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MGI:Ezh2
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Ezh2 ( synonyms: Enx-1, Enx1h, KMT6 ) | |
| Protein Name(s) | enhancer of zeste homolog 2 (Drosophila), | |
| External Links | ||
| MGI | MGI:107940 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000084 |
S phase of mitotic cell cycle |
MGI:MGI:3846264 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2661097 |
P |
From MGI |
||
| GO:0001047 |
core promoter binding |
MGI:MGI:4833736 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0001932 |
regulation of protein phosphorylation |
MGI:MGI:3846264 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2661097 |
P |
From MGI |
||
| GO:0003677 |
DNA binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0003682 |
chromatin binding |
MGI:MGI:3057067 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:1203943 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2668801 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4431292 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4436818 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:1203943 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3057067 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3846264 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005694 |
chromosome |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0158 |
C |
From MGI |
||
| GO:0006351 |
transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0804 |
P |
From MGI |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0805 |
P |
From MGI |
||
| GO:0008168 |
methyltransferase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0489 |
F |
From MGI |
||
| GO:0010468 |
regulation of gene expression |
MGI:MGI:4833736 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2661097 |
P |
From MGI |
||
| GO:0014013 |
regulation of gliogenesis |
MGI:MGI:4833736 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2661097 |
P |
From MGI |
||
| GO:0016568 |
chromatin modification |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0156 |
P |
From MGI |
||
| GO:0016571 |
histone methylation |
MGI:MGI:2668801 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0016571 |
histone methylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0016740 |
transferase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0808 |
F |
From MGI |
||
| GO:0018022 |
peptidyl-lysine methylation |
MGI:MGI:2152096 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0018022 |
peptidyl-lysine methylation |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0018024 |
histone-lysine N-methyltransferase activity |
MGI:MGI:2152096 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0018024 |
histone-lysine N-methyltransferase activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0021695 |
cerebellar cortex development |
MGI:MGI:4833736 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2661097 |
P |
From MGI |
||
| GO:0032259 |
methylation |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0489 |
P |
From MGI |
||
| GO:0034244 |
negative regulation of transcription elongation from RNA polymerase II promoter |
MGI:MGI:3846264 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2661097 |
P |
From MGI |
||
| GO:0034968 |
histone lysine methylation |
MGI:MGI:2152096 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0034968 |
histone lysine methylation |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0035098 |
ESC/E(Z) complex |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0035098 |
ESC/E(Z) complex |
MGI:MGI:4431292 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0035098 |
ESC/E(Z) complex |
MGI:MGI:4436818 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0042054 |
histone methyltransferase activity |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0042054 |
histone methyltransferase activity |
MGI:MGI:2668801 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0042127 |
regulation of cell proliferation |
MGI:MGI:3846264 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2661097 |
P |
From MGI |
||
| GO:0043565 |
sequence-specific DNA binding |
MGI:MGI:4838928 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0045120 |
pronucleus |
MGI:MGI:2668801 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0045605 |
negative regulation of epidermal cell differentiation |
MGI:MGI:3846264 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2661097 |
P |
From MGI |
||
| GO:0045892 |
negative regulation of transcription, DNA-dependent |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0048387 |
negative regulation of retinoic acid receptor signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0050767 |
regulation of neurogenesis |
MGI:MGI:4833736 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2661097 |
P |
From MGI |
||
| GO:0051154 |
negative regulation of striated muscle cell differentiation |
MGI:MGI:3057067 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0070314 |
G1 to G0 transition |
MGI:MGI:3846264 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2661097 |
P |
From MGI |
||
| GO:0070734 |
histone H3-K27 methylation |
MGI:MGI:4833736 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2661097 |
P |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Ezhkova E et al. (2009) Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells. Cell 136: 1122-35 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Pereira JD et al. (2010) Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex. Proc Natl Acad Sci U S A 107: 15957-62 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Caretti G et al. (2004) The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation. Genes Dev 18: 2627-38 PubMed GONUTS page
- ↑ 4.0 4.1 van Lohuizen M et al. (1998) Interaction of mouse polycomb-group (Pc-G) proteins Enx1 and Enx2 with Eed: indication for separate Pc-G complexes. Mol Cell Biol 18: 3572-9 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Erhardt S et al. (2003) Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse development. Development 130: 4235-48 PubMed GONUTS page
- ↑ 6.0 6.1 Peng JC et al. (2009) Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells. Cell 139: 1290-302 PubMed GONUTS page
- ↑ 7.0 7.1 Shen X et al. (2009) Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells. Cell 139: 1303-14 PubMed GONUTS page
- ↑ Onodera A et al. (2010) STAT6-mediated displacement of polycomb by trithorax complex establishes long-term maintenance of GATA3 expression in T helper type 2 cells. J Exp Med 207: 2493-506 PubMed GONUTS page
