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MGI:Dmpk
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Dmpk ( synonyms: DM, Dm15 ) | |
| Protein Name(s) | dystrophia myotonica-protein kinase, | |
| External Links | ||
| MGI | MGI:94906 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000166 |
nucleotide binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0547 |
F |
From MGI |
||
| GO:0002028 |
regulation of sodium ion transport |
MGI:MGI:3721737 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2182402 |
P |
From MGI |
||
| GO:0004672 |
protein kinase activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0004674 |
protein serine/threonine kinase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005524 |
ATP binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:1097019 |
IMP: Inferred from Mutant Phenotype |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0539 |
C |
From MGI |
||
| GO:0005737 |
cytoplasm |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0963 |
C |
From MGI |
||
| GO:0005739 |
mitochondrion |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0496 |
C |
From MGI |
||
| GO:0005741 |
mitochondrial outer membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-1000 |
C |
From MGI |
||
| GO:0005783 |
endoplasmic reticulum |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0256 |
C |
From MGI |
||
| GO:0005789 |
endoplasmic reticulum membrane |
MGI:MGI:3529390 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005829 |
cytosol |
MGI:MGI:3529390 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:3806406 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006468 |
protein phosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006874 |
cellular calcium ion homeostasis |
MGI:MGI:1097019 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0006998 |
nuclear envelope organization |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006998 |
nuclear envelope organization |
MGI:MGI:5298442 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0008016 |
regulation of heart contraction |
MGI:MGI:3575053 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0008016 |
regulation of heart contraction |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0010657 |
muscle cell apoptotic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0010830 |
regulation of myotube differentiation |
MGI:MGI:3806406 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0014722 |
regulation of skeletal muscle contraction by calcium ion signaling |
MGI:MGI:1097019 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0014853 |
regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction |
MGI:MGI:3721737 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2182402 |
P |
From MGI |
||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016021 |
integral to membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0812 |
C |
From MGI |
||
| GO:0016301 |
kinase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0418 |
F |
From MGI |
||
| GO:0016310 |
phosphorylation |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0418 |
P |
From MGI |
||
| GO:0016529 |
sarcoplasmic reticulum |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0703 |
C |
From MGI |
||
| GO:0016740 |
transferase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0808 |
F |
From MGI |
||
| GO:0016772 |
transferase activity, transferring phosphorus-containing groups |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0017020 |
myosin phosphatase regulator activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0031307 |
integral to mitochondrial outer membrane |
MGI:MGI:3529390 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0031307 |
integral to mitochondrial outer membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0031965 |
nuclear membrane |
MGI:MGI:3529390 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0033017 |
sarcoplasmic reticulum membrane |
MGI:MGI:3575053 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0046872 |
metal ion binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0479 |
F |
From MGI |
||
| GO:0050790 |
regulation of catalytic activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051823 |
regulation of synapse structural plasticity |
MGI:MGI:3608373 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Mistry DJ et al. (2001) Skeletal muscle Na currents in mice heterozygous for Six5 deficiency. Physiol Genomics 6: 153-8 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Benders AA et al. (1997) Myotonic dystrophy protein kinase is involved in the modulation of the Ca2+ homeostasis in skeletal muscle cells. J Clin Invest 100: 1440-7 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 van Herpen RE et al. (2005) Divergent mitochondrial and endoplasmic reticulum association of DMPK splice isoforms depends on unique sequence arrangements in tail anchors. Mol Cell Biol 25: 1402-14 PubMed GONUTS page
- ↑ 4.0 4.1 Harmon EB et al. (2008) Myotonic dystrophy protein kinase is expressed in embryonic myocytes and is required for myotube formation. Dev Dyn 237: 2353-66 PubMed GONUTS page
- ↑ Harmon EB et al. (2011) Myotonic dystrophy protein kinase is critical for nuclear envelope integrity. J Biol Chem 286: 40296-306 PubMed GONUTS page
- ↑ 6.0 6.1 Kaliman P et al. (2005) Myotonic dystrophy protein kinase phosphorylates phospholamban and regulates calcium uptake in cardiomyocyte sarcoplasmic reticulum. J Biol Chem 280: 8016-21 PubMed GONUTS page
- ↑ Schulz PE et al. (2003) A role for myotonic dystrophy protein kinase in synaptic plasticity. J Neurophysiol 89: 1177-86 PubMed GONUTS page
