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MGI:Eed

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Contents

Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Eed ( synonyms: l(7)5Rn, l7Rn5 )
Protein Name(s) embryonic ectoderm development,
External Links
MGI MGI:95286

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0001739

sex chromatin

MGI:MGI:3513221
PMID:15525528[1]

IDA: Inferred from Direct Assay

C

From MGI

GO:0003682

chromatin binding

MGI:MGI:3629244
PMID:16687444[2]

IDA: Inferred from Direct Assay

F

From MGI

GO:0005515

protein binding

MGI:MGI:1203943
PMID:9584197[3]

IPI: Inferred from Physical Interaction

UniProtKB:P70351
UniProtKB:Q61188

F

From MGI

GO:0005515

protein binding

MGI:MGI:2668801
PMID:12900441[4]

IPI: Inferred from Physical Interaction

UniProtKB:Q61188
UniProtKB:O09106

F

From MGI

GO:0005515

protein binding

MGI:MGI:2674187
PMID:12943661[5]

IPI: Inferred from Physical Interaction

UniProtKB:Q8R0W9

F

From MGI

GO:0005515

protein binding

MGI:MGI:4431292
PMID:20064375[6]

IPI: Inferred from Physical Interaction

UniProtKB:Q62315

F

From MGI

GO:0005515

protein binding

MGI:MGI:4436818
PMID:20064376[7]

IPI: Inferred from Physical Interaction

UniProtKB:Q02395
UniProtKB:Q62315

F

From MGI

GO:0005634

nucleus

MGI:MGI:1203943
PMID:9584197[3]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:2150845
PMID:11555636[8]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:4367296
PMID:19796622[9]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005694

chromosome

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0158

C

From MGI

GO:0006349

regulation of gene expression by genetic imprinting

MGI:MGI:2655036
PMID:12627233[10]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856856

P

From MGI

GO:0006351

transcription, DNA-dependent

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0804

P

From MGI

GO:0006355

regulation of transcription, DNA-dependent

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0805

P

From MGI

GO:0016568

chromatin modification

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0156

P

From MGI

GO:0016571

histone methylation

MGI:MGI:3581456
PMID:15916951[11]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1856856

P

From MGI

GO:0016571

histone methylation

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:O75530

P

From MGI

GO:0035098

ESC/E(Z) complex

MGI:MGI:2154458

ISO: Inferred from Sequence Orthology

UniProtKB:O75530

C

From MGI

GO:0035098

ESC/E(Z) complex

MGI:MGI:4431292
PMID:20064375[6]

IDA: Inferred from Direct Assay

C

From MGI

GO:0035098

ESC/E(Z) complex

MGI:MGI:4436818
PMID:20064376[7]

IDA: Inferred from Direct Assay

C

From MGI

GO:0042054

histone methyltransferase activity

MGI:MGI:2154458

ISO: Inferred from Sequence Orthology

UniProtKB:O75530

F

From MGI

GO:0042802

identical protein binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:O75530

F

From MGI

GO:0045120

pronucleus

MGI:MGI:2668801
PMID:12900441[4]

IDA: Inferred from Direct Assay

C

From MGI


Notes

References

See Help:References for how to manage references in GONUTS.
  1. de Napoles M et al. (2004) Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation. Dev Cell 7: 663-76 PubMed GONUTS page
  2. Fujimura Y et al. (2006) Distinct roles of Polycomb group gene products in transcriptionally repressed and active domains of Hoxb8. Development 133: 2371-81 PubMed GONUTS page
  3. 3.0 3.1 van Lohuizen M et al. (1998) Interaction of mouse polycomb-group (Pc-G) proteins Enx1 and Enx2 with Eed: indication for separate Pc-G complexes. Mol Cell Biol 18: 3572-9 PubMed GONUTS page
  4. 4.0 4.1 Erhardt S et al. (2003) Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse development. Development 130: 4235-48 PubMed GONUTS page
  5. Enünlü I et al. (2003) Different isoforms of PRIP-interacting protein with methyltransferase domain/trimethylguanosine synthase localizes to the cytoplasm and nucleus. Biochem Biophys Res Commun 309: 44-51 PubMed GONUTS page
  6. 6.0 6.1 Peng JC et al. (2009) Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells. Cell 139: 1290-302 PubMed GONUTS page
  7. 7.0 7.1 Shen X et al. (2009) Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells. Cell 139: 1303-14 PubMed GONUTS page
  8. Sutherland HG et al. (2001) Large-scale identification of mammalian proteins localized to nuclear sub-compartments. Hum Mol Genet 10: 1995-2011 PubMed GONUTS page
  9. Nishiyama A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell 5: 420-33 PubMed GONUTS page
  10. Mager J et al. (2003) Genome imprinting regulated by the mouse Polycomb group protein Eed. Nat Genet 33: 502-7 PubMed GONUTS page
  11. Montgomery ND et al. (2005) The murine polycomb group protein Eed is required for global histone H3 lysine-27 methylation. Curr Biol 15: 942-7 PubMed GONUTS page
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