MGI:Egf

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000186	activation of MAPKK activity	MGI:MGI:3614383 PMID:16339969^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0001525	angiogenesis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01133	P	From MGI
	GO:0005154	epidermal growth factor receptor binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P07522	F	From MGI
	GO:0005154	epidermal growth factor receptor binding	MGI:MGI:63909 PMID:6315706^[2]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0005509	calcium ion binding	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR001881 InterPro:IPR018097	F	From MGI
	GO:0005515	protein binding	MGI:MGI:4887327 PMID:17626015^[3]	IPI: Inferred from Physical Interaction	UniProtKB:Q8VD37	F	From MGI
	GO:0005615	extracellular space	MGI:MGI:63540 PMID:8240367^[4]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:75839 PMID:7641815^[5]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005622	intracellular	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01133	C	From MGI
	GO:0005622	intracellular	MGI:MGI:5284803 PMID:15156153^[6]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005625	soluble fraction	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P07522	C	From MGI
	GO:0005886	plasma membrane	MGI:MGI:4887327 PMID:17626015^[3]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0007173	epidermal growth factor receptor signaling pathway	MGI:MGI:3531070 PMID:15695332^[7]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0007173	epidermal growth factor receptor signaling pathway	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P07522	P	From MGI
	GO:0007173	epidermal growth factor receptor signaling pathway	MGI:MGI:63909 PMID:6315706^[2]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0007173	epidermal growth factor receptor signaling pathway	MGI:MGI:75839 PMID:7641815^[5]	IGI: Inferred from Genetic Interaction	MGI:MGI:95294	P	From MGI
	GO:0007262	STAT protein import into nucleus	MGI:MGI:5284803 PMID:15156153^[6]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0008083	growth factor activity	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:P01133	F	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:P01133	P	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:3032880 PMID:14712229^[8]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:3039221 PMID:15051883^[9]	IGI: Inferred from Genetic Interaction	MGI:MGI:95516	P	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:3521553 PMID:15509736^[10]	IGI: Inferred from Genetic Interaction	MGI:MGI:96522	P	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:3531070 PMID:15695332^[7]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:75839 PMID:7641815^[5]	IGI: Inferred from Genetic Interaction	MGI:MGI:95705 MGI:MGI:95294	P	From MGI
	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01133	P	From MGI
	GO:0016020	membrane	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0472	C	From MGI
	GO:0016021	integral to membrane	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0812	C	From MGI
	GO:0018108	peptidyl-tyrosine phosphorylation	MGI:MGI:2683380 PMID:14561752^[11]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0021940	positive regulation of cerebellar granule cell precursor proliferation	MGI:MGI:1329746 PMID:10027293^[12]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0035413	positive regulation of catenin import into nucleus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01133	P	From MGI
	GO:0042327	positive regulation of phosphorylation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01133	P	From MGI
	GO:0043388	positive regulation of DNA binding	MGI:MGI:5284803 PMID:15156153^[6]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0043406	positive regulation of MAP kinase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01133	P	From MGI
	GO:0045741	positive regulation of epidermal growth factor-activated receptor activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01133	P	From MGI
	GO:0045840	positive regulation of mitosis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01133	P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01133	P	From MGI
	GO:0048754	branching morphogenesis of a tube	MGI:MGI:3575981 PMID:15831470^[13]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0050708	regulation of protein secretion	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P07522	P	From MGI
	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	MGI:MGI:2182234 PMID:11940581^[14]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0051048	negative regulation of secretion	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01133	P	From MGI
