MGI:Egfr

From GONUTS

Jump to: navigation, search

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000166	nucleotide binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0547	F	From MGI
	GO:0000186	activation of MAPKK activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62954	P	From MGI
	GO:0000902	cell morphogenesis	MGI:MGI:3766849 PMID:17686994^[1]	IGI: Inferred from Genetic Interaction	MGI:MGI:107708	P	From MGI
	GO:0001892	embryonic placenta development	MGI:MGI:74263 PMID:7618084^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856402	P	From MGI
	GO:0001942	hair follicle development	MGI:MGI:74263 PMID:7618084^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856402	P	From MGI
	GO:0001948	glycoprotein binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62954	F	From MGI
	GO:0004672	protein kinase activity	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR000719 InterPro:IPR001245	F	From MGI
	GO:0004713	protein tyrosine kinase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P00533	F	From MGI
	GO:0004714	transmembrane receptor protein tyrosine kinase activity	MGI:MGI:2152096	IEA: Inferred from Electronic Annotation	EC:2.7.10.1	F	From MGI
	GO:0004714	transmembrane receptor protein tyrosine kinase activity	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR006211	F	From MGI
	GO:0004716	receptor signaling protein tyrosine kinase activity	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR016245	F	From MGI
	GO:0004871	signal transducer activity	MGI:MGI:2182234 PMID:11940581^[3]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0004872	receptor activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0675	F	From MGI
	GO:0004888	transmembrane signaling receptor activity	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:P00533	F	From MGI
	GO:0005006	epidermal growth factor-activated receptor activity	MGI:MGI:3032880 PMID:14712229^[4]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0005006	epidermal growth factor-activated receptor activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62954	F	From MGI
	GO:0005006	epidermal growth factor-activated receptor activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P00533	F	From MGI
	GO:0005102	receptor binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62954	F	From MGI
	GO:0005178	integrin binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62954	F	From MGI
	GO:0005515	protein binding	MGI:MGI:2429328 PMID:11274221^[5]	IPI: Inferred from Physical Interaction	UniProtKB:P05480	F	From MGI
	GO:0005515	protein binding	MGI:MGI:2675970 PMID:12919676^[6]	IPI: Inferred from Physical Interaction	UniProtKB:P49070	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3531070 PMID:15695332^[7]	IPI: Inferred from Physical Interaction	RefSeq:NP_851419	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3587490 PMID:15728722^[8]	IPI: Inferred from Physical Interaction	RefSeq:NP_851419	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3620312 PMID:16120644^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q80U87	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3722980 PMID:17726113^[10]	IPI: Inferred from Physical Interaction	RefSeq:NP_851419	F	From MGI
	GO:0005524	ATP binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0067	F	From MGI
	GO:0005524	ATP binding	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR006211 InterPro:IPR000719 InterPro:IPR017441 InterPro:IPR016245	F	From MGI
	GO:0005622	intracellular	MGI:MGI:1349243 PMID:10534613^[11]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62954	C	From MGI
	GO:0005634	nucleus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P00533	C	From MGI
	GO:0005634	nucleus	MGI:MGI:4887523 PMID:20208556^[12]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:E9PFD7	C	From MGI
	GO:0005768	endosome	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62954	C	From MGI
	GO:0005768	endosome	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P00533	C	From MGI
	GO:0005783	endoplasmic reticulum	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0256	C	From MGI
	GO:0005794	Golgi apparatus	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0333	C	From MGI
	GO:0005886	plasma membrane	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62954	C	From MGI
	GO:0005886	plasma membrane	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:E9PFD7	C	From MGI
	GO:0005886	plasma membrane	MGI:MGI:75839 PMID:7641815^[13]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0006412	translation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62954	P	From MGI
	GO:0006468	protein phosphorylation	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR006211 InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266 InterPro:IPR020635 InterPro:IPR016245	P	From MGI
	GO:0007165	signal transduction	MGI:MGI:2182234 PMID:11940581^[3]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0007165	signal transduction	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62954	P	From MGI
	GO:0007165	signal transduction	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P00533	P	From MGI
	GO:0007166	cell surface receptor signaling pathway	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:P00533	P	From MGI
	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR006211 InterPro:IPR016245	P	From MGI
	GO:0007173	epidermal growth factor receptor signaling pathway	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:P00533	P	From MGI
	GO:0007173	epidermal growth factor receptor signaling pathway	MGI:MGI:3032880 PMID:14712229^[4]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0007173	epidermal growth factor receptor signaling pathway	MGI:MGI:3531070 PMID:15695332^[7]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0007173	epidermal growth factor receptor signaling pathway	MGI:MGI:3766849 PMID:17686994^[1]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0007173	epidermal growth factor receptor signaling pathway	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62954	P	From MGI
