301
PMID:12702495[12]

IDA: Inferred from Direct Assay

P

From MGI

GO:0006924

activation-induced cell death of T cells

MGI:MGI:73864
PMID:7602121[13]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856334
MGI:MGI:1856384

P

From MGI

GO:0006924

activation-induced cell death of T cells

MGI:MGI:79355
PMID:8640868[2]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856334

P

From MGI

GO:0006925

inflammatory cell apoptotic process

MGI:MGI:2687085
PMID:12801066[14]

IDA: Inferred from Direct Assay

P

From MGI

GO:0006925

inflammatory cell apoptotic process

MGI:MGI:2687085
PMID:12801066[14]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0006927

transformed cell apoptotic process

MGI:MGI:2687085
PMID:12801066[14]

IDA: Inferred from Direct Assay

P

From MGI

GO:0006955

immune response

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR008063

P

From MGI

GO:0007165

signal transduction

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR000488
InterPro:IPR008063

P

From MGI

GO:0008624

induction of apoptosis by extracellular signals

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q63199

P

From MGI

GO:0008624

induction of apoptosis by extracellular signals

MGI:MGI:65483
PMID:7511063[15]

IDA: Inferred from Direct Assay

P

From MGI

GO:0008624

induction of apoptosis by extracellular signals

MGI:MGI:80946
PMID:8666928[16]

IDA: Inferred from Direct Assay

P

From MGI

GO:0008625

induction of apoptosis via death domain receptors

MGI:MGI:1340173
PMID:10429671[17]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856334

P

From MGI

GO:0008625

induction of apoptosis via death domain receptors

MGI:MGI:2687085
PMID:12801066[14]

IDA: Inferred from Direct Assay

P

From MGI

GO:0008625

induction of apoptosis via death domain receptors

MGI:MGI:2687085
PMID:12801066[14]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0008625

induction of apoptosis via death domain receptors

MGI:MGI:3029504
PMID:12431371[18]

IGI: Inferred from Genetic Interaction

MGI:MGI:1096330

P

From MGI

GO:0008625

induction of apoptosis via death domain receptors

MGI:MGI:77677
PMID:8524870[19]

IDA: Inferred from Direct Assay

P

From MGI

GO:0008625

induction of apoptosis via death domain receptors

MGI:MGI:77677
PMID:8524870[19]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0009636

response to toxin

MGI:MGI:78883
PMID:8557033[20]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856334

P

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:2687085
PMID:12801066[14]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:3612236
PMID:16365167[9]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:3759923
PMID:16493007[21]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:78866
PMID:8788039[22]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009986

cell surface

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q63199

C

From MGI

GO:0009986

cell surface

MGI:MGI:76989
PMID:7595210[8]

IDA: Inferred from Direct Assay

C

From MGI

GO:0010467

gene expression

MGI:MGI:73864
PMID:7602121[13]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856334
MGI:MGI:1856384

P

From MGI

GO:0010940

positive regulation of necrotic cell death

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P25445

P

From MGI

GO:0016020

membrane

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

From MGI

GO:0016020

membrane

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR008063

C

From MGI

GO:0016021

integral to membrane

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0812

C

From MGI

GO:0019724

B cell mediated immunity

MGI:MGI:3773559
PMID:18199416[1]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0019900

kinase binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P25445

F

From MGI

GO:0031104

dendrite regeneration

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q63199

P

From MGI

GO:0031264

death-inducing signaling complex

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P25445

C

From MGI

GO:0031265

CD95 death-inducing signaling complex

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q63199

C

From MGI

GO:0031265

CD95 death-inducing signaling complex

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P25445

C

From MGI

GO:0031265

CD95 death-inducing signaling complex

MGI:MGI:5294527
PMID:20935634[6]

IDA: Inferred from Direct Assay

C

From MGI

GO:0032464

positive regulation of protein homooligomerization

MGI:MGI:5009197
PMID:10950869[23]

IDA: Inferred from Direct Assay

P

From MGI

GO:0033209

tumor necrosis factor-mediated signaling pathway

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q63199

P

From MGI

GO:0042127

regulation of cell proliferation

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q63199

P

From MGI

GO:0042802

identical protein binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P25445

F

From MGI

GO:0043029

T cell homeostasis

MGI:MGI:79355
PMID:8640868[2]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856384

