MGI:Ednrb

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	MGI:MGI:1330409 PMID:10021336^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P24530	P	From MGI
	GO:0001755	neural crest cell migration	MGI:MGI:1349495 PMID:10591209^[2]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0001934	positive regulation of protein phosphorylation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P21451	P	From MGI
	GO:0004871	signal transducer activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0807	F	From MGI
	GO:0004872	receptor activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0675	F	From MGI
	GO:0004930	G-protein coupled receptor activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0297	F	From MGI
	GO:0004962	endothelin receptor activity	MGI:MGI:2136077 PMID:11413164^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857161	F	From MGI
	GO:0004962	endothelin receptor activity	MGI:MGI:2449880 PMID:12441350^[4]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0004962	endothelin receptor activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P21451	F	From MGI
	GO:0004962	endothelin receptor activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P24530	F	From MGI
	GO:0005515	protein binding	MGI:MGI:2449880 PMID:12441350^[4]	IPI: Inferred from Physical Interaction	UniProtKB:P22387	F	From MGI
	GO:0005624	membrane fraction	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P21451	C	From MGI
	GO:0005886	plasma membrane	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P21451	C	From MGI
	GO:0006885	regulation of pH	MGI:MGI:2136077 PMID:11413164^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857161	P	From MGI
	GO:0007165	signal transduction	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0807	P	From MGI
	GO:0007186	G-protein coupled receptor signaling pathway	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0297	P	From MGI
	GO:0007186	G-protein coupled receptor signaling pathway	MGI:MGI:2449880 PMID:12441350^[4]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0007186	G-protein coupled receptor signaling pathway	MGI:MGI:2449880 PMID:12441350^[4]	IGI: Inferred from Genetic Interaction	MGI:MGI:95768	P	From MGI
	GO:0007200	activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P21451	P	From MGI
	GO:0007204	elevation of cytosolic calcium ion concentration	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P21451	P	From MGI
	GO:0007422	peripheral nervous system development	MGI:MGI:77408 PMID:8582288^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856149	P	From MGI
	GO:0007497	posterior midgut development	MGI:MGI:77408 PMID:8582288^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856149	P	From MGI
	GO:0008217	regulation of blood pressure	MGI:MGI:1352592 PMID:10626068^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857161	P	From MGI
	GO:0008217	regulation of blood pressure	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P21451	P	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P21451	P	From MGI
	GO:0014043	negative regulation of neuron maturation	MGI:MGI:1330409 PMID:10021336^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0014826	vein smooth muscle contraction	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P24530	P	From MGI
	GO:0016020	membrane	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0472	C	From MGI
	GO:0016021	integral to membrane	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0812	C	From MGI
	GO:0016021	integral to membrane	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR000276 InterPro:IPR000499 InterPro:IPR001112	C	From MGI
	GO:0017046	peptide hormone binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P24530	F	From MGI
	GO:0019233	sensory perception of pain	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P21451	P	From MGI
	GO:0019934	cGMP-mediated signaling	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P21451	P	From MGI
	GO:0030318	melanocyte differentiation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P21451	P	From MGI
	GO:0030318	melanocyte differentiation	MGI:MGI:77000 PMID:2379821^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856148	P	From MGI
	GO:0030318	melanocyte differentiation	MGI:MGI:85072 PMID:9012511^[8]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0031702	type 1 angiotensin receptor binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P21451	F	From MGI
	GO:0031965	nuclear membrane	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P21451	C	From MGI
	GO:0032269	negative regulation of cellular protein metabolic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P24530	P	From MGI
	GO:0032496	response to lipopolysaccharide	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P21451	P	From MGI
	GO:0035645	enteric smooth muscle cell differentiation	MGI:MGI:1330409 PMID:10021336^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0035810	positive regulation of urine volume	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P21451	P	From MGI
	GO:0035815	positive regulation of renal sodium excretion	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P21451	P	From MGI
	GO:0042045	epithelial fluid transport	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P21451	P	From MGI
	GO:0042310	vasoconstriction	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P21451	P	From MGI
	GO:0042310	vasoconstriction	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P24530	P	From MGI
	GO:0042311	vasodilation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P21451	P	From MGI
	GO:0043066	negative regulation of apoptotic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P21451	P	From MGI
	GO:0043473	pigmentation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P21451	P	From MGI
	GO:0043473	pigmentation	MGI:MGI:77000 PMID:2379821^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856148	P	From MGI
	GO:0045121	membrane raft	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P21451	C	From MGI
	GO:0048066	developmental pigmentation	MGI:MGI:3055244 PMID:15322542^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856149	P	From MGI
	GO:0048246	macrophage chemotaxis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P24530	P	From MGI
	GO:0048265	response to pain	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P21451	P	From MGI
	GO:0048484	enteric nervous system development	MGI:MGI:1330409 PMID:10021336^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0048484	enteric nervous system development	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P21451	P	From MGI
	GO:0050678	regulation of epithelial cell proliferation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P21451	P	From MGI
	GO:0051930	regulation of sensory perception of pain	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P21451	P	From MGI
	GO:0060406	positive regulation of penile erection	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P21451	P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Wu JJ et al. (1999) Inhibition of in vitro enteric neuronal development by endothelin-3: mediation by endothelin B receptors. Development 126: 1161-73 PubMed GONUTS page
↑ Shin MK et al. (1999) The temporal requirement for endothelin receptor-B signalling during neural crest development. Nature 402: 496-501 PubMed GONUTS page
↑ ^3.0 ^3.1 Laghmani K et al. (2001) Endothelin-1/endothelin-B receptor-mediated increases in NHE3 activity in chronic metabolic acidosis. J Clin Invest 107: 1563-9 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Liu B & Wu D (2003) The first inner loop of endothelin receptor type B is necessary for specific coupling to Galpha 13. J Biol Chem 278: 2384-7 PubMed GONUTS page
↑ ^5.0 ^5.1 Kapur RP et al. (1995) Intercellular signals downstream of endothelin receptor-B mediate colonization of the large intestine by enteric neuroblasts. Development 121: 3787-95 PubMed GONUTS page
↑ Kuwaki T et al. (1999) Endothelin in the central control of cardiovascular and respiratory functions. Clin Exp Pharmacol Physiol 26: 989-94 PubMed GONUTS page
↑ ^7.0 ^7.1 Moore KJ et al. (1990) Interaction of the murine dilute suppressor gene (dsu) with fourteen coat color mutations. Genetics 125: 421-30 PubMed GONUTS page
↑ Reid K et al. (1996) Multiple roles for endothelin in melanocyte development: regulation of progenitor number and stimulation of differentiation. Development 122: 3911-9 PubMed GONUTS page
↑ Van Raamsdonk CD et al. (2004) Effects of G-protein mutations on skin color. Nat Genet 36: 961-8 PubMed GONUTS page