	GO:0007173	epidermal growth factor receptor signaling pathway	MGI:MGI:75839 PMID:7641815^[13]	IGI: Inferred from Genetic Interaction	MGI:MGI:95290	P	From MGI
	GO:0007243	intracellular protein kinase cascade	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62954	P	From MGI
	GO:0007275	multicellular organismal development	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0217	P	From MGI
	GO:0007435	salivary gland morphogenesis	MGI:MGI:1934551 PMID:10521784^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1935113	P	From MGI
	GO:0008283	cell proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P00533	P	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:P00533	P	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:3032880 PMID:14712229^[4]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:3807093 PMID:18656477^[15]	IGI: Inferred from Genetic Interaction	MGI:MGI:99439 MGI:MGI:88039	P	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:75839 PMID:7641815^[13]	IGI: Inferred from Genetic Interaction	MGI:MGI:95290 MGI:MGI:95705	P	From MGI
	GO:0008544	epidermis development	MGI:MGI:74263 PMID:7618084^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856402	P	From MGI
	GO:0009986	cell surface	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62954	C	From MGI
	GO:0016020	membrane	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P00533	C	From MGI
	GO:0016021	integral to membrane	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0812	C	From MGI
	GO:0016021	integral to membrane	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR016245	C	From MGI
	GO:0016301	kinase activity	MGI:MGI:2664443 PMID:12808090^[16]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0016310	phosphorylation	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0418	P	From MGI
	GO:0016323	basolateral plasma membrane	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62954	C	From MGI
	GO:0016323	basolateral plasma membrane	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P00533	C	From MGI
	GO:0016323	basolateral plasma membrane	MGI:MGI:70770 PMID:7723235^[17]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0016324	apical plasma membrane	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62954	C	From MGI
	GO:0016337	cell-cell adhesion	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P00533	P	From MGI
	GO:0016740	transferase activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0808	F	From MGI
	GO:0016772	transferase activity, transferring phosphorus-containing groups	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR011009	F	From MGI
	GO:0019899	enzyme binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P00533	F	From MGI
	GO:0019901	protein kinase binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62954	F	From MGI
	GO:0019903	protein phosphatase binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P00533	F	From MGI
	GO:0021795	cerebral cortex cell migration	MGI:MGI:74263 PMID:7618084^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856402	P	From MGI
	GO:0030139	endocytic vesicle	MGI:MGI:1349243 PMID:10534613^[11]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0030139	endocytic vesicle	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62954	C	From MGI
	GO:0030335	positive regulation of cell migration	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P00533	P	From MGI
	GO:0031659	positive regulation of cyclin-dependent protein kinase activity involved in G1/S	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P00533	P	From MGI
	GO:0035413	positive regulation of catenin import into nucleus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P00533	P	From MGI
	GO:0042127	regulation of cell proliferation	MGI:MGI:2158569 PMID:11818567^[18]	IGI: Inferred from Genetic Interaction	MGI:MGI:88039	P	From MGI
	GO:0042177	negative regulation of protein catabolic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P00533	P	From MGI
	GO:0042327	positive regulation of phosphorylation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P00533	P	From MGI
	GO:0042698	ovulation cycle	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62954	P	From MGI
	GO:0042802	identical protein binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P00533	F	From MGI
	GO:0043066	negative regulation of apoptotic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62954	P	From MGI
	GO:0043066	negative regulation of apoptotic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P00533	P	From MGI
	GO:0043406	positive regulation of MAP kinase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P00533	P	From MGI
	GO:0045121	membrane raft	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P00533	C	From MGI
	GO:0045429	positive regulation of nitric oxide biosynthetic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P00533	P	From MGI
	GO:0045739	positive regulation of DNA repair	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P00533	P	From MGI
	GO:0045740	positive regulation of DNA replication	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P00533	P	From MGI
	GO:0045930	negative regulation of mitotic cell cycle	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62954	P	From MGI
	GO:0046777	protein autophosphorylation	MGI:MGI:3054501 PMID:15314156^[19]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0046777	protein autophosphorylation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62954	P	From MGI
	GO:0046777	protein autophosphorylation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P00533	P	From MGI
	GO:0046982	protein heterodimerization activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62954	F	From MGI
	GO:0046982	protein heterodimerization activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P00533	F	From MGI
	GO:0048143	astrocyte activation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62954	P	From MGI
