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MGI:Drd1a
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Drd1a ( synonyms: D1 receptor, Drd-1, Drd1, Gpcr15 ) | |
| Protein Name(s) | dopamine receptor D1A, | |
| External Links | ||
| MGI | MGI:99578 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001588 |
dopamine receptor activity, coupled via Gs |
MGI:MGI:1098091 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857158 |
F |
From MGI |
||
| GO:0001588 |
dopamine receptor activity, coupled via Gs |
MGI:MGI:1927281 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0001588 |
dopamine receptor activity, coupled via Gs |
MGI:MGI:2679747 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0001588 |
dopamine receptor activity, coupled via Gs |
MGI:MGI:3586401 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2159306 |
F |
From MGI |
||
| GO:0001588 |
dopamine receptor activity, coupled via Gs |
MGI:MGI:3626135 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0001588 |
dopamine receptor activity, coupled via Gs |
MGI:MGI:3689286 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0001588 |
dopamine receptor activity, coupled via Gs |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0001588 |
dopamine receptor activity, coupled via Gs |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0001588 |
dopamine receptor activity, coupled via Gs |
MGI:MGI:64569 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0001588 |
dopamine receptor activity, coupled via Gs |
MGI:MGI:69539 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0001588 |
dopamine receptor activity, coupled via Gs |
MGI:MGI:69969 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857158 |
F |
From MGI |
||
| GO:0001588 |
dopamine receptor activity, coupled via Gs |
MGI:MGI:76570 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0001588 |
dopamine receptor activity, coupled via Gs |
MGI:MGI:80600 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0001659 |
temperature homeostasis |
MGI:MGI:3797707 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857158 |
P |
From MGI |
||
| GO:0001661 |
conditioned taste aversion |
MGI:MGI:3590453 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857158 |
P |
From MGI |
||
| GO:0001662 |
behavioral fear response |
MGI:MGI:1930467 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857158 |
P |
From MGI |
||
| GO:0001662 |
behavioral fear response |
MGI:MGI:2136089 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857158 |
P |
From MGI |
||
| GO:0001963 |
synaptic transmission, dopaminergic |
MGI:MGI:3663985 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2159306 |
P |
From MGI |
||
| GO:0001963 |
synaptic transmission, dopaminergic |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0001975 |
response to amphetamine |
MGI:MGI:1195902 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857158 |
P |
From MGI |
||
| GO:0001975 |
response to amphetamine |
MGI:MGI:1351083 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2159306 |
P |
From MGI |
||
| GO:0001975 |
response to amphetamine |
MGI:MGI:2137377 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0001975 |
response to amphetamine |
MGI:MGI:3610905 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:94927 |
P |
From MGI |
||
| GO:0001975 |
response to amphetamine |
MGI:MGI:3626135 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:94924 |
P |
From MGI |
||
| GO:0001975 |
response to amphetamine |
MGI:MGI:3711455 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3527157 |
P |
From MGI |
||
| GO:0001975 |
response to amphetamine |
MGI:MGI:3797707 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857158 |
P |
From MGI |
||
| GO:0004871 |
signal transducer activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0807 |
F |
From MGI |
||
| GO:0004872 |
receptor activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0675 |
F |
From MGI |
||
| GO:0004930 |
G-protein coupled receptor activity |
MGI:MGI:3032880 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004930 |
G-protein coupled receptor activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004952 |
dopamine receptor activity |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004952 |
dopamine receptor activity |
MGI:MGI:3811680 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:85829 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:2387279 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:99673 |
C |
From MGI |
||
| GO:0005622 |
intracellular |
MGI:MGI:3701153 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:94924 |
C |
From MGI |
