MGI:F2r

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000186	activation of MAPKK activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P26824	P	From MGI
	GO:0001965	G-protein alpha-subunit binding	MGI:MGI:5285163 PMID:20215560^[1]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0002248	connective tissue replacement involved in inflammatory response wound healing	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P25116	P	From MGI
	GO:0003105	negative regulation of glomerular filtration	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P26824	P	From MGI
	GO:0004871	signal transducer activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0807	F	From MGI
	GO:0004872	receptor activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0675	F	From MGI
	GO:0004930	G-protein coupled receptor activity	MGI:MGI:5285163 PMID:20215560^[1]	IMP: Inferred from Mutant Phenotype		F	From MGI
	GO:0005102	receptor binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P25116	F	From MGI
	GO:0005886	plasma membrane	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P26824	C	From MGI
	GO:0005886	plasma membrane	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P25116	C	From MGI
	GO:0005901	caveola	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P25116	C	From MGI
	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P25116	P	From MGI
	GO:0006954	inflammatory response	MGI:MGI:3784647 PMID:18305483^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3038377	P	From MGI
	GO:0007165	signal transduction	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0807	P	From MGI
	GO:0007186	G-protein coupled receptor signaling pathway	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P26824	P	From MGI
	GO:0007204	elevation of cytosolic calcium ion concentration	MGI:MGI:5285163 PMID:20215560^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0007205	activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P26824	P	From MGI
	GO:0007260	tyrosine phosphorylation of STAT protein	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P25116	P	From MGI
	GO:0007262	STAT protein import into nucleus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P25116	P	From MGI
	GO:0007529	establishment of synaptic specificity at neuromuscular junction	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P26824	P	From MGI
	GO:0007596	blood coagulation	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0094	P	From MGI
	GO:0007596	blood coagulation	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR003912 InterPro:IPR000935	P	From MGI
	GO:0007599	hemostasis	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0356	P	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P26824	P	From MGI
	GO:0008285	negative regulation of cell proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P25116	P	From MGI
	GO:0009611	response to wounding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P25116	P	From MGI
	GO:0014068	positive regulation of phosphatidylinositol 3-kinase cascade	MGI:MGI:3810206 PMID:18398001^[3]	IGI: Inferred from Genetic Interaction	MGI:MGI:88380	P	From MGI
	GO:0014068	positive regulation of phosphatidylinositol 3-kinase cascade	MGI:MGI:5285163 PMID:20215560^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0015057	thrombin receptor activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P25116	F	From MGI
	GO:0016020	membrane	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0472	C	From MGI
	GO:0016021	integral to membrane	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0812	C	From MGI
	GO:0016021	integral to membrane	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR000276 InterPro:IPR003912 InterPro:IPR000935	C	From MGI
	GO:0016265	death	MGI:MGI:3784647 PMID:18305483^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3038377	P	From MGI
	GO:0030168	platelet activation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P25116	P	From MGI
	GO:0030193	regulation of blood coagulation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P25116	P	From MGI
	GO:0030194	positive regulation of blood coagulation	MGI:MGI:3784647 PMID:18305483^[2]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0030194	positive regulation of blood coagulation	MGI:MGI:3784647 PMID:18305483^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3038377	P	From MGI
	GO:0030194	positive regulation of blood coagulation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P25116	P	From MGI
	GO:0030335	positive regulation of cell migration	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P25116	P	From MGI
	GO:0030335	positive regulation of cell migration	MGI:MGI:5285163 PMID:20215560^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0031094	platelet dense tubular network	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P25116	C	From MGI
	GO:0031594	neuromuscular junction	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P26824	C	From MGI
	GO:0031681	G-protein beta-subunit binding	MGI:MGI:5285163 PMID:20215560^[1]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0032496	response to lipopolysaccharide	MGI:MGI:3784647 PMID:18305483^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3038377	P	From MGI
