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MGI:F2
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | F2 ( synonyms: Cf-2, Cf2, FII, prothrombin, thrombin ) | |
| Protein Name(s) | coagulation factor II, | |
| External Links | ||
| MGI | MGI:88380 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001934 |
positive regulation of protein phosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0003824 |
catalytic activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0004252 |
serine-type endopeptidase activity |
MGI:MGI:3810206 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004252 |
serine-type endopeptidase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004252 |
serine-type endopeptidase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005102 |
receptor binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005509 |
calcium ion binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:74282 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005576 |
extracellular region |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005615 |
extracellular space |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005615 |
extracellular space |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006508 |
proteolysis |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0645 |
P |
From MGI |
||
| GO:0006508 |
proteolysis |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR018114 |
P |
From MGI |
||
| GO:0006953 |
acute-phase response |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0011 |
P |
From MGI |
||
| GO:0007166 |
cell surface receptor signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007596 |
blood coagulation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007599 |
hemostasis |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0356 |
P |
From MGI |
||
| GO:0008233 |
peptidase activity |
MGI:MGI:3784647 |
IMP: Inferred from Mutant Phenotype |
F |
From MGI |
|||
| GO:0008236 |
serine-type peptidase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0720 |
F |
From MGI |
||
| GO:0008284 |
positive regulation of cell proliferation |
MGI:MGI:3810206 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:101780 |
P |
From MGI |
||
| GO:0008360 |
regulation of cell shape |
MGI:MGI:3810206 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:101780 |
P |
From MGI |
||
| GO:0009611 |
response to wounding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0014068 |
positive regulation of phosphatidylinositol 3-kinase cascade |
MGI:MGI:3810206 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:101780 |
P |
From MGI |
||
| GO:0016787 |
hydrolase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0378 |
F |
From MGI |
||
| GO:0030168 |
platelet activation |
MGI:MGI:3709713 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0030168 |
platelet activation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030194 |
positive regulation of blood coagulation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030307 |
positive regulation of cell growth |
MGI:MGI:3810206 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:101780 |
P |
From MGI |
||
| GO:0032967 |
positive regulation of collagen biosynthetic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042730 |
fibrinolysis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045861 |
negative regulation of proteolysis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0048712 |
negative regulation of astrocyte differentiation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051281 |
positive regulation of release of sequestered calcium ion into cytosol |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051480 |
cytosolic calcium ion homeostasis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0070053 |
thrombospondin receptor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0070493 |
thrombin receptor signaling pathway |
MGI:MGI:3810206 |
ISO: Inferred from Sequence Orthology |
MGI:MGI:101802 |
P |
From MGI |
||
| GO:2000379 |
positive regulation of reactive oxygen species metabolic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Feutz AC et al. (2008) Control of thrombin signaling through PI3K is a mechanism underlying plasticity between hair follicle dermal sheath and papilla cells. J Cell Sci 121: 1435-43 PubMed GONUTS page
- ↑ Sun J et al. (1995) Gene structure, chromosomal localization, and expression of the murine homologue of human proteinase inhibitor 6 (PI-6) suggests divergence of PI-6 from the ovalbumin serpins. J Biol Chem 270: 16089-96 PubMed GONUTS page
- ↑ Niessen F et al. (2008) Dendritic cell PAR1-S1P3 signalling couples coagulation and inflammation. Nature 452: 654-8 PubMed GONUTS page
- ↑ Dubois C et al. (2007) Thrombin-initiated platelet activation in vivo is vWF independent during thrombus formation in a laser injury model. J Clin Invest 117: 953-60 PubMed GONUTS page
