MGI:Erbb2

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Erbb2 ( synonyms: c-erbB2, c-neu, ErbB-2, HER-2, HER2, Neu, Neu oncogene )
Protein Name(s)	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian),
External Links
MGI	MGI:95410

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000166	nucleotide binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0547	F	From MGI
	GO:0001042	RNA polymerase I core binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P04626	F	From MGI
	GO:0001934	positive regulation of protein phosphorylation	MGI:MGI:5297297 PMID:22019888^[1]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0001948	glycoprotein binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P06494	F	From MGI
	GO:0004672	protein kinase activity	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR000719 InterPro:IPR001245	F	From MGI
	GO:0004713	protein tyrosine kinase activity	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:P04626	F	From MGI
	GO:0004713	protein tyrosine kinase activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P06494	F	From MGI
	GO:0004714	transmembrane receptor protein tyrosine kinase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P04626	F	From MGI
	GO:0004716	receptor signaling protein tyrosine kinase activity	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR016245	F	From MGI
	GO:0004872	receptor activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0675	F	From MGI
	GO:0004888	transmembrane signaling receptor activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P04626	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3688080 PMID:11276227^[2]	IPI: Inferred from Physical Interaction	UniProtKB:P49615 UniProtKB:P61809	F	From MGI
	GO:0005515	protein binding	MGI:MGI:4888096 PMID:20639901^[3]	IPI: Inferred from Physical Interaction	UniProtKB:Q61526	F	From MGI
	GO:0005524	ATP binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0067	F	From MGI
	GO:0005524	ATP binding	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR006211 InterPro:IPR000719 InterPro:IPR017441 InterPro:IPR016245	F	From MGI
	GO:0005634	nucleus	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P06494	C	From MGI
	GO:0005634	nucleus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P04626	C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:3512707 PMID:15306553^[4]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005886	plasma membrane	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-1003	C	From MGI
	GO:0005902	microvillus	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P06494	C	From MGI
	GO:0006351	transcription, DNA-dependent	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0804	P	From MGI
	GO:0006355	regulation of transcription, DNA-dependent	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0805	P	From MGI
	GO:0006468	protein phosphorylation	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR006211 InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266 InterPro:IPR020635 InterPro:IPR016245	P	From MGI
	GO:0007165	signal transduction	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P04626	P	From MGI
	GO:0007166	cell surface receptor signaling pathway	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:P04626	P	From MGI
	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P04626	P	From MGI
	GO:0007399	nervous system development	MGI:MGI:3512703 PMID:15496447^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3521860 MGI:MGI:3521857 MGI:MGI:1929071	P	From MGI
	GO:0007422	peripheral nervous system development	MGI:MGI:1194988 PMID:9362461^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1928827	P	From MGI
	GO:0007422	peripheral nervous system development	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P06494	P	From MGI
	GO:0007507	heart development	MGI:MGI:1194988 PMID:9362461^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1928827	P	From MGI
	GO:0007507	heart development	MGI:MGI:2181462 PMID:12072561^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2177255	P	From MGI
	GO:0007528	neuromuscular junction development	MGI:MGI:1352956 PMID:10655525^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1929070	P	From MGI
	GO:0008022	protein C-terminus binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P04626	F	From MGI
	GO:0008045	motor axon guidance	MGI:MGI:1352956 PMID:10655525^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1929070	P	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P06494	P	From MGI
	GO:0009925	basal plasma membrane	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P06494	C	From MGI
	GO:0010001	glial cell differentiation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P06494	P	From MGI
	GO:0010008	endosome membrane	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P04626	C	From MGI
	GO:0014065	phosphatidylinositol 3-kinase cascade	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P04626	P	From MGI
	GO:0014068	positive regulation of phosphatidylinositol 3-kinase cascade	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P06494	P	From MGI
	GO:0016020	membrane	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0472	C	From MGI
	GO:0016020	membrane	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR000494 InterPro:IPR006211	C	From MGI
	GO:0016021	integral to membrane	MGI:MGI:3688352 PMID:15609325^[9]	NAS: Non-traceable Author Statement		C	From MGI
	GO:0016301	kinase activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0418	F	From MGI
	GO:0016310	phosphorylation	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0418	P	From MGI
	GO:0016323	basolateral plasma membrane	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P06494	C	From MGI
	GO:0016323	basolateral plasma membrane	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P04626	C	From MGI
	GO:0016324	apical plasma membrane	MGI:MGI:3512707 PMID:15306553^[4]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0016324	apical plasma membrane	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P06494	C	From MGI