	GO:0048146	positive regulation of fibroblast proliferation	MGI:MGI:4887523 PMID:20208556^[12]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0048408	epidermal growth factor binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62954	F	From MGI
	GO:0048471	perinuclear region of cytoplasm	MGI:MGI:4887523 PMID:20208556^[12]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0048546	digestive tract morphogenesis	MGI:MGI:74263 PMID:7618084^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856402	P	From MGI
	GO:0048661	positive regulation of smooth muscle cell proliferation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62954	P	From MGI
	GO:0048812	neuron projection morphogenesis	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62954	P	From MGI
	GO:0050679	positive regulation of epithelial cell proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P00533	P	From MGI
	GO:0050679	positive regulation of epithelial cell proliferation	MGI:MGI:74263 PMID:7618084^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856402	P	From MGI
	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	MGI:MGI:2182234 PMID:11940581^[3]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P00533	P	From MGI
	GO:0050999	regulation of nitric-oxide synthase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P00533	P	From MGI
	GO:0051015	actin filament binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P00533	F	From MGI
	GO:0051592	response to calcium ion	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62954	P	From MGI
	GO:0051897	positive regulation of protein kinase B signaling cascade	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P00533	P	From MGI
	GO:0051968	positive regulation of synaptic transmission, glutamatergic	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62954	P	From MGI
	GO:0060571	morphogenesis of an epithelial fold	MGI:MGI:74263 PMID:7618084^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856402	P	From MGI
	GO:0070141	response to UV-A	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P00533	P	From MGI
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Barco R et al. (2007) The synovial sarcoma SYT-SSX2 oncogene remodels the cytoskeleton through activation of the ephrin pathway. Mol Biol Cell 18: 4003-12 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Threadgill DW et al. (1995) Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype. Science 269: 230-4 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Saito Y et al. (2002) Protein kinase C-alpha and protein kinase C-epsilon are required for Grb2-associated binder-1 tyrosine phosphorylation in response to platelet-derived growth factor. J Biol Chem 277: 23216-22 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Weissman JT et al. (2004) G-protein-coupled receptor-mediated activation of rap GTPases: characterization of a novel Galphai regulated pathway. Oncogene 23: 241-9 PubMed GONUTS page
↑ Andreev J et al. (2001) Src and Pyk2 mediate G-protein-coupled receptor activation of epidermal growth factor receptor (EGFR) but are not required for coupling to the mitogen-activated protein (MAP) kinase signaling cascade. J Biol Chem 276: 20130-5 PubMed GONUTS page
↑ Tran DD et al. (2003) CAML is required for efficient EGF receptor recycling. Dev Cell 5: 245-56 PubMed GONUTS page
↑ ^7.0 ^7.1 Nicholson SE et al. (2005) Suppressor of cytokine signaling (SOCS)-5 is a potential negative regulator of epidermal growth factor signaling. Proc Natl Acad Sci U S A 102: 2328-33 PubMed GONUTS page
↑ Aoki K et al. (2005) Local phosphatidylinositol 3,4,5-trisphosphate accumulation recruits Vav2 and Vav3 to activate Rac1/Cdc42 and initiate neurite outgrowth in nerve growth factor-stimulated PC12 cells. Mol Biol Cell 16: 2207-17 PubMed GONUTS page
↑ Mizuno E et al. (2005) Regulation of epidermal growth factor receptor down-regulation by UBPY-mediated deubiquitination at endosomes. Mol Biol Cell 16: 5163-74 PubMed GONUTS page
↑ Inoue H et al. (2007) Inhibition of the leucine-rich repeat protein LINGO-1 enhances survival, structure, and function of dopaminergic neurons in Parkinson's disease models. Proc Natl Acad Sci U S A 104: 14430-5 PubMed GONUTS page
↑ ^11.0 ^11.1 Mikkola ML et al. (1999) Ectodysplasin, a protein required for epithelial morphogenesis, is a novel TNF homologue and promotes cell-matrix adhesion. Mech Dev 88: 133-46 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Rocher-Ros V et al. (2010) Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7. Oncogene 29: 2950-61 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Hinton DA et al. (1995) Altering the expression of cell surface beta 1,4-galactosyltransferase modulates cell growth. Exp Cell Res 219: 640-9 PubMed GONUTS page
↑ Jaskoll T & Melnick M (1999) Submandibular gland morphogenesis: stage-specific expression of TGF-alpha/EGF, IGF, TGF-beta, TNF, and IL-6 signal transduction in normal embryonic mice and the phenotypic effects of TGF-beta2, TGF-beta3, and EGF-r null mutations. Anat Rec 256: 252-68 PubMed GONUTS page
↑ Dahlhoff M et al. (2008) Betacellulin stimulates growth of the mouse intestinal epithelium and increases adenoma multiplicity in Apc+/Min mice. FEBS Lett 582: 2911-5 PubMed GONUTS page
↑ Holgado-Madruga M & Wong AJ (2003) Gab1 is an integrator of cell death versus cell survival signals in oxidative stress. Mol Cell Biol 23: 4471-84 PubMed GONUTS page
↑ Orellana SA et al. (1995) Epidermal growth factor receptor expression is abnormal in murine polycystic kidney. Kidney Int 47: 490-9 PubMed GONUTS page
↑ Roberts RB et al. (2002) Importance of epidermal growth factor receptor signaling in establishment of adenomas and maintenance of carcinomas during intestinal tumorigenesis. Proc Natl Acad Sci U S A 99: 1521-6 PubMed GONUTS page
↑ Higuchi T et al. (2004) MUC20 suppresses the hepatocyte growth factor-induced Grb2-Ras pathway by binding to a multifunctional docking site of met. Mol Cell Biol 24: 7456-68 PubMed GONUTS page

