MGI:Esr2

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62986	P	From MGI
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q92731	P	From MGI
	GO:0001046	core promoter sequence-specific DNA binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q92731	F	From MGI
	GO:0001541	ovarian follicle development	MGI:MGI:1321430 PMID:9861029^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2152217	P	From MGI
	GO:0001541	ovarian follicle development	MGI:MGI:1889238 PMID:10976058^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2386761	P	From MGI
	GO:0001662	behavioral fear response	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62986	P	From MGI
	GO:0001764	neuron migration	MGI:MGI:2449269 PMID:12515851^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2152217	P	From MGI
	GO:0003677	DNA binding	MGI:MGI:86169 PMID:9058381^[4]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003700	sequence-specific DNA binding transcription factor activity	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR008946 InterPro:IPR000536 InterPro:IPR001628	F	From MGI
	GO:0003707	steroid hormone receptor activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62986	F	From MGI
	GO:0004872	receptor activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0675	F	From MGI
	GO:0005496	steroid binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62986	F	From MGI
	GO:0005515	protein binding	MGI:MGI:5013670 PMID:21565615^[5]	IPI: Inferred from Physical Interaction	UniProtKB:P01101	F	From MGI
	GO:0005634	nucleus	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62986	C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62986	C	From MGI
	GO:0005739	mitochondrion	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:Q62986 UniProtKB:Q92731	C	From MGI
	GO:0005886	plasma membrane	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62986	C	From MGI
	GO:0006351	transcription, DNA-dependent	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0804	P	From MGI
	GO:0006355	regulation of transcription, DNA-dependent	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0805	P	From MGI
	GO:0006355	regulation of transcription, DNA-dependent	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR008946 InterPro:IPR000536 InterPro:IPR024178 InterPro:IPR001723 InterPro:IPR001628 InterPro:IPR013088	P	From MGI
	GO:0007420	brain development	MGI:MGI:2449269 PMID:12515851^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2152217	P	From MGI
	GO:0007611	learning or memory	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62986	P	From MGI
	GO:0008270	zinc ion binding	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR024178 InterPro:IPR001628 InterPro:IPR013088	F	From MGI
	GO:0008285	negative regulation of cell proliferation	MGI:MGI:3805661 PMID:18464259^[6]	IGI: Inferred from Genetic Interaction	MGI:MGI:88039	P	From MGI
	GO:0008289	lipid binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0446	F	From MGI
	GO:0019899	enzyme binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q92731	F	From MGI
	GO:0030284	estrogen receptor activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62986	F	From MGI
	GO:0030518	intracellular steroid hormone receptor signaling pathway	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62986	P	From MGI
	GO:0030520	intracellular estrogen receptor signaling pathway	MGI:MGI:3761900 PMID:12370428^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2152217	P	From MGI
	GO:0032355	response to estradiol stimulus	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62986	P	From MGI
	GO:0033574	response to testosterone stimulus	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62986	P	From MGI
	GO:0034056	estrogen response element binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62986	F	From MGI
	GO:0034056	estrogen response element binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q92731	F	From MGI
	GO:0042127	regulation of cell proliferation	MGI:MGI:1277637 PMID:9697695^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857936	P	From MGI
	GO:0042562	hormone binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62986	F	From MGI
	GO:0043005	neuron projection	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62986	C	From MGI
	GO:0043065	positive regulation of apoptotic process	MGI:MGI:3047056 PMID:15187231^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2152217	P	From MGI
	GO:0043204	perikaryon	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62986	C	From MGI
	GO:0043401	steroid hormone mediated signaling pathway	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62986	P	From MGI
	GO:0043526	neuroprotection	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62986	P	From MGI
	GO:0043565	sequence-specific DNA binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62986	F	From MGI
	GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62986	P	From MGI
	GO:0045885	positive regulation of survival gene product expression	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62986	P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62986	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62986	P	From MGI
	GO:0046872	metal ion binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0479	F	From MGI
	GO:0048471	perinuclear region of cytoplasm	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62986	C	From MGI
	GO:0048521	negative regulation of behavior	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62986	P	From MGI
	GO:0050680	negative regulation of epithelial cell proliferation	MGI:MGI:3047056 PMID:15187231^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2152217	P	From MGI
	GO:0050680	negative regulation of epithelial cell proliferation	MGI:MGI:3761900 PMID:12370428^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2152217	P	From MGI
	GO:0050680	negative regulation of epithelial cell proliferation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62986	P	From MGI
	GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q92731	P	From MGI
	GO:0060011	Sertoli cell proliferation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62986	P	From MGI
	GO:0060065	uterus development	MGI:MGI:1889238 PMID:10976058^[2]	IGI: Inferred from Genetic Interaction	MGI:MGI:1352467	P	From MGI
	GO:0060068	vagina development	MGI:MGI:1889238 PMID:10976058^[2]	IGI: Inferred from Genetic Interaction	MGI:MGI:1352467	P	From MGI
	GO:0060548	negative regulation of cell death	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62986	P	From MGI
	GO:0060740	prostate gland epithelium morphogenesis	MGI:MGI:3047056 PMID:15187231^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2152217	P	From MGI
	GO:0060740	prostate gland epithelium morphogenesis	MGI:MGI:3761900 PMID:12370428^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2152217	P	From MGI
	GO:0060743	epithelial cell maturation involved in prostate gland development	MGI:MGI:3047056 PMID:15187231^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2152217	P	From MGI
	GO:0060766	negative regulation of androgen receptor signaling pathway	MGI:MGI:3761900 PMID:12370428^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2152217	P	From MGI
	GO:0070374	positive regulation of ERK1 and ERK2 cascade	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62986	P	From MGI
	GO:0071392	cellular response to estradiol stimulus	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62986	P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Krege JH et al. (1998) Generation and reproductive phenotypes of mice lacking estrogen receptor beta. Proc Natl Acad Sci U S A 95: 15677-82 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Dupont S et al. (2000) Effect of single and compound knockouts of estrogen receptors alpha (ERalpha) and beta (ERbeta) on mouse reproductive phenotypes. Development 127: 4277-91 PubMed GONUTS page
↑ ^3.0 ^3.1 Wang L et al. (2003) Estrogen receptor (ER)beta knockout mice reveal a role for ERbeta in migration of cortical neurons in the developing brain. Proc Natl Acad Sci U S A 100: 703-8 PubMed GONUTS page
↑ Tremblay GB et al. (1997) Cloning, chromosomal localization, and functional analysis of the murine estrogen receptor beta. Mol Endocrinol 11: 353-65 PubMed GONUTS page
↑ Saijo K et al. (2011) An ADIOL-ERβ-CtBP transrepression pathway negatively regulates microglia-mediated inflammation. Cell 145: 584-95 PubMed GONUTS page
↑ Giroux V et al. (2008) Estrogen receptor beta deficiency enhances small intestinal tumorigenesis in ApcMin/+ mice. Int J Cancer 123: 303-11 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Weihua Z et al. (2002) An endocrine pathway in the prostate, ERbeta, AR, 5alpha-androstane-3beta,17beta-diol, and CYP7B1, regulates prostate growth. Proc Natl Acad Sci U S A 99: 13589-94 PubMed GONUTS page
↑ Di Cristofano A et al. (1998) Pten is essential for embryonic development and tumour suppression. Nat Genet 19: 348-55 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Imamov O et al. (2004) Estrogen receptor beta regulates epithelial cellular differentiation in the mouse ventral prostate. Proc Natl Acad Sci U S A 101: 9375-80 PubMed GONUTS page