	GO:0016740	transferase activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0808	F	From MGI
	GO:0016772	transferase activity, transferring phosphorus-containing groups	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR011009	F	From MGI
	GO:0019903	protein phosphatase binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P04626	F	From MGI
	GO:0030307	positive regulation of cell growth	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P04626	P	From MGI
	GO:0031625	ubiquitin protein ligase binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P06494	F	From MGI
	GO:0032321	positive regulation of Rho GTPase activity	MGI:MGI:5297297 PMID:22019888^[1]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0032886	regulation of microtubule-based process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P04626	P	From MGI
	GO:0033088	negative regulation of immature T cell proliferation in thymus	MGI:MGI:3695084 PMID:16230479^[10]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0042060	wound healing	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P04626	P	From MGI
	GO:0042552	myelination	MGI:MGI:2176559 PMID:10704452^[11]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2177255	P	From MGI
	GO:0042802	identical protein binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P04626	F	From MGI
	GO:0043066	negative regulation of apoptotic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P06494	P	From MGI
	GO:0043219	lateral loop	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P06494	C	From MGI
	GO:0043235	receptor complex	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P04626	C	From MGI
	GO:0043406	positive regulation of MAP kinase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P04626	P	From MGI
	GO:0043410	positive regulation of MAPK cascade	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P06494	P	From MGI
	GO:0045121	membrane raft	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P06494	C	From MGI
	GO:0045211	postsynaptic membrane	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P06494	C	From MGI
	GO:0045727	positive regulation of translation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P04626	P	From MGI
	GO:0045785	positive regulation of cell adhesion	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P04626	P	From MGI
	GO:0045943	positive regulation of transcription from RNA polymerase I promoter	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P04626	P	From MGI
	GO:0045945	positive regulation of transcription from RNA polymerase III promoter	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P04626	P	From MGI
	GO:0046579	positive regulation of Ras protein signal transduction	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P06494	P	From MGI
	GO:0046777	protein autophosphorylation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P06494	P	From MGI
	GO:0046777	protein autophosphorylation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P04626	P	From MGI
	GO:0046982	protein heterodimerization activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P06494	F	From MGI
	GO:0046982	protein heterodimerization activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P04626	F	From MGI
	GO:0048471	perinuclear region of cytoplasm	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P06494	C	From MGI
	GO:0048485	sympathetic nervous system development	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P06494	P	From MGI
	GO:0048678	response to axon injury	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P06494	P	From MGI
	GO:0050679	positive regulation of epithelial cell proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P04626	P	From MGI
	GO:0051879	Hsp90 protein binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P06494	F	From MGI
	GO:0060209	estrus	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P06494	P	From MGI
	GO:0070372	regulation of ERK1 and ERK2 cascade	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P04626	P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Negishi-Koga T et al. (2011) Suppression of bone formation by osteoclastic expression of semaphorin 4D. Nat Med 17: 1473-80 PubMed GONUTS page
↑ Fu AK et al. (2001) Cdk5 is involved in neuregulin-induced AChR expression at the neuromuscular junction. Nat Neurosci 4: 374-81 PubMed GONUTS page
↑ Sakamoto K et al. (2010) Janus kinase 2 is required for the initiation but not maintenance of prolactin-induced mammary cancer. Oncogene 29: 5359-69 PubMed GONUTS page
↑ ^4.0 ^4.1 Brown N et al. (2004) Embryo-uterine interactions via the neuregulin family of growth factors during implantation in the mouse. Biol Reprod 71: 2003-11 PubMed GONUTS page
↑ Chan R et al. (2004) Modulation of Erbb2 signaling during development: a threshold level of Erbb2 signaling is required for development. Development 131: 5551-60 PubMed GONUTS page
↑ ^6.0 ^6.1 Erickson SL et al. (1997) ErbB3 is required for normal cerebellar and cardiac development: a comparison with ErbB2-and heregulin-deficient mice. Development 124: 4999-5011 PubMed GONUTS page
↑ Ozcelik C et al. (2002) Conditional mutation of the ErbB2 (HER2) receptor in cardiomyocytes leads to dilated cardiomyopathy. Proc Natl Acad Sci U S A 99: 8880-5 PubMed GONUTS page
↑ ^8.0 ^8.1 Lin W et al. (2000) Aberrant development of motor axons and neuromuscular synapses in erbB2-deficient mice. Proc Natl Acad Sci U S A 97: 1299-304 PubMed GONUTS page
↑ Beckers J et al. (2005) Identification and validation of novel ERBB2 (HER2, NEU) targets including genes involved in angiogenesis. Int J Cancer 114: 590-7 PubMed GONUTS page
↑ Chang X et al. (2005) The Scurfy mutation of FoxP3 in the thymus stroma leads to defective thymopoiesis. J Exp Med 202: 1141-51 PubMed GONUTS page
↑ Garratt AN et al. (2000) A dual role of erbB2 in myelination and in expansion of the schwann cell precursor pool. J Cell Biol 148: 1035-46 PubMed GONUTS page