	GO:0051223	regulation of protein transport	MGI:MGI:4420359 PMID:19723622^[15]	ISO: Inferred from Sequence Orthology	UniProtKB:P07522	P	From MGI
	GO:0060749	mammary gland alveolus development	MGI:MGI:1336843 PMID:10331984^[16]	IGI: Inferred from Genetic Interaction	MGI:MGI:98724 MGI:MGI:88068	P	From MGI
	GO:0070371	ERK1 and ERK2 cascade	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01133	P	From MGI
	GO:0090279	regulation of calcium ion import	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01133	P	From MGI
	GO:0090370	negative regulation of cholesterol efflux	MGI:MGI:4460848 PMID:20037141^[17]	IDA: Inferred from Direct Assay		P	From MGI
	GO:1900127	positive regulation of hyaluronan biosynthetic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01133	P	From MGI
	GO:2000008	regulation of protein localization at cell surface	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01133	P	From MGI
	GO:2000060	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process	MGI:MGI:4887523 PMID:20208556^[18]	IDA: Inferred from Direct Assay		P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Ozaki K et al. (2005) Efficient suppression of FGF-2-induced ERK activation by the cooperative interaction among mammalian Sprouty isoforms. J Cell Sci 118: 5861-71 PubMed GONUTS page
↑ ^2.0 ^2.1 Massagué J (1983) Epidermal growth factor-like transforming growth factor. II. Interaction with epidermal growth factor receptors in human placenta membranes and A431 cells. J Biol Chem 258: 13614-20 PubMed GONUTS page
↑ ^3.0 ^3.1 Uezu A et al. (2007) SGIP1alpha is an endocytic protein that directly interacts with phospholipids and Eps15. J Biol Chem 282: 26481-9 PubMed GONUTS page
↑ Lakshmanan J & Fisher DA (1993) An inborn error in epidermal growth factor prohormone metabolism in a mouse model of autosomal recessive polycystic kidney disease. Biochem Biophys Res Commun 196: 892-901 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Hinton DA et al. (1995) Altering the expression of cell surface beta 1,4-galactosyltransferase modulates cell growth. Exp Cell Res 219: 640-9 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Kamakura S et al. (2004) Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling. Nat Cell Biol 6: 547-54 PubMed GONUTS page
↑ ^7.0 ^7.1 Nicholson SE et al. (2005) Suppressor of cytokine signaling (SOCS)-5 is a potential negative regulator of epidermal growth factor signaling. Proc Natl Acad Sci U S A 102: 2328-33 PubMed GONUTS page
↑ Weissman JT et al. (2004) G-protein-coupled receptor-mediated activation of rap GTPases: characterization of a novel Galphai regulated pathway. Oncogene 23: 241-9 PubMed GONUTS page
↑ Derouet D et al. (2004) Neuropoietin, a new IL-6-related cytokine signaling through the ciliary neurotrophic factor receptor. Proc Natl Acad Sci U S A 101: 4827-32 PubMed GONUTS page
↑ Yoon K et al. (2004) Fibroblast growth factor receptor signaling promotes radial glial identity and interacts with Notch1 signaling in telencephalic progenitors. J Neurosci 24: 9497-506 PubMed GONUTS page
↑ Guo HB et al. (2003) N-acetylglucosaminyltransferase V expression levels regulate cadherin-associated homotypic cell-cell adhesion and intracellular signaling pathways. J Biol Chem 278: 52412-24 PubMed GONUTS page
↑ Wechsler-Reya RJ & Scott MP (1999) Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog. Neuron 22: 103-14 PubMed GONUTS page
↑ Leung-Hagesteijn C et al. (2005) Integrin-linked kinase mediates bone morphogenetic protein 7-dependent renal epithelial cell morphogenesis. Mol Cell Biol 25: 3648-57 PubMed GONUTS page
↑ Saito Y et al. (2002) Protein kinase C-alpha and protein kinase C-epsilon are required for Grb2-associated binder-1 tyrosine phosphorylation in response to platelet-derived growth factor. J Biol Chem 277: 23216-22 PubMed GONUTS page
↑ Sato M et al. (2009) Activator of G protein signaling 8 (AGS8) is required for hypoxia-induced apoptosis of cardiomyocytes: role of G betagamma and connexin 43 (CX43). J Biol Chem 284: 31431-40 PubMed GONUTS page
↑ Luetteke NC et al. (1999) Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development. Development 126: 2739-50 PubMed GONUTS page
↑ Zhou X et al. (2010) Inhibition of ERK1/2 and activation of liver X receptor synergistically induce macrophage ABCA1 expression and cholesterol efflux. J Biol Chem 285: 6316-26 PubMed GONUTS page
↑ Rocher-Ros V et al. (2010) Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7. Oncogene 29: 2950-61 PubMed GONUTS page

