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MGI:Elane
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Elane ( synonyms: Ela2, NE ) | |
| Protein Name(s) | elastase, neutrophil expressed, | |
| External Links | ||
| MGI | MGI:2679229 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001878 |
response to yeast |
MGI:MGI:4353632 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2182177 |
P |
From MGI |
||
| GO:0002020 |
protease binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0002438 |
acute inflammatory response to antigenic stimulus |
MGI:MGI:4358050 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0003824 |
catalytic activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0004175 |
endopeptidase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004252 |
serine-type endopeptidase activity |
MGI:MGI:4358050 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4358050 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006508 |
proteolysis |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006909 |
phagocytosis |
MGI:MGI:3036957 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2182771 |
P |
From MGI |
||
| GO:0008152 |
metabolic process |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0378 |
P |
From MGI |
||
| GO:0008152 |
metabolic process |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0008201 |
heparin binding |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0008233 |
peptidase activity |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0008236 |
serine-type peptidase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0720 |
F |
From MGI |
||
| GO:0009411 |
response to UV |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0009986 |
cell surface |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0016787 |
hydrolase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0378 |
F |
From MGI |
||
| GO:0019955 |
cytokine binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0030141 |
secretory granule |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0032496 |
response to lipopolysaccharide |
MGI:MGI:2182072 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:88563 |
P |
From MGI |
||
| GO:0032496 |
response to lipopolysaccharide |
MGI:MGI:2182072 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2182177 |
P |
From MGI |
||
| GO:0044130 |
negative regulation of growth of symbiont in host |
MGI:MGI:2182072 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:88563 |
P |
From MGI |
||
| GO:0044130 |
negative regulation of growth of symbiont in host |
MGI:MGI:2182072 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2182177 |
P |
From MGI |
||
| GO:0045079 |
negative regulation of chemokine biosynthetic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045415 |
negative regulation of interleukin-8 biosynthetic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045416 |
positive regulation of interleukin-8 biosynthetic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0048661 |
positive regulation of smooth muscle cell proliferation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0050778 |
positive regulation of immune response |
MGI:MGI:2182072 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:88563 |
P |
From MGI |
||
| GO:0050778 |
positive regulation of immune response |
MGI:MGI:2182072 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2182177 |
P |
From MGI |
||
| GO:0050832 |
defense response to fungus |
MGI:MGI:2182072 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:88563 |
P |
From MGI |
||
| GO:0050832 |
defense response to fungus |
MGI:MGI:2182072 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2182177 |
P |
From MGI |
||
| GO:0050832 |
defense response to fungus |
MGI:MGI:4353632 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2182177 |
P |
From MGI |
||
| GO:0050900 |
leukocyte migration |
MGI:MGI:3036957 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2182771 |
P |
From MGI |
||
| GO:0070947 |
neutrophil mediated killing of fungus |
MGI:MGI:4353632 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2182177 |
P |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Reeves EP et al. (2002) Killing activity of neutrophils is mediated through activation of proteases by K+ flux. Nature 416: 291-7 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Zhang M et al. (2007) Serine protease inhibitor 6-deficient mice have increased neutrophil immunity to Pseudomonas aeruginosa. J Immunol 179: 4390-6 PubMed GONUTS page
- ↑ 3.0 3.1 Young RE et al. (2004) Neutrophil elastase (NE)-deficient mice demonstrate a nonredundant role for NE in neutrophil migration, generation of proinflammatory mediators, and phagocytosis in response to zymosan particles in vivo. J Immunol 172: 4493-502 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 Tkalcevic J et al. (2000) Impaired immunity and enhanced resistance to endotoxin in the absence of neutrophil elastase and cathepsin G. Immunity 12: 201-10 PubMed GONUTS page
