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MGI:Dnmt1
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Dnmt1 ( synonyms: Cxxc9, Dnmt1o, MommeD2, MTase ) | |
| Protein Name(s) | DNA methyltransferase (cytosine-5) 1, | |
| External Links | ||
| MGI | MGI:94912 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000792 |
heterochromatin |
MGI:MGI:2682084 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:2152690 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0003690 |
double-stranded DNA binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_445806 |
F |
From MGI |
||
| GO:0003723 |
RNA binding |
MGI:MGI:4830046 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003824 |
catalytic activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0021 |
F |
From MGI |
||
| GO:0003886 |
DNA (cytosine-5-)-methyltransferase activity |
MGI:MGI:2152690 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003886 |
DNA (cytosine-5-)-methyltransferase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_445806 |
F |
From MGI |
||
| GO:0005515 |
protein binding |
MGI:MGI:2448855 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3587127 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3687778 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3778150 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4441123 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:2389598 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3051927 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3778150 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_445806 |
C |
From MGI |
||
| GO:0005657 |
replication fork |
MGI:MGI:2448855 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005721 |
centromeric heterochromatin |
MGI:MGI:3852629 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0963 |
C |
From MGI |
||
| GO:0006306 |
DNA methylation |
MGI:MGI:2152690 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006351 |
transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0804 |
P |
From MGI |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0805 |
P |
From MGI |
||
| GO:0008134 |
transcription factor binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0008152 |
metabolic process |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0021 |
P |
From MGI |
||
| GO:0008168 |
methyltransferase activity |
MGI:MGI:3687778 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0008270 |
zinc ion binding |
MGI:MGI:2152690 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0008327 |
methyl-CpG binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_445806 |
F |
From MGI |
||
| GO:0008327 |
methyl-CpG binding |
MGI:MGI:4830046 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0009008 |
DNA-methyltransferase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0010216 |
maintenance of DNA methylation |
MGI:MGI:3852629 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0010216 |
maintenance of DNA methylation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_445806 |
P |
From MGI |
||
| GO:0010216 |
maintenance of DNA methylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0010424 |
DNA methylation on cytosine within a CG sequence |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_445806 |
P |
From MGI |
||
| GO:0010468 |
regulation of gene expression |
MGI:MGI:3662835 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2156895 |
P |
From MGI |
||
| GO:0010628 |
positive regulation of gene expression |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0016458 |
gene silencing |
MGI:MGI:3687778 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0016568 |
chromatin modification |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0156 |
P |
From MGI |
||
| GO:0016740 |
transferase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0808 |
F |
From MGI |
||
| GO:0019904 |
protein domain specific binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_445806 |
F |
From MGI |
||
| GO:0032259 |
methylation |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0489 |
P |
From MGI |
||
| GO:0042127 |
regulation of cell proliferation |
MGI:MGI:1861347 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:88039 |
P |
From MGI |
||
| GO:0042826 |
histone deacetylase binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_445806 |
F |
From MGI |
||
| GO:0043234 |
protein complex |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_445806 |
C |
From MGI |
||
| GO:0045322 |
unmethylated CpG binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_445806 |
F |
From MGI |
||
| GO:0045892 |
negative regulation of transcription, DNA-dependent |
MGI:MGI:2448855 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045892 |
negative regulation of transcription, DNA-dependent |
MGI:MGI:3698916 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2156895 |
P |
From MGI |
||
| GO:0046498 |
S-adenosylhomocysteine metabolic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_445806 |
P |
From MGI |
||
| GO:0046499 |
S-adenosylmethioninamine metabolic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_445806 |
P |
From MGI |
||
| GO:0046500 |
S-adenosylmethionine metabolic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_445806 |
P |
From MGI |
||
| GO:0046872 |
metal ion binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0479 |
F |
From MGI |
||
| GO:0051571 |
positive regulation of histone H3-K4 methylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051573 |
negative regulation of histone H3-K9 methylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051718 |
DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_445806 |
F |
From MGI |
||
| GO:0071230 |
cellular response to amino acid stimulus |
MGI:MGI:4833768 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0090116 |
C-5 methylation of cytosine |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_445806 |
P |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Craig JM et al. (2003) Analysis of mammalian proteins involved in chromatin modification reveals new metaphase centromeric proteins and distinct chromosomal distribution patterns. Hum Mol Genet 12: 3109-21 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Fatemi M et al. (2001) The activity of the murine DNA methyltransferase Dnmt1 is controlled by interaction of the catalytic domain with the N-terminal part of the enzyme leading to an allosteric activation of the enzyme after binding to methylated DNA. J Mol Biol 309: 1189-99 PubMed GONUTS page
- ↑ 3.0 3.1 Mohammad F et al. (2010) Kcnq1ot1 noncoding RNA mediates transcriptional gene silencing by interacting with Dnmt1. Development 137: 2493-9 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Rountree MR et al. (2000) DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci. Nat Genet 25: 269-77 PubMed GONUTS page
- ↑ Zhou Y & Grummt I (2005) The PHD finger/bromodomain of NoRC interacts with acetylated histone H4K16 and is sufficient for rDNA silencing. Curr Biol 15: 1434-8 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Fuks F et al. (2000) DNA methyltransferase Dnmt1 associates with histone deacetylase activity. Nat Genet 24: 88-91 PubMed GONUTS page
- ↑ 7.0 7.1 Sajedi E et al. (2008) DNMT1 interacts with the developmental transcriptional repressor HESX1. Biochim Biophys Acta 1783: 131-43 PubMed GONUTS page
- ↑ Easwaran HP et al. (2004) Replication-independent chromatin loading of Dnmt1 during G2 and M phases. EMBO Rep 5: 1181-6 PubMed GONUTS page
- ↑ Sakai Y et al. (2001) Expression of DNA methyltransferase (Dnmt1) in testicular germ cells during development of mouse embryo. Cell Struct Funct 26: 685-91 PubMed GONUTS page
- ↑ La Salle S et al. (2004) Windows for sex-specific methylation marked by DNA methyltransferase expression profiles in mouse germ cells. Dev Biol 268: 403-15 PubMed GONUTS page
- ↑ 11.0 11.1 Schermelleh L et al. (2007) Dynamics of Dnmt1 interaction with the replication machinery and its role in postreplicative maintenance of DNA methylation. Nucleic Acids Res 35: 4301-12 PubMed GONUTS page
- ↑ Bilic I et al. (2006) Negative regulation of CD8 expression via Cd8 enhancer-mediated recruitment of the zinc finger protein MAZR. Nat Immunol 7: 392-400 PubMed GONUTS page
- ↑ Cormier RT & Dove WF (2000) Dnmt1N/+ reduces the net growth rate and multiplicity of intestinal adenomas in C57BL/6-multiple intestinal neoplasia (Min)/+ mice independently of p53 but demonstrates strong synergy with the modifier of Min 1(AKR) resistance allele. Cancer Res 60: 3965-70 PubMed GONUTS page
- ↑ Green K et al. (2007) A developmental window of opportunity for imprinted gene silencing mediated by DNA methylation and the Kcnq1ot1 noncoding RNA. Mamm Genome 18: 32-42 PubMed GONUTS page
- ↑ Pogribny IP et al. (2010) Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice. Lab Invest 90: 1437-46 PubMed GONUTS page