[PMID:10021336-0] 1.0 ^1.1 ^1.2 ^1.3 Wu JJ et al. (1999) Inhibition of in vitro enteric neuronal development by endothelin-3: mediation by endothelin B receptors. Development 126: 1161-73 PubMed GONUTS page

[PMID:10591209-1] Shin MK et al. (1999) The temporal requirement for endothelin receptor-B signalling during neural crest development. Nature 402: 496-501 PubMed GONUTS page

[PMID:11413164-2] 3.0 ^3.1 Laghmani K et al. (2001) Endothelin-1/endothelin-B receptor-mediated increases in NHE3 activity in chronic metabolic acidosis. J Clin Invest 107: 1563-9 PubMed GONUTS page

[PMID:12441350-3] 4.0 ^4.1 ^4.2 ^4.3 Liu B & Wu D (2003) The first inner loop of endothelin receptor type B is necessary for specific coupling to Galpha 13. J Biol Chem 278: 2384-7 PubMed GONUTS page

[PMID:8582288-4] 5.0 ^5.1 Kapur RP et al. (1995) Intercellular signals downstream of endothelin receptor-B mediate colonization of the large intestine by enteric neuroblasts. Development 121: 3787-95 PubMed GONUTS page

[PMID:10626068-5] Kuwaki T et al. (1999) Endothelin in the central control of cardiovascular and respiratory functions. Clin Exp Pharmacol Physiol 26: 989-94 PubMed GONUTS page

[PMID:2379821-6] 7.0 ^7.1 Moore KJ et al. (1990) Interaction of the murine dilute suppressor gene (dsu) with fourteen coat color mutations. Genetics 125: 421-30 PubMed GONUTS page

[PMID:9012511-7] Reid K et al. (1996) Multiple roles for endothelin in melanocyte development: regulation of progenitor number and stimulation of differentiation. Development 122: 3911-9 PubMed GONUTS page

[PMID:15322542-8] Van Raamsdonk CD et al. (2004) Effects of G-protein mutations on skin color. Nat Genet 36: 961-8 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Ednrb ( synonyms: ETb, ETR-b, Sox10m1 )
Protein Name(s)	endothelin receptor type B,
External Links
MGI	MGI:102720

MGI:Ednrb

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