[PMID:22019888-0] 1.0 ^1.1 Negishi-Koga T et al. (2011) Suppression of bone formation by osteoclastic expression of semaphorin 4D. Nat Med 17: 1473-80 PubMed GONUTS page

[PMID:11276227-1] Fu AK et al. (2001) Cdk5 is involved in neuregulin-induced AChR expression at the neuromuscular junction. Nat Neurosci 4: 374-81 PubMed GONUTS page

[PMID:20639901-2] Sakamoto K et al. (2010) Janus kinase 2 is required for the initiation but not maintenance of prolactin-induced mammary cancer. Oncogene 29: 5359-69 PubMed GONUTS page

[PMID:15306553-3] 4.0 ^4.1 Brown N et al. (2004) Embryo-uterine interactions via the neuregulin family of growth factors during implantation in the mouse. Biol Reprod 71: 2003-11 PubMed GONUTS page

[PMID:15496447-4] Chan R et al. (2004) Modulation of Erbb2 signaling during development: a threshold level of Erbb2 signaling is required for development. Development 131: 5551-60 PubMed GONUTS page

[PMID:9362461-5] 6.0 ^6.1 Erickson SL et al. (1997) ErbB3 is required for normal cerebellar and cardiac development: a comparison with ErbB2-and heregulin-deficient mice. Development 124: 4999-5011 PubMed GONUTS page

[PMID:12072561-6] Ozcelik C et al. (2002) Conditional mutation of the ErbB2 (HER2) receptor in cardiomyocytes leads to dilated cardiomyopathy. Proc Natl Acad Sci U S A 99: 8880-5 PubMed GONUTS page

[PMID:10655525-7] 8.0 ^8.1 Lin W et al. (2000) Aberrant development of motor axons and neuromuscular synapses in erbB2-deficient mice. Proc Natl Acad Sci U S A 97: 1299-304 PubMed GONUTS page

[PMID:15609325-8] Beckers J et al. (2005) Identification and validation of novel ERBB2 (HER2, NEU) targets including genes involved in angiogenesis. Int J Cancer 114: 590-7 PubMed GONUTS page

[PMID:16230479-9] Chang X et al. (2005) The Scurfy mutation of FoxP3 in the thymus stroma leads to defective thymopoiesis. J Exp Med 202: 1141-51 PubMed GONUTS page

[PMID:10704452-10] Garratt AN et al. (2000) A dual role of erbB2 in myelination and in expansion of the schwann cell precursor pool. J Cell Biol 148: 1035-46 PubMed GONUTS page

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MGI:Erbb2

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