[PMID:9861029-0] Krege JH et al. (1998) Generation and reproductive phenotypes of mice lacking estrogen receptor beta. Proc Natl Acad Sci U S A 95: 15677-82 PubMed GONUTS page

[PMID:10976058-1] 2.0 ^2.1 ^2.2 Dupont S et al. (2000) Effect of single and compound knockouts of estrogen receptors alpha (ERalpha) and beta (ERbeta) on mouse reproductive phenotypes. Development 127: 4277-91 PubMed GONUTS page

[PMID:12515851-2] 3.0 ^3.1 Wang L et al. (2003) Estrogen receptor (ER)beta knockout mice reveal a role for ERbeta in migration of cortical neurons in the developing brain. Proc Natl Acad Sci U S A 100: 703-8 PubMed GONUTS page

[PMID:9058381-3] Tremblay GB et al. (1997) Cloning, chromosomal localization, and functional analysis of the murine estrogen receptor beta. Mol Endocrinol 11: 353-65 PubMed GONUTS page

[PMID:21565615-4] Saijo K et al. (2011) An ADIOL-ERβ-CtBP transrepression pathway negatively regulates microglia-mediated inflammation. Cell 145: 584-95 PubMed GONUTS page

[PMID:18464259-5] Giroux V et al. (2008) Estrogen receptor beta deficiency enhances small intestinal tumorigenesis in ApcMin/+ mice. Int J Cancer 123: 303-11 PubMed GONUTS page

[PMID:12370428-6] 7.0 ^7.1 ^7.2 ^7.3 Weihua Z et al. (2002) An endocrine pathway in the prostate, ERbeta, AR, 5alpha-androstane-3beta,17beta-diol, and CYP7B1, regulates prostate growth. Proc Natl Acad Sci U S A 99: 13589-94 PubMed GONUTS page

[PMID:9697695-7] Di Cristofano A et al. (1998) Pten is essential for embryonic development and tumour suppression. Nat Genet 19: 348-55 PubMed GONUTS page

[PMID:15187231-8] 9.0 ^9.1 ^9.2 ^9.3 Imamov O et al. (2004) Estrogen receptor beta regulates epithelial cellular differentiation in the mouse ventral prostate. Proc Natl Acad Sci U S A 101: 9375-80 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Esr2 ( synonyms: ER beta, ERbeta, Estrb, oestrogen receptor beta )
Protein Name(s)	estrogen receptor 2 (beta),
External Links
MGI	MGI:109392

MGI:Esr2

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