P

From MGI

GO:0043065

positive regulation of apoptotic process

MGI:MGI:3038547
PMID:15039234[24]

IGI: Inferred from Genetic Interaction

MGI:MGI:96974

P

From MGI

GO:0043065

positive regulation of apoptotic process

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P25445

P

From MGI

GO:0043065

positive regulation of apoptotic process

MGI:MGI:5009197
PMID:10950869[23]

IDA: Inferred from Direct Assay

P

From MGI

GO:0043066

negative regulation of apoptotic process

MGI:MGI:76989
PMID:7595210[8]

IDA: Inferred from Direct Assay

P

From MGI

GO:0045060

negative thymic T cell selection

MGI:MGI:1340173
PMID:10429671[17]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856334

P

From MGI

GO:0045121

membrane raft

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q63199

C

From MGI

GO:0045121

membrane raft

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P25445

C

From MGI

GO:0045619

regulation of lymphocyte differentiation

MGI:MGI:55958
PMID:6610701[25]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856334

P

From MGI

GO:0045637

regulation of myeloid cell differentiation

MGI:MGI:1275871
PMID:9697835[26]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856334

P

From MGI

GO:0048471

perinuclear region of cytoplasm

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q63199

C

From MGI

GO:0048536

spleen development

MGI:MGI:3773559
PMID:18199416[1]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856334

P

From MGI

GO:0050869

negative regulation of B cell activation

MGI:MGI:55958
PMID:6610701[25]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856334

P

From MGI

GO:0051260

protein homooligomerization

MGI:MGI:77677
PMID:8524870[19]

IDA: Inferred from Direct Assay

P

From MGI

GO:0051384

response to glucocorticoid stimulus

MGI:MGI:73864
PMID:7602121[13]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856334
MGI:MGI:1856384

P

From MGI

GO:0051384

response to glucocorticoid stimulus

MGI:MGI:79355
PMID:8640868[2]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856334

P

From MGI

GO:0051402

neuron apoptotic process

MGI:MGI:4829576
PMID:20530871[27]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856334

P

From MGI

GO:0071285

cellular response to lithium ion

MGI:MGI:4829576
PMID:20530871[27]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856334

P

From MGI

GO:0071455

cellular response to hyperoxia

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P25445

P

From MGI

GO:0090200

positive regulation of release of cytochrome c from mitochondria

MGI:MGI:5009197
PMID:10950869[23]

