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MGI:Eif2ak4
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Eif2ak4 ( synonyms: GCN2 ) | |
| Protein Name(s) | eukaryotic translation initiation factor 2 alpha kinase 4, | |
| External Links | ||
| MGI | MGI:1353427 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000049 |
tRNA binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0000166 |
nucleotide binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0547 |
F |
From MGI |
||
| GO:0003743 |
translation initiation factor activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0396 |
F |
From MGI |
||
| GO:0004672 |
protein kinase activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0004674 |
protein serine/threonine kinase activity |
MGI:MGI:1346365 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004694 |
eukaryotic translation initiation factor 2alpha kinase activity |
MGI:MGI:1346365 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005524 |
ATP binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0067 |
F |
From MGI |
||
| GO:0005524 |
ATP binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0006413 |
translational initiation |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0396 |
P |
From MGI |
||
| GO:0006446 |
regulation of translational initiation |
MGI:MGI:1346365 |
ISS: Inferred from Sequence or Structural Similarity |
P |
From MGI |
|||
| GO:0006468 |
protein phosphorylation |
MGI:MGI:1346365 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0009267 |
cellular response to starvation |
MGI:MGI:3589702 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0016301 |
kinase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0418 |
F |
From MGI |
||
| GO:0016310 |
phosphorylation |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0418 |
P |
From MGI |
||
| GO:0016740 |
transferase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0808 |
F |
From MGI |
||
| GO:0016772 |
transferase activity, transferring phosphorus-containing groups |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0017148 |
negative regulation of translation |
MGI:MGI:3620306 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1341830 |
P |
From MGI |
||
| GO:0022626 |
cytosolic ribosome |
MGI:MGI:3687696 |
ISS: Inferred from Sequence or Structural Similarity |
C |
From MGI |
|||
| GO:0030968 |
endoplasmic reticulum unfolded protein response |
MGI:MGI:3620306 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2387965 |
P |
From MGI |
||
| GO:0042803 |
protein homodimerization activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0043558 |
regulation of translational initiation in response to stress |
MGI:MGI:3589702 |
IDA: Inferred from Direct Assay |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Berlanga JJ et al. (1999) Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase. Eur J Biochem 265: 754-62 PubMed GONUTS page
- ↑ 2.0 2.1 Pereira CM et al. (2005) IMPACT, a protein preferentially expressed in the mouse brain, binds GCN1 and inhibits GCN2 activation. J Biol Chem 280: 28316-23 PubMed GONUTS page
- ↑ 3.0 3.1 Hamanaka RB et al. (2005) PERK and GCN2 contribute to eIF2alpha phosphorylation and cell cycle arrest after activation of the unfolded protein response pathway. Mol Biol Cell 16: 5493-501 PubMed GONUTS page
- ↑ Dever TE et al. (1992) Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast. Cell 68: 585-96 PubMed GONUTS page