||
| GO:0005622 |
intracellular |
MGI:MGI:3797712 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857158 |
C |
From MGI |
||
| GO:0005622 |
intracellular |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:85829 |
IMP: Inferred from Mutant Phenotype |
C |
From MGI |
|||
| GO:0005624 |
membrane fraction |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005624 |
membrane fraction |
MGI:MGI:69969 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005624 |
membrane fraction |
MGI:MGI:80600 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005624 |
membrane fraction |
MGI:MGI:85829 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:1098091 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005783 |
endoplasmic reticulum |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005901 |
caveola |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006469 |
negative regulation of protein kinase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006606 |
protein import into nucleus |
MGI:MGI:3797712 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857158 |
P |
From MGI |
||
| GO:0006886 |
intracellular protein transport |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006936 |
muscle contraction |
MGI:MGI:3703826 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3707260 |
P |
From MGI |
||
| GO:0007165 |
signal transduction |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0807 |
P |
From MGI |
||
| GO:0007186 |
G-protein coupled receptor signaling pathway |
MGI:MGI:3032880 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007186 |
G-protein coupled receptor signaling pathway |
MGI:MGI:3719553 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857158 |
P |
From MGI |
||
| GO:0007187 |
G-protein signaling, coupled to cyclic nucleotide second messenger |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007189 |
activation of adenylate cyclase activity by G-protein signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007190 |
activation of adenylate cyclase activity |
MGI:MGI:2450485 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007190 |
activation of adenylate cyclase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007190 |
activation of adenylate cyclase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007191 |
activation of adenylate cyclase activity by dopamine receptor signaling pathway |
MGI:MGI:2178201 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007191 |
activation of adenylate cyclase activity by dopamine receptor signaling pathway |
MGI:MGI:2387279 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:99673 |
P |
From MGI |
||
| GO:0007191 |
activation of adenylate cyclase activity by dopamine receptor signaling pathway |
MGI:MGI:2660986 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007191 |
activation of adenylate cyclase activity by dopamine receptor signaling pathway |
MGI:MGI:3701153 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:95774 |
P |
From MGI |
||
| GO:0007191 |
activation of adenylate cyclase activity by dopamine receptor signaling pathway |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007191 |
activation of adenylate cyclase activity by dopamine receptor signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007191 |
activation of adenylate cyclase activity by dopamine receptor signaling pathway |
MGI:MGI:80600 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007191 |
activation of adenylate cyclase activity by dopamine receptor signaling pathway |
MGI:MGI:85829 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0007212 |
dopamine receptor signaling pathway |
MGI:MGI:2181304 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:94924 |
P |
From MGI |
||
| GO:0007212 |
dopamine receptor signaling pathway |
MGI:MGI:3626135 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:94924 |
P |
From MGI |
||
| GO:0007212 |
dopamine receptor signaling pathway |
MGI:MGI:3663985 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2159306 |
P |
From MGI |
||
| GO:0007212 |
dopamine receptor signaling pathway |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007268 |
synaptic transmission |
MGI:MGI:1927281 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007268 |
synaptic transmission |
MGI:MGI:2679747 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007268 |
synaptic transmission |
MGI:MGI:3626135 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007268 |
synaptic transmission |
MGI:MGI:3689286 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007268 |
synaptic transmission |
MGI:MGI:3811680 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007268 |
