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MGI:Eng
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Eng ( synonyms: CD105 ) | |
| Protein Name(s) | endoglin, | |
| External Links | ||
| MGI | MGI:95392 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0001525 |
angiogenesis |
MGI:MGI:2155227 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2177822 |
P |
From MGI |
||
| GO:0001525 |
angiogenesis |
MGI:MGI:2674189 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2177823 |
P |
From MGI |
||
| GO:0001569 |
patterning of blood vessels |
MGI:MGI:1337912 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0001570 |
vasculogenesis |
MGI:MGI:1337912 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0001570 |
vasculogenesis |
MGI:MGI:1347732 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2177824 |
P |
From MGI |
||
| GO:0001570 |
vasculogenesis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0001666 |
response to hypoxia |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0001934 |
positive regulation of protein phosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0001937 |
negative regulation of endothelial cell proliferation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0001947 |
heart looping |
MGI:MGI:1337912 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0003084 |
positive regulation of systemic arterial blood pressure |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0003273 |
cell migration involved in endocardial cushion formation |
MGI:MGI:4368063 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2177824 |
P |
From MGI |
||
| GO:0005024 |
transforming growth factor beta-activated receptor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005072 |
transforming growth factor beta receptor, cytoplasmic mediator activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005114 |
type II transforming growth factor beta receptor binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005534 |
galactose binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005539 |
glycosaminoglycan binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005615 |
extracellular space |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005624 |
membrane fraction |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007155 |
cell adhesion |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0130 |
P |
From MGI |
||
| GO:0007179 |
transforming growth factor beta receptor signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007179 |
transforming growth factor beta receptor signaling pathway |
MGI:MGI:66318 |
IC: Inferred by Curator |
GO:0050431 |
P |
From MGI |
||
| GO:0007507 |
heart development |
MGI:MGI:1347732 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2177824 |
P |
From MGI |
||
| GO:0007507 |
heart development |
MGI:MGI:2155227 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2177822 |
P |
From MGI |
||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0009986 |
cell surface |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0010862 |
positive regulation of pathway-restricted SMAD protein phosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016021 |
integral to membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0812 |
C |
From MGI |
||
| GO:0016477 |
cell migration |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0017015 |
regulation of transforming growth factor beta receptor signaling pathway |
MGI:MGI:2155227 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0017015 |
regulation of transforming growth factor beta receptor signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0022009 |
central nervous system vasculogenesis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0022617 |
extracellular matrix disassembly |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030336 |
negative regulation of cell migration |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030513 |
positive regulation of BMP signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0031953 |
negative regulation of protein autophosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0034713 |
type I transforming growth factor beta receptor binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0042060 |
wound healing |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042803 |
protein homodimerization activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0042803 |
protein homodimerization activity |
MGI:MGI:66318 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0045766 |
positive regulation of angiogenesis |
MGI:MGI:4830635 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0048745 |
smooth muscle tissue development |
MGI:MGI:1337912 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0048844 |
artery morphogenesis |
MGI:MGI:1337912 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0048845 |
venous blood vessel morphogenesis |
MGI:MGI:1337912 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0048870 |
cell motility |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0050431 |
transforming growth factor beta binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0050431 |
transforming growth factor beta binding |
MGI:MGI:66318 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0051001 |
negative regulation of nitric-oxide synthase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0060326 |
cell chemotaxis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0060394 |
negative regulation of pathway-restricted SMAD protein phosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0070483 |
detection of hypoxia |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0072563 |
endothelial microparticle |
MGI:MGI:4850200 |
IDA: Inferred from Direct Assay |
C |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Arthur HM et al. (2000) Endoglin, an ancillary TGFbeta receptor, is required for extraembryonic angiogenesis and plays a key role in heart development. Dev Biol 217: 42-53 PubMed GONUTS page
- ↑ Sorensen LK et al. (2003) Loss of distinct arterial and venous boundaries in mice lacking endoglin, a vascular-specific TGFbeta coreceptor. Dev Biol 261: 235-50 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 Li DY et al. (1999) Defective angiogenesis in mice lacking endoglin. Science 284: 1534-7 PubMed GONUTS page
- ↑ 4.0 4.1 Bourdeau A et al. (1999) A murine model of hereditary hemorrhagic telangiectasia. J Clin Invest 104: 1343-51 PubMed GONUTS page
- ↑ Nomura-Kitabayashi A et al. (2009) Endoglin is dispensable for angiogenesis, but required for endocardial cushion formation in the midgestation mouse embryo. Dev Biol 335: 66-77 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 St-Jacques S et al. (1994) Molecular characterization and in situ localization of murine endoglin reveal that it is a transforming growth factor-beta binding protein of endothelial and stromal cells. Endocrinology 134: 2645-57 PubMed GONUTS page
- ↑ Suzuki Y et al. (2010) BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo. J Cell Sci 123: 1684-92 PubMed GONUTS page
- ↑ Li W et al. (2010) CD36 participates in a signaling pathway that regulates ROS formation in murine VSMCs. J Clin Invest 120: 3996-4006 PubMed GONUTS page
