MGI:Epas1

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	MGI:MGI:5306879 PMID:21856340^[1]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0001525	angiogenesis	MGI:MGI:2181852 PMID:12053176^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2663583	P	From MGI
	GO:0001525	angiogenesis	MGI:MGI:3530393 PMID:15728559^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1861921	P	From MGI
	GO:0001525	angiogenesis	MGI:MGI:3588546 PMID:15851592^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2386334	P	From MGI
	GO:0001666	response to hypoxia	MGI:MGI:2176655 PMID:11782478^[5]	ISO: Inferred from Sequence Orthology	UniProtKB:Q99814	P	From MGI
	GO:0001666	response to hypoxia	MGI:MGI:3578492 PMID:15626745^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1861921	P	From MGI
	GO:0001666	response to hypoxia	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_075578	P	From MGI
	GO:0001892	embryonic placenta development	MGI:MGI:3703383 PMID:16287860^[7]	IGI: Inferred from Genetic Interaction	MGI:MGI:106918	P	From MGI
	GO:0001974	blood vessel remodeling	MGI:MGI:1860986 PMID:10880563^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2386334	P	From MGI
	GO:0002027	regulation of heart rate	MGI:MGI:1313089 PMID:9808618^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1861921	P	From MGI
	GO:0003677	DNA binding	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:Q99814	F	From MGI
	GO:0003677	DNA binding	MGI:MGI:2451217 PMID:12464608^[10]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003677	DNA binding	MGI:MGI:3709688 PMID:17404621^[11]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003677	DNA binding	MGI:MGI:894004 PMID:9113979^[12]	IGI: Inferred from Genetic Interaction	MGI:MGI:88071	F	From MGI
	GO:0003700	sequence-specific DNA binding transcription factor activity	MGI:MGI:2451217 PMID:12464608^[10]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003700	sequence-specific DNA binding transcription factor activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_075578	F	From MGI
	GO:0004871	signal transducer activity	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR000014	F	From MGI
	GO:0005634	nucleus	MGI:MGI:2451217 PMID:12464608^[10]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_075578	C	From MGI
	GO:0005667	transcription factor complex	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:Q99814	C	From MGI
	GO:0005667	transcription factor complex	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:Q99814	C	From MGI
	GO:0005667	transcription factor complex	MGI:MGI:2451217 PMID:12464608^[10]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:2667513 PMID:12832481^[13]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_075578	C	From MGI
	GO:0006351	transcription, DNA-dependent	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0804	P	From MGI
	GO:0006355	regulation of transcription, DNA-dependent	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0805	P	From MGI
	GO:0006355	regulation of transcription, DNA-dependent	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR001067 InterPro:IPR001610 InterPro:IPR013767	P	From MGI
	GO:0006979	response to oxidative stress	MGI:MGI:2681387 PMID:14608355^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1861921	P	From MGI
	GO:0006979	response to oxidative stress	MGI:MGI:3709427 PMID:17322295^[15]	IGI: Inferred from Genetic Interaction	MGI:MGI:98352	P	From MGI
	GO:0007005	mitochondrion organization	MGI:MGI:2681387 PMID:14608355^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1861921	P	From MGI
	GO:0007165	signal transduction	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR001610 InterPro:IPR000014	P	From MGI
	GO:0007275	multicellular organismal development	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0217	P	From MGI
	GO:0007601	visual perception	MGI:MGI:3530393 PMID:15728559^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1861921	P	From MGI
	GO:0008134	transcription factor binding	MGI:MGI:2451217 PMID:12464608^[10]	IPI: Inferred from Physical Interaction	UniProtKB:P27577	F	From MGI
	GO:0008134	transcription factor binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q99814	F	From MGI
	GO:0030097	hemopoiesis	MGI:MGI:2673768 PMID:12750163^[16]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1861921	P	From MGI
	GO:0030097	hemopoiesis	MGI:MGI:3578492 PMID:15626745^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1861921	P	From MGI
	GO:0030154	cell differentiation	MGI:MGI:3703383 PMID:16287860^[7]	IGI: Inferred from Genetic Interaction	MGI:MGI:106918	P	From MGI
	GO:0030218	erythrocyte differentiation	MGI:MGI:3703197 PMID:17284606^[17]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3710344	P	From MGI
	GO:0030324	lung development	MGI:MGI:2181852 PMID:12053176^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2663583	P	From MGI
	GO:0035035	histone acetyltransferase binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q99814	F	From MGI
	GO:0042415	norepinephrine metabolic process	MGI:MGI:1313089 PMID:9808618^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1861921	P	From MGI