synaptic transmission |
MGI:MGI:64569 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007268 |
synaptic transmission |
MGI:MGI:69539 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007268 |
synaptic transmission |
MGI:MGI:76570 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007268 |
synaptic transmission |
MGI:MGI:80600 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007610 |
behavior |
MGI:MGI:1932164 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857158 |
P |
From MGI |
||
| GO:0007610 |
behavior |
MGI:MGI:3575240 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857158 |
P |
From MGI |
||
| GO:0007610 |
behavior |
MGI:MGI:3703826 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3707260 |
P |
From MGI |
||
| GO:0007610 |
behavior |
MGI:MGI:69969 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857158 |
P |
From MGI |
||
| GO:0007612 |
learning |
MGI:MGI:3530728 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2159306 |
P |
From MGI |
||
| GO:0007613 |
memory |
MGI:MGI:3607825 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857158 |
P |
From MGI |
||
| GO:0007617 |
mating behavior |
MGI:MGI:1314754 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007625 |
grooming behavior |
MGI:MGI:1313196 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857158 |
P |
From MGI |
||
| GO:0007625 |
grooming behavior |
MGI:MGI:1339880 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857158 |
P |
From MGI |
||
| GO:0007626 |
locomotory behavior |
MGI:MGI:1195902 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857158 |
P |
From MGI |
||
| GO:0007626 |
locomotory behavior |
MGI:MGI:1274984 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857158 |
P |
From MGI |
||
| GO:0007626 |
locomotory behavior |
MGI:MGI:1351083 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2159306 |
P |
From MGI |
||
| GO:0007626 |
locomotory behavior |
MGI:MGI:1929539 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:94862 |
P |
From MGI |
||
| GO:0007626 |
locomotory behavior |
MGI:MGI:2137377 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0007626 |
locomotory behavior |
MGI:MGI:3050733 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:94924 |
P |
From MGI |
||
| GO:0007626 |
locomotory behavior |
MGI:MGI:3530728 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2159306 |
P |
From MGI |
||
| GO:0007626 |
locomotory behavior |
MGI:MGI:3586401 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2159306 |
P |
From MGI |
||
| GO:0007626 |
locomotory behavior |
MGI:MGI:3607822 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1857159 |
P |
From MGI |
||
| GO:0007626 |
locomotory behavior |
MGI:MGI:3664164 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2159306 |
P |
From MGI |
||
| GO:0007626 |
locomotory behavior |
MGI:MGI:3703826 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3707260 |
P |
From MGI |
||
| GO:0007626 |
locomotory behavior |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007628 |
adult walking behavior |
MGI:MGI:1098940 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:94925 |
P |
From MGI |
||
| GO:0007628 |
adult walking behavior |
MGI:MGI:3610833 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:94925 |
P |
From MGI |
||
| GO:0007628 |
adult walking behavior |
MGI:MGI:69539 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2159306 |
P |
From MGI |
||
| GO:0007631 |
feeding behavior |
MGI:MGI:3050733 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:94924 |
P |
From MGI |
||
| GO:0008144 |
drug binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0008306 |
associative learning |
MGI:MGI:1274984 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857158 |
P |
From MGI |
||
| GO:0008306 |
associative learning |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008542 |
visual learning |
MGI:MGI:1274984 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857158 |
P |
From MGI |
||
| GO:0008542 |
visual learning |
MGI:MGI:3530728 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2159306 |
P |
From MGI |
||
| GO:0008542 |
visual learning |
MGI:MGI:3607822 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857159 |
P |
From MGI |
||
| GO:0008542 |
visual learning |
MGI:MGI:3607825 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857158 |
P |
From MGI |
||
| GO:0008542 |
visual learning |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0014002 |
astrocyte development |
MGI:MGI:3703826 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3707260 |
P |
From MGI |
||
| GO:0015872 |