[PMID:17686994-0] 1.0 ^1.1 Barco R et al. (2007) The synovial sarcoma SYT-SSX2 oncogene remodels the cytoskeleton through activation of the ephrin pathway. Mol Biol Cell 18: 4003-12 PubMed GONUTS page

[PMID:7618084-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Threadgill DW et al. (1995) Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype. Science 269: 230-4 PubMed GONUTS page

[PMID:11940581-2] 3.0 ^3.1 ^3.2 Saito Y et al. (2002) Protein kinase C-alpha and protein kinase C-epsilon are required for Grb2-associated binder-1 tyrosine phosphorylation in response to platelet-derived growth factor. J Biol Chem 277: 23216-22 PubMed GONUTS page

[PMID:14712229-3] 4.0 ^4.1 ^4.2 Weissman JT et al. (2004) G-protein-coupled receptor-mediated activation of rap GTPases: characterization of a novel Galphai regulated pathway. Oncogene 23: 241-9 PubMed GONUTS page

[PMID:11274221-4] Andreev J et al. (2001) Src and Pyk2 mediate G-protein-coupled receptor activation of epidermal growth factor receptor (EGFR) but are not required for coupling to the mitogen-activated protein (MAP) kinase signaling cascade. J Biol Chem 276: 20130-5 PubMed GONUTS page

[PMID:12919676-5] Tran DD et al. (2003) CAML is required for efficient EGF receptor recycling. Dev Cell 5: 245-56 PubMed GONUTS page