	GO:0043129	surfactant homeostasis	MGI:MGI:2181852 PMID:12053176^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2663583	P	From MGI
	GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress	MGI:MGI:2681387 PMID:14608355^[14]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress	MGI:MGI:3703197 PMID:17284606^[17]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3710344	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:Q99814	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:Q99814	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:2451217 PMID:12464608^[10]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:2451217 PMID:12464608^[10]	IGI: Inferred from Genetic Interaction	MGI:MGI:95455	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:3709427 PMID:17322295^[15]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:3709688 PMID:17404621^[11]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3526731	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_075578	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:894004 PMID:9113979^[12]	IGI: Inferred from Genetic Interaction	MGI:MGI:88071	P	From MGI
	GO:0046982	protein heterodimerization activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q99814	F	From MGI
	GO:0046982	protein heterodimerization activity	MGI:MGI:894004 PMID:9113979^[12]	IPI: Inferred from Physical Interaction	UniProtKB:P53762	F	From MGI
	GO:0048469	cell maturation	MGI:MGI:2181852 PMID:12053176^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2663583	P	From MGI
	GO:0048625	myoblast cell fate commitment	MGI:MGI:4867337 PMID:21106753^[18]	IMP: Inferred from Mutant Phenotype		P	From MGI
NOT	GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress	MGI:MGI:2667513 PMID:12832481^[13]	IGI: Inferred from Genetic Interaction	MGI:MGI:106918	P	From MGI
contributes_to	GO:0043565	sequence-specific DNA binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_075578	F	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ An HJ et al. (2011) The survival effect of mitochondrial Higd-1a is associated with suppression of cytochrome C release and prevention of caspase activation. Biochim Biophys Acta 1813: 2088-98 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Compernolle V et al. (2002) Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice. Nat Med 8: 702-10 PubMed GONUTS page
↑ ^3.0 ^3.1 Ding K et al. (2005) Retinal disease in mice lacking hypoxia-inducible transcription factor-2alpha. Invest Ophthalmol Vis Sci 46: 1010-6 PubMed GONUTS page
↑ Duan LJ et al. (2005) Endothelium-intrinsic requirement for Hif-2alpha during vascular development. Circulation 111: 2227-32 PubMed GONUTS page
↑ Woods SL & Whitelaw ML (2002) Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors. J Biol Chem 277: 10236-43 PubMed GONUTS page
↑ ^6.0 ^6.1 Scortegagna M et al. (2005) HIF-2alpha regulates murine hematopoietic development in an erythropoietin-dependent manner. Blood 105: 3133-40 PubMed GONUTS page
↑ ^7.0 ^7.1 Cowden Dahl KD et al. (2005) Hypoxia-inducible factors 1alpha and 2alpha regulate trophoblast differentiation. Mol Cell Biol 25: 10479-91 PubMed GONUTS page
↑ Peng J et al. (2000) The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling. Proc Natl Acad Sci U S A 97: 8386-91 PubMed GONUTS page
↑ ^9.0 ^9.1 Tian H et al. (1998) The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development. Genes Dev 12: 3320-4 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 Elvert G et al. (2003) Cooperative interaction of hypoxia-inducible factor-2alpha (HIF-2alpha ) and Ets-1 in the transcriptional activation of vascular endothelial growth factor receptor-2 (Flk-1). J Biol Chem 278: 7520-30 PubMed GONUTS page
↑ ^11.0 ^11.1 Rankin EB et al. (2007) Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo. J Clin Invest 117: 1068-77 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Ema M et al. (1997) A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development. Proc Natl Acad Sci U S A 94: 4273-8 PubMed GONUTS page
↑ ^13.0 ^13.1 Park SK et al. (2003) Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alpha. Mol Cell Biol 23: 4959-71 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Scortegagna M et al. (2003) Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1-/- mice. Nat Genet 35: 331-40 PubMed GONUTS page
↑ ^15.0 ^15.1 Oktay Y et al. (2007) Hypoxia-inducible factor 2alpha regulates expression of the mitochondrial aconitase chaperone protein frataxin. J Biol Chem 282: 11750-6 PubMed GONUTS page
↑ Scortegagna M et al. (2003) The HIF family member EPAS1/HIF-2alpha is required for normal hematopoiesis in mice. Blood 102: 1634-40 PubMed GONUTS page
↑ ^17.0 ^17.1 Gruber M et al. (2007) Acute postnatal ablation of Hif-2alpha results in anemia. Proc Natl Acad Sci U S A 104: 2301-6 PubMed GONUTS page
↑ Rasbach KA et al. (2010) PGC-1alpha regulates a HIF2alpha-dependent switch in skeletal muscle fiber types. Proc Natl Acad Sci U S A 107: 21866-71 PubMed GONUTS page

