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MGI:Eea1
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Eea1 ( synonyms: ZFYVE2 ) | |
| Protein Name(s) | early endosome antigen 1, | |
| External Links | ||
| MGI | MGI:2442192 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0005515 |
protein binding |
MGI:MGI:4458973 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005545 |
1-phosphatidylinositol binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0963 |
C |
From MGI |
||
| GO:0005768 |
endosome |
MGI:MGI:2669048 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005768 |
endosome |
MGI:MGI:3042801 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005768 |
endosome |
MGI:MGI:3718161 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005769 |
early endosome |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005769 |
early endosome |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005769 |
early endosome |
MGI:MGI:2653713 |
ISA: Inferred from Sequence Alignment |
C |
From MGI |
|||
| GO:0005769 |
early endosome |
MGI:MGI:2669061 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005769 |
early endosome |
MGI:MGI:3040541 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005769 |
early endosome |
MGI:MGI:3042340 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005769 |
early endosome |
MGI:MGI:3513645 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005769 |
early endosome |
MGI:MGI:3527911 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005769 |
early endosome |
MGI:MGI:3610864 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005769 |
early endosome |
MGI:MGI:3611144 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005769 |
early endosome |
MGI:MGI:3697008 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005769 |
early endosome |
MGI:MGI:3758128 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005769 |
early endosome |
MGI:MGI:4868574 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005829 |
cytosol |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005969 |
serine-pyruvate aminotransferase complex |
MGI:MGI:3619505 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006897 |
endocytosis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006906 |
vesicle fusion |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008270 |
zinc ion binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0019897 |
extrinsic to plasma membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0030742 |
GTP-dependent protein binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0042803 |
protein homodimerization activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0046872 |
metal ion binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0479 |
F |
From MGI |
||
| GO:0046872 |
metal ion binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0055037 |
recycling endosome |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001101556 |
C |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Mishra A et al. (2010) Structural basis for Rab GTPase recognition and endosome tethering by the C2H2 zinc finger of Early Endosomal Autoantigen 1 (EEA1). Proc Natl Acad Sci U S A 107: 10866-71 PubMed GONUTS page
- ↑ Cataldo AM et al. (2003) App gene dosage modulates endosomal abnormalities of Alzheimer's disease in a segmental trisomy 16 mouse model of down syndrome. J Neurosci 23: 6788-92 PubMed GONUTS page
- ↑ Du G et al. (2004) Phospholipase D2 localizes to the plasma membrane and regulates angiotensin II receptor endocytosis. Mol Biol Cell 15: 1024-30 PubMed GONUTS page
- ↑ Itoh T et al. (2006) Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity. Genes Cells 11: 1023-37 PubMed GONUTS page
- ↑ Gurung R et al. (2003) Identification of a novel domain in two mammalian inositol-polyphosphate 5-phosphatases that mediates membrane ruffle localization. The inositol 5-phosphatase skip localizes to the endoplasmic reticulum and translocates to membrane ruffles following epidermal growth factor stimulation. J Biol Chem 278: 11376-85 PubMed GONUTS page
- ↑ Jones C et al. (2003) Normal sorting but defective endocytosis of the low density lipoprotein receptor in mice with autosomal recessive hypercholesterolemia. J Biol Chem 278: 29024-30 PubMed GONUTS page
- ↑ Seaman MN (2004) Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer. J Cell Biol 165: 111-22 PubMed GONUTS page
- ↑ Richardson SC et al. (2004) Mammalian late vacuole protein sorting orthologues participate in early endosomal fusion and interact with the cytoskeleton. Mol Biol Cell 15: 1197-210 PubMed GONUTS page
- ↑ Coumailleau F et al. (2004) Over-expression of Rififylin, a new RING finger and FYVE-like domain-containing protein, inhibits recycling from the endocytic recycling compartment. Mol Biol Cell 15: 4444-56 PubMed GONUTS page
- ↑ Fossale E et al. (2004) Membrane trafficking and mitochondrial abnormalities precede subunit c deposition in a cerebellar cell model of juvenile neuronal ceroid lipofuscinosis. BMC Neurosci 5: 57 PubMed GONUTS page
- ↑ Reed BC et al. (2005) GLUT1CBP(TIP2/GIPC1) interactions with GLUT1 and myosin VI: evidence supporting an adapter function for GLUT1CBP. Mol Biol Cell 16: 4183-201 PubMed GONUTS page
- ↑ Maric J et al. (2005) Intracellular lipidation of newly synthesized apolipoprotein A-I in primary murine hepatocytes. J Biol Chem 280: 39942-9 PubMed GONUTS page
- ↑ Hatanaka T et al. (2006) Regulation of amino acid transporter ATA2 by ubiquitin ligase Nedd4-2. J Biol Chem 281: 35922-30 PubMed GONUTS page
- ↑ Stober CB et al. (2007) Slc11a1, formerly Nramp1, is expressed in dendritic cells and influences major histocompatibility complex class II expression and antigen-presenting cell function. Infect Immun 75: 5059-67 PubMed GONUTS page
- ↑ Mayer PR et al. (2010) Expression, localization, and biochemical characterization of nicotinamide mononucleotide adenylyltransferase 2. J Biol Chem 285: 40387-96 PubMed GONUTS page
- ↑ Berger P et al. (2006) Multi-level regulation of myotubularin-related protein-2 phosphatase activity by myotubularin-related protein-13/set-binding factor-2. Hum Mol Genet 15: 569-79 PubMed GONUTS page
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