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MGI:Eps8

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Contents

Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Eps8
Protein Name(s) epidermal growth factor receptor pathway substrate 8,
External Links
MGI MGI:104684

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005515

protein binding

MGI:MGI:3690183
PMID:9010225[1]

IPI: Inferred from Physical Interaction

UniProtKB:Q8CBW3
UniProtKB:Q8IZP0

F

From MGI

GO:0005515

protein binding

MGI:MGI:3799612
PMID:15289329[2]

IPI: Inferred from Physical Interaction

UniProtKB:Q8IZP0
UniProtKB:Q9UQB8

F

From MGI

GO:0005515

protein binding

MGI:MGI:3846509
PMID:19208628[3]

IPI: Inferred from Physical Interaction

UniProtKB:Q8BKX1

F

From MGI

GO:0005515

protein binding

MGI:MGI:4412430
PMID:19528316[4]

IPI: Inferred from Physical Interaction

UniProtKB:O43813

F

From MGI

GO:0008344

adult locomotory behavior

MGI:MGI:3692803
PMID:17018287[5]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3693626

P

From MGI

GO:0014069

postsynaptic density

MGI:MGI:3692803
PMID:17018287[5]

IDA: Inferred from Direct Assay

C

From MGI

GO:0017146

N-methyl-D-aspartate selective glutamate receptor complex

MGI:MGI:3692803
PMID:17018287[5]

IDA: Inferred from Direct Assay

C

From MGI

GO:0019717

synaptosome

MGI:MGI:3692803
PMID:17018287[5]

IDA: Inferred from Direct Assay

C

From MGI

GO:0031532

actin cytoskeleton reorganization

MGI:MGI:3692803
PMID:17018287[5]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3693626

P

From MGI

GO:0048149

behavioral response to ethanol

MGI:MGI:3692803
PMID:17018287[5]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3693626

P

From MGI

GO:0051017

actin filament bundle assembly

MGI:MGI:3846509
PMID:19208628[3]

IGI: Inferred from Genetic Interaction

MGI:MGI:2137336

P

From MGI


Notes

References

See Help:References for how to manage references in GONUTS.
  1. Biesova Z et al. (1997) Isolation and characterization of e3B1, an eps8 binding protein that regulates cell growth. Oncogene 14: 233-41 PubMed GONUTS page
  2. Funato Y et al. (2004) IRSp53/Eps8 complex is important for positive regulation of Rac and cancer cell motility/invasiveness. Cancer Res 64: 5237-44 PubMed GONUTS page
  3. 3.0 3.1 Sawallisch C et al. (2009) The insulin receptor substrate of 53 kDa (IRSp53) limits hippocampal synaptic plasticity. J Biol Chem 284: 9225-36 PubMed GONUTS page
  4. Zhang W et al. (2009) Structure of human lanthionine synthetase C-like protein 1 and its interaction with Eps8 and glutathione. Genes Dev 23: 1387-92 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 5.4 5.5 Offenhäuser N et al. (2006) Increased ethanol resistance and consumption in Eps8 knockout mice correlates with altered actin dynamics. Cell 127: 213-26 PubMed GONUTS page
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