GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.
You can help reduce stress on the server by:
- not reloading pages frequently - this just adds
- opening links in new windows (so you can read the old page)
MGI:Dst
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Dst ( synonyms: ah, athetoid, Bpag, BPAG1, BPAG1-n, bullous pemphigoid antigen 1, Macf2, nmf203, nmf339 ) | |
| Protein Name(s) | dystonin, | |
| External Links | ||
| MGI | MGI:104627 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000226 |
microtubule cytoskeleton organization |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0001725 |
stress fiber |
MGI:MGI:2681367 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0003779 |
actin binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0009 |
F |
From MGI |
||
| GO:0003779 |
actin binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005178 |
integrin binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005509 |
calcium ion binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:1330496 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3807136 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4421360 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:2679412 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2429314 |
C |
From MGI |
||
| GO:0005634 |
nucleus |
MGI:MGI:2681367 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3612006 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005635 |
nuclear envelope |
MGI:MGI:3807136 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4421360 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005783 |
endoplasmic reticulum |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0256 |
C |
From MGI |
||
| GO:0005789 |
endoplasmic reticulum membrane |
MGI:MGI:3807136 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005856 |
cytoskeleton |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0206 |
C |
From MGI |
||
| GO:0005856 |
cytoskeleton |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0005874 |
microtubule |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0493 |
C |
From MGI |
||
| GO:0005882 |
intermediate filament |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0403 |
C |
From MGI |
||
| GO:0005886 |
plasma membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-1003 |
C |
From MGI |
||
| GO:0005925 |
focal adhesion |
MGI:MGI:2681367 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005925 |
focal adhesion |
MGI:MGI:3612006 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0007010 |
cytoskeleton organization |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007050 |
cell cycle arrest |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0007155 |
cell adhesion |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0130 |
P |
From MGI |
||
| GO:0007409 |
axonogenesis |
MGI:MGI:60062 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856672 |
P |
From MGI |
||
| GO:0008017 |
microtubule binding |
MGI:MGI:1341473 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0008022 |
protein C-terminus binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0008090 |
retrograde axon cargo transport |
MGI:MGI:2679412 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2429314 |
P |
From MGI |
||
| GO:0009611 |
response to wounding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0009898 |
internal side of plasma membrane |
MGI:MGI:3612006 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0014704 |
intercalated disc |
MGI:MGI:4421360 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0015629 |
actin cytoskeleton |
MGI:MGI:1341473 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0015629 |
actin cytoskeleton |
MGI:MGI:2681367 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0015629 |
actin cytoskeleton |
MGI:MGI:3612006 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0015629 |
actin cytoskeleton |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0015630 |
microtubule cytoskeleton |
MGI:MGI:1341473 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0015630 |
microtubule cytoskeleton |
MGI:MGI:3612006 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0015630 |
microtubule cytoskeleton |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:3612006 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0016021 |
integral to membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0812 |
C |
From MGI |
||
| GO:0016023 |
cytoplasmic membrane-bounded vesicle |
MGI:MGI:2679412 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0030011 |
maintenance of cell polarity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030018 |
Z disc |
MGI:MGI:4421360 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0030018 |
Z disc |
MGI:MGI:4439443 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0030018 |
Z disc |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0030054 |
cell junction |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0965 |
C |
From MGI |
||
| GO:0030056 |
hemidesmosome |
MGI:MGI:2182206 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0030056 |
hemidesmosome |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0030056 |
hemidesmosome |
MGI:MGI:72689 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0031110 |
regulation of microtubule polymerization or depolymerization |
MGI:MGI:1341473 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2429314 |
P |
From MGI |
||
| GO:0031122 |
cytoplasmic microtubule organization |
MGI:MGI:1341473 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2429314 |
P |
From MGI |
||
| GO:0031252 |
cell leading edge |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0031581 |
hemidesmosome assembly |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0031673 |
H zone |
MGI:MGI:4439443 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0033267 |
axon part |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0035371 |
microtubule plus end |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0042383 |
sarcolemma |
MGI:MGI:4439443 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0042803 |
protein homodimerization activity |
MGI:MGI:2681367 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0042803 |
protein homodimerization activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0042995 |
cell projection |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0966 |
C |
From MGI |
||
| GO:0045111 |
intermediate filament cytoskeleton |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0046907 |
intracellular transport |
MGI:MGI:2681367 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0048471 |
perinuclear region of cytoplasm |
MGI:MGI:3612006 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0048870 |
cell motility |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051010 |
microtubule plus-end binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0060053 |
neurofilament cytoskeleton |
MGI:MGI:1341473 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0097038 |
perinuclear endoplasmic reticulum |
MGI:MGI:3612006 |
IDA: Inferred from Direct Assay |
C |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Young KG et al. (2003) Bpag1 localization to actin filaments and to the nucleus is regulated by its N-terminus. J Cell Sci 116: 4543-55 PubMed GONUTS page
- ↑ Leung CL et al. (1999) The intermediate filament protein peripherin is the specific interaction partner of mouse BPAG1-n (dystonin) in neurons. J Cell Biol 144: 435-46 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Young KG & Kothary R (2008) Dystonin/Bpag1 is a necessary endoplasmic reticulum/nuclear envelope protein in sensory neurons. Exp Cell Res 314: 2750-61 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Steiner-Champliaud MF et al. (2010) BPAG1 isoform-b: complex distribution pattern in striated and heart muscle and association with plectin and alpha-actinin. Exp Cell Res 316: 297-313 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Liu JJ et al. (2003) BPAG1n4 is essential for retrograde axonal transport in sensory neurons. J Cell Biol 163: 223-9 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 6.7 Young KG et al. (2006) A Bpag1 isoform involved in cytoskeletal organization surrounding the nucleus. Exp Cell Res 312: 121-34 PubMed GONUTS page
- ↑ Bronson RT et al. (1992) Genetic and age related models of neurodegeneration in mice: dystrophic axons. J Neurogenet 8: 71-83 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 8.4 8.5 Yang Y et al. (1999) Integrators of the cytoskeleton that stabilize microtubules. Cell 98: 229-38 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 Boyer JG et al. (2010) Hearts of dystonia musculorum mice display normal morphological and histological features but show signs of cardiac stress. PLoS One 5: e9465 PubMed GONUTS page
- ↑ Dowling J et al. (1996) Beta4 integrin is required for hemidesmosome formation, cell adhesion and cell survival. J Cell Biol 134: 559-72 PubMed GONUTS page
- ↑ Guo L et al. (1995) Gene targeting of BPAG1: abnormalities in mechanical strength and cell migration in stratified epithelia and neurologic degeneration. Cell 81: 233-43 PubMed GONUTS page
