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MGI:Eea1

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Contents

Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Eea1 ( synonyms: ZFYVE2 )
Protein Name(s) early endosome antigen 1,
External Links
MGI MGI:2442192

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005515

protein binding

MGI:MGI:4458973
PMID:20534488[1]

IPI: Inferred from Physical Interaction

UniProtKB:Q9CQD1
UniProtKB:P35278

F

From MGI

GO:0005545

1-phosphatidylinositol binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q15075

F

From MGI

GO:0005622

intracellular

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR007087
InterPro:IPR015880

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0963

C

From MGI

GO:0005768

endosome

MGI:MGI:2669048
PMID:12890772[2]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005768

endosome

MGI:MGI:3042801
PMID:14718562[3]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005768

endosome

MGI:MGI:3718161
PMID:16923123[4]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005769

early endosome

MGI:MGI:2154458

ISO: Inferred from Sequence Orthology

UniProtKB:Q15075

C

From MGI

GO:0005769

early endosome

MGI:MGI:2154458

ISO: Inferred from Sequence Orthology

UniProtKB:Q15075

C

From MGI

GO:0005769

early endosome

MGI:MGI:2653713
PMID:12536145[5]

ISA: Inferred from Sequence Alignment

UniProtKB:Q15075

C

From MGI

GO:0005769

early endosome

MGI:MGI:2669061
PMID:12746448[6]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005769

early endosome

MGI:MGI:3040541
PMID:15078902[7]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005769

early endosome

MGI:MGI:3042340
PMID:14668490[8]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005769

early endosome

MGI:MGI:3513645
PMID:15229288[9]

ISO: Inferred from Sequence Orthology

UniProtKB:Q15075

C

From MGI

GO:0005769

early endosome

MGI:MGI:3527911
PMID:15588329[10]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005769

early endosome

MGI:MGI:3610864
PMID:15975910[11]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005769

early endosome

MGI:MGI:3611144
PMID:16204232[12]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005769

early endosome

MGI:MGI:3697008
PMID:17003038[13]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005769

early endosome

MGI:MGI:3758128
PMID:17620357[14]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005769

early endosome

MGI:MGI:4868574
PMID:20943658[15]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005829

cytosol

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q15075

C

From MGI

GO:0005969

serine-pyruvate aminotransferase complex

MGI:MGI:3619505
PMID:16399794[16]

IDA: Inferred from Direct Assay

C

From MGI

GO:0006897

endocytosis

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q15075

P

From MGI

GO:0006906

vesicle fusion

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q15075

P

From MGI

GO:0008270

zinc ion binding

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR007087
InterPro:IPR015880

F

From MGI

GO:0016020

membrane

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

From MGI

GO:0019897

extrinsic to plasma membrane

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q15075

C

From MGI

GO:0030742

GTP-dependent protein binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q15075

F

From MGI

GO:0042803

protein homodimerization activity

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q15075

F

From MGI

GO:0046872

metal ion binding

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0479

F

From MGI

GO:0046872

metal ion binding

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR000306

F

From MGI

GO:0055037

recycling endosome

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_001101556

C

From MGI


Notes

References

See Help:References for how to manage references in GONUTS.
  1. Mishra A et al. (2010) Structural basis for Rab GTPase recognition and endosome tethering by the C2H2 zinc finger of Early Endosomal Autoantigen 1 (EEA1). Proc Natl Acad Sci U S A 107: 10866-71 PubMed GONUTS page
  2. Cataldo AM et al. (2003) App gene dosage modulates endosomal abnormalities of Alzheimer's disease in a segmental trisomy 16 mouse model of down syndrome. J Neurosci 23: 6788-92 PubMed GONUTS page
  3. Du G et al. (2004) Phospholipase D2 localizes to the plasma membrane and regulates angiotensin II receptor endocytosis. Mol Biol Cell 15: 1024-30 PubMed GONUTS page
  4. Itoh T et al. (2006) Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity. Genes Cells 11: 1023-37 PubMed GONUTS page
  5. Gurung R et al. (2003) Identification of a novel domain in two mammalian inositol-polyphosphate 5-phosphatases that mediates membrane ruffle localization. The inositol 5-phosphatase skip localizes to the endoplasmic reticulum and translocates to membrane ruffles following epidermal growth factor stimulation. J Biol Chem 278: 11376-85 PubMed GONUTS page
  6. Jones C et al. (2003) Normal sorting but defective endocytosis of the low density lipoprotein receptor in mice with autosomal recessive hypercholesterolemia. J Biol Chem 278: 29024-30 PubMed GONUTS page
  7. Seaman MN (2004) Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer. J Cell Biol 165: 111-22 PubMed GONUTS page
  8. Richardson SC et al. (2004) Mammalian late vacuole protein sorting orthologues participate in early endosomal fusion and interact with the cytoskeleton. Mol Biol Cell 15: 1197-210 PubMed GONUTS page
  9. Coumailleau F et al. (2004) Over-expression of Rififylin, a new RING finger and FYVE-like domain-containing protein, inhibits recycling from the endocytic recycling compartment. Mol Biol Cell 15: 4444-56 PubMed GONUTS page
  10. Fossale E et al. (2004) Membrane trafficking and mitochondrial abnormalities precede subunit c deposition in a cerebellar cell model of juvenile neuronal ceroid lipofuscinosis. BMC Neurosci 5: 57 PubMed GONUTS page
  11. Reed BC et al. (2005) GLUT1CBP(TIP2/GIPC1) interactions with GLUT1 and myosin VI: evidence supporting an adapter function for GLUT1CBP. Mol Biol Cell 16: 4183-201 PubMed GONUTS page
  12. Maric J et al. (2005) Intracellular lipidation of newly synthesized apolipoprotein A-I in primary murine hepatocytes. J Biol Chem 280: 39942-9 PubMed GONUTS page
  13. Hatanaka T et al. (2006) Regulation of amino acid transporter ATA2 by ubiquitin ligase Nedd4-2. J Biol Chem 281: 35922-30 PubMed GONUTS page
  14. Stober CB et al. (2007) Slc11a1, formerly Nramp1, is expressed in dendritic cells and influences major histocompatibility complex class II expression and antigen-presenting cell function. Infect Immun 75: 5059-67 PubMed GONUTS page
  15. Mayer PR et al. (2010) Expression, localization, and biochemical characterization of nicotinamide mononucleotide adenylyltransferase 2. J Biol Chem 285: 40387-96 PubMed GONUTS page
  16. Berger P et al. (2006) Multi-level regulation of myotubularin-related protein-2 phosphatase activity by myotubularin-related protein-13/set-binding factor-2. Hum Mol Genet 15: 569-79 PubMed GONUTS page
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