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MGI:Ehmt2
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Ehmt2 ( synonyms: Bat8, D17Ertd710e, G9a, KMT1C, NG36 ) | |
| Protein Name(s) | euchromatic histone lysine N-methyltransferase 2, | |
| External Links | ||
| MGI | MGI:2148922 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3710033 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0000239 |
pachytene |
MGI:MGI:3717933 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3718790 |
P |
From MGI |
||
| GO:0002039 |
p53 binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3575040 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3826717 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4441247 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3511615 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3575040 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005694 |
chromosome |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0158 |
C |
From MGI |
||
| GO:0006306 |
DNA methylation |
MGI:MGI:3826717 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006357 |
regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3717933 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3718790 |
P |
From MGI |
||
| GO:0007130 |
synaptonemal complex assembly |
MGI:MGI:3717933 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3718790 |
P |
From MGI |
||
| GO:0007281 |
germ cell development |
MGI:MGI:3717933 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3718790 |
P |
From MGI |
||
| GO:0007286 |
spermatid development |
MGI:MGI:3717933 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3718790 |
P |
From MGI |
||
| GO:0008168 |
methyltransferase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0489 |
F |
From MGI |
||
| GO:0008270 |
zinc ion binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0009566 |
fertilization |
MGI:MGI:3717933 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3718790 |
P |
From MGI |
||
| GO:0010424 |
DNA methylation on cytosine within a CG sequence |
MGI:MGI:3718157 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0016279 |
protein-lysine N-methyltransferase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0016568 |
chromatin modification |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0156 |
P |
From MGI |
||
| GO:0016740 |
transferase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0808 |
F |
From MGI |
||
| GO:0018022 |
peptidyl-lysine methylation |
MGI:MGI:2152096 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0018022 |
peptidyl-lysine methylation |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0018022 |
peptidyl-lysine methylation |
MGI:MGI:3575040 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0018022 |
peptidyl-lysine methylation |
MGI:MGI:3826717 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0018024 |
histone-lysine N-methyltransferase activity |
MGI:MGI:2152096 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0018024 |
histone-lysine N-methyltransferase activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0018027 |
peptidyl-lysine dimethylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032259 |
methylation |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0489 |
P |
From MGI |
||
| GO:0034968 |
histone lysine methylation |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0035265 |
organ growth |
MGI:MGI:3717933 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3718790 |
P |
From MGI |
||
| GO:0046872 |
metal ion binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0479 |
F |
From MGI |
||
| GO:0046974 |
histone methyltransferase activity (H3-K9 specific) |
MGI:MGI:3575040 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0046974 |
histone methyltransferase activity (H3-K9 specific) |
MGI:MGI:3826717 |
IMP: Inferred from Mutant Phenotype |
F |
From MGI |
|||
| GO:0046976 |
histone methyltransferase activity (H3-K27 specific) |
MGI:MGI:3575040 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0051567 |
histone H3-K9 methylation |
MGI:MGI:3575040 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0051567 |
histone H3-K9 methylation |
MGI:MGI:3589499 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0051567 |
histone H3-K9 methylation |
MGI:MGI:3717933 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3718790 |
P |
From MGI |
||
| GO:0051567 |
histone H3-K9 methylation |
MGI:MGI:3718157 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0070734 |
histone H3-K27 methylation |
MGI:MGI:3575040 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0070734 |
histone H3-K27 methylation |
MGI:MGI:3718157 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Wang J et al. (2007) Opposing LSD1 complexes function in developmental gene activation and repression programmes. Nature 446: 882-7 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Tachibana M et al. (2007) Functional dynamics of H3K9 methylation during meiotic prophase progression. EMBO J 26: 3346-59 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 Tachibana M et al. (2005) Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9. Genes Dev 19: 815-26 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Tachibana M et al. (2008) G9a/GLP complexes independently mediate H3K9 and DNA methylation to silence transcription. EMBO J 27: 2681-90 PubMed GONUTS page
- ↑ Shirato H et al. (2009) A jumonji (Jarid2) protein complex represses cyclin D1 expression by methylation of histone H3-K9. J Biol Chem 284: 733-9 PubMed GONUTS page
- ↑ Ohhata T et al. (2004) X-inactivation is stably maintained in mouse embryos deficient for histone methyl transferase G9a. Genesis 40: 151-6 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 Ikegami K et al. (2007) Genome-wide and locus-specific DNA hypomethylation in G9a deficient mouse embryonic stem cells. Genes Cells 12: 1-11 PubMed GONUTS page
- ↑ Wu R et al. (2005) Differential subnuclear localization and replication timing of histone H3 lysine 9 methylation states. Mol Biol Cell 16: 2872-81 PubMed GONUTS page