[PMID:16339969-0] Ozaki K et al. (2005) Efficient suppression of FGF-2-induced ERK activation by the cooperative interaction among mammalian Sprouty isoforms. J Cell Sci 118: 5861-71 PubMed GONUTS page

[PMID:6315706-1] 2.0 ^2.1 Massagué J (1983) Epidermal growth factor-like transforming growth factor. II. Interaction with epidermal growth factor receptors in human placenta membranes and A431 cells. J Biol Chem 258: 13614-20 PubMed GONUTS page

[PMID:17626015-2] 3.0 ^3.1 Uezu A et al. (2007) SGIP1alpha is an endocytic protein that directly interacts with phospholipids and Eps15. J Biol Chem 282: 26481-9 PubMed GONUTS page

[PMID:8240367-3] Lakshmanan J & Fisher DA (1993) An inborn error in epidermal growth factor prohormone metabolism in a mouse model of autosomal recessive polycystic kidney disease. Biochem Biophys Res Commun 196: 892-901 PubMed GONUTS page

[PMID:7641815-4] 5.0 ^5.1 ^5.2 Hinton DA et al. (1995) Altering the expression of cell surface beta 1,4-galactosyltransferase modulates cell growth. Exp Cell Res 219: 640-9 PubMed GONUTS page

[PMID:15156153-5] 6.0 ^6.1 ^6.2 Kamakura S et al. (2004) Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling. Nat Cell Biol 6: 547-54 PubMed GONUTS page

[PMID:15695332-6] 7.0 ^7.1 Nicholson SE et al. (2005) Suppressor of cytokine signaling (SOCS)-5 is a potential negative regulator of epidermal growth factor signaling. Proc Natl Acad Sci U S A 102: 2328-33 PubMed GONUTS page

[PMID:14712229-7] Weissman JT et al. (2004) G-protein-coupled receptor-mediated activation of rap GTPases: characterization of a novel Galphai regulated pathway. Oncogene 23: 241-9 PubMed GONUTS page

[PMID:15051883-8] Derouet D et al. (2004) Neuropoietin, a new IL-6-related cytokine signaling through the ciliary neurotrophic factor receptor. Proc Natl Acad Sci U S A 101: 4827-32 PubMed GONUTS page

[PMID:15509736-9] Yoon K et al. (2004) Fibroblast growth factor receptor signaling promotes radial glial identity and interacts with Notch1 signaling in telencephalic progenitors. J Neurosci 24: 9497-506 PubMed GONUTS page

[PMID:14561752-10] Guo HB et al. (2003) N-acetylglucosaminyltransferase V expression levels regulate cadherin-associated homotypic cell-cell adhesion and intracellular signaling pathways. J Biol Chem 278: 52412-24 PubMed GONUTS page

[PMID:10027293-11] Wechsler-Reya RJ & Scott MP (1999) Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog. Neuron 22: 103-14 PubMed GONUTS page

[PMID:15831470-12] Leung-Hagesteijn C et al. (2005) Integrin-linked kinase mediates bone morphogenetic protein 7-dependent renal epithelial cell morphogenesis. Mol Cell Biol 25: 3648-57 PubMed GONUTS page

[PMID:11940581-13] Saito Y et al. (2002) Protein kinase C-alpha and protein kinase C-epsilon are required for Grb2-associated binder-1 tyrosine phosphorylation in response to platelet-derived growth factor. J Biol Chem 277: 23216-22 PubMed GONUTS page

[PMID:19723622-14] Sato M et al. (2009) Activator of G protein signaling 8 (AGS8) is required for hypoxia-induced apoptosis of cardiomyocytes: role of G betagamma and connexin 43 (CX43). J Biol Chem 284: 31431-40 PubMed GONUTS page

[PMID:10331984-15] Luetteke NC et al. (1999) Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development. Development 126: 2739-50 PubMed GONUTS page

[PMID:20037141-16] Zhou X et al. (2010) Inhibition of ERK1/2 and activation of liver X receptor synergistically induce macrophage ABCA1 expression and cholesterol efflux. J Biol Chem 285: 6316-26 PubMed GONUTS page

[PMID:20208556-17] Rocher-Ros V et al. (2010) Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7. Oncogene 29: 2950-61 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Egf
Protein Name(s)	epidermal growth factor,
External Links
MGI	MGI:95290

MGI:Egf

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