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MGI:Erbb4
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Erbb4 ( synonyms: ErbB4, Her4 ) | |
| Protein Name(s) | v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian), | |
| External Links | ||
| MGI | MGI:104771 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000166 |
nucleotide binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0547 |
F |
From MGI |
||
| GO:0001755 |
neural crest cell migration |
MGI:MGI:1352955 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0004672 |
protein kinase activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0004713 |
protein tyrosine kinase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004714 |
transmembrane receptor protein tyrosine kinase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004716 |
receptor signaling protein tyrosine kinase activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0004872 |
receptor activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0675 |
F |
From MGI |
||
| GO:0005154 |
epidermal growth factor receptor binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:5294301 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005524 |
ATP binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0067 |
F |
From MGI |
||
| GO:0005524 |
ATP binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR006211 |
F |
From MGI |
||
| GO:0005634 |
nucleus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005739 |
mitochondrion |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005901 |
caveola |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006351 |
transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0804 |
P |
From MGI |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0805 |
P |
From MGI |
||
| GO:0006468 |
protein phosphorylation |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR006211 |
P |
From MGI |
||
| GO:0006915 |
apoptotic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007165 |
signal transduction |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007169 |
transmembrane receptor protein tyrosine kinase signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007275 |
multicellular organismal development |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0217 |
P |
From MGI |
||
| GO:0007399 |
nervous system development |
MGI:MGI:77495 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1929607 |
P |
From MGI |
||
| GO:0007507 |
heart development |
MGI:MGI:77495 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1929607 |
P |
From MGI |
||
| GO:0007595 |
lactation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007595 |
lactation |
MGI:MGI:5297795 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0008284 |
positive regulation of cell proliferation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008285 |
negative regulation of cell proliferation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0009880 |
embryonic pattern specification |
MGI:MGI:1352955 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0014069 |
postsynaptic density |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016020 |
membrane |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0016021 |
integral to membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0812 |
C |
From MGI |
||
| GO:0016021 |
integral to membrane |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0016301 |
kinase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0418 |
F |
From MGI |
||
| GO:0016310 |
phosphorylation |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0418 |
P |
From MGI |
||
| GO:0016323 |
basolateral plasma membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0016477 |
cell migration |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0016740 |
transferase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0808 |
F |
From MGI |
||
| GO:0016772 |
transferase activity, transferring phosphorus-containing groups |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0018108 |
peptidyl-tyrosine phosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0021551 |
central nervous system morphogenesis |
MGI:MGI:1352955 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0021889 |
olfactory bulb interneuron differentiation |
MGI:MGI:3527369 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0030334 |
regulation of cell migration |
MGI:MGI:3527369 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0030335 |
positive regulation of cell migration |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032230 |
positive regulation of synaptic transmission, GABAergic |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042523 |
positive regulation of tyrosine phosphorylation of Stat5 protein |
MGI:MGI:3689173 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0042523 |
positive regulation of tyrosine phosphorylation of Stat5 protein |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042523 |
positive regulation of tyrosine phosphorylation of Stat5 protein |
MGI:MGI:5297795 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0042803 |
protein homodimerization activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0043066 |
negative regulation of apoptotic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043129 |
surfactant homeostasis |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043552 |
positive regulation of phosphatidylinositol 3-kinase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0044212 |
transcription regulatory region DNA binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0045121 |
membrane raft |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0045165 |
cell fate commitment |
MGI:MGI:2445853 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045768 |
positive regulation of anti-apoptosis |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:3689173 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0046326 |
positive regulation of glucose import |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0046777 |
protein autophosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0050679 |
positive regulation of epithelial cell proliferation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0060045 |
positive regulation of cardiac muscle cell proliferation |
MGI:MGI:4430666 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0060074 |
synapse maturation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0060644 |
mammary gland epithelial cell differentiation |
MGI:MGI:3689173 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0060749 |
mammary gland alveolus development |
MGI:MGI:5297795 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0061026 |
cardiac muscle tissue regeneration |
MGI:MGI:4430666 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0070374 |
positive regulation of ERK1 and ERK2 cascade |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:2000366 |
positive regulation of STAT protein import into nucleus |
MGI:MGI:3689173 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:2000366 |
positive regulation of STAT protein import into nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Golding JP et al. (2000) Defects in pathfinding by cranial neural crest cells in mice lacking the neuregulin receptor ErbB4. Nat Cell Biol 2: 103-9 PubMed GONUTS page
- ↑ Aqeilan RI et al. (2005) WW domain-containing proteins, WWOX and YAP, compete for interaction with ErbB-4 and modulate its transcriptional function. Cancer Res 65: 6764-72 PubMed GONUTS page
- ↑ 3.0 3.1 Gassmann M et al. (1995) Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor. Nature 378: 390-4 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Jones FE et al. (1999) ErbB4 signaling in the mammary gland is required for lobuloalveolar development and Stat5 activation during lactation. J Cell Biol 147: 77-88 PubMed GONUTS page
- ↑ 5.0 5.1 Anton ES et al. (2004) Receptor tyrosine kinase ErbB4 modulates neuroblast migration and placement in the adult forebrain. Nat Neurosci 7: 1319-28 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 Muraoka-Cook RS et al. (2006) The intracellular domain of ErbB4 induces differentiation of mammary epithelial cells. Mol Biol Cell 17: 4118-29 PubMed GONUTS page
- ↑ Huotari MA et al. (2002) ErbB signaling regulates lineage determination of developing pancreatic islet cells in embryonic organ culture. Endocrinology 143: 4437-46 PubMed GONUTS page
- ↑ 8.0 8.1 Bersell K et al. (2009) Neuregulin1/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury. Cell 138: 257-70 PubMed GONUTS page