[PMID:15695332-6] 7.0 ^7.1 Nicholson SE et al. (2005) Suppressor of cytokine signaling (SOCS)-5 is a potential negative regulator of epidermal growth factor signaling. Proc Natl Acad Sci U S A 102: 2328-33 PubMed GONUTS page

[PMID:15728722-7] Aoki K et al. (2005) Local phosphatidylinositol 3,4,5-trisphosphate accumulation recruits Vav2 and Vav3 to activate Rac1/Cdc42 and initiate neurite outgrowth in nerve growth factor-stimulated PC12 cells. Mol Biol Cell 16: 2207-17 PubMed GONUTS page

[PMID:16120644-8] Mizuno E et al. (2005) Regulation of epidermal growth factor receptor down-regulation by UBPY-mediated deubiquitination at endosomes. Mol Biol Cell 16: 5163-74 PubMed GONUTS page

[PMID:17726113-9] Inoue H et al. (2007) Inhibition of the leucine-rich repeat protein LINGO-1 enhances survival, structure, and function of dopaminergic neurons in Parkinson's disease models. Proc Natl Acad Sci U S A 104: 14430-5 PubMed GONUTS page

[PMID:10534613-10] 11.0 ^11.1 Mikkola ML et al. (1999) Ectodysplasin, a protein required for epithelial morphogenesis, is a novel TNF homologue and promotes cell-matrix adhesion. Mech Dev 88: 133-46 PubMed GONUTS page

[PMID:20208556-11] 12.0 ^12.1 ^12.2 Rocher-Ros V et al. (2010) Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7. Oncogene 29: 2950-61 PubMed GONUTS page

[PMID:7641815-12] 13.0 ^13.1 ^13.2 Hinton DA et al. (1995) Altering the expression of cell surface beta 1,4-galactosyltransferase modulates cell growth. Exp Cell Res 219: 640-9 PubMed GONUTS page

[PMID:10521784-13] Jaskoll T & Melnick M (1999) Submandibular gland morphogenesis: stage-specific expression of TGF-alpha/EGF, IGF, TGF-beta, TNF, and IL-6 signal transduction in normal embryonic mice and the phenotypic effects of TGF-beta2, TGF-beta3, and EGF-r null mutations. Anat Rec 256: 252-68 PubMed GONUTS page

[PMID:18656477-14] Dahlhoff M et al. (2008) Betacellulin stimulates growth of the mouse intestinal epithelium and increases adenoma multiplicity in Apc+/Min mice. FEBS Lett 582: 2911-5 PubMed GONUTS page

[PMID:12808090-15] Holgado-Madruga M & Wong AJ (2003) Gab1 is an integrator of cell death versus cell survival signals in oxidative stress. Mol Cell Biol 23: 4471-84 PubMed GONUTS page

[PMID:7723235-16] Orellana SA et al. (1995) Epidermal growth factor receptor expression is abnormal in murine polycystic kidney. Kidney Int 47: 490-9 PubMed GONUTS page

[PMID:11818567-17] Roberts RB et al. (2002) Importance of epidermal growth factor receptor signaling in establishment of adenomas and maintenance of carcinomas during intestinal tumorigenesis. Proc Natl Acad Sci U S A 99: 1521-6 PubMed GONUTS page

[PMID:15314156-18] Higuchi T et al. (2004) MUC20 suppresses the hepatocyte growth factor-induced Grb2-Ras pathway by binding to a multifunctional docking site of met. Mol Cell Biol 24: 7456-68 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

[19]

Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Egfr ( synonyms: avian erythroblastic leukemia viral (v-erb-b) oncogene homolog, Erbb, Wa5 )
Protein Name(s)	epidermal growth factor receptor,
External Links
MGI	MGI:95294

MGI:Egfr

Contents

Annotations

Notes

References

a

b

c

d

e

g

h

i

i cont.

k

m

n

o

p

p cont.

r

s

t

Personal tools

Namespaces

Variants

Views

Actions

Search

Navigation

Cacao

Journal Clubs

page contributors

Toolbox