IC: Inferred by Curator

GO:0032464

P

From MGI


edit table

Notes

References

See Help:References for how to manage references in GONUTS.
  1. ↑ 1.0 1.1 1.2 Haraldsson MK et al. (2008) The lupus-related Lmb3 locus contains a disease-suppressing Coronin-1A gene mutation. Immunity 28: 40-51 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 Tamura A et al. (1996) Inhibition of apoptosis and augmentation of lymphoproliferation in bcl-2 transgenic Fas/Fas ligand-defective mice. Cell Immunol 168: 220-8 PubMed GONUTS page
  3. ↑ Rochat-Steiner V et al. (2000) FIST/HIPK3: a Fas/FADD-interacting serine/threonine kinase that induces FADD phosphorylation and inhibits fas-mediated Jun NH(2)-terminal kinase activation. J Exp Med 192: 1165-74 PubMed GONUTS page
  4. ↑ Boldin MP et al. (1995) A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain. J Biol Chem 270: 7795-8 PubMed GONUTS page
  5. ↑ Perlman R et al. (2001) TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation. Nat Cell Biol 3: 708-14 PubMed GONUTS page
  6. ↑ 6.0 6.1 Wang L et al. (2010) The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations. Nat Struct Mol Biol 17: 1324-9 PubMed GONUTS page
  7. ↑ Yang X et al. (1997) Daxx, a novel Fas-binding protein that activates JNK and apoptosis. Cell 89: 1067-76 PubMed GONUTS page
  8. ↑ 8.0 8.1 8.2 Hughes DP & Crispe IN (1995) A naturally occurring soluble isoform of murine Fas generated by alternative splicing. J Exp Med 182: 1395-401 PubMed GONUTS page
  9. ↑ 9.0 9.1 Piazzolla D et al. (2005) Raf-1 sets the threshold of Fas sensitivity by modulating Rok-alpha signaling. J Cell Biol 171: 1013-22 PubMed GONUTS page
  10. ↑ Camargo FD et al. (2007) YAP1 increases organ size and expands undifferentiated progenitor cells. Curr Biol 17: 2054-60 PubMed GONUTS page
  11. ↑ Suzuki A et al. (1996) Down regulation of Bcl-2 is the first step on Fas-mediated apoptosis of male reproductive tract. Oncogene 13: 31-7 PubMed GONUTS page
  12. ↑ Boone DL et al. (2003) Fas is not essential for lamina propria T lymphocyte homeostasis. Am J Physiol Gastrointest Liver Physiol 285: G382-8 PubMed GONUTS page
  13. ↑ 13.0 13.1 13.2 Tamura A & Yui K (1995) Age-dependent reduction of Bcl-2 expression in peripheral T cells of lpr and gld mutant mice. J Immunol 155: 499-507 PubMed GONUTS page
  14. ↑ 14.0 14.1 14.2 14.3 14.4 14.5 Yokota A et al. (2003) Cell-mediated fas-based lysis of dendritic cells which are apparently resistant to anti-Fas antibody. Microbiol Immunol 47: 285-93 PubMed GONUTS page
  15. ↑ Takahashi T et al. (1994) Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell 76: 969-76 PubMed GONUTS page
  16. ↑ Byth KF et al. (1996) CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation. J Exp Med 183: 1707-18 PubMed GONUTS page
  17. ↑ 17.0 17.1 Kishimoto H & Sprent J (1999) Several different cell surface molecules control negative selection of medullary thymocytes. J Exp Med 190: 65-73 PubMed GONUTS page
  18. ↑ Datta SR et al. (2002) Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis. Dev Cell 3: 631-43 PubMed GONUTS page
  19. ↑ 19.0 19.1 19.2 Chu K et al. (1995) A Fas-associated protein factor, FAF1, potentiates Fas-mediated apoptosis. Proc Natl Acad Sci U S A 92: 11894-8 PubMed GONUTS page
  20. ↑ Strasser A et al. (1995) Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis. EMBO J 14: 6136-47 PubMed GONUTS page
  21. ↑ Schenten D et al. (2006) M17, a gene specific for germinal center (GC) B cells and a prognostic marker for GC B-cell lymphomas, is dispensable for the GC reaction in mice. Blood 107: 4849-56 PubMed GONUTS page
  22. ↑ Li T et al. (1996) Distinct patterns of Fas cell surface expression during development of T- or B-lymphocyte lineages in normal, scid, and mutant mice lacking or overexpressing p53, bcl-2, or rag-2 genes. Cell Growth Differ 7: 107-14 PubMed GONUTS page
  23. ↑ 23.0 23.1 23.2 Wei MC et al. (2000) tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c. Genes Dev 14: 2060-71 PubMed GONUTS page
  24. ↑ Hiatt K et al. (2004) Loss of the nf1 tumor suppressor gene decreases fas antigen expression in myeloid cells. Am J Pathol 164: 1471-9 PubMed GONUTS page
  25. ↑ 25.0 25.1 Davidson WF et al. (1984) Dissociation of severe lupus-like disease from polyclonal B cell activation and IL 2 deficiency in C3H-lpr/lpr mice. J Immunol 133: 1048-56 PubMed GONUTS page
  26. ↑ Traver D et al. (1998) Mice defective in two apoptosis pathways in the myeloid lineage develop acute myeloblastic leukemia. Immunity 9: 47-57 PubMed GONUTS page
  27. ↑ 27.0 27.1 Gómez-Sintes R & Lucas JJ (2010) NFAT/Fas signaling mediates the neuronal apoptosis and motor side effects of GSK-3 inhibition in a mouse model of lithium therapy. J Clin Invest 120: 2432-45 PubMed GONUTS page
Retrieved from "http://gowiki.tamu.edu/wiki/index.php/MGI:Fas"
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