	GO:0032651	regulation of interleukin-1 beta production	MGI:MGI:3784647 PMID:18305483^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3038377	P	From MGI
	GO:0032795	heterotrimeric G-protein binding	MGI:MGI:5285163 PMID:20215560^[1]	TAS: Traceable Author Statement		F	From MGI
	GO:0032967	positive regulation of collagen biosynthetic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P25116	P	From MGI
	GO:0035025	positive regulation of Rho protein signal transduction	MGI:MGI:5285163 PMID:20215560^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P25116	P	From MGI
	GO:0043410	positive regulation of MAPK cascade	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P25116	P	From MGI
	GO:0043524	negative regulation of neuron apoptotic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P26824	P	From MGI
	GO:0045211	postsynaptic membrane	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P26824	C	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P25116	P	From MGI
	GO:0045907	positive regulation of vasoconstriction	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P26824	P	From MGI
	GO:0045907	positive regulation of vasoconstriction	MGI:MGI:5315674 PMID:21859963^[4]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045987	positive regulation of smooth muscle contraction	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P26824	P	From MGI
	GO:0046427	positive regulation of JAK-STAT cascade	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P25116	P	From MGI
	GO:0048873	homeostasis of number of cells within a tissue	MGI:MGI:3784647 PMID:18305483^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3038377	P	From MGI
	GO:0051209	release of sequestered calcium ion into cytosol	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P26824	P	From MGI
	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P25116	P	From MGI
	GO:0051482	elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P26824	P	From MGI
	GO:0051928	positive regulation of calcium ion transport	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P26824	P	From MGI
	GO:0051930	regulation of sensory perception of pain	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P26824	P	From MGI
	GO:0070374	positive regulation of ERK1 and ERK2 cascade	MGI:MGI:5285163 PMID:20215560^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0070493	thrombin receptor signaling pathway	MGI:MGI:3810206 PMID:18398001^[3]	IGI: Inferred from Genetic Interaction	MGI:MGI:88380	P	From MGI
	GO:0070493	thrombin receptor signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P25116	P	From MGI
	GO:1900134	negative regulation of renin secretion into blood stream	MGI:MGI:5315674 PMID:21859963^[4]	IDA: Inferred from Direct Assay		P	From MGI
	GO:2000484	positive regulation of interleukin-8 secretion	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P25116	P	From MGI
	GO:2000778	positive regulation of interleukin-6 secretion	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P25116	P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 McCoy KL et al. (2010) PAR1 and PAR2 couple to overlapping and distinct sets of G proteins and linked signaling pathways to differentially regulate cell physiology. Mol Pharmacol 77: 1005-15 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Niessen F et al. (2008) Dendritic cell PAR1-S1P3 signalling couples coagulation and inflammation. Nature 452: 654-8 PubMed GONUTS page
↑ ^3.0 ^3.1 Feutz AC et al. (2008) Control of thrombin signaling through PI3K is a mechanism underlying plasticity between hair follicle dermal sheath and papilla cells. J Cell Sci 121: 1435-43 PubMed GONUTS page
↑ ^4.0 ^4.1 Höcherl K et al. (2011) Proteinase-activated receptors 1 and 2 exert opposite effects on renal renin release. Hypertension 58: 611-8 PubMed GONUTS page

[PMID:20215560-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 McCoy KL et al. (2010) PAR1 and PAR2 couple to overlapping and distinct sets of G proteins and linked signaling pathways to differentially regulate cell physiology. Mol Pharmacol 77: 1005-15 PubMed GONUTS page

[PMID:18305483-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Niessen F et al. (2008) Dendritic cell PAR1-S1P3 signalling couples coagulation and inflammation. Nature 452: 654-8 PubMed GONUTS page

[PMID:18398001-2] 3.0 ^3.1 Feutz AC et al. (2008) Control of thrombin signaling through PI3K is a mechanism underlying plasticity between hair follicle dermal sheath and papilla cells. J Cell Sci 121: 1435-43 PubMed GONUTS page

[PMID:21859963-3] 4.0 ^4.1 Höcherl K et al. (2011) Proteinase-activated receptors 1 and 2 exert opposite effects on renal renin release. Hypertension 58: 611-8 PubMed GONUTS page

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[2]

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[4]

Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	F2r ( synonyms: Cf2r, Par1, thrombin receptor, ThrR )
Protein Name(s)	coagulation factor II (thrombin) receptor,
External Links
MGI	MGI:101802

MGI:F2r

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