[PMID:21856340-0] An HJ et al. (2011) The survival effect of mitochondrial Higd-1a is associated with suppression of cytochrome C release and prevention of caspase activation. Biochim Biophys Acta 1813: 2088-98 PubMed GONUTS page

[PMID:12053176-1] 2.0 ^2.1 ^2.2 ^2.3 Compernolle V et al. (2002) Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice. Nat Med 8: 702-10 PubMed GONUTS page

[PMID:15728559-2] 3.0 ^3.1 Ding K et al. (2005) Retinal disease in mice lacking hypoxia-inducible transcription factor-2alpha. Invest Ophthalmol Vis Sci 46: 1010-6 PubMed GONUTS page

[PMID:15851592-3] Duan LJ et al. (2005) Endothelium-intrinsic requirement for Hif-2alpha during vascular development. Circulation 111: 2227-32 PubMed GONUTS page

[PMID:11782478-4] Woods SL & Whitelaw ML (2002) Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors. J Biol Chem 277: 10236-43 PubMed GONUTS page

[PMID:15626745-5] 6.0 ^6.1 Scortegagna M et al. (2005) HIF-2alpha regulates murine hematopoietic development in an erythropoietin-dependent manner. Blood 105: 3133-40 PubMed GONUTS page

[PMID:16287860-6] 7.0 ^7.1 Cowden Dahl KD et al. (2005) Hypoxia-inducible factors 1alpha and 2alpha regulate trophoblast differentiation. Mol Cell Biol 25: 10479-91 PubMed GONUTS page

[PMID:10880563-7] Peng J et al. (2000) The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling. Proc Natl Acad Sci U S A 97: 8386-91 PubMed GONUTS page

[PMID:9808618-8] 9.0 ^9.1 Tian H et al. (1998) The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development. Genes Dev 12: 3320-4 PubMed GONUTS page

[PMID:12464608-9] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 Elvert G et al. (2003) Cooperative interaction of hypoxia-inducible factor-2alpha (HIF-2alpha ) and Ets-1 in the transcriptional activation of vascular endothelial growth factor receptor-2 (Flk-1). J Biol Chem 278: 7520-30 PubMed GONUTS page

[PMID:17404621-10] 11.0 ^11.1 Rankin EB et al. (2007) Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo. J Clin Invest 117: 1068-77 PubMed GONUTS page

[PMID:9113979-11] 12.0 ^12.1 ^12.2 Ema M et al. (1997) A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development. Proc Natl Acad Sci U S A 94: 4273-8 PubMed GONUTS page

[PMID:12832481-12] 13.0 ^13.1 Park SK et al. (2003) Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alpha. Mol Cell Biol 23: 4959-71 PubMed GONUTS page

[PMID:14608355-13] 14.0 ^14.1 ^14.2 Scortegagna M et al. (2003) Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1-/- mice. Nat Genet 35: 331-40 PubMed GONUTS page

[PMID:17322295-14] 15.0 ^15.1 Oktay Y et al. (2007) Hypoxia-inducible factor 2alpha regulates expression of the mitochondrial aconitase chaperone protein frataxin. J Biol Chem 282: 11750-6 PubMed GONUTS page

[PMID:12750163-15] Scortegagna M et al. (2003) The HIF family member EPAS1/HIF-2alpha is required for normal hematopoiesis in mice. Blood 102: 1634-40 PubMed GONUTS page

[PMID:17284606-16] 17.0 ^17.1 Gruber M et al. (2007) Acute postnatal ablation of Hif-2alpha results in anemia. Proc Natl Acad Sci U S A 104: 2301-6 PubMed GONUTS page

[PMID:21106753-17] Rasbach KA et al. (2010) PGC-1alpha regulates a HIF2alpha-dependent switch in skeletal muscle fiber types. Proc Natl Acad Sci U S A 107: 21866-71 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Epas1 ( synonyms: bHLHe73, Hif like protein, HIF-2alpha, HIF2A, HLF, HRF, hypoxia inducible transcription factor 2alpha, MOP2 )
Protein Name(s)	endothelial PAS domain protein 1,
External Links
MGI	MGI:109169

MGI:Epas1

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