dopamine transport |
MGI:MGI:3719553 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857158 |
P |
From MGI |
||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016021 |
integral to membrane |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0019226 |
transmission of nerve impulse |
MGI:MGI:2667765 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2159306 |
P |
From MGI |
||
| GO:0019228 |
regulation of action potential in neuron |
MGI:MGI:3663985 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2159306 |
P |
From MGI |
||
| GO:0019722 |
calcium-mediated signaling |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0021542 |
dentate gyrus development |
MGI:MGI:3703826 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3707260 |
P |
From MGI |
||
| GO:0021756 |
striatum development |
MGI:MGI:3703826 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3707260 |
P |
From MGI |
||
| GO:0021766 |
hippocampus development |
MGI:MGI:3703826 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3707260 |
P |
From MGI |
||
| GO:0021853 |
cerebral cortex GABAergic interneuron migration |
MGI:MGI:3709536 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857875 |
P |
From MGI |
||
| GO:0030335 |
positive regulation of cell migration |
MGI:MGI:3709536 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857875 |
P |
From MGI |
||
| GO:0030336 |
negative regulation of cell migration |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030424 |
axon |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0030425 |
dendrite |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0030432 |
peristalsis |
MGI:MGI:3050733 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:94924 |
P |
From MGI |
||
| GO:0030819 |
positive regulation of cAMP biosynthetic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030819 |
positive regulation of cAMP biosynthetic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0031161 |
phosphatidylinositol catabolic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0035106 |
operant conditioning |
MGI:MGI:3622838 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857158 |
P |
From MGI |
||
| GO:0035106 |
operant conditioning |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0035240 |
dopamine binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0042053 |
regulation of dopamine metabolic process |
MGI:MGI:2136539 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857158 |
P |
From MGI |
||
| GO:0042220 |
response to cocaine |
MGI:MGI:1098091 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857158 |
P |
From MGI |
||
| GO:0042220 |
response to cocaine |
MGI:MGI:1351083 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2159306 |
P |
From MGI |
||
| GO:0042220 |
response to cocaine |
MGI:MGI:2137377 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0042220 |
response to cocaine |
MGI:MGI:3663985 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2159306 |
P |
From MGI |
||
| GO:0042220 |
response to cocaine |
MGI:MGI:3761901 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2159306 |
P |
From MGI |
||
| GO:0042220 |
response to cocaine |
MGI:MGI:3765089 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2159306 |
P |
From MGI |
||
| GO:0042321 |
negative regulation of circadian sleep/wake cycle, sleep |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042493 |
response to drug |
MGI:MGI:1932164 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857158 |
P |
From MGI |
||
| GO:0042493 |
response to drug |
MGI:MGI:77732 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0042755 |
eating behavior |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043025 |
neuronal cell body |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0043197 |
dendritic spine |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0043269 |
regulation of ion transport |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045762 |
positive regulation of adenylate cyclase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0046323 |
glucose import |
MGI:MGI:1932164 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857158 |
P |
From MGI |
||
| GO:0046488 |
phosphatidylinositol metabolic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0046960 |
sensitization |
MGI:MGI:3610905 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:94927 |
P |
From MGI |
||
| GO:0048148 |
behavioral response to cocaine |
MGI:MGI:3711455 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3527157 |
P |
From MGI |
||
| GO:0048148 |
behavioral response to cocaine |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0048169 |
regulation of long-term neuronal synaptic plasticity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051281 |
positive regulation of release of sequestered calcium ion into cytosol |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051482 |
elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051968 |
positive regulation of synaptic transmission, glutamatergic |
MGI:MGI:82736 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857158 |
P |
From MGI |
||
| GO:0060158 |
activation of phospholipase C activity by dopamine receptor signaling pathway |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0060158 |
activation of phospholipase C activity by dopamine receptor signaling pathway |
MGI:MGI:3621386 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0060158 |
activation of phospholipase C activity by dopamine receptor signaling pathway |
MGI:MGI:3701153 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:94924 |
P |
From MGI |
||
| GO:0060291 |
long-term synaptic potentiation |
MGI:MGI:3036431 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857158 |
P |
From MGI |
||
| GO:0060291 |
long-term synaptic potentiation |
MGI:MGI:3586401 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2159306 |
P |
From MGI |
||
| GO:0060291 |
long-term synaptic potentiation |
MGI:MGI:3610662 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857158 |
P |
From MGI |
||
| GO:0060292 |
long term synaptic depression |
MGI:MGI:3036431 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857158 |
P |
From MGI |
||
| GO:0071870 |
cellular response to catecholamine stimulus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
|
NOT |
GO:0001964 |
startle response |
MGI:MGI:3721754 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857158 |
P |
From MGI |
|
|
NOT |
GO:0001964 |
startle response |
MGI:MGI:3757792 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
||
|
NOT |
GO:0060134 |
prepulse inhibition |
MGI:MGI:3654415 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857158 |
P |
From MGI |
|
|
NOT |
GO:0060134 |
prepulse inhibition |
MGI:MGI:3721754 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857158 |
P |
From MGI |
|
|
NOT |
GO:0060134 |
prepulse inhibition |
MGI:MGI:3757792 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Bender M et al. (1997) D1 receptors mediate dopamine action in the fetal suprachiasmatic nuclei: studies of mice with targeted deletion of the D1 dopamine receptor gene. Brain Res Mol Brain Res 49: 271-7 PubMed GONUTS page
- ↑ 2.0 2.1 Wang Y et al. (2000) Dopamine D2 long receptor-deficient mice display alterations in striatum-dependent functions. J Neurosci 20: 8305-14 PubMed GONUTS page
- ↑ 3.0 3.1 Goldberg MS et al. (2003) Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons. J Biol Chem 278: 43628-35 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Centonze D et al. (2003) Distinct roles of D1 and D5 dopamine receptors in motor activity and striatal synaptic plasticity. J Neurosci 23: 8506-12 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Glickstein SB et al. (2002) Mice lacking dopamine D2 and D3 receptors have spatial working memory deficits. J Neurosci 22: 5619-29 PubMed GONUTS page
- ↑ 6.0 6.1 Leonard SK et al. (2006) Low affinity binding of the classical D1 antagonist SCH23390 in rodent brain: potential interaction with A2A and D2-like receptors. Brain Res 1117: 25-37 PubMed GONUTS page
- ↑ 7.0 7.1 Qin ZH et al. (1994) Lesions of mouse striatum induced by 6-hydroxydopamine differentially alter the density, rate of synthesis, and level of gene expression of D1 and D2 dopamine receptors. J Neurochem 62: 411-20 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 Xu M et al. (1994) Dopamine D1 receptor mutant mice are deficient in striatal expression of dynorphin and in dopamine-mediated behavioral responses. Cell 79: 729-42 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 Drago J et al. (1994) Altered striatal function in a mutant mouse lacking D1A dopamine receptors. Proc Natl Acad Sci U S A 91: 12564-8 PubMed GONUTS page
- ↑ 10.0 10.1 Baik JH et al. (1995) Parkinsonian-like locomotor impairment in mice lacking dopamine D2 receptors. Nature 377: 424-8 PubMed GONUTS page
- ↑ 11.0 11.1 11.2 11.3 Noble F & Cox BM (1996) Differences among mouse strains in the regulation by mu, delta 1 and delta 2 opioid receptors of striatal adenylyl cyclases activated by dopamine D1 or adenosine A2a receptors. Brain Res 716: 107-17 PubMed GONUTS page
- ↑ 12.0 12.1 Ito M et al. (2008) Hyperthermic and lethal effects of methamphetamine: roles of dopamine D1 and D2 receptors. Neurosci Lett 438: 327-9 PubMed GONUTS page
- ↑ Cannon CM et al. (2005) Mice lacking dopamine D1 receptors express normal lithium chloride-induced conditioned taste aversion for salt but not sucrose. Eur J Neurosci 21: 2600-4 PubMed GONUTS page
- ↑ El-Ghundi M et al. (2001) Prolonged fear responses in mice lacking dopamine D1 receptor. Brain Res 892: 86-93 PubMed GONUTS page
- ↑ Kojima T et al. (2001) Genomic organization of the Shc-related phosphotyrosine adapters and characterization of the full-length Sck/ShcB: specific association of p68-Sck/ShcB with pp135. Biochem Biophys Res Commun 284: 1039-47 PubMed GONUTS page
- ↑ 16.0 16.1 16.2 16.3 Naccache SN et al. (2006) Binding of internalized receptors to the PDZ domain of GIPC/synectin recruits myosin VI to endocytic vesicles. Proc Natl Acad Sci U S A 103: 12735-40 PubMed GONUTS page
- ↑ 17.0 17.1 Crawford CA et al. (1997) Effects of repeated amphetamine treatment on the locomotor activity of the dopamine D1A-deficient mouse. Neuroreport 8: 2523-7 PubMed GONUTS page
- ↑ 18.0 18.1 18.2 Xu M et al. (2000) Behavioral responses to cocaine and amphetamine administration in mice lacking the dopamine D1 receptor. Brain Res 852: 198-207 PubMed GONUTS page
- ↑ 19.0 19.1 19.2 Dracheva S et al. (1999) Paradoxical locomotor behavior of dopamine D1 receptor transgenic mice. Exp Neurol 157: 169-79 PubMed GONUTS page
- ↑ 20.0 20.1 Karper PE et al. (2002) Role of D1-like receptors in amphetamine-induced behavioral sensitization: a study using D1A receptor knockout mice. Psychopharmacology (Berl) 159: 407-14 PubMed GONUTS page
- ↑ 21.0 21.1 Heusner CL & Palmiter RD (2005) Expression of mutant NMDA receptors in dopamine D1 receptor-containing cells prevents cocaine sensitization and decreases cocaine preference. J Neurosci 25: 6651-7 PubMed GONUTS page
- ↑ 22.0 22.1 Weissman JT et al. (2004) G-protein-coupled receptor-mediated activation of rap GTPases: characterization of a novel Galphai regulated pathway. Oncogene 23: 241-9 PubMed GONUTS page
- ↑ 23.0 23.1 Bailey A et al. (2008) Decrease of D2 receptor binding but increase in D2-stimulated G-protein activation, dopamine transporter binding and behavioural sensitization in brains of mice treated with a chronic escalating dose 'binge' cocaine administration paradigm. Eur J Neurosci 28: 759-70 PubMed GONUTS page
- ↑ 24.0 24.1 24.2 24.3 Friedman E et al. (1997) D1-like dopaminergic activation of phosphoinositide hydrolysis is independent of D1A dopamine receptors: evidence from D1A knockout mice. Mol Pharmacol 51: 6-11 PubMed GONUTS page
- ↑ 25.0 25.1 Lee KW et al. (2002) Impaired D2 dopamine receptor function in mice lacking type 5 adenylyl cyclase. J Neurosci 22: 7931-40 PubMed GONUTS page
- ↑ 26.0 26.1 26.2 Rashid AJ et al. (2007) D1-D2 dopamine receptor heterooligomers with unique pharmacology are coupled to rapid activation of Gq/11 in the striatum. Proc Natl Acad Sci U S A 104: 654-9 PubMed GONUTS page
- ↑ 27.0 27.1 Stipanovich A et al. (2008) A phosphatase cascade by which rewarding stimuli control nucleosomal response. Nature 453: 879-84 PubMed GONUTS page
- ↑ 28.0 28.1 28.2 28.3 28.4 28.5 28.6 Gantois I et al. (2007) Ablation of D1 dopamine receptor-expressing cells generates mice with seizures, dystonia, hyperactivity, and impaired oral behavior. Proc Natl Acad Sci U S A 104: 4182-7 PubMed GONUTS page
- ↑ 29.0 29.1 Hervé D et al. (2001) Galpha(olf) levels are regulated by receptor usage and control dopamine and adenosine action in the striatum. J Neurosci 21: 4390-9 PubMed GONUTS page
- ↑ Schwindinger WF et al. (2003) Loss of G protein gamma 7 alters behavior and reduces striatal alpha(olf) level and cAMP production. J Biol Chem 278: 6575-9 PubMed GONUTS page
- ↑ Drouin C et al. (2002) Alpha1b-adrenergic receptors control locomotor and rewarding effects of psychostimulants and opiates. J Neurosci 22: 2873-84 PubMed GONUTS page
- ↑ Iwamoto T et al. (2003) Motor dysfunction in type 5 adenylyl cyclase-null mice. J Biol Chem 278: 16936-40 PubMed GONUTS page
- ↑ Usiello A et al. (2000) Distinct functions of the two isoforms of dopamine D2 receptors. Nature 408: 199-203 PubMed GONUTS page
- ↑ 34.0 34.1 34.2 Miyamoto S et al. (2001) Blunted brain metabolic response to ketamine in mice lacking D(1A) dopamine receptors. Brain Res 894: 167-80 PubMed GONUTS page
- ↑ Tomiyama K et al. (2002) Phenotypic resolution of spontaneous and D1-like agonist-induced orofacial movement topographies in congenic dopamine D1A receptor 'knockout' mice. Neuropharmacology 42: 644-52 PubMed GONUTS page
- ↑ 36.0 36.1 36.2 Tran AH et al. (2005) Dopamine D1 receptors involved in locomotor activity and accumbens neural responses to prediction of reward associated with place. Proc Natl Acad Sci U S A 102: 2117-22 PubMed GONUTS page
- ↑ 37.0 37.1 El-Ghundi M et al. (1999) Spatial learning deficit in dopamine D(1) receptor knockout mice. Eur J Pharmacol 383: 95-106 PubMed GONUTS page
- ↑ Szczypka MS et al. (1998) Dopamine-stimulated sexual behavior is testosterone dependent in mice. Behav Neurosci 112: 1229-35 PubMed GONUTS page
- ↑ Cromwell HC et al. (1998) Action sequencing is impaired in D1A-deficient mutant mice. Eur J Neurosci 10: 2426-32 PubMed GONUTS page
- ↑ Drago F et al. (1999) The expression of neuropeptide-induced excessive grooming behavior in dopamine D1 and D2 receptor-deficient mice. Eur J Pharmacol 365: 125-31 PubMed GONUTS page
- ↑ 41.0 41.1 41.2 Smith DR et al. (1998) Behavioural assessment of mice lacking D1A dopamine receptors. Neuroscience 86: 135-46 PubMed GONUTS page
- ↑ Ralph RJ et al. (2001) Prepulse inhibition deficits and perseverative motor patterns in dopamine transporter knock-out mice: differential effects of D1 and D2 receptor antagonists. J Neurosci 21: 305-13 PubMed GONUTS page
- ↑ 43.0 43.1 43.2 Kobayashi M et al. (2004) Simultaneous absence of dopamine D1 and D2 receptor-mediated signaling is lethal in mice. Proc Natl Acad Sci U S A 101: 11465-70 PubMed GONUTS page
- ↑ 44.0 44.1 Karasinska JM et al. (2000) Modification of dopamine D(1) receptor knockout phenotype in mice lacking both dopamine D(1) and D(3) receptors. Eur J Pharmacol 399: 171-81 PubMed GONUTS page
- ↑ Xu M et al. (1994) Elimination of cocaine-induced hyperactivity and dopamine-mediated neurophysiological effects in dopamine D1 receptor mutant mice. Cell 79: 945-55 PubMed GONUTS page
- ↑ Xu M et al. (1997) Dopamine D3 receptor mutant mice exhibit increased behavioral sensitivity to concurrent stimulation of D1 and D2 receptors. Neuron 19: 837-48 PubMed GONUTS page
- ↑ Wong JY et al. (2003) Essential conservation of D1 mutant phenotype at the level of individual topographies of behaviour in mice lacking both D1 and D3 dopamine receptors. Psychopharmacology (Berl) 167: 167-73 PubMed GONUTS page
- ↑ Centonze D et al. (2003) Receptor subtypes involved in the presynaptic and postsynaptic actions of dopamine on striatal interneurons. J Neurosci 23: 6245-54 PubMed GONUTS page
- ↑ 49.0 49.1 Crandall JE et al. (2007) Dopamine receptor activation modulates GABA neuron migration from the basal forebrain to the cerebral cortex. J Neurosci 27: 3813-22 PubMed GONUTS page
- ↑ El-Ghundi M et al. (2003) Attenuation of sucrose reinforcement in dopamine D1 receptor deficient mice. Eur J Neurosci 17: 851-62 PubMed GONUTS page
- ↑ Parish CL et al. (2001) The role of dopamine receptors in regulating the size of axonal arbors. J Neurosci 21: 5147-57 PubMed GONUTS page
- ↑ Zhang D et al. (2002) The dopamine D1 receptor is a critical mediator for cocaine-induced gene expression. J Neurochem 82: 1453-64 PubMed GONUTS page
- ↑ Caine SB et al. (2007) Lack of self-administration of cocaine in dopamine D1 receptor knock-out mice. J Neurosci 27: 13140-50 PubMed GONUTS page
- ↑ Verma A & Kulkarni SK (1995) Role of D1/D2 dopamine and N-methyl-D-aspartate (NMDA) receptors in morphine tolerance and dependence in mice. Eur Neuropsychopharmacol 5: 81-7 PubMed GONUTS page
- ↑ Levine MS et al. (1996) Modulatory actions of dopamine on NMDA receptor-mediated responses are reduced in D1A-deficient mutant mice. J Neurosci 16: 5870-82 PubMed GONUTS page
- ↑ Mizuo K et al. (2004) Enhancement of dopamine-induced signaling responses in the forebrain of mice lacking dopamine D3 receptor. Neurosci Lett 358: 13-6 PubMed GONUTS page
- ↑ 57.0 57.1 Huang YY et al. (2004) Genetic evidence for the bidirectional modulation of synaptic plasticity in the prefrontal cortex by D1 receptors. Proc Natl Acad Sci U S A 101: 3236-41 PubMed GONUTS page
- ↑ Matthies H et al. (1997) Dopamine D1-deficient mutant mice do not express the late phase of hippocampal long-term potentiation. Neuroreport 8: 3533-5 PubMed GONUTS page
- ↑ 59.0 59.1 Vinkers CH et al. (2007) Role of dopamine D1 and D2 receptors in CRF-induced disruption of sensorimotor gating. Pharmacol Biochem Behav 86: 550-8 PubMed GONUTS page
- ↑ 60.0 60.1 Mohr D et al. (2007) Accumbal dopamine D2 receptors are important for sensorimotor gating in C3H mice. Neuroreport 18: 1493-7 PubMed GONUTS page
- ↑ Ralph-Williams RJ et al. (2002) Differential effects of direct and indirect dopamine agonists on prepulse inhibition: a study in D1 and D2 receptor knock-out mice. J Neurosci 22: 9604-11 PubMed